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Insider Trading Arrangements

3 Months Ended

Sep. 30, 2025

shares

Trading Arrangements, by Individual

Material Terms of Trading Arrangement

The following table describes, for the quarterly period covered by this report, each trading arrangement for the sale or purchase of our securities adopted or terminated by our directors and officers that is either (1) a contract, instruction or written plan intended to satisfy the affirmative defense conditions of Rule 10b5-1(c), or a Rule 10b5-1 trading arrangement, or (2) a “non-Rule 10b5-1 trading arrangement” (as defined in Item 408(c) of Regulation S-K):

Name (Title)

Action Taken  (Date of Action)

Type of Trading Arrangement

Nature of Trading Arrangement

Duration of Trading Arrangement

Aggregate Number of  Securities

Cedric G Francois President and Chief Executive Officer

Termination 8/14/2025

Rule 10b5-1 trading arrangement

Sale

(1

)

(1

)

Caroline Baumal Chief Medical Officer

Adoption 8/19/2025

Rule 10b5-1 trading arrangement

Sale

Until 2/27/2027, or such earlier date upon which all transactions are completed or expire without execution

Up to 14,698 shares

James Chopas Vice President, Corporate Controller and Chief Accounting Officer

Adoption 9/15/2025

Rule 10b5-1 trading arrangement

Sale

Until 1/29/2027, or such earlier date upon which all transactions are completed or expire without execution

Up to 25,947 shares

(1) This trading plan related to 358,090 shares of our common stock and had a scheduled expiration date of 7/31/2025.

Cedric G Francois [Member]

Trading Arrangements, by Individual

Name

Cedric G Francois

Title

President and Chief ExecutiveOfficer

Rule 10b5-1 Arrangement Terminated

true

Termination Date

8/14/2025

Expiration Date

7/31/2025

Aggregate Available

358,090

Caroline Baumal [Member]

Trading Arrangements, by Individual

Name

Caroline Baumal

Title

Chief Medical Officer

Rule 10b5-1 Arrangement Adopted

true

Adoption Date

8/19/2025

Expiration Date

2/27/2027

Aggregate Available

14,698

James Chopas [Member]

Trading Arrangements, by Individual

Name

James Chopas

Title

Vice President, Corporate Controller andChief Accounting Officer

Rule 10b5-1 Arrangement Adopted

true

Adoption Date

9/15/2025

Expiration Date

1/29/2027

Aggregate Available

25,947

X

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