<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2021 Workiva-->
<!--r:ec00730f-762b-46bc-8129-35ed9e118824,g:8015d53c-ba62-4fdf-81c5-b80d960aa246-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://simmonsbank.com/role/CoverPage" xlink:type="simple" xlink:href="sfnc-20210930.xsd#CoverPage"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/CoverPage" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_5a11e7bc-3743-4e86-b91d-c8360218a04d" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:to="loc_dei_DocumentType_5a11e7bc-3743-4e86-b91d-c8360218a04d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentQuarterlyReport_e76f997c-d963-44d2-a874-68c9981b6e2b" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_DocumentQuarterlyReport"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:to="loc_dei_DocumentQuarterlyReport_e76f997c-d963-44d2-a874-68c9981b6e2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_198a7f52-011a-4d55-8d81-44cc2787420d" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:to="loc_dei_DocumentPeriodEndDate_198a7f52-011a-4d55-8d81-44cc2787420d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentTransitionReport_d3ed0898-d8c2-4175-a885-9112a2f96b33" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_DocumentTransitionReport"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:to="loc_dei_DocumentTransitionReport_d3ed0898-d8c2-4175-a885-9112a2f96b33" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_aed56c0c-a103-4fb2-a780-dc82dee2b17b" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:to="loc_dei_EntityFileNumber_aed56c0c-a103-4fb2-a780-dc82dee2b17b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_5a18a328-9440-4bb2-852b-51077c619dab" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:to="loc_dei_EntityRegistrantName_5a18a328-9440-4bb2-852b-51077c619dab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_7da789a8-831f-477d-b506-7a859f97eb25" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:to="loc_dei_EntityIncorporationStateCountryCode_7da789a8-831f-477d-b506-7a859f97eb25" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_15d49d55-01ee-4613-9144-2d7b3c7c2bf4" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:to="loc_dei_EntityTaxIdentificationNumber_15d49d55-01ee-4613-9144-2d7b3c7c2bf4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_9c7a7221-e0d5-4a2e-a284-afc6fd40f883" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:to="loc_dei_EntityAddressAddressLine1_9c7a7221-e0d5-4a2e-a284-afc6fd40f883" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_36ac96f1-37ba-477f-84ff-72fefa8d7071" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:to="loc_dei_EntityAddressCityOrTown_36ac96f1-37ba-477f-84ff-72fefa8d7071" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_2b2ee5f2-0421-4120-a849-dc7fa22bb989" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:to="loc_dei_EntityAddressStateOrProvince_2b2ee5f2-0421-4120-a849-dc7fa22bb989" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_bd9a5455-0b59-4a32-b67f-72546ed48639" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:to="loc_dei_EntityAddressPostalZipCode_bd9a5455-0b59-4a32-b67f-72546ed48639" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_3a644b3a-0725-402a-a31d-401e45cf045d" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:to="loc_dei_CityAreaCode_3a644b3a-0725-402a-a31d-401e45cf045d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_a1d17ef3-a69b-41f3-beff-ddd6d4ec7b54" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:to="loc_dei_LocalPhoneNumber_a1d17ef3-a69b-41f3-beff-ddd6d4ec7b54" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_932165f1-8ae5-4d82-be25-da41338a6e88" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:to="loc_dei_Security12bTitle_932165f1-8ae5-4d82-be25-da41338a6e88" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_d3f47cee-5bb5-447a-9ca0-a887f669c9b8" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:to="loc_dei_TradingSymbol_d3f47cee-5bb5-447a-9ca0-a887f669c9b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_c9a347ac-a3cd-45aa-8b4a-d5819fa47184" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:to="loc_dei_SecurityExchangeName_c9a347ac-a3cd-45aa-8b4a-d5819fa47184" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCurrentReportingStatus_501373f9-f0f9-4c24-a194-084a06d7c9e3" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityCurrentReportingStatus"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:to="loc_dei_EntityCurrentReportingStatus_501373f9-f0f9-4c24-a194-084a06d7c9e3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInteractiveDataCurrent_7f212682-fff2-49a9-abd4-faf98190e067" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityInteractiveDataCurrent"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:to="loc_dei_EntityInteractiveDataCurrent_7f212682-fff2-49a9-abd4-faf98190e067" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFilerCategory_6f1cf707-41cf-49f4-9e8f-849e1538ccce" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityFilerCategory"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:to="loc_dei_EntityFilerCategory_6f1cf707-41cf-49f4-9e8f-849e1538ccce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitySmallBusiness_215b246e-a387-40f2-9c8c-8afbda45c603" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntitySmallBusiness"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:to="loc_dei_EntitySmallBusiness_215b246e-a387-40f2-9c8c-8afbda45c603" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_7ae5ca9b-4617-4325-ab7e-c73814a08b9b" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:to="loc_dei_EntityEmergingGrowthCompany_7ae5ca9b-4617-4325-ab7e-c73814a08b9b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityShellCompany_273c1021-860c-44d6-ae6e-a566097cb52b" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityShellCompany"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:to="loc_dei_EntityShellCompany_273c1021-860c-44d6-ae6e-a566097cb52b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_b581c29d-a4b7-49a2-8910-409652332a32" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityCommonStockSharesOutstanding"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_b581c29d-a4b7-49a2-8910-409652332a32" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus_378b3fb2-8b2c-4fef-9673-fa17153f34d6" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_DocumentFiscalYearFocus"/>
    <link:presentationArc order="25" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:to="loc_dei_DocumentFiscalYearFocus_378b3fb2-8b2c-4fef-9673-fa17153f34d6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus_746c30f7-1a32-4988-82e9-1aa5fe187c81" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_DocumentFiscalPeriodFocus"/>
    <link:presentationArc order="26" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:to="loc_dei_DocumentFiscalPeriodFocus_746c30f7-1a32-4988-82e9-1aa5fe187c81" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_2e1712ad-7cf1-4852-a99f-6862e6ee45f9" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="27" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:to="loc_dei_AmendmentFlag_2e1712ad-7cf1-4852-a99f-6862e6ee45f9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_b86bbff9-4da2-4947-94ff-597ad3073dae" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="28" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:to="loc_dei_EntityCentralIndexKey_b86bbff9-4da2-4947-94ff-597ad3073dae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_b89acfaf-75a2-4e8f-9b90-d84b1362f8a3" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:presentationArc order="29" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a2e02e05-954a-47f6-8fe5-2c547e320684" xlink:to="loc_dei_CurrentFiscalYearEndDate_b89acfaf-75a2-4e8f-9b90-d84b1362f8a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/ConsolidatedBalanceSheets" xlink:type="simple" xlink:href="sfnc-20210930.xsd#ConsolidatedBalanceSheets"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_c0108226-3f3b-44c4-b424-4c156ddc4234" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsAbstract_dd2fe7d6-0e4f-46d5-8f75-1c4df8380738" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_c0108226-3f3b-44c4-b424-4c156ddc4234" xlink:to="loc_us-gaap_AssetsAbstract_dd2fe7d6-0e4f-46d5-8f75-1c4df8380738" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndDueFromBanks_f6992d9c-9c5f-44bf-9868-edf28abec566" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndDueFromBanks"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_dd2fe7d6-0e4f-46d5-8f75-1c4df8380738" xlink:to="loc_us-gaap_CashAndDueFromBanks_f6992d9c-9c5f-44bf-9868-edf28abec566" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestBearingDepositsInBanks_ae3036ee-aaa5-46dc-96ae-6a6a0c995e5f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestBearingDepositsInBanks"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_dd2fe7d6-0e4f-46d5-8f75-1c4df8380738" xlink:to="loc_us-gaap_InterestBearingDepositsInBanks_ae3036ee-aaa5-46dc-96ae-6a6a0c995e5f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsAndFederalFundsSold_a0a704e8-0e29-41ad-99cb-e31c639c7e88" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashCashEquivalentsAndFederalFundsSold"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_dd2fe7d6-0e4f-46d5-8f75-1c4df8380738" xlink:to="loc_us-gaap_CashCashEquivalentsAndFederalFundsSold_a0a704e8-0e29-41ad-99cb-e31c639c7e88" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_InterestBearingBalancesDueFromBanksTime_3d57e128-9028-4c11-b80f-c6b6d1dcd8f5" xlink:href="sfnc-20210930.xsd#sfnc_InterestBearingBalancesDueFromBanksTime"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_dd2fe7d6-0e4f-46d5-8f75-1c4df8380738" xlink:to="loc_sfnc_InterestBearingBalancesDueFromBanksTime_3d57e128-9028-4c11-b80f-c6b6d1dcd8f5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_InvestmentSecuritiesAbstract_c8c81cee-3389-4fe0-823e-5ee10433e889" xlink:href="sfnc-20210930.xsd#sfnc_InvestmentSecuritiesAbstract"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_dd2fe7d6-0e4f-46d5-8f75-1c4df8380738" xlink:to="loc_sfnc_InvestmentSecuritiesAbstract_c8c81cee-3389-4fe0-823e-5ee10433e889" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestAfterAllowanceForCreditLoss_194756de-d3bf-460b-964b-aa6b85544a11" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestAfterAllowanceForCreditLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_sfnc_InvestmentSecuritiesAbstract_c8c81cee-3389-4fe0-823e-5ee10433e889" xlink:to="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestAfterAllowanceForCreditLoss_194756de-d3bf-460b-964b-aa6b85544a11" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_addbf90c-9519-4645-8c69-312275961e23" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_sfnc_InvestmentSecuritiesAbstract_c8c81cee-3389-4fe0-823e-5ee10433e889" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_addbf90c-9519-4645-8c69-312275961e23" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecurities_1ff9de14-dbc0-4c26-b0b1-1f816b0234a0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecurities"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_sfnc_InvestmentSecuritiesAbstract_c8c81cee-3389-4fe0-823e-5ee10433e889" xlink:to="loc_us-gaap_DebtSecurities_1ff9de14-dbc0-4c26-b0b1-1f816b0234a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansReceivableHeldForSaleNetNotPartOfDisposalGroup_c1324408-acb4-4941-934a-9c2e13123879" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoansReceivableHeldForSaleNetNotPartOfDisposalGroup"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_dd2fe7d6-0e4f-46d5-8f75-1c4df8380738" xlink:to="loc_us-gaap_LoansReceivableHeldForSaleNetNotPartOfDisposalGroup_c1324408-acb4-4941-934a-9c2e13123879" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_6b31e9c1-2e79-42cc-a4c2-86751ccfa09a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_dd2fe7d6-0e4f-46d5-8f75-1c4df8380738" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_6b31e9c1-2e79-42cc-a4c2-86751ccfa09a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableAllowanceForCreditLossExcludingAccruedInterest_d2ed59e1-cefb-4aed-a1c3-916af2cbcb60" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossExcludingAccruedInterest"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_dd2fe7d6-0e4f-46d5-8f75-1c4df8380738" xlink:to="loc_us-gaap_FinancingReceivableAllowanceForCreditLossExcludingAccruedInterest_d2ed59e1-cefb-4aed-a1c3-916af2cbcb60" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss_18c8f099-2b75-4cca-a59b-a42acb0b5960" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_dd2fe7d6-0e4f-46d5-8f75-1c4df8380738" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestAfterAllowanceForCreditLoss_18c8f099-2b75-4cca-a59b-a42acb0b5960" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_PropertyPlantandEquipmentandRightofUseAssetafterAccumulatedDepreciationandAmortization_7f0c7bf5-4ddb-46bf-b6de-5d4c38c53e2b" xlink:href="sfnc-20210930.xsd#sfnc_PropertyPlantandEquipmentandRightofUseAssetafterAccumulatedDepreciationandAmortization"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_dd2fe7d6-0e4f-46d5-8f75-1c4df8380738" xlink:to="loc_sfnc_PropertyPlantandEquipmentandRightofUseAssetafterAccumulatedDepreciationandAmortization_7f0c7bf5-4ddb-46bf-b6de-5d4c38c53e2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RealEstateHeldforsale_7028c5b2-a21d-41fb-8d72-a87b08eddf28" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RealEstateHeldforsale"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_dd2fe7d6-0e4f-46d5-8f75-1c4df8380738" xlink:to="loc_us-gaap_RealEstateHeldforsale_7028c5b2-a21d-41fb-8d72-a87b08eddf28" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RealEstateAcquiredThroughForeclosure_1be3e1a1-8a72-4091-a8bf-3ae39a7dd6b4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RealEstateAcquiredThroughForeclosure"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_dd2fe7d6-0e4f-46d5-8f75-1c4df8380738" xlink:to="loc_us-gaap_RealEstateAcquiredThroughForeclosure_1be3e1a1-8a72-4091-a8bf-3ae39a7dd6b4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestReceivable_b1a2b575-7105-4020-aebd-067ca8b6b8b9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestReceivable"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_dd2fe7d6-0e4f-46d5-8f75-1c4df8380738" xlink:to="loc_us-gaap_InterestReceivable_b1a2b575-7105-4020-aebd-067ca8b6b8b9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankOwnedLifeInsurance_11ea481a-ff61-4e66-bbed-4b7b45c99bce" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BankOwnedLifeInsurance"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_dd2fe7d6-0e4f-46d5-8f75-1c4df8380738" xlink:to="loc_us-gaap_BankOwnedLifeInsurance_11ea481a-ff61-4e66-bbed-4b7b45c99bce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_64ef8d6e-e486-4cfb-8212-6308900dc284" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Goodwill"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_dd2fe7d6-0e4f-46d5-8f75-1c4df8380738" xlink:to="loc_us-gaap_Goodwill_64ef8d6e-e486-4cfb-8212-6308900dc284" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherIntangibleAssetsNet_54396a21-7527-44f9-83c6-249564f78846" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherIntangibleAssetsNet"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_dd2fe7d6-0e4f-46d5-8f75-1c4df8380738" xlink:to="loc_us-gaap_OtherIntangibleAssetsNet_54396a21-7527-44f9-83c6-249564f78846" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssets_27581d96-da6f-41b8-9542-5f214ad01002" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherAssets"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_dd2fe7d6-0e4f-46d5-8f75-1c4df8380738" xlink:to="loc_us-gaap_OtherAssets_27581d96-da6f-41b8-9542-5f214ad01002" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_3a49a442-630c-42a4-aecb-6b4f082bcf03" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Assets"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_dd2fe7d6-0e4f-46d5-8f75-1c4df8380738" xlink:to="loc_us-gaap_Assets_3a49a442-630c-42a4-aecb-6b4f082bcf03" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_5c400710-7ffb-4585-a2f4-fc60b3c92781" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_c0108226-3f3b-44c4-b424-4c156ddc4234" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_5c400710-7ffb-4585-a2f4-fc60b3c92781" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepositsAbstract_97a06d1d-05eb-48c1-bfe5-e3c6a8eb9a79" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DepositsAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_5c400710-7ffb-4585-a2f4-fc60b3c92781" xlink:to="loc_us-gaap_DepositsAbstract_97a06d1d-05eb-48c1-bfe5-e3c6a8eb9a79" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestBearingDepositLiabilities_ee77b689-e42e-4f3e-8914-d8d8f24249b1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoninterestBearingDepositLiabilities"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DepositsAbstract_97a06d1d-05eb-48c1-bfe5-e3c6a8eb9a79" xlink:to="loc_us-gaap_NoninterestBearingDepositLiabilities_ee77b689-e42e-4f3e-8914-d8d8f24249b1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestBearingDepositLiabilities_c7eff8b9-521b-4779-be13-5e0ac7b09b42" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestBearingDepositLiabilities"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DepositsAbstract_97a06d1d-05eb-48c1-bfe5-e3c6a8eb9a79" xlink:to="loc_us-gaap_InterestBearingDepositLiabilities_c7eff8b9-521b-4779-be13-5e0ac7b09b42" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDeposits_86293d5b-abba-411b-9d83-e51e46a1b479" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TimeDeposits"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DepositsAbstract_97a06d1d-05eb-48c1-bfe5-e3c6a8eb9a79" xlink:to="loc_us-gaap_TimeDeposits_86293d5b-abba-411b-9d83-e51e46a1b479" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Deposits_a8912ce7-26f2-4d65-89de-de20fbcad827" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Deposits"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DepositsAbstract_97a06d1d-05eb-48c1-bfe5-e3c6a8eb9a79" xlink:to="loc_us-gaap_Deposits_a8912ce7-26f2-4d65-89de-de20fbcad827" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase_8f5073c7-a46e-4616-a60b-6277a33533d4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_5c400710-7ffb-4585-a2f4-fc60b3c92781" xlink:to="loc_us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase_8f5073c7-a46e-4616-a60b-6277a33533d4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherBorrowings_4bbe04f6-0368-497c-8570-b9480c9b7764" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherBorrowings"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_5c400710-7ffb-4585-a2f4-fc60b3c92781" xlink:to="loc_us-gaap_OtherBorrowings_4bbe04f6-0368-497c-8570-b9480c9b7764" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubordinatedDebt_8204b705-db9d-4564-b23f-5a039dfee510" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubordinatedDebt"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_5c400710-7ffb-4585-a2f4-fc60b3c92781" xlink:to="loc_us-gaap_SubordinatedDebt_8204b705-db9d-4564-b23f-5a039dfee510" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_OtherLiabilitiesHeldForSale_4c0b7303-f640-4363-927b-bf5129e563d4" xlink:href="sfnc-20210930.xsd#sfnc_OtherLiabilitiesHeldForSale"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_5c400710-7ffb-4585-a2f4-fc60b3c92781" xlink:to="loc_sfnc_OtherLiabilitiesHeldForSale_4c0b7303-f640-4363-927b-bf5129e563d4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent_3111a6ae-c42f-4ae8-b9fc-cdd92e9432a4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_5c400710-7ffb-4585-a2f4-fc60b3c92781" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent_3111a6ae-c42f-4ae8-b9fc-cdd92e9432a4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_28ca6b35-0b4e-4401-b09f-e60db5037aa0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_5c400710-7ffb-4585-a2f4-fc60b3c92781" xlink:to="loc_us-gaap_Liabilities_28ca6b35-0b4e-4401-b09f-e60db5037aa0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityAbstract_245456bf-bd9d-4ad3-8dee-a2b1431578ec" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquityAbstract"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_5c400710-7ffb-4585-a2f4-fc60b3c92781" xlink:to="loc_us-gaap_StockholdersEquityAbstract_245456bf-bd9d-4ad3-8dee-a2b1431578ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_643d3525-1d95-4f24-a2ea-942dd8cc451c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_245456bf-bd9d-4ad3-8dee-a2b1431578ec" xlink:to="loc_us-gaap_PreferredStockValue_643d3525-1d95-4f24-a2ea-942dd8cc451c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_6cdf9ebf-07dd-432b-b435-d8a1573bae3d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_245456bf-bd9d-4ad3-8dee-a2b1431578ec" xlink:to="loc_us-gaap_CommonStockValue_6cdf9ebf-07dd-432b-b435-d8a1573bae3d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_10e16f14-abb7-4ed6-8890-71f8dbbac789" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_245456bf-bd9d-4ad3-8dee-a2b1431578ec" xlink:to="loc_us-gaap_AdditionalPaidInCapital_10e16f14-abb7-4ed6-8890-71f8dbbac789" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_dee7622d-7f5b-48ef-b462-3ebfb755a212" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_245456bf-bd9d-4ad3-8dee-a2b1431578ec" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_dee7622d-7f5b-48ef-b462-3ebfb755a212" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_eb43d909-461a-472b-b85d-fb49b784b095" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_245456bf-bd9d-4ad3-8dee-a2b1431578ec" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_eb43d909-461a-472b-b85d-fb49b784b095" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_2f3b69a2-13a6-4d16-93c6-a32c4e07b5d2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_245456bf-bd9d-4ad3-8dee-a2b1431578ec" xlink:to="loc_us-gaap_StockholdersEquity_2f3b69a2-13a6-4d16-93c6-a32c4e07b5d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_19c3ff0c-47f6-4abb-856c-e1cd19f8d1e6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_5c400710-7ffb-4585-a2f4-fc60b3c92781" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquity_19c3ff0c-47f6-4abb-856c-e1cd19f8d1e6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="simple" xlink:href="sfnc-20210930.xsd#ConsolidatedBalanceSheetsParenthetical"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_7a1999a5-4958-4484-ac73-becaed7dce13" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLoss_b51a8622-7e4c-410f-8e11-0c82e24508d3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_7a1999a5-4958-4484-ac73-becaed7dce13" xlink:to="loc_us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLoss_b51a8622-7e4c-410f-8e11-0c82e24508d3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLoss_4c8c6519-e26c-4648-b7b3-0f37790ca264" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLoss"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_7a1999a5-4958-4484-ac73-becaed7dce13" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLoss_4c8c6519-e26c-4648-b7b3-0f37790ca264" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_da294d62-1cad-48ee-a5c5-2a4f655d35b8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_7a1999a5-4958-4484-ac73-becaed7dce13" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_da294d62-1cad-48ee-a5c5-2a4f655d35b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_0124cced-4c81-43ce-be5e-db354ca6b3da" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockSharesAuthorized"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_7a1999a5-4958-4484-ac73-becaed7dce13" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_0124cced-4c81-43ce-be5e-db354ca6b3da" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockParOrStatedValuePerShare_b7a83659-82f7-4b20-b66d-9451c0412871" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockParOrStatedValuePerShare"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_7a1999a5-4958-4484-ac73-becaed7dce13" xlink:to="loc_us-gaap_PreferredStockParOrStatedValuePerShare_b7a83659-82f7-4b20-b66d-9451c0412871" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockLiquidationPreference_95382b52-8efd-41a7-aba6-43550a0d8b2e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockLiquidationPreference"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_7a1999a5-4958-4484-ac73-becaed7dce13" xlink:to="loc_us-gaap_PreferredStockLiquidationPreference_95382b52-8efd-41a7-aba6-43550a0d8b2e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesIssued_59455625-3e47-4c2e-9fe9-9134a2d250dd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockSharesIssued"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_7a1999a5-4958-4484-ac73-becaed7dce13" xlink:to="loc_us-gaap_PreferredStockSharesIssued_59455625-3e47-4c2e-9fe9-9134a2d250dd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesOutstanding_dae1b7f6-adcd-4cbf-87b7-950dc1a0c92e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockSharesOutstanding"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_7a1999a5-4958-4484-ac73-becaed7dce13" xlink:to="loc_us-gaap_PreferredStockSharesOutstanding_dae1b7f6-adcd-4cbf-87b7-950dc1a0c92e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_faab95f0-67e8-47f6-864c-a21d96457937" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_7a1999a5-4958-4484-ac73-becaed7dce13" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_faab95f0-67e8-47f6-864c-a21d96457937" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_a1b1c529-da04-4bd4-afbf-7680381bd82e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_7a1999a5-4958-4484-ac73-becaed7dce13" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_a1b1c529-da04-4bd4-afbf-7680381bd82e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_e64a5154-37c6-40a4-bf5e-6d671630ea5a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_7a1999a5-4958-4484-ac73-becaed7dce13" xlink:to="loc_us-gaap_CommonStockSharesIssued_e64a5154-37c6-40a4-bf5e-6d671630ea5a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_9a215a7c-52f4-4758-97c5-5c99ed2ce621" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_7a1999a5-4958-4484-ac73-becaed7dce13" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_9a215a7c-52f4-4758-97c5-5c99ed2ce621" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/ConsolidatedStatementsofIncome" xlink:type="simple" xlink:href="sfnc-20210930.xsd#ConsolidatedStatementsofIncome"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/ConsolidatedStatementsofIncome" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementAbstract_e3286cc2-ed65-408f-b66b-6b2f705aa7ae" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_c3fcb1d7-12e8-49f0-b42e-c93205c96909" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_e3286cc2-ed65-408f-b66b-6b2f705aa7ae" xlink:to="loc_us-gaap_StatementTable_c3fcb1d7-12e8-49f0-b42e-c93205c96909" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_a6a6bf0b-8e6f-46dd-b910-f8fef07ff305" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_c3fcb1d7-12e8-49f0-b42e-c93205c96909" xlink:to="loc_srt_ProductOrServiceAxis_a6a6bf0b-8e6f-46dd-b910-f8fef07ff305" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_42c9c9b3-1401-4422-9491-09f7e68ec83e" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_a6a6bf0b-8e6f-46dd-b910-f8fef07ff305" xlink:to="loc_srt_ProductsAndServicesDomain_42c9c9b3-1401-4422-9491-09f7e68ec83e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiduciaryAndTrustMember_5610a6f0-2ce9-4193-88ec-b88f5e014e98" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiduciaryAndTrustMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_42c9c9b3-1401-4422-9491-09f7e68ec83e" xlink:to="loc_us-gaap_FiduciaryAndTrustMember_5610a6f0-2ce9-4193-88ec-b88f5e014e98" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepositAccountMember_5fc9743a-6ce6-43eb-9a0d-389f9937ef94" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DepositAccountMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_42c9c9b3-1401-4422-9491-09f7e68ec83e" xlink:to="loc_us-gaap_DepositAccountMember_5fc9743a-6ce6-43eb-9a0d-389f9937ef94" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialServiceOtherMember_b462c642-3a28-4d9e-9eec-4a5d54704f66" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialServiceOtherMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_42c9c9b3-1401-4422-9491-09f7e68ec83e" xlink:to="loc_us-gaap_FinancialServiceOtherMember_b462c642-3a28-4d9e-9eec-4a5d54704f66" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_MortgageLoansMember_1767215e-a88d-4d1e-b4b8-5302c4b9b2cc" xlink:href="sfnc-20210930.xsd#sfnc_MortgageLoansMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_42c9c9b3-1401-4422-9491-09f7e68ec83e" xlink:to="loc_sfnc_MortgageLoansMember_1767215e-a88d-4d1e-b4b8-5302c4b9b2cc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_SBALoansMember_1f72fc4c-80ba-4c1f-8b64-a0d22920512d" xlink:href="sfnc-20210930.xsd#sfnc_SBALoansMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_42c9c9b3-1401-4422-9491-09f7e68ec83e" xlink:to="loc_sfnc_SBALoansMember_1f72fc4c-80ba-4c1f-8b64-a0d22920512d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditAndDebitCardMember_0c011b8a-ccd8-47bb-874c-d162309d2932" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CreditAndDebitCardMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_42c9c9b3-1401-4422-9491-09f7e68ec83e" xlink:to="loc_us-gaap_CreditAndDebitCardMember_0c011b8a-ccd8-47bb-874c-d162309d2932" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_ced34257-e96a-4bb4-84e4-8fd13607f103" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_c3fcb1d7-12e8-49f0-b42e-c93205c96909" xlink:to="loc_us-gaap_StatementLineItems_ced34257-e96a-4bb4-84e4-8fd13607f103" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndDividendIncomeOperatingAbstract_9edc7c2b-bbc7-4a61-bb8f-0e880e759914" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestAndDividendIncomeOperatingAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ced34257-e96a-4bb4-84e4-8fd13607f103" xlink:to="loc_us-gaap_InterestAndDividendIncomeOperatingAbstract_9edc7c2b-bbc7-4a61-bb8f-0e880e759914" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndFeeIncomeLoansAndLeases_56c0c4cb-5585-4df4-a8bc-18fe64295db2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestAndFeeIncomeLoansAndLeases"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperatingAbstract_9edc7c2b-bbc7-4a61-bb8f-0e880e759914" xlink:to="loc_us-gaap_InterestAndFeeIncomeLoansAndLeases_56c0c4cb-5585-4df4-a8bc-18fe64295db2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeDepositsWithFinancialInstitutions_79bbca86-12c1-4432-8d52-9d7d92eafbb0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeDepositsWithFinancialInstitutions"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperatingAbstract_9edc7c2b-bbc7-4a61-bb8f-0e880e759914" xlink:to="loc_us-gaap_InterestIncomeDepositsWithFinancialInstitutions_79bbca86-12c1-4432-8d52-9d7d92eafbb0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_9eac7b89-f593-47bb-be90-2c9914788c60" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperatingAbstract_9edc7c2b-bbc7-4a61-bb8f-0e880e759914" xlink:to="loc_us-gaap_InvestmentIncomeInterest_9eac7b89-f593-47bb-be90-2c9914788c60" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_InterestandFeeIncomeMortgageLoansHeldforsale_2afd1aba-2c10-4c3b-81d5-30b9a362cf3a" xlink:href="sfnc-20210930.xsd#sfnc_InterestandFeeIncomeMortgageLoansHeldforsale"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperatingAbstract_9edc7c2b-bbc7-4a61-bb8f-0e880e759914" xlink:to="loc_sfnc_InterestandFeeIncomeMortgageLoansHeldforsale_2afd1aba-2c10-4c3b-81d5-30b9a362cf3a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndDividendIncomeOperating_ce95cd28-dee3-4d76-b7d1-33fb397433c2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestAndDividendIncomeOperating"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperatingAbstract_9edc7c2b-bbc7-4a61-bb8f-0e880e759914" xlink:to="loc_us-gaap_InterestAndDividendIncomeOperating_ce95cd28-dee3-4d76-b7d1-33fb397433c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseAbstract_ee33c38b-2e7e-45d5-bd22-df1fa2790a04" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpenseAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ced34257-e96a-4bb4-84e4-8fd13607f103" xlink:to="loc_us-gaap_InterestExpenseAbstract_ee33c38b-2e7e-45d5-bd22-df1fa2790a04" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDeposits_04399c16-9f79-45b6-ac0c-55c691795c2a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpenseDeposits"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InterestExpenseAbstract_ee33c38b-2e7e-45d5-bd22-df1fa2790a04" xlink:to="loc_us-gaap_InterestExpenseDeposits_04399c16-9f79-45b6-ac0c-55c691795c2a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase_4bac3ce0-60d6-4725-a3c0-00a7942874a5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpenseFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InterestExpenseAbstract_ee33c38b-2e7e-45d5-bd22-df1fa2790a04" xlink:to="loc_us-gaap_InterestExpenseFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase_4bac3ce0-60d6-4725-a3c0-00a7942874a5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseOther_36115883-3274-4ca3-9627-36fcb86ba0c1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpenseOther"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InterestExpenseAbstract_ee33c38b-2e7e-45d5-bd22-df1fa2790a04" xlink:to="loc_us-gaap_InterestExpenseOther_36115883-3274-4ca3-9627-36fcb86ba0c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseSubordinatedNotesAndDebentures_24ec422d-5141-4d47-bc86-d35ba43007a8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpenseSubordinatedNotesAndDebentures"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InterestExpenseAbstract_ee33c38b-2e7e-45d5-bd22-df1fa2790a04" xlink:to="loc_us-gaap_InterestExpenseSubordinatedNotesAndDebentures_24ec422d-5141-4d47-bc86-d35ba43007a8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_fd5a3d3a-8ee6-4940-b1e6-040edd8fa222" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpense"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InterestExpenseAbstract_ee33c38b-2e7e-45d5-bd22-df1fa2790a04" xlink:to="loc_us-gaap_InterestExpense_fd5a3d3a-8ee6-4940-b1e6-040edd8fa222" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_7f263d84-cad4-4edd-8011-34ef953d110a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeExpenseNet"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ced34257-e96a-4bb4-84e4-8fd13607f103" xlink:to="loc_us-gaap_InterestIncomeExpenseNet_7f263d84-cad4-4edd-8011-34ef953d110a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForLoanLossesExpensed_c84e605b-5439-4a38-a7c1-63405f93d07a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProvisionForLoanLossesExpensed"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ced34257-e96a-4bb4-84e4-8fd13607f103" xlink:to="loc_us-gaap_ProvisionForLoanLossesExpensed_c84e605b-5439-4a38-a7c1-63405f93d07a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_5cc5097f-5d94-4f90-9231-0d1b5242172c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ced34257-e96a-4bb4-84e4-8fd13607f103" xlink:to="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_5cc5097f-5d94-4f90-9231-0d1b5242172c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncomeAbstract_dcabb698-7ecd-4e48-b2dc-8e375cba99de" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoninterestIncomeAbstract"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ced34257-e96a-4bb4-84e4-8fd13607f103" xlink:to="loc_us-gaap_NoninterestIncomeAbstract_dcabb698-7ecd-4e48-b2dc-8e375cba99de" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_52214c2e-0ae7-4987-8b82-992860c3e612" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestIncomeAbstract_dcabb698-7ecd-4e48-b2dc-8e375cba99de" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_52214c2e-0ae7-4987-8b82-992860c3e612" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentBankingRevenue_801db5f8-a937-4235-9cbb-faca9f7fd14e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentBankingRevenue"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestIncomeAbstract_dcabb698-7ecd-4e48-b2dc-8e375cba99de" xlink:to="loc_us-gaap_InvestmentBankingRevenue_801db5f8-a937-4235-9cbb-faca9f7fd14e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankOwnedLifeInsuranceIncome_3a608552-3be7-43f2-b009-08312e6e9db1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BankOwnedLifeInsuranceIncome"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestIncomeAbstract_dcabb698-7ecd-4e48-b2dc-8e375cba99de" xlink:to="loc_us-gaap_BankOwnedLifeInsuranceIncome_3a608552-3be7-43f2-b009-08312e6e9db1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtAndEquitySecuritiesGainLoss_19e584e5-6a74-4c82-9f90-b2d10ab717a3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtAndEquitySecuritiesGainLoss"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestIncomeAbstract_dcabb698-7ecd-4e48-b2dc-8e375cba99de" xlink:to="loc_us-gaap_DebtAndEquitySecuritiesGainLoss_19e584e5-6a74-4c82-9f90-b2d10ab717a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncomeOtherOperatingIncome_0f95ca3a-774a-4830-b6bc-541da1a7e249" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoninterestIncomeOtherOperatingIncome"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestIncomeAbstract_dcabb698-7ecd-4e48-b2dc-8e375cba99de" xlink:to="loc_us-gaap_NoninterestIncomeOtherOperatingIncome_0f95ca3a-774a-4830-b6bc-541da1a7e249" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncome_de798c42-3bda-427b-9e54-0e3b9cf2ef69" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoninterestIncome"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestIncomeAbstract_dcabb698-7ecd-4e48-b2dc-8e375cba99de" xlink:to="loc_us-gaap_NoninterestIncome_de798c42-3bda-427b-9e54-0e3b9cf2ef69" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestExpenseAbstract_ed31de0d-9784-4bd3-8bf7-bc427d90bc27" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoninterestExpenseAbstract"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ced34257-e96a-4bb4-84e4-8fd13607f103" xlink:to="loc_us-gaap_NoninterestExpenseAbstract_ed31de0d-9784-4bd3-8bf7-bc427d90bc27" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LaborAndRelatedExpense_fb2170b4-c6fd-4880-9108-4b41fe7da63b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LaborAndRelatedExpense"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestExpenseAbstract_ed31de0d-9784-4bd3-8bf7-bc427d90bc27" xlink:to="loc_us-gaap_LaborAndRelatedExpense_fb2170b4-c6fd-4880-9108-4b41fe7da63b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OccupancyNet_825117eb-2ea3-4bed-8d2a-dbd5723f7601" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OccupancyNet"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestExpenseAbstract_ed31de0d-9784-4bd3-8bf7-bc427d90bc27" xlink:to="loc_us-gaap_OccupancyNet_825117eb-2ea3-4bed-8d2a-dbd5723f7601" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquipmentExpense_b04ad52e-3004-49f9-8b39-6fce11f41254" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquipmentExpense"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestExpenseAbstract_ed31de0d-9784-4bd3-8bf7-bc427d90bc27" xlink:to="loc_us-gaap_EquipmentExpense_b04ad52e-3004-49f9-8b39-6fce11f41254" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeclosedRealEstateExpense_02d86842-c948-424c-9663-26ce7ee4878a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ForeclosedRealEstateExpense"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestExpenseAbstract_ed31de0d-9784-4bd3-8bf7-bc427d90bc27" xlink:to="loc_us-gaap_ForeclosedRealEstateExpense_02d86842-c948-424c-9663-26ce7ee4878a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalDepositInsuranceCorporationPremiumExpense_4eea890c-fabb-4fcd-b017-5c612d7e5e07" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FederalDepositInsuranceCorporationPremiumExpense"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestExpenseAbstract_ed31de0d-9784-4bd3-8bf7-bc427d90bc27" xlink:to="loc_us-gaap_FederalDepositInsuranceCorporationPremiumExpense_4eea890c-fabb-4fcd-b017-5c612d7e5e07" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AcquisitionCosts_d8da6ca3-4659-4a88-9ed8-d72dee037f07" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AcquisitionCosts"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestExpenseAbstract_ed31de0d-9784-4bd3-8bf7-bc427d90bc27" xlink:to="loc_us-gaap_AcquisitionCosts_d8da6ca3-4659-4a88-9ed8-d72dee037f07" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoninterestExpense_d0600319-dd9f-4217-a178-dcf58d1c5988" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherNoninterestExpense"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestExpenseAbstract_ed31de0d-9784-4bd3-8bf7-bc427d90bc27" xlink:to="loc_us-gaap_OtherNoninterestExpense_d0600319-dd9f-4217-a178-dcf58d1c5988" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestExpense_ec6cecf0-6ede-49d3-a12a-d4e9f248bb1c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoninterestExpense"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoninterestExpenseAbstract_ed31de0d-9784-4bd3-8bf7-bc427d90bc27" xlink:to="loc_us-gaap_NoninterestExpense_ec6cecf0-6ede-49d3-a12a-d4e9f248bb1c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossAttributableToParent_1423edfe-7e4c-4284-ae97-2cf8654ddbd1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossAttributableToParent"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ced34257-e96a-4bb4-84e4-8fd13607f103" xlink:to="loc_us-gaap_IncomeLossAttributableToParent_1423edfe-7e4c-4284-ae97-2cf8654ddbd1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_ba739b2c-948f-411b-b589-e850e4535ad2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ced34257-e96a-4bb4-84e4-8fd13607f103" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_ba739b2c-948f-411b-b589-e850e4535ad2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_9702c3b5-13c8-4652-873e-881d0ef23b72" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ced34257-e96a-4bb4-84e4-8fd13607f103" xlink:to="loc_us-gaap_NetIncomeLoss_9702c3b5-13c8-4652-873e-881d0ef23b72" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_5c9ed424-cfb0-4b29-852f-5ade6915b3a7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockDividendsIncomeStatementImpact"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ced34257-e96a-4bb4-84e4-8fd13607f103" xlink:to="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_5c9ed424-cfb0-4b29-852f-5ade6915b3a7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_b1506114-1952-4cb4-b5bf-7f7833b5ea9b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ced34257-e96a-4bb4-84e4-8fd13607f103" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_b1506114-1952-4cb4-b5bf-7f7833b5ea9b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_d05e0e81-b11e-4843-8253-f8284452a7ee" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ced34257-e96a-4bb4-84e4-8fd13607f103" xlink:to="loc_us-gaap_EarningsPerShareBasic_d05e0e81-b11e-4843-8253-f8284452a7ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_c5908436-e387-4aef-a8b5-d5cfe8827ff0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_ced34257-e96a-4bb4-84e4-8fd13607f103" xlink:to="loc_us-gaap_EarningsPerShareDiluted_c5908436-e387-4aef-a8b5-d5cfe8827ff0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/ConsolidatedStatementsofComprehensiveIncomeLoss" xlink:type="simple" xlink:href="sfnc-20210930.xsd#ConsolidatedStatementsofComprehensiveIncomeLoss"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/ConsolidatedStatementsofComprehensiveIncomeLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_85d85c5d-3006-4bec-9ba9-9178216b5dc7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_ffd71644-64ce-4c1f-8287-1cb854007079" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_85d85c5d-3006-4bec-9ba9-9178216b5dc7" xlink:to="loc_us-gaap_NetIncomeLoss_ffd71644-64ce-4c1f-8287-1cb854007079" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParentAbstract_99575135-c7e1-498a-970f-7538075ad3fa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParentAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_85d85c5d-3006-4bec-9ba9-9178216b5dc7" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParentAbstract_99575135-c7e1-498a-970f-7538075ad3fa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax_c632e923-6ad8-4780-9777-1f8ea628bcca" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParentAbstract_99575135-c7e1-498a-970f-7538075ad3fa" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax_c632e923-6ad8-4780-9777-1f8ea628bcca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_a2d5dc4a-e16b-493c-8362-3dc543e10277" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParentAbstract_99575135-c7e1-498a-970f-7538075ad3fa" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_a2d5dc4a-e16b-493c-8362-3dc543e10277" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_54f983df-8e98-4d72-ad49-ece4817b6dbf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParentAbstract_99575135-c7e1-498a-970f-7538075ad3fa" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_54f983df-8e98-4d72-ad49-ece4817b6dbf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_OtherComprehensiveIncomeUnrealizedGainsOnSecuritiesTransferredFromAvailableForSaleToHeldToMaturity_2eab8f13-1f3e-4948-88cd-ec98894200f2" xlink:href="sfnc-20210930.xsd#sfnc_OtherComprehensiveIncomeUnrealizedGainsOnSecuritiesTransferredFromAvailableForSaleToHeldToMaturity"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParentAbstract_99575135-c7e1-498a-970f-7538075ad3fa" xlink:to="loc_sfnc_OtherComprehensiveIncomeUnrealizedGainsOnSecuritiesTransferredFromAvailableForSaleToHeldToMaturity_2eab8f13-1f3e-4948-88cd-ec98894200f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent_5223fc2e-8767-4472-b733-d79e42f2b2d8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParentAbstract_99575135-c7e1-498a-970f-7538075ad3fa" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent_5223fc2e-8767-4472-b733-d79e42f2b2d8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossTax_e591025e-e0ac-420f-84c3-c43181e11d0c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossTax"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParentAbstract_99575135-c7e1-498a-970f-7538075ad3fa" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossTax_e591025e-e0ac-420f-84c3-c43181e11d0c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_1446be9b-2a17-4072-a24c-aa19fc30820e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParentAbstract_99575135-c7e1-498a-970f-7538075ad3fa" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_1446be9b-2a17-4072-a24c-aa19fc30820e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_0c01b645-867e-4625-b544-b98a72aae5a1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_85d85c5d-3006-4bec-9ba9-9178216b5dc7" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_0c01b645-867e-4625-b544-b98a72aae5a1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/ConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="sfnc-20210930.xsd#ConsolidatedStatementsofCashFlows"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/ConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract_f20af208-4d45-4a92-a0b3-cb97b973f1de" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementOfCashFlowsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_f2a39bdf-f4f2-475a-8b4f-8679a5b685ff" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_f20af208-4d45-4a92-a0b3-cb97b973f1de" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_f2a39bdf-f4f2-475a-8b4f-8679a5b685ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_512cbbee-3961-4e32-a8e1-487f59025239" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_f2a39bdf-f4f2-475a-8b4f-8679a5b685ff" xlink:to="loc_us-gaap_NetIncomeLoss_512cbbee-3961-4e32-a8e1-487f59025239" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_69db5a55-e57c-46e7-97ba-65610a1eb800" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_f2a39bdf-f4f2-475a-8b4f-8679a5b685ff" xlink:to="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_69db5a55-e57c-46e7-97ba-65610a1eb800" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_8cd895c2-05ba-4d17-a041-0712d9b2bf32" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_69db5a55-e57c-46e7-97ba-65610a1eb800" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_8cd895c2-05ba-4d17-a041-0712d9b2bf32" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForLoanLossesExpensed_8a76dc8d-ec18-4b1f-b20b-0ad0deefcfa0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProvisionForLoanLossesExpensed"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_69db5a55-e57c-46e7-97ba-65610a1eb800" xlink:to="loc_us-gaap_ProvisionForLoanLossesExpensed_8a76dc8d-ec18-4b1f-b20b-0ad0deefcfa0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfInvestments_90dc2669-a411-43e8-9d0c-1eef47f29d2e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainLossOnSaleOfInvestments"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_69db5a55-e57c-46e7-97ba-65610a1eb800" xlink:to="loc_us-gaap_GainLossOnSaleOfInvestments_90dc2669-a411-43e8-9d0c-1eef47f29d2e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_aad706e4-995f-4d5e-a159-34700a1539eb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_69db5a55-e57c-46e7-97ba-65610a1eb800" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_aad706e4-995f-4d5e-a159-34700a1539eb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_60c4a4ef-6b9c-4e2f-b9c3-a011a00948ec" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AmortizationOfFinancingCostsAndDiscounts"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_69db5a55-e57c-46e7-97ba-65610a1eb800" xlink:to="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_60c4a4ef-6b9c-4e2f-b9c3-a011a00948ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_c76ca659-2845-41d9-82cc-4e2c97f1d85c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_69db5a55-e57c-46e7-97ba-65610a1eb800" xlink:to="loc_us-gaap_ShareBasedCompensation_c76ca659-2845-41d9-82cc-4e2c97f1d85c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_fec49e72-4f82-48d7-9c1e-577a627dfcfc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainLossOnSaleOfPropertyPlantEquipment"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_69db5a55-e57c-46e7-97ba-65610a1eb800" xlink:to="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_fec49e72-4f82-48d7-9c1e-577a627dfcfc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnSalesOfOtherRealEstate_c7abcf09-48b2-4f55-a580-8012b3592978" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainsLossesOnSalesOfOtherRealEstate"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_69db5a55-e57c-46e7-97ba-65610a1eb800" xlink:to="loc_us-gaap_GainsLossesOnSalesOfOtherRealEstate_c7abcf09-48b2-4f55-a580-8012b3592978" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfMortgageLoans_10e29a6c-4c16-43cd-b943-82ec252aaf99" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainLossOnSaleOfMortgageLoans"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_69db5a55-e57c-46e7-97ba-65610a1eb800" xlink:to="loc_us-gaap_GainLossOnSaleOfMortgageLoans_10e29a6c-4c16-43cd-b943-82ec252aaf99" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDispositionOfIntangibleAssets_356d56e3-832f-4add-a4d4-8304ebd02461" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainLossOnDispositionOfIntangibleAssets"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_69db5a55-e57c-46e7-97ba-65610a1eb800" xlink:to="loc_us-gaap_GainLossOnDispositionOfIntangibleAssets_356d56e3-832f-4add-a4d4-8304ebd02461" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupNotDiscontinuedOperationGainLossOnDisposal_9bffa022-6460-4b4a-9660-43ac6cb7bd94" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisposalGroupNotDiscontinuedOperationGainLossOnDisposal"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_69db5a55-e57c-46e7-97ba-65610a1eb800" xlink:to="loc_us-gaap_DisposalGroupNotDiscontinuedOperationGainLossOnDisposal_9bffa022-6460-4b4a-9660-43ac6cb7bd94" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf_f09267ff-4b03-44a0-95d6-8181a7f86451" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_69db5a55-e57c-46e7-97ba-65610a1eb800" xlink:to="loc_us-gaap_ImpairmentOfLongLivedAssetsToBeDisposedOf_f09267ff-4b03-44a0-95d6-8181a7f86451" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_9bf837a2-388f-4b8d-86c6-9322b9f85614" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_69db5a55-e57c-46e7-97ba-65610a1eb800" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_9bf837a2-388f-4b8d-86c6-9322b9f85614" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_BankOwnedLifeInsuranceandDeathBenefitsIncome_91df874b-2ee9-440b-aae8-5623388d5394" xlink:href="sfnc-20210930.xsd#sfnc_BankOwnedLifeInsuranceandDeathBenefitsIncome"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_69db5a55-e57c-46e7-97ba-65610a1eb800" xlink:to="loc_sfnc_BankOwnedLifeInsuranceandDeathBenefitsIncome_91df874b-2ee9-440b-aae8-5623388d5394" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForOriginationOfMortgageLoansHeldForSale_43dad9a1-32cc-49ea-836e-0f12de58439a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsForOriginationOfMortgageLoansHeldForSale"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_69db5a55-e57c-46e7-97ba-65610a1eb800" xlink:to="loc_us-gaap_PaymentsForOriginationOfMortgageLoansHeldForSale_43dad9a1-32cc-49ea-836e-0f12de58439a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfMortgageLoansHeldForSale_fe86ccaf-7670-47c4-840e-82ba2c2afb1c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromSaleOfMortgageLoansHeldForSale"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_69db5a55-e57c-46e7-97ba-65610a1eb800" xlink:to="loc_us-gaap_ProceedsFromSaleOfMortgageLoansHeldForSale_fe86ccaf-7670-47c4-840e-82ba2c2afb1c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_c653aeda-b4a1-464e-9b23-0917175ab910" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsNoncashItemsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_69db5a55-e57c-46e7-97ba-65610a1eb800" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_c653aeda-b4a1-464e-9b23-0917175ab910" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedInterestReceivableNet_4641b8e6-dadd-40ed-9e49-70fa3ffb0cb3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedInterestReceivableNet"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_c653aeda-b4a1-464e-9b23-0917175ab910" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedInterestReceivableNet_4641b8e6-dadd-40ed-9e49-70fa3ffb0cb3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_8adc37ff-e501-4aca-b412-cec422fcd69b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_c653aeda-b4a1-464e-9b23-0917175ab910" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_8adc37ff-e501-4aca-b412-cec422fcd69b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities_b0fa3305-d521-4ba8-8cbc-d8fd1fef76fe" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_c653aeda-b4a1-464e-9b23-0917175ab910" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities_b0fa3305-d521-4ba8-8cbc-d8fd1fef76fe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_6e574b28-eade-4d98-a400-955ec9d7b421" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_c653aeda-b4a1-464e-9b23-0917175ab910" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_6e574b28-eade-4d98-a400-955ec9d7b421" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_e3095498-f01e-460b-9478-8e2f76a16b28" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_c653aeda-b4a1-464e-9b23-0917175ab910" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_e3095498-f01e-460b-9478-8e2f76a16b28" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_527c7bdc-a58d-40e4-aba4-d72668f26406" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_f20af208-4d45-4a92-a0b3-cb97b973f1de" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_527c7bdc-a58d-40e4-aba4-d72668f26406" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_ProceedsFromLoanOriginationsAndPrincipalCollectionsNet_3d8292b5-c516-471e-b6a8-b6997c3949c1" xlink:href="sfnc-20210930.xsd#sfnc_ProceedsFromLoanOriginationsAndPrincipalCollectionsNet"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_527c7bdc-a58d-40e4-aba4-d72668f26406" xlink:to="loc_sfnc_ProceedsFromLoanOriginationsAndPrincipalCollectionsNet_3d8292b5-c516-471e-b6a8-b6997c3949c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfLoansReceivable_b0536ee0-1349-4b57-a3f9-045dca2e63c5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromSaleOfLoansReceivable"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_527c7bdc-a58d-40e4-aba4-d72668f26406" xlink:to="loc_us-gaap_ProceedsFromSaleOfLoansReceivable_b0536ee0-1349-4b57-a3f9-045dca2e63c5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForInInterestBearingDepositsInBanks_f58fbd93-6a2c-48f5-a606-21435d6ef4b0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromPaymentsForInInterestBearingDepositsInBanks"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_527c7bdc-a58d-40e4-aba4-d72668f26406" xlink:to="loc_us-gaap_ProceedsFromPaymentsForInInterestBearingDepositsInBanks_f58fbd93-6a2c-48f5-a606-21435d6ef4b0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_f039ae2e-41ce-4da4-afcb-851683c2f0ae" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_527c7bdc-a58d-40e4-aba4-d72668f26406" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_f039ae2e-41ce-4da4-afcb-851683c2f0ae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_c5e6ee33-d06e-4852-8004-65d9206edb25" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_527c7bdc-a58d-40e4-aba4-d72668f26406" xlink:to="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_c5e6ee33-d06e-4852-8004-65d9206edb25" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfForeclosedAssets_3b17f2e5-4474-49b2-94dc-51279484d048" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromSaleOfForeclosedAssets"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_527c7bdc-a58d-40e4-aba4-d72668f26406" xlink:to="loc_us-gaap_ProceedsFromSaleOfForeclosedAssets_3b17f2e5-4474-49b2-94dc-51279484d048" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_57256456-5d77-4112-899c-f840a8509ddd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_527c7bdc-a58d-40e4-aba4-d72668f26406" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_57256456-5d77-4112-899c-f840a8509ddd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_db019fd8-8672-400d-8d41-1d40ab9501b9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_527c7bdc-a58d-40e4-aba4-d72668f26406" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_db019fd8-8672-400d-8d41-1d40ab9501b9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_2cb616bb-4652-4a89-93ff-80e6bdb9c1ea" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_527c7bdc-a58d-40e4-aba4-d72668f26406" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_2cb616bb-4652-4a89-93ff-80e6bdb9c1ea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfHeldToMaturitySecurities_93124270-a7e7-4e86-a0af-83dda313060a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfHeldToMaturitySecurities"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_527c7bdc-a58d-40e4-aba4-d72668f26406" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfHeldToMaturitySecurities_93124270-a7e7-4e86-a0af-83dda313060a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireHeldToMaturitySecurities_836f3b7a-783d-4e6f-b13a-5569f65a612c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquireHeldToMaturitySecurities"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_527c7bdc-a58d-40e4-aba4-d72668f26406" xlink:to="loc_us-gaap_PaymentsToAcquireHeldToMaturitySecurities_836f3b7a-783d-4e6f-b13a-5569f65a612c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireLifeInsurancePolicies_3a21d4a0-4a27-419d-ada0-fc5f7e1202c3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquireLifeInsurancePolicies"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_527c7bdc-a58d-40e4-aba4-d72668f26406" xlink:to="loc_us-gaap_PaymentsToAcquireLifeInsurancePolicies_3a21d4a0-4a27-419d-ada0-fc5f7e1202c3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromLifeInsurancePolicies_a288b474-816f-4df8-a1d1-a99a4b506a3f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromLifeInsurancePolicies"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_527c7bdc-a58d-40e4-aba4-d72668f26406" xlink:to="loc_us-gaap_ProceedsFromLifeInsurancePolicies_a288b474-816f-4df8-a1d1-a99a4b506a3f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_ProceedsFromDivestitureOfBusinessesNetOfLiabilities_adfa6546-3d30-4b1e-9ea1-be62606be283" xlink:href="sfnc-20210930.xsd#sfnc_ProceedsFromDivestitureOfBusinessesNetOfLiabilities"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_527c7bdc-a58d-40e4-aba4-d72668f26406" xlink:to="loc_sfnc_ProceedsFromDivestitureOfBusinessesNetOfLiabilities_adfa6546-3d30-4b1e-9ea1-be62606be283" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_12464873-95a1-40ca-a728-83d5e52127a8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_527c7bdc-a58d-40e4-aba4-d72668f26406" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_12464873-95a1-40ca-a728-83d5e52127a8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_dfef9051-92c4-4694-a26f-e2d1fd7ae6c4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_f20af208-4d45-4a92-a0b3-cb97b973f1de" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_dfef9051-92c4-4694-a26f-e2d1fd7ae6c4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeposits_262f02a5-e542-4b24-b66f-89619d9c36af" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInDeposits"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_dfef9051-92c4-4694-a26f-e2d1fd7ae6c4" xlink:to="loc_us-gaap_IncreaseDecreaseInDeposits_262f02a5-e542-4b24-b66f-89619d9c36af" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfSubordinatedDebt_687dc4a9-c1ec-4aff-b62a-d4d9933c392b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepaymentsOfSubordinatedDebt"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_dfef9051-92c4-4694-a26f-e2d1fd7ae6c4" xlink:to="loc_us-gaap_RepaymentsOfSubordinatedDebt_687dc4a9-c1ec-4aff-b62a-d4d9933c392b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock_03622d1a-1cf1-4be1-8330-f256d884a935" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_dfef9051-92c4-4694-a26f-e2d1fd7ae6c4" xlink:to="loc_us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock_03622d1a-1cf1-4be1-8330-f256d884a935" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDividendsCommonStock_24f0aecb-6d23-4bd2-8fce-6dd566e8fb41" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsOfDividendsCommonStock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_dfef9051-92c4-4694-a26f-e2d1fd7ae6c4" xlink:to="loc_us-gaap_PaymentsOfDividendsCommonStock_24f0aecb-6d23-4bd2-8fce-6dd566e8fb41" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromRepaymentsOfOtherDebt_5013b0a1-3794-4ccd-a367-0d3fb81aec89" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromRepaymentsOfOtherDebt"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_dfef9051-92c4-4694-a26f-e2d1fd7ae6c4" xlink:to="loc_us-gaap_ProceedsFromRepaymentsOfOtherDebt_5013b0a1-3794-4ccd-a367-0d3fb81aec89" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForInSecuritiesSoldUnderAgreementsToRepurchase_dab0afea-0a63-44c0-a4b1-c3bb1027896e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromPaymentsForInSecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_dfef9051-92c4-4694-a26f-e2d1fd7ae6c4" xlink:to="loc_us-gaap_ProceedsFromPaymentsForInSecuritiesSoldUnderAgreementsToRepurchase_dab0afea-0a63-44c0-a4b1-c3bb1027896e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_ProceedsFromPaymentsForIssuanceofSharesSharebasedPaymentArrangementIncludingOptionExercisedAndCanceled_a8f6a4e6-5d66-4866-9867-b98e126555f7" xlink:href="sfnc-20210930.xsd#sfnc_ProceedsFromPaymentsForIssuanceofSharesSharebasedPaymentArrangementIncludingOptionExercisedAndCanceled"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_dfef9051-92c4-4694-a26f-e2d1fd7ae6c4" xlink:to="loc_sfnc_ProceedsFromPaymentsForIssuanceofSharesSharebasedPaymentArrangementIncludingOptionExercisedAndCanceled_a8f6a4e6-5d66-4866-9867-b98e126555f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockPlans_eae474a8-f6f0-40e7-9920-db80aa34fec9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromStockPlans"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_dfef9051-92c4-4694-a26f-e2d1fd7ae6c4" xlink:to="loc_us-gaap_ProceedsFromStockPlans_eae474a8-f6f0-40e7-9920-db80aa34fec9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_56d72073-41ae-4f74-8f59-da17bd612d0a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_dfef9051-92c4-4694-a26f-e2d1fd7ae6c4" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_56d72073-41ae-4f74-8f59-da17bd612d0a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_be4cf3ec-1a50-4b1e-be2c-4e461bc40505" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_dfef9051-92c4-4694-a26f-e2d1fd7ae6c4" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_be4cf3ec-1a50-4b1e-be2c-4e461bc40505" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_e695b017-a8a7-4d7f-ac1e-56e650077f84" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_f20af208-4d45-4a92-a0b3-cb97b973f1de" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_e695b017-a8a7-4d7f-ac1e-56e650077f84" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_ca8e25be-4ada-47f5-8ea6-830466bff72e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_f20af208-4d45-4a92-a0b3-cb97b973f1de" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_ca8e25be-4ada-47f5-8ea6-830466bff72e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_a5712dbc-668c-48e3-9932-45d0163daea0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_f20af208-4d45-4a92-a0b3-cb97b973f1de" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_a5712dbc-668c-48e3-9932-45d0163daea0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/ConsolidatedStatementsofStockholdersEquity" xlink:type="simple" xlink:href="sfnc-20210930.xsd#ConsolidatedStatementsofStockholdersEquity"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/ConsolidatedStatementsofStockholdersEquity" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract_90c79967-b110-4d39-94c1-fe0e0f39c1ff" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementOfStockholdersEquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_31f3820c-f3f2-4fe2-a968-e772fe962871" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_90c79967-b110-4d39-94c1-fe0e0f39c1ff" xlink:to="loc_us-gaap_StatementTable_31f3820c-f3f2-4fe2-a968-e772fe962871" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_000edcc0-b8da-4db2-a535-c9618c27bed5" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CumulativeEffectPeriodOfAdoptionAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_31f3820c-f3f2-4fe2-a968-e772fe962871" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_000edcc0-b8da-4db2-a535-c9618c27bed5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_202ecb5c-b78e-4ecf-a1db-e1c72713e707" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CumulativeEffectPeriodOfAdoptionDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_000edcc0-b8da-4db2-a535-c9618c27bed5" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_202ecb5c-b78e-4ecf-a1db-e1c72713e707" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember_604d3428-dff4-4348-952e-8be7420209ac" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_202ecb5c-b78e-4ecf-a1db-e1c72713e707" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember_604d3428-dff4-4348-952e-8be7420209ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_53adc635-3a68-48cc-a48c-b9e797489edd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_31f3820c-f3f2-4fe2-a968-e772fe962871" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_53adc635-3a68-48cc-a48c-b9e797489edd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_51528a6d-a996-4ace-a4d2-a7273ee89f69" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_53adc635-3a68-48cc-a48c-b9e797489edd" xlink:to="loc_us-gaap_EquityComponentDomain_51528a6d-a996-4ace-a4d2-a7273ee89f69" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockMember_cdb81e8f-0e4b-459e-a73d-340184941c29" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_51528a6d-a996-4ace-a4d2-a7273ee89f69" xlink:to="loc_us-gaap_PreferredStockMember_cdb81e8f-0e4b-459e-a73d-340184941c29" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_c8e9bf13-48e8-42ed-bce7-516dee2fde84" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_51528a6d-a996-4ace-a4d2-a7273ee89f69" xlink:to="loc_us-gaap_CommonStockMember_c8e9bf13-48e8-42ed-bce7-516dee2fde84" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_74079804-b204-4bd8-9e18-b2fa8625f2c0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_51528a6d-a996-4ace-a4d2-a7273ee89f69" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_74079804-b204-4bd8-9e18-b2fa8625f2c0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_43c348b8-6393-4aa6-801a-5c040f0e2413" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_51528a6d-a996-4ace-a4d2-a7273ee89f69" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_43c348b8-6393-4aa6-801a-5c040f0e2413" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_69ea5eb2-f94d-4f1d-8aef-047f63a40710" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetainedEarningsMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_51528a6d-a996-4ace-a4d2-a7273ee89f69" xlink:to="loc_us-gaap_RetainedEarningsMember_69ea5eb2-f94d-4f1d-8aef-047f63a40710" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_f884934d-4730-46db-97a4-b82c1966ed22" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_31f3820c-f3f2-4fe2-a968-e772fe962871" xlink:to="loc_us-gaap_StatementLineItems_f884934d-4730-46db-97a4-b82c1966ed22" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_0172c735-53df-4fbf-9f5c-c3027470723d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_f884934d-4730-46db-97a4-b82c1966ed22" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_0172c735-53df-4fbf-9f5c-c3027470723d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_a88eb9db-5283-4f4e-8b09-1869fc656bdc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_0172c735-53df-4fbf-9f5c-c3027470723d" xlink:to="loc_us-gaap_StockholdersEquity_a88eb9db-5283-4f4e-8b09-1869fc656bdc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_8200aea4-c84e-4b0e-8d9e-ebdda00958cf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_0172c735-53df-4fbf-9f5c-c3027470723d" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_8200aea4-c84e-4b0e-8d9e-ebdda00958cf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_3cb53b5b-609d-4d5f-aab4-72ac63946f29" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_0172c735-53df-4fbf-9f5c-c3027470723d" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_3cb53b5b-609d-4d5f-aab4-72ac63946f29" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_4cbddf64-6064-4fff-af96-0be3631175eb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_0172c735-53df-4fbf-9f5c-c3027470723d" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_4cbddf64-6064-4fff-af96-0be3631175eb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_c01acb66-c1ee-4efa-a001-fc6ed0593068" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_0172c735-53df-4fbf-9f5c-c3027470723d" xlink:to="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_c01acb66-c1ee-4efa-a001-fc6ed0593068" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsPreferredStock_e9ccc41b-a924-4989-b63c-1c65f138bb67" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DividendsPreferredStock"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_0172c735-53df-4fbf-9f5c-c3027470723d" xlink:to="loc_us-gaap_DividendsPreferredStock_e9ccc41b-a924-4989-b63c-1c65f138bb67" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsCommonStock_c69ad1eb-ec01-4cad-856f-42cd274367e9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DividendsCommonStock"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_0172c735-53df-4fbf-9f5c-c3027470723d" xlink:to="loc_us-gaap_DividendsCommonStock_c69ad1eb-ec01-4cad-856f-42cd274367e9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_b69fd7f6-9250-431c-aa60-2acd3c0a4f76" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_0172c735-53df-4fbf-9f5c-c3027470723d" xlink:to="loc_us-gaap_StockholdersEquity_b69fd7f6-9250-431c-aa60-2acd3c0a4f76" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdateExtensibleList_a6fe86e5-79b6-4447-a9b2-716faed85c07" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountingStandardsUpdateExtensibleList"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_f884934d-4730-46db-97a4-b82c1966ed22" xlink:to="loc_us-gaap_AccountingStandardsUpdateExtensibleList_a6fe86e5-79b6-4447-a9b2-716faed85c07" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/ConsolidatedStatementsofStockholdersEquityParenthetical" xlink:type="simple" xlink:href="sfnc-20210930.xsd#ConsolidatedStatementsofStockholdersEquityParenthetical"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/ConsolidatedStatementsofStockholdersEquityParenthetical" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract_12d05814-01f7-4d7f-8e2f-a945c3801299" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementOfStockholdersEquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_40c3c444-0a95-416a-a5c0-d7ff68c62a63" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_12d05814-01f7-4d7f-8e2f-a945c3801299" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_40c3c444-0a95-416a-a5c0-d7ff68c62a63" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_68b91678-2b74-4302-ba8d-127431bb2901" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_12d05814-01f7-4d7f-8e2f-a945c3801299" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_68b91678-2b74-4302-ba8d-127431bb2901" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockSharesAcquired_63c0a728-f80b-454f-a8bf-c2498c9e220e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockSharesAcquired"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_12d05814-01f7-4d7f-8e2f-a945c3801299" xlink:to="loc_us-gaap_TreasuryStockSharesAcquired_63c0a728-f80b-454f-a8bf-c2498c9e220e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockDividendsPerShareDeclared_d1b8cf71-23bc-440d-b251-51f82c9867dc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockDividendsPerShareDeclared"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_12d05814-01f7-4d7f-8e2f-a945c3801299" xlink:to="loc_us-gaap_CommonStockDividendsPerShareDeclared_d1b8cf71-23bc-440d-b251-51f82c9867dc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/PreparationofInterimFinancialStatements" xlink:type="simple" xlink:href="sfnc-20210930.xsd#PreparationofInterimFinancialStatements"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/PreparationofInterimFinancialStatements" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_c03e0d7e-9e81-467f-9ec6-c8476371383c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_70a43392-a82a-4290-8cca-431b73b2f086" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_c03e0d7e-9e81-467f-9ec6-c8476371383c" xlink:to="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_70a43392-a82a-4290-8cca-431b73b2f086" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/PreparationofInterimFinancialStatementsPolicies" xlink:type="simple" xlink:href="sfnc-20210930.xsd#PreparationofInterimFinancialStatementsPolicies"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/PreparationofInterimFinancialStatementsPolicies" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_923b2fc1-79c9-4333-b749-bc3377d2e7ed" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_eea37c45-fed8-42c0-a1c2-44e7f570befb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BasisOfAccountingPolicyPolicyTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_923b2fc1-79c9-4333-b749-bc3377d2e7ed" xlink:to="loc_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_eea37c45-fed8-42c0-a1c2-44e7f570befb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PriorPeriodReclassificationAdjustmentDescription_26c107c1-6e19-40a4-9051-1e35937a4a34" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PriorPeriodReclassificationAdjustmentDescription"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_923b2fc1-79c9-4333-b749-bc3377d2e7ed" xlink:to="loc_us-gaap_PriorPeriodReclassificationAdjustmentDescription_26c107c1-6e19-40a4-9051-1e35937a4a34" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_b25b50b6-2d8a-444d-a2f2-3ada6f975da9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_923b2fc1-79c9-4333-b749-bc3377d2e7ed" xlink:to="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_b25b50b6-2d8a-444d-a2f2-3ada6f975da9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxPolicyTextBlock_a0a6f0b8-df93-4cb4-a7d5-a8bd200aabb7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxPolicyTextBlock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_923b2fc1-79c9-4333-b749-bc3377d2e7ed" xlink:to="loc_us-gaap_IncomeTaxPolicyTextBlock_a0a6f0b8-df93-4cb4-a7d5-a8bd200aabb7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/PreparationofInterimFinancialStatementsDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#PreparationofInterimFinancialStatementsDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/PreparationofInterimFinancialStatementsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_802d85ae-baad-4ebe-a5ce-04a0ccc22cc4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionTable_cd377389-a527-4ba1-80b0-5852e1277b31" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeLeaseDescriptionTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_802d85ae-baad-4ebe-a5ce-04a0ccc22cc4" xlink:to="loc_us-gaap_LesseeLeaseDescriptionTable_cd377389-a527-4ba1-80b0-5852e1277b31" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_769f700e-cb44-4cbb-bc3f-694cc847729d" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CumulativeEffectPeriodOfAdoptionAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_cd377389-a527-4ba1-80b0-5852e1277b31" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_769f700e-cb44-4cbb-bc3f-694cc847729d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_e0d48a76-a4c5-45d1-be20-39936144f662" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CumulativeEffectPeriodOfAdoptionDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_769f700e-cb44-4cbb-bc3f-694cc847729d" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_e0d48a76-a4c5-45d1-be20-39936144f662" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember_5a1c636e-1ff0-4056-9373-e12ad878fb10" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_e0d48a76-a4c5-45d1-be20-39936144f662" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember_5a1c636e-1ff0-4056-9373-e12ad878fb10" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionLineItems_30377c26-6c0a-4fe8-b16d-a81012c10c79" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeLeaseDescriptionLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_cd377389-a527-4ba1-80b0-5852e1277b31" xlink:to="loc_us-gaap_LesseeLeaseDescriptionLineItems_30377c26-6c0a-4fe8-b16d-a81012c10c79" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_NumberOfFinancialCenters_2ad0725b-b1b4-45ae-a333-8fd53e4c1391" xlink:href="sfnc-20210930.xsd#sfnc_NumberOfFinancialCenters"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_30377c26-6c0a-4fe8-b16d-a81012c10c79" xlink:to="loc_sfnc_NumberOfFinancialCenters_2ad0725b-b1b4-45ae-a333-8fd53e4c1391" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableAllowanceForCreditLossExcludingAccruedInterest_2ff6cbc3-982d-4469-9a28-5064bec81c78" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossExcludingAccruedInterest"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_30377c26-6c0a-4fe8-b16d-a81012c10c79" xlink:to="loc_us-gaap_FinancingReceivableAllowanceForCreditLossExcludingAccruedInterest_2ff6cbc3-982d-4469-9a28-5064bec81c78" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OffBalanceSheetCreditLossLiability_f450fafe-59f5-4122-8079-167e526ca4d4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OffBalanceSheetCreditLossLiability"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_30377c26-6c0a-4fe8-b16d-a81012c10c79" xlink:to="loc_us-gaap_OffBalanceSheetCreditLossLiability_f450fafe-59f5-4122-8079-167e526ca4d4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_DebtSecuritiesAllowanceforCreditLoss_bf06a02a-d906-4d77-b6d1-080a5eeba15f" xlink:href="sfnc-20210930.xsd#sfnc_DebtSecuritiesAllowanceforCreditLoss"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_30377c26-6c0a-4fe8-b16d-a81012c10c79" xlink:to="loc_sfnc_DebtSecuritiesAllowanceforCreditLoss_bf06a02a-d906-4d77-b6d1-080a5eeba15f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_1905334b-e606-4223-94a3-4dc64e8a46d2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_30377c26-6c0a-4fe8-b16d-a81012c10c79" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_1905334b-e606-4223-94a3-4dc64e8a46d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSalePurchasedWithCreditDeteriorationAllowanceForCreditLossAtAcquisitionDate_b96dc347-5d15-4923-ac3c-7e07aa7e157b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSalePurchasedWithCreditDeteriorationAllowanceForCreditLossAtAcquisitionDate"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_30377c26-6c0a-4fe8-b16d-a81012c10c79" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSalePurchasedWithCreditDeteriorationAllowanceForCreditLossAtAcquisitionDate_b96dc347-5d15-4923-ac3c-7e07aa7e157b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/AcquisitionsSubsequentEvent" xlink:type="simple" xlink:href="sfnc-20210930.xsd#AcquisitionsSubsequentEvent"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/AcquisitionsSubsequentEvent" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationAndAssetAcquisitionAbstract_1a2261ff-2e0e-4975-bf97-224f39c495de" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationAndAssetAcquisitionAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationDisclosureTextBlock_cd73dfd1-c16b-456f-8b83-700c5f86f18f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessCombinationAndAssetAcquisitionAbstract_1a2261ff-2e0e-4975-bf97-224f39c495de" xlink:to="loc_us-gaap_BusinessCombinationDisclosureTextBlock_cd73dfd1-c16b-456f-8b83-700c5f86f18f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/AcquisitionsSubsequentEventTextualDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#AcquisitionsSubsequentEventTextualDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/AcquisitionsSubsequentEventTextualDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationAndAssetAcquisitionAbstract_59bf0e7a-bcbd-40cf-a005-a32d998a73b5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationAndAssetAcquisitionAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_e9fb7dc6-d826-4750-ba46-42d71758b86c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessCombinationAndAssetAcquisitionAbstract_59bf0e7a-bcbd-40cf-a005-a32d998a73b5" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_e9fb7dc6-d826-4750-ba46-42d71758b86c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_e6410218-f45b-4de9-8fd8-157db67400a4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_e9fb7dc6-d826-4750-ba46-42d71758b86c" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_e6410218-f45b-4de9-8fd8-157db67400a4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_38fce9d8-64fb-40e6-be2a-f45269293306" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_e6410218-f45b-4de9-8fd8-157db67400a4" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_38fce9d8-64fb-40e6-be2a-f45269293306" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_LandmarkCommunityBankMember_f64d9209-4544-4869-abd3-dee884cf4663" xlink:href="sfnc-20210930.xsd#sfnc_LandmarkCommunityBankMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_38fce9d8-64fb-40e6-be2a-f45269293306" xlink:to="loc_sfnc_LandmarkCommunityBankMember_f64d9209-4544-4869-abd3-dee884cf4663" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_TriumphBancsharesMember_a3bb0a12-1974-4475-997b-2db958a0e049" xlink:href="sfnc-20210930.xsd#sfnc_TriumphBancsharesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_38fce9d8-64fb-40e6-be2a-f45269293306" xlink:to="loc_sfnc_TriumphBancsharesMember_a3bb0a12-1974-4475-997b-2db958a0e049" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_5672ded7-d02b-45c5-9d46-00f25017e069" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_e9fb7dc6-d826-4750-ba46-42d71758b86c" xlink:to="loc_us-gaap_BusinessAcquisitionLineItems_5672ded7-d02b-45c5-9d46-00f25017e069" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_b6f2fbe9-3411-4eb7-84f4-a4be9ee8fe7f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5672ded7-d02b-45c5-9d46-00f25017e069" xlink:to="loc_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_b6f2fbe9-3411-4eb7-84f4-a4be9ee8fe7f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesGross_1b7d904c-aaa3-4a3a-b4b8-17148eed66e8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesGross"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5672ded7-d02b-45c5-9d46-00f25017e069" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesGross_1b7d904c-aaa3-4a3a-b4b8-17148eed66e8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_BusinessCombinationNumberOfBankBranchesAcquired_ab5c9f1f-6c4f-4e1b-82b2-890c7a62f0d5" xlink:href="sfnc-20210930.xsd#sfnc_BusinessCombinationNumberOfBankBranchesAcquired"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5672ded7-d02b-45c5-9d46-00f25017e069" xlink:to="loc_sfnc_BusinessCombinationNumberOfBankBranchesAcquired_ab5c9f1f-6c4f-4e1b-82b2-890c7a62f0d5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_fcbfacc7-fddd-4691-8023-2ceb46899668" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5672ded7-d02b-45c5-9d46-00f25017e069" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_fcbfacc7-fddd-4691-8023-2ceb46899668" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationAcquiredReceivablesGrossContractualAmount_a49c55a8-146b-4825-ae4f-322958add92e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationAcquiredReceivablesGrossContractualAmount"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5672ded7-d02b-45c5-9d46-00f25017e069" xlink:to="loc_us-gaap_BusinessCombinationAcquiredReceivablesGrossContractualAmount_a49c55a8-146b-4825-ae4f-322958add92e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilitiesDeposits_d397e3f8-f8c4-4da8-8954-acc5e9c79006" xlink:href="sfnc-20210930.xsd#sfnc_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilitiesDeposits"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_5672ded7-d02b-45c5-9d46-00f25017e069" xlink:to="loc_sfnc_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilitiesDeposits_d397e3f8-f8c4-4da8-8954-acc5e9c79006" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/InvestmentSecurities" xlink:type="simple" xlink:href="sfnc-20210930.xsd#InvestmentSecurities"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/InvestmentSecurities" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_24dbc9e1-d0d4-42cc-8d3b-1186a43f10f0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsInDebtAndMarketableEquitySecuritiesAndCertainTradingAssetsDisclosureTextBlock_1bd3f7a8-5e0c-492d-9c9f-5dbd9a0516a0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentsInDebtAndMarketableEquitySecuritiesAndCertainTradingAssetsDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_24dbc9e1-d0d4-42cc-8d3b-1186a43f10f0" xlink:to="loc_us-gaap_InvestmentsInDebtAndMarketableEquitySecuritiesAndCertainTradingAssetsDisclosureTextBlock_1bd3f7a8-5e0c-492d-9c9f-5dbd9a0516a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/InvestmentSecuritiesTables" xlink:type="simple" xlink:href="sfnc-20210930.xsd#InvestmentSecuritiesTables"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/InvestmentSecuritiesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_6e13172c-91ff-4111-971f-5784c15faca8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesTextBlock_1787de1f-85f4-4ae5-a66b-263dde005949" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_6e13172c-91ff-4111-971f-5784c15faca8" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesTextBlock_1787de1f-85f4-4ae5-a66b-263dde005949" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock_b03df71f-2e31-4ed7-9a42-94b51c65060d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_6e13172c-91ff-4111-971f-5784c15faca8" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock_b03df71f-2e31-4ed7-9a42-94b51c65060d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfUnrealizedLossOnInvestmentsTableTextBlock_4fa2feab-1c59-4ac3-8cec-3652d282ddc5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfUnrealizedLossOnInvestmentsTableTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_6e13172c-91ff-4111-971f-5784c15faca8" xlink:to="loc_us-gaap_ScheduleOfUnrealizedLossOnInvestmentsTableTextBlock_4fa2feab-1c59-4ac3-8cec-3652d282ddc5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_DebtSecuritiesAllowanceforCreditLossTableTextBlock_c87f0edb-0ec8-4e24-9f6a-db036e3752be" xlink:href="sfnc-20210930.xsd#sfnc_DebtSecuritiesAllowanceforCreditLossTableTextBlock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_6e13172c-91ff-4111-971f-5784c15faca8" xlink:to="loc_sfnc_DebtSecuritiesAllowanceforCreditLossTableTextBlock_c87f0edb-0ec8-4e24-9f6a-db036e3752be" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityCreditQualityIndicatorTableTextBlock_afd00008-1fca-4448-ac50-87edf824eb2d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesHeldToMaturityCreditQualityIndicatorTableTextBlock"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_6e13172c-91ff-4111-971f-5784c15faca8" xlink:to="loc_us-gaap_DebtSecuritiesHeldToMaturityCreditQualityIndicatorTableTextBlock_afd00008-1fca-4448-ac50-87edf824eb2d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeTextBlock_52110141-26aa-4a74-8c2d-db57a74092f5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentIncomeTextBlock"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_6e13172c-91ff-4111-971f-5784c15faca8" xlink:to="loc_us-gaap_InvestmentIncomeTextBlock_52110141-26aa-4a74-8c2d-db57a74092f5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsClassifiedByContractualMaturityDateTableTextBlock_1b887c61-06eb-45bd-813f-108babb9ac07" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentsClassifiedByContractualMaturityDateTableTextBlock"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_6e13172c-91ff-4111-971f-5784c15faca8" xlink:to="loc_us-gaap_InvestmentsClassifiedByContractualMaturityDateTableTextBlock_1b887c61-06eb-45bd-813f-108babb9ac07" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/InvestmentSecuritiesSummaryofInvestmentSecuritiesDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#InvestmentSecuritiesSummaryofInvestmentSecuritiesDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/InvestmentSecuritiesSummaryofInvestmentSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0926375f-d4e4-420e-b097-5671b7ab6e15" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_7ed81ea3-6fda-4033-8c34-3c70852d37c1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0926375f-d4e4-420e-b097-5671b7ab6e15" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_7ed81ea3-6fda-4033-8c34-3c70852d37c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_f795c1d3-667b-4aeb-9da2-ea25263d17f1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_7ed81ea3-6fda-4033-8c34-3c70852d37c1" xlink:to="loc_us-gaap_FinancialInstrumentAxis_f795c1d3-667b-4aeb-9da2-ea25263d17f1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_ac7f7001-71ef-42c9-ac76-33a3f74b310c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_f795c1d3-667b-4aeb-9da2-ea25263d17f1" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_ac7f7001-71ef-42c9-ac76-33a3f74b310c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_5a476b15-71f0-4f19-9f53-8255abb0c899" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_ac7f7001-71ef-42c9-ac76-33a3f74b310c" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_5a476b15-71f0-4f19-9f53-8255abb0c899" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_c8dd3926-4bf5-42cb-a986-687a015d9c8a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_ac7f7001-71ef-42c9-ac76-33a3f74b310c" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_c8dd3926-4bf5-42cb-a986-687a015d9c8a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_cdbe5e06-248a-4f41-a3de-1db78d008f71" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_ac7f7001-71ef-42c9-ac76-33a3f74b310c" xlink:to="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_cdbe5e06-248a-4f41-a3de-1db78d008f71" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USStatesAndPoliticalSubdivisionsMember_1cf9a2dc-8ab1-4a4f-9dbd-89585af8aac8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USStatesAndPoliticalSubdivisionsMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_ac7f7001-71ef-42c9-ac76-33a3f74b310c" xlink:to="loc_us-gaap_USStatesAndPoliticalSubdivisionsMember_1cf9a2dc-8ab1-4a4f-9dbd-89585af8aac8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_OtherSecuritiesMember_1df2bfcb-7e88-4f39-9b28-8761b0baf43d" xlink:href="sfnc-20210930.xsd#sfnc_OtherSecuritiesMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_ac7f7001-71ef-42c9-ac76-33a3f74b310c" xlink:to="loc_sfnc_OtherSecuritiesMember_1df2bfcb-7e88-4f39-9b28-8761b0baf43d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_d38ef5b4-1d1e-4744-8f2a-410d99461a23" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_7ed81ea3-6fda-4033-8c34-3c70852d37c1" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_d38ef5b4-1d1e-4744-8f2a-410d99461a23" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesAbstract_e2e0aab1-e7d5-40c8-8bef-621a295b24e7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_d38ef5b4-1d1e-4744-8f2a-410d99461a23" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesAbstract_e2e0aab1-e7d5-40c8-8bef-621a295b24e7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss_8d34d179-582d-4142-80fc-e0f20c23eef7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HeldToMaturitySecuritiesAbstract_e2e0aab1-e7d5-40c8-8bef-621a295b24e7" xlink:to="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss_8d34d179-582d-4142-80fc-e0f20c23eef7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLossExcludingAccruedInterest_bf355663-a1cd-40e6-add7-36a4ad100333" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLossExcludingAccruedInterest"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HeldToMaturitySecuritiesAbstract_e2e0aab1-e7d5-40c8-8bef-621a295b24e7" xlink:to="loc_us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLossExcludingAccruedInterest_bf355663-a1cd-40e6-add7-36a4ad100333" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestAfterAllowanceForCreditLoss_616a55de-e0dc-4563-a4ce-8c08db03c207" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestAfterAllowanceForCreditLoss"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HeldToMaturitySecuritiesAbstract_e2e0aab1-e7d5-40c8-8bef-621a295b24e7" xlink:to="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestAfterAllowanceForCreditLoss_616a55de-e0dc-4563-a4ce-8c08db03c207" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingGain_ee8cc707-231a-49fe-9599-a47ab0ed29ce" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingGain"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HeldToMaturitySecuritiesAbstract_e2e0aab1-e7d5-40c8-8bef-621a295b24e7" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingGain_ee8cc707-231a-49fe-9599-a47ab0ed29ce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss_bc5546aa-7d03-4247-8117-7092ddabcd0f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HeldToMaturitySecuritiesAbstract_e2e0aab1-e7d5-40c8-8bef-621a295b24e7" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss_bc5546aa-7d03-4247-8117-7092ddabcd0f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesFairValue_6a29a44c-2326-4dd2-b0ac-5b534f3475e6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesFairValue"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_HeldToMaturitySecuritiesAbstract_e2e0aab1-e7d5-40c8-8bef-621a295b24e7" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesFairValue_6a29a44c-2326-4dd2-b0ac-5b534f3475e6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAbstract_60bc927c-5ab6-4171-b8a0-8126539f6e5c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_d38ef5b4-1d1e-4744-8f2a-410d99461a23" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAbstract_60bc927c-5ab6-4171-b8a0-8126539f6e5c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_07e7c53a-3dfb-4902-a3f0-0c04ea76ccd9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAbstract_60bc927c-5ab6-4171-b8a0-8126539f6e5c" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_07e7c53a-3dfb-4902-a3f0-0c04ea76ccd9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostAllowanceForCreditLossExcludingAccruedInterest_4790020c-69ef-44da-870b-7b8aeff0ddd8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostAllowanceForCreditLossExcludingAccruedInterest"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAbstract_60bc927c-5ab6-4171-b8a0-8126539f6e5c" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostAllowanceForCreditLossExcludingAccruedInterest_4790020c-69ef-44da-870b-7b8aeff0ddd8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_47425ae7-2986-4bee-8047-706ce433ac47" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAbstract_60bc927c-5ab6-4171-b8a0-8126539f6e5c" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_47425ae7-2986-4bee-8047-706ce433ac47" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_44bf4b3d-c85a-4876-b753-2d68b63a770a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAbstract_60bc927c-5ab6-4171-b8a0-8126539f6e5c" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_44bf4b3d-c85a-4876-b753-2d68b63a770a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_bb0721bd-edd6-424b-85ff-13d8d5da9847" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAbstract_60bc927c-5ab6-4171-b8a0-8126539f6e5c" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_bb0721bd-edd6-424b-85ff-13d8d5da9847" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/InvestmentSecuritiesSummaryofInvestmentSecuritiesDetails_1" xlink:type="simple" xlink:href="sfnc-20210930.xsd#InvestmentSecuritiesSummaryofInvestmentSecuritiesDetails_1"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/InvestmentSecuritiesSummaryofInvestmentSecuritiesDetails_1" xlink:type="extended"/>
  <link:roleRef roleURI="http://simmonsbank.com/role/InvestmentSecuritiesTextualDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#InvestmentSecuritiesTextualDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/InvestmentSecuritiesTextualDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_aba65fbc-cb7b-49b1-9db8-aabf123b9f3e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_caf2f98e-45d4-474d-bfec-0d83d6ab3258" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_aba65fbc-cb7b-49b1-9db8-aabf123b9f3e" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_caf2f98e-45d4-474d-bfec-0d83d6ab3258" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_54bf331c-934a-4bd6-b4fa-87ab2d986c18" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_caf2f98e-45d4-474d-bfec-0d83d6ab3258" xlink:to="loc_us-gaap_FinancialInstrumentAxis_54bf331c-934a-4bd6-b4fa-87ab2d986c18" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_61d2301a-e8a1-4797-a6a8-a727e4e9bb04" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_54bf331c-934a-4bd6-b4fa-87ab2d986c18" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_61d2301a-e8a1-4797-a6a8-a727e4e9bb04" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_4e732271-5fee-4d4e-8aa5-fa7c67a7bf53" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommercialMortgageBackedSecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_61d2301a-e8a1-4797-a6a8-a727e4e9bb04" xlink:to="loc_us-gaap_CommercialMortgageBackedSecuritiesMember_4e732271-5fee-4d4e-8aa5-fa7c67a7bf53" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResidentialMortgageBackedSecuritiesMember_37a94343-0f42-418c-b92a-083c50ad754a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ResidentialMortgageBackedSecuritiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_61d2301a-e8a1-4797-a6a8-a727e4e9bb04" xlink:to="loc_us-gaap_ResidentialMortgageBackedSecuritiesMember_37a94343-0f42-418c-b92a-083c50ad754a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USStatesAndPoliticalSubdivisionsMember_f55eedd4-27cf-4854-ba60-ca643397ca11" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USStatesAndPoliticalSubdivisionsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_61d2301a-e8a1-4797-a6a8-a727e4e9bb04" xlink:to="loc_us-gaap_USStatesAndPoliticalSubdivisionsMember_f55eedd4-27cf-4854-ba60-ca643397ca11" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_TypeofGuaranteeAxis_92d9a4a6-fe61-40f8-abbf-c8241efd43a4" xlink:href="sfnc-20210930.xsd#sfnc_TypeofGuaranteeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_caf2f98e-45d4-474d-bfec-0d83d6ab3258" xlink:to="loc_sfnc_TypeofGuaranteeAxis_92d9a4a6-fe61-40f8-abbf-c8241efd43a4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_TypeofGuaranteeDomain_74d6e08c-f1c6-4863-ba03-c4e9bfcf08a8" xlink:href="sfnc-20210930.xsd#sfnc_TypeofGuaranteeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_sfnc_TypeofGuaranteeAxis_92d9a4a6-fe61-40f8-abbf-c8241efd43a4" xlink:to="loc_sfnc_TypeofGuaranteeDomain_74d6e08c-f1c6-4863-ba03-c4e9bfcf08a8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_OtherCreditEnhancementorInsuranceMember_9735a541-bf48-4652-8329-389d8cc2cf59" xlink:href="sfnc-20210930.xsd#sfnc_OtherCreditEnhancementorInsuranceMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_sfnc_TypeofGuaranteeDomain_74d6e08c-f1c6-4863-ba03-c4e9bfcf08a8" xlink:to="loc_sfnc_OtherCreditEnhancementorInsuranceMember_9735a541-bf48-4652-8329-389d8cc2cf59" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_cae89285-578f-48b4-9fdc-db71bf75cd9c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_caf2f98e-45d4-474d-bfec-0d83d6ab3258" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_cae89285-578f-48b4-9fdc-db71bf75cd9c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTransferToHeldToMaturityAllowanceForCreditLossExpense_5d592dc8-b187-4e71-8c7f-fc4511dc6325" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleTransferToHeldToMaturityAllowanceForCreditLossExpense"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_cae89285-578f-48b4-9fdc-db71bf75cd9c" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTransferToHeldToMaturityAllowanceForCreditLossExpense_5d592dc8-b187-4e71-8c7f-fc4511dc6325" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_OtherComprehensiveIncomeUnrealizedGainsOnSecuritiesTransferredFromAvailableForSaleToHeldToMaturity_e6cdc637-5081-48c2-b1ea-b6409fa6db33" xlink:href="sfnc-20210930.xsd#sfnc_OtherComprehensiveIncomeUnrealizedGainsOnSecuritiesTransferredFromAvailableForSaleToHeldToMaturity"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_cae89285-578f-48b4-9fdc-db71bf75cd9c" xlink:to="loc_sfnc_OtherComprehensiveIncomeUnrealizedGainsOnSecuritiesTransferredFromAvailableForSaleToHeldToMaturity_e6cdc637-5081-48c2-b1ea-b6409fa6db33" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_DebtSecuritiesAvailableForSaleTransferToHeldToMaturityGainLoss_7138b5e6-23ef-498b-8f8e-cb4492c9fc04" xlink:href="sfnc-20210930.xsd#sfnc_DebtSecuritiesAvailableForSaleTransferToHeldToMaturityGainLoss"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_cae89285-578f-48b4-9fdc-db71bf75cd9c" xlink:to="loc_sfnc_DebtSecuritiesAvailableForSaleTransferToHeldToMaturityGainLoss_7138b5e6-23ef-498b-8f8e-cb4492c9fc04" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss_242d2abe-984d-40ac-9cb6-c315e222a8c6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_cae89285-578f-48b4-9fdc-db71bf75cd9c" xlink:to="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss_242d2abe-984d-40ac-9cb6-c315e222a8c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_97ecec09-017a-478b-b58a-25f3ea31d6ae" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_cae89285-578f-48b4-9fdc-db71bf75cd9c" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_97ecec09-017a-478b-b58a-25f3ea31d6ae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_DebtSecuritiesHeldtomaturityInterestReceivable_f3037b6b-5a8a-46e7-a291-89d4b38465c7" xlink:href="sfnc-20210930.xsd#sfnc_DebtSecuritiesHeldtomaturityInterestReceivable"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_cae89285-578f-48b4-9fdc-db71bf75cd9c" xlink:to="loc_sfnc_DebtSecuritiesHeldtomaturityInterestReceivable_f3037b6b-5a8a-46e7-a291-89d4b38465c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_DebtSecuritiesAvailableforsaleInterestReceivable_e401a2de-13d9-4f68-b6cb-480b9f541d33" xlink:href="sfnc-20210930.xsd#sfnc_DebtSecuritiesAvailableforsaleInterestReceivable"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_cae89285-578f-48b4-9fdc-db71bf75cd9c" xlink:to="loc_sfnc_DebtSecuritiesAvailableforsaleInterestReceivable_e401a2de-13d9-4f68-b6cb-480b9f541d33" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_5e775507-123b-4f64-8fb3-4340553baf96" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_cae89285-578f-48b4-9fdc-db71bf75cd9c" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_5e775507-123b-4f64-8fb3-4340553baf96" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_97e4b0a6-5715-4af5-a9dd-fdc5189303d8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_cae89285-578f-48b4-9fdc-db71bf75cd9c" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_97e4b0a6-5715-4af5-a9dd-fdc5189303d8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_DebtSecuritiesUnrealizedLossPositionQuantitativeDisclosurePercent_fde33e69-e438-4266-ae44-397d9200dce4" xlink:href="sfnc-20210930.xsd#sfnc_DebtSecuritiesUnrealizedLossPositionQuantitativeDisclosurePercent"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_cae89285-578f-48b4-9fdc-db71bf75cd9c" xlink:to="loc_sfnc_DebtSecuritiesUnrealizedLossPositionQuantitativeDisclosurePercent_fde33e69-e438-4266-ae44-397d9200dce4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleChangeInPresentValueExpenseReversal_88ab6666-7878-456e-9c32-1e9ecebcfdd7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleChangeInPresentValueExpenseReversal"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_cae89285-578f-48b4-9fdc-db71bf75cd9c" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleChangeInPresentValueExpenseReversal_88ab6666-7878-456e-9c32-1e9ecebcfdd7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLossPeriodIncreaseDecrease_757dcdcf-7e74-4ff8-a418-e2f8e123bea6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLossPeriodIncreaseDecrease"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_cae89285-578f-48b4-9fdc-db71bf75cd9c" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLossPeriodIncreaseDecrease_757dcdcf-7e74-4ff8-a418-e2f8e123bea6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLossExcludingAccruedInterest_40d1550d-467d-4665-895d-c9db543543e2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLossExcludingAccruedInterest"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_cae89285-578f-48b4-9fdc-db71bf75cd9c" xlink:to="loc_us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLossExcludingAccruedInterest_40d1550d-467d-4665-895d-c9db543543e2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleRestricted_1046035d-58df-4fe9-be99-4f29e01f0ded" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleRestricted"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_cae89285-578f-48b4-9fdc-db71bf75cd9c" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleRestricted_1046035d-58df-4fe9-be99-4f29e01f0ded" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedGain_32be968a-bcb3-4524-86f3-9c978739bdb2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleRealizedGain"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_cae89285-578f-48b4-9fdc-db71bf75cd9c" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedGain_32be968a-bcb3-4524-86f3-9c978739bdb2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedLoss_d6b04809-3a69-4a9f-be9a-d658cb9f7b8d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleRealizedLoss"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_cae89285-578f-48b4-9fdc-db71bf75cd9c" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedLoss_d6b04809-3a69-4a9f-be9a-d658cb9f7b8d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableforsaleSecuritiesSoldAtPar_076dc1a4-6fa4-42b4-bfb5-4c6180bd194e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableforsaleSecuritiesSoldAtPar"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_cae89285-578f-48b4-9fdc-db71bf75cd9c" xlink:to="loc_us-gaap_AvailableforsaleSecuritiesSoldAtPar_076dc1a4-6fa4-42b4-bfb5-4c6180bd194e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_IncomeTaxBenefitRelatedToSecurityGainsLossesPercentage_05ac5127-cdee-418c-b29f-035d1fb05d48" xlink:href="sfnc-20210930.xsd#sfnc_IncomeTaxBenefitRelatedToSecurityGainsLossesPercentage"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_cae89285-578f-48b4-9fdc-db71bf75cd9c" xlink:to="loc_sfnc_IncomeTaxBenefitRelatedToSecurityGainsLossesPercentage_05ac5127-cdee-418c-b29f-035d1fb05d48" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/InvestmentSecuritiesSecuritiesWithUnrealizedLossesDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#InvestmentSecuritiesSecuritiesWithUnrealizedLossesDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/InvestmentSecuritiesSecuritiesWithUnrealizedLossesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_31e329eb-7d15-4f28-8fdd-5ed0d9722102" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_8cee67f1-f0da-45cf-9485-45ccd3d4d288" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_31e329eb-7d15-4f28-8fdd-5ed0d9722102" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_8cee67f1-f0da-45cf-9485-45ccd3d4d288" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_a0d628a6-7573-462e-8a7b-5e6472119622" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_8cee67f1-f0da-45cf-9485-45ccd3d4d288" xlink:to="loc_us-gaap_FinancialInstrumentAxis_a0d628a6-7573-462e-8a7b-5e6472119622" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_dafc53f9-bd9a-4333-8df5-8c0b2eda9369" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_a0d628a6-7573-462e-8a7b-5e6472119622" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_dafc53f9-bd9a-4333-8df5-8c0b2eda9369" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_947a3459-afd0-463f-9761-c4146500b58c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_dafc53f9-bd9a-4333-8df5-8c0b2eda9369" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_947a3459-afd0-463f-9761-c4146500b58c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_79624eb5-9940-4221-8291-e347ea8f483f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_dafc53f9-bd9a-4333-8df5-8c0b2eda9369" xlink:to="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_79624eb5-9940-4221-8291-e347ea8f483f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USStatesAndPoliticalSubdivisionsMember_4fce7fcb-4206-45f6-881b-92e3cc11a588" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USStatesAndPoliticalSubdivisionsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_dafc53f9-bd9a-4333-8df5-8c0b2eda9369" xlink:to="loc_us-gaap_USStatesAndPoliticalSubdivisionsMember_4fce7fcb-4206-45f6-881b-92e3cc11a588" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_OtherSecuritiesMember_242dd69a-c615-42f9-8803-4d5df4d9aeba" xlink:href="sfnc-20210930.xsd#sfnc_OtherSecuritiesMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_dafc53f9-bd9a-4333-8df5-8c0b2eda9369" xlink:to="loc_sfnc_OtherSecuritiesMember_242dd69a-c615-42f9-8803-4d5df4d9aeba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_8daa309b-46ba-442e-8583-11fe43f9165d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_8cee67f1-f0da-45cf-9485-45ccd3d4d288" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_8daa309b-46ba-442e-8583-11fe43f9165d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_826d9c9a-3e65-4153-998a-eba11564ecdb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_8daa309b-46ba-442e-8583-11fe43f9165d" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_826d9c9a-3e65-4153-998a-eba11564ecdb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_b714d277-2290-49fa-b7e6-a6a7f135ca43" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_8daa309b-46ba-442e-8583-11fe43f9165d" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_b714d277-2290-49fa-b7e6-a6a7f135ca43" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_ef801bf8-47dd-4ccc-93d6-e53785da596e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_8daa309b-46ba-442e-8583-11fe43f9165d" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_ef801bf8-47dd-4ccc-93d6-e53785da596e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_41e56e1b-b7a3-4ce2-800b-0401b5802ae0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_8daa309b-46ba-442e-8583-11fe43f9165d" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_41e56e1b-b7a3-4ce2-800b-0401b5802ae0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_3b7987c9-c05c-43b0-aa96-ad2ec3a2b2f3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_8daa309b-46ba-442e-8583-11fe43f9165d" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_3b7987c9-c05c-43b0-aa96-ad2ec3a2b2f3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_3f450feb-0f08-40ea-b31c-0195d34c5bac" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_8daa309b-46ba-442e-8583-11fe43f9165d" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_3f450feb-0f08-40ea-b31c-0195d34c5bac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTotalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/InvestmentSecuritiesAllowanceforCreditLossesHTMDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#InvestmentSecuritiesAllowanceforCreditLossesHTMDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/InvestmentSecuritiesAllowanceforCreditLossesHTMDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_d60b3957-32c7-49d2-91f9-801b90a2034c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLossTable_81d55d64-f865-49ac-9a09-aca2c89c3405" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLossTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_d60b3957-32c7-49d2-91f9-801b90a2034c" xlink:to="loc_us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLossTable_81d55d64-f865-49ac-9a09-aca2c89c3405" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_2158f5aa-80c4-4f4d-8a27-dc4c6ad91a98" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CumulativeEffectPeriodOfAdoptionAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLossTable_81d55d64-f865-49ac-9a09-aca2c89c3405" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_2158f5aa-80c4-4f4d-8a27-dc4c6ad91a98" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_9ff11dd4-4130-4bb8-bbf2-3e8bf786cd8e" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CumulativeEffectPeriodOfAdoptionDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_2158f5aa-80c4-4f4d-8a27-dc4c6ad91a98" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_9ff11dd4-4130-4bb8-bbf2-3e8bf786cd8e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember_8ed0b745-8195-4f5d-8bc1-9b68ea05cfbe" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_9ff11dd4-4130-4bb8-bbf2-3e8bf786cd8e" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember_8ed0b745-8195-4f5d-8bc1-9b68ea05cfbe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_8ceefb45-686e-40a2-8c24-a87f43744f49" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLossTable_81d55d64-f865-49ac-9a09-aca2c89c3405" xlink:to="loc_us-gaap_FinancialInstrumentAxis_8ceefb45-686e-40a2-8c24-a87f43744f49" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_dd716378-af2c-4113-a071-2c644f1bbfa4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_8ceefb45-686e-40a2-8c24-a87f43744f49" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_dd716378-af2c-4113-a071-2c644f1bbfa4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USStatesAndPoliticalSubdivisionsMember_65162554-cb65-4cd0-bf33-174f08d8c0e8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USStatesAndPoliticalSubdivisionsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_dd716378-af2c-4113-a071-2c644f1bbfa4" xlink:to="loc_us-gaap_USStatesAndPoliticalSubdivisionsMember_65162554-cb65-4cd0-bf33-174f08d8c0e8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_OtherSecuritiesMember_98ca7b67-54b2-477e-94c6-b0fec21c1656" xlink:href="sfnc-20210930.xsd#sfnc_OtherSecuritiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_dd716378-af2c-4113-a071-2c644f1bbfa4" xlink:to="loc_sfnc_OtherSecuritiesMember_98ca7b67-54b2-477e-94c6-b0fec21c1656" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldtomaturityAllowanceForCreditLossLineItems_a784adf7-ff91-452b-9456-0498d07074e9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesHeldtomaturityAllowanceForCreditLossLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLossTable_81d55d64-f865-49ac-9a09-aca2c89c3405" xlink:to="loc_us-gaap_DebtSecuritiesHeldtomaturityAllowanceForCreditLossLineItems_a784adf7-ff91-452b-9456-0498d07074e9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLossExcludingAccruedInterest_221d8a35-2bbd-436a-bfcc-33c12ee61fdd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLossExcludingAccruedInterest"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesHeldtomaturityAllowanceForCreditLossLineItems_a784adf7-ff91-452b-9456-0498d07074e9" xlink:to="loc_us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLossExcludingAccruedInterest_221d8a35-2bbd-436a-bfcc-33c12ee61fdd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityCreditLossExpenseReversal_b161338f-09ff-4baa-8689-cac7d7b79ea6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesHeldToMaturityCreditLossExpenseReversal"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesHeldtomaturityAllowanceForCreditLossLineItems_a784adf7-ff91-452b-9456-0498d07074e9" xlink:to="loc_us-gaap_DebtSecuritiesHeldToMaturityCreditLossExpenseReversal_b161338f-09ff-4baa-8689-cac7d7b79ea6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLossWriteoff_52da3f12-e7fb-46b4-a153-b133ded490ea" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLossWriteoff"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesHeldtomaturityAllowanceForCreditLossLineItems_a784adf7-ff91-452b-9456-0498d07074e9" xlink:to="loc_us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLossWriteoff_52da3f12-e7fb-46b4-a153-b133ded490ea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLossRecovery_2295913a-f7e4-4b20-a16b-99bd626603a3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLossRecovery"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesHeldtomaturityAllowanceForCreditLossLineItems_a784adf7-ff91-452b-9456-0498d07074e9" xlink:to="loc_us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLossRecovery_2295913a-f7e4-4b20-a16b-99bd626603a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLossExcludingAccruedInterest_4276793b-0798-49f3-b244-782bf4faf0d3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLossExcludingAccruedInterest"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesHeldtomaturityAllowanceForCreditLossLineItems_a784adf7-ff91-452b-9456-0498d07074e9" xlink:to="loc_us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLossExcludingAccruedInterest_4276793b-0798-49f3-b244-782bf4faf0d3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/InvestmentSecuritiesAllowanceforCreditLossesAFSDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#InvestmentSecuritiesAllowanceforCreditLossesAFSDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/InvestmentSecuritiesAllowanceforCreditLossesAFSDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_51a0d535-ff87-4eb3-9590-65f4c9fb4757" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLossTable_47fef3de-e1b7-4909-9b54-ac8fbc26942a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLossTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_51a0d535-ff87-4eb3-9590-65f4c9fb4757" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLossTable_47fef3de-e1b7-4909-9b54-ac8fbc26942a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_67067e0d-15f6-41db-a5d8-4d19684d7b2b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLossTable_47fef3de-e1b7-4909-9b54-ac8fbc26942a" xlink:to="loc_us-gaap_FinancialInstrumentAxis_67067e0d-15f6-41db-a5d8-4d19684d7b2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_8f2b56e1-aad9-4161-8f4c-0b98841ff1a7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_67067e0d-15f6-41db-a5d8-4d19684d7b2b" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_8f2b56e1-aad9-4161-8f4c-0b98841ff1a7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USStatesAndPoliticalSubdivisionsMember_7eb14e6d-fb89-4176-889f-3493f0f3c4b4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USStatesAndPoliticalSubdivisionsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_8f2b56e1-aad9-4161-8f4c-0b98841ff1a7" xlink:to="loc_us-gaap_USStatesAndPoliticalSubdivisionsMember_7eb14e6d-fb89-4176-889f-3493f0f3c4b4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_OtherSecuritiesMember_3fe44aee-499d-488d-8e2e-78c9e2d00ef6" xlink:href="sfnc-20210930.xsd#sfnc_OtherSecuritiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_8f2b56e1-aad9-4161-8f4c-0b98841ff1a7" xlink:to="loc_sfnc_OtherSecuritiesMember_3fe44aee-499d-488d-8e2e-78c9e2d00ef6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_8ede4e4a-7cb8-489c-8d5f-5b40bc699fe1" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CumulativeEffectPeriodOfAdoptionAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLossTable_47fef3de-e1b7-4909-9b54-ac8fbc26942a" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_8ede4e4a-7cb8-489c-8d5f-5b40bc699fe1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_7d688f1a-abf0-4c41-b9d3-700a8d959d32" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CumulativeEffectPeriodOfAdoptionDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_8ede4e4a-7cb8-489c-8d5f-5b40bc699fe1" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_7d688f1a-abf0-4c41-b9d3-700a8d959d32" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember_3c8e7d6e-9aa4-4529-9289-4064d29addbb" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_7d688f1a-abf0-4c41-b9d3-700a8d959d32" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember_3c8e7d6e-9aa4-4529-9289-4064d29addbb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableforsaleAllowanceForCreditLossLineItems_2ce3cb62-6763-42c6-8b36-51b0f2206c07" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableforsaleAllowanceForCreditLossLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLossTable_47fef3de-e1b7-4909-9b54-ac8fbc26942a" xlink:to="loc_us-gaap_DebtSecuritiesAvailableforsaleAllowanceForCreditLossLineItems_2ce3cb62-6763-42c6-8b36-51b0f2206c07" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLossRollForward_bccd6e8e-4ce4-485d-85d9-eb373db08360" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLossRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableforsaleAllowanceForCreditLossLineItems_2ce3cb62-6763-42c6-8b36-51b0f2206c07" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLossRollForward_bccd6e8e-4ce4-485d-85d9-eb373db08360" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostAllowanceForCreditLossExcludingAccruedInterest_bcc12a24-b4d7-4dd3-ba15-55ca3b55289f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostAllowanceForCreditLossExcludingAccruedInterest"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLossRollForward_bccd6e8e-4ce4-485d-85d9-eb373db08360" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostAllowanceForCreditLossExcludingAccruedInterest_bcc12a24-b4d7-4dd3-ba15-55ca3b55289f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLossNotPreviouslyRecorded_f8daf494-4b3d-4c51-8b80-f2a202f73463" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLossNotPreviouslyRecorded"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLossRollForward_bccd6e8e-4ce4-485d-85d9-eb373db08360" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLossNotPreviouslyRecorded_f8daf494-4b3d-4c51-8b80-f2a202f73463" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLossSecuritiesSold_37cf0f1f-b0f4-48d8-b7ab-51e3f33fd712" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLossSecuritiesSold"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLossRollForward_bccd6e8e-4ce4-485d-85d9-eb373db08360" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLossSecuritiesSold_37cf0f1f-b0f4-48d8-b7ab-51e3f33fd712" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLossNotToSellBeforeRecoveryCreditLossPreviouslyRecordedExpenseReversal_136e7626-8ec3-4615-8792-cb29f4b1dea5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLossNotToSellBeforeRecoveryCreditLossPreviouslyRecordedExpenseReversal"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLossRollForward_bccd6e8e-4ce4-485d-85d9-eb373db08360" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLossNotToSellBeforeRecoveryCreditLossPreviouslyRecordedExpenseReversal_136e7626-8ec3-4615-8792-cb29f4b1dea5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostAllowanceForCreditLossExcludingAccruedInterest_437ee682-5856-46e6-9e8d-3c3d9bd32c55" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostAllowanceForCreditLossExcludingAccruedInterest"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLossRollForward_bccd6e8e-4ce4-485d-85d9-eb373db08360" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostAllowanceForCreditLossExcludingAccruedInterest_437ee682-5856-46e6-9e8d-3c3d9bd32c55" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/InvestmentSecuritiesCreditQualityIndicatorDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#InvestmentSecuritiesCreditQualityIndicatorDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/InvestmentSecuritiesCreditQualityIndicatorDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_d3da9179-2ab1-41a6-a78e-5de28fe15b78" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityCreditQualityIndicatorTable_9bad1618-36f8-48d5-8eb6-123342a0efed" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesHeldToMaturityCreditQualityIndicatorTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_d3da9179-2ab1-41a6-a78e-5de28fe15b78" xlink:to="loc_us-gaap_DebtSecuritiesHeldToMaturityCreditQualityIndicatorTable_9bad1618-36f8-48d5-8eb6-123342a0efed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_TypeofGuaranteeAxis_93d34cd0-02bf-4bad-9310-21f72b1f201c" xlink:href="sfnc-20210930.xsd#sfnc_TypeofGuaranteeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesHeldToMaturityCreditQualityIndicatorTable_9bad1618-36f8-48d5-8eb6-123342a0efed" xlink:to="loc_sfnc_TypeofGuaranteeAxis_93d34cd0-02bf-4bad-9310-21f72b1f201c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_TypeofGuaranteeDomain_f123b348-ae96-4583-b704-dc50dc389b69" xlink:href="sfnc-20210930.xsd#sfnc_TypeofGuaranteeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_sfnc_TypeofGuaranteeAxis_93d34cd0-02bf-4bad-9310-21f72b1f201c" xlink:to="loc_sfnc_TypeofGuaranteeDomain_f123b348-ae96-4583-b704-dc50dc389b69" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_NotGuaranteedorPreRefundedMember_8647ff0f-85f3-4c78-8b12-75ba665fa405" xlink:href="sfnc-20210930.xsd#sfnc_NotGuaranteedorPreRefundedMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_sfnc_TypeofGuaranteeDomain_f123b348-ae96-4583-b704-dc50dc389b69" xlink:to="loc_sfnc_NotGuaranteedorPreRefundedMember_8647ff0f-85f3-4c78-8b12-75ba665fa405" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_OtherCreditEnhancementorInsuranceMember_f919dddf-714e-4333-9bd7-63330de7c339" xlink:href="sfnc-20210930.xsd#sfnc_OtherCreditEnhancementorInsuranceMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_sfnc_TypeofGuaranteeDomain_f123b348-ae96-4583-b704-dc50dc389b69" xlink:to="loc_sfnc_OtherCreditEnhancementorInsuranceMember_f919dddf-714e-4333-9bd7-63330de7c339" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_PreRefundedMember_cd2be9ad-f94e-4e1c-a1fa-eec14af740b3" xlink:href="sfnc-20210930.xsd#sfnc_PreRefundedMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_sfnc_TypeofGuaranteeDomain_f123b348-ae96-4583-b704-dc50dc389b69" xlink:to="loc_sfnc_PreRefundedMember_cd2be9ad-f94e-4e1c-a1fa-eec14af740b3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_CreditRatingBondAxis_7bbd094b-be84-4413-8608-d48085c56293" xlink:href="sfnc-20210930.xsd#sfnc_CreditRatingBondAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesHeldToMaturityCreditQualityIndicatorTable_9bad1618-36f8-48d5-8eb6-123342a0efed" xlink:to="loc_sfnc_CreditRatingBondAxis_7bbd094b-be84-4413-8608-d48085c56293" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_CreditRatingBondDomain_0e431bf4-c559-419f-84e5-a5b823b1d70f" xlink:href="sfnc-20210930.xsd#sfnc_CreditRatingBondDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_sfnc_CreditRatingBondAxis_7bbd094b-be84-4413-8608-d48085c56293" xlink:to="loc_sfnc_CreditRatingBondDomain_0e431bf4-c559-419f-84e5-a5b823b1d70f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_BondAaaAAARatingMember_23d25be0-e4c2-40a2-a42b-ce842408fda4" xlink:href="sfnc-20210930.xsd#sfnc_BondAaaAAARatingMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_sfnc_CreditRatingBondDomain_0e431bf4-c559-419f-84e5-a5b823b1d70f" xlink:to="loc_sfnc_BondAaaAAARatingMember_23d25be0-e4c2-40a2-a42b-ce842408fda4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_BondAaAARatingMember_4cd82a09-5f07-4185-8d25-7bd621bd0a4c" xlink:href="sfnc-20210930.xsd#sfnc_BondAaAARatingMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_sfnc_CreditRatingBondDomain_0e431bf4-c559-419f-84e5-a5b823b1d70f" xlink:to="loc_sfnc_BondAaAARatingMember_4cd82a09-5f07-4185-8d25-7bd621bd0a4c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_BondARatingMember_c7a0e5dd-8a18-4f08-bbb8-aad6fa778b25" xlink:href="sfnc-20210930.xsd#sfnc_BondARatingMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_sfnc_CreditRatingBondDomain_0e431bf4-c559-419f-84e5-a5b823b1d70f" xlink:to="loc_sfnc_BondARatingMember_c7a0e5dd-8a18-4f08-bbb8-aad6fa778b25" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_BondBaaBBBRatingMember_f132a5ec-5e6b-4ddf-81ec-bdfadef7c689" xlink:href="sfnc-20210930.xsd#sfnc_BondBaaBBBRatingMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_sfnc_CreditRatingBondDomain_0e431bf4-c559-419f-84e5-a5b823b1d70f" xlink:to="loc_sfnc_BondBaaBBBRatingMember_f132a5ec-5e6b-4ddf-81ec-bdfadef7c689" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_BondNotRatedMember_dc89062c-9a7c-4c1e-8549-1aa187ee3591" xlink:href="sfnc-20210930.xsd#sfnc_BondNotRatedMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_sfnc_CreditRatingBondDomain_0e431bf4-c559-419f-84e5-a5b823b1d70f" xlink:to="loc_sfnc_BondNotRatedMember_dc89062c-9a7c-4c1e-8549-1aa187ee3591" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_642904f2-023f-4305-ad39-512df9d68179" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesHeldToMaturityCreditQualityIndicatorTable_9bad1618-36f8-48d5-8eb6-123342a0efed" xlink:to="loc_us-gaap_FinancialInstrumentAxis_642904f2-023f-4305-ad39-512df9d68179" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1f2dd45c-4169-4e4e-bc48-f13ab99a0d4c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_642904f2-023f-4305-ad39-512df9d68179" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1f2dd45c-4169-4e4e-bc48-f13ab99a0d4c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USStatesAndPoliticalSubdivisionsMember_47ef3473-76d3-44c7-a85f-5bc5338752ce" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USStatesAndPoliticalSubdivisionsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1f2dd45c-4169-4e4e-bc48-f13ab99a0d4c" xlink:to="loc_us-gaap_USStatesAndPoliticalSubdivisionsMember_47ef3473-76d3-44c7-a85f-5bc5338752ce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_OtherSecuritiesMember_f5f79579-110c-4a89-aa71-74b638820b64" xlink:href="sfnc-20210930.xsd#sfnc_OtherSecuritiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1f2dd45c-4169-4e4e-bc48-f13ab99a0d4c" xlink:to="loc_sfnc_OtherSecuritiesMember_f5f79579-110c-4a89-aa71-74b638820b64" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityCreditQualityIndicatorLineItems_6b7969e0-6da3-4eb1-b5da-98486e979c29" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesHeldToMaturityCreditQualityIndicatorLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesHeldToMaturityCreditQualityIndicatorTable_9bad1618-36f8-48d5-8eb6-123342a0efed" xlink:to="loc_us-gaap_DebtSecuritiesHeldToMaturityCreditQualityIndicatorLineItems_6b7969e0-6da3-4eb1-b5da-98486e979c29" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss_68dd19e1-42f1-4e70-b480-294bbf4dd764" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesHeldToMaturityCreditQualityIndicatorLineItems_6b7969e0-6da3-4eb1-b5da-98486e979c29" xlink:to="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss_68dd19e1-42f1-4e70-b480-294bbf4dd764" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/InvestmentSecuritiesIncomeEarnedonSecuritiesDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#InvestmentSecuritiesIncomeEarnedonSecuritiesDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/InvestmentSecuritiesIncomeEarnedonSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_3a7840de-69aa-4c28-9a1d-e7a4073d5a88" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_d9d6e38a-46fc-459f-a07e-0538f60ee913" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_3a7840de-69aa-4c28-9a1d-e7a4073d5a88" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_d9d6e38a-46fc-459f-a07e-0538f60ee913" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InformationByCategoryOfDebtSecurityAxis_7447b658-3a44-4013-8c68-3262f90f6fb0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InformationByCategoryOfDebtSecurityAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_d9d6e38a-46fc-459f-a07e-0538f60ee913" xlink:to="loc_us-gaap_InformationByCategoryOfDebtSecurityAxis_7447b658-3a44-4013-8c68-3262f90f6fb0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherThanTemporaryImpairmentCreditLossesRecognizedInEarningsCategoriesOfInvestmentsDomain_54075b08-d77a-4953-93f6-0f5195e84bd0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherThanTemporaryImpairmentCreditLossesRecognizedInEarningsCategoriesOfInvestmentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InformationByCategoryOfDebtSecurityAxis_7447b658-3a44-4013-8c68-3262f90f6fb0" xlink:to="loc_us-gaap_OtherThanTemporaryImpairmentCreditLossesRecognizedInEarningsCategoriesOfInvestmentsDomain_54075b08-d77a-4953-93f6-0f5195e84bd0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldtomaturitySecuritiesMember_eb67badf-7ada-4d3f-9e2a-280496b7a3ca" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldtomaturitySecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherThanTemporaryImpairmentCreditLossesRecognizedInEarningsCategoriesOfInvestmentsDomain_54075b08-d77a-4953-93f6-0f5195e84bd0" xlink:to="loc_us-gaap_HeldtomaturitySecuritiesMember_eb67badf-7ada-4d3f-9e2a-280496b7a3ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableforsaleSecuritiesMember_cd2b18f6-267c-49b2-8ce6-3f93dddf0d91" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableforsaleSecuritiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherThanTemporaryImpairmentCreditLossesRecognizedInEarningsCategoriesOfInvestmentsDomain_54075b08-d77a-4953-93f6-0f5195e84bd0" xlink:to="loc_us-gaap_AvailableforsaleSecuritiesMember_cd2b18f6-267c-49b2-8ce6-3f93dddf0d91" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_32621e03-69c1-4b93-a4c6-0a69280cfda1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_d9d6e38a-46fc-459f-a07e-0538f60ee913" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_32621e03-69c1-4b93-a4c6-0a69280cfda1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeSecuritiesOperatingByTaxableStatusAbstract_ef66a03b-a110-4e94-aa38-32dd874f6fec" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeSecuritiesOperatingByTaxableStatusAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_32621e03-69c1-4b93-a4c6-0a69280cfda1" xlink:to="loc_us-gaap_InterestIncomeSecuritiesOperatingByTaxableStatusAbstract_ef66a03b-a110-4e94-aa38-32dd874f6fec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeSecuritiesTaxable_ce4d9eb3-eab0-4177-91a9-da29a88e36c0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeSecuritiesTaxable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InterestIncomeSecuritiesOperatingByTaxableStatusAbstract_ef66a03b-a110-4e94-aa38-32dd874f6fec" xlink:to="loc_us-gaap_InterestIncomeSecuritiesTaxable_ce4d9eb3-eab0-4177-91a9-da29a88e36c0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_InterestIncomeSecuritiesOperatingByNonTaxableStatusAbstract_8c9d70e4-9f55-46dc-a36a-171625d85c78" xlink:href="sfnc-20210930.xsd#sfnc_InterestIncomeSecuritiesOperatingByNonTaxableStatusAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_32621e03-69c1-4b93-a4c6-0a69280cfda1" xlink:to="loc_sfnc_InterestIncomeSecuritiesOperatingByNonTaxableStatusAbstract_8c9d70e4-9f55-46dc-a36a-171625d85c78" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeSecuritiesTaxExempt_759af702-68d5-45f5-90b3-86b55c9d8b56" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeSecuritiesTaxExempt"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_sfnc_InterestIncomeSecuritiesOperatingByNonTaxableStatusAbstract_8c9d70e4-9f55-46dc-a36a-171625d85c78" xlink:to="loc_us-gaap_InterestIncomeSecuritiesTaxExempt_759af702-68d5-45f5-90b3-86b55c9d8b56" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_84c3ef22-7a0b-4693-9d57-01cc664dacf9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_32621e03-69c1-4b93-a4c6-0a69280cfda1" xlink:to="loc_us-gaap_InvestmentIncomeInterest_84c3ef22-7a0b-4693-9d57-01cc664dacf9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/InvestmentSecuritiesMaturitiesofInvestmentSecuritiesDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#InvestmentSecuritiesMaturitiesofInvestmentSecuritiesDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/InvestmentSecuritiesMaturitiesofInvestmentSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0bb0ab53-bf6b-4f87-9393-d53ca60b0b2b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearNetCarryingAmount_ecbff0fb-277c-48a6-bb00-68850c5e9078" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearNetCarryingAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0bb0ab53-bf6b-4f87-9393-d53ca60b0b2b" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearNetCarryingAmount_ecbff0fb-277c-48a6-bb00-68850c5e9078" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsNetCarryingAmount_fa40be2e-a5d4-4a9c-81bd-489c34ae50af" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsNetCarryingAmount"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0bb0ab53-bf6b-4f87-9393-d53ca60b0b2b" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsNetCarryingAmount_fa40be2e-a5d4-4a9c-81bd-489c34ae50af" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterFiveThroughTenYearsNetCarryingAmount_5f876f74-a71b-4033-85c3-4cbaae39e254" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterFiveThroughTenYearsNetCarryingAmount"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0bb0ab53-bf6b-4f87-9393-d53ca60b0b2b" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterFiveThroughTenYearsNetCarryingAmount_5f876f74-a71b-4033-85c3-4cbaae39e254" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsNetCarryingAmount_6b1c6b00-3c97-4137-9a6d-d86a8fbd0145" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsNetCarryingAmount"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0bb0ab53-bf6b-4f87-9393-d53ca60b0b2b" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsNetCarryingAmount_6b1c6b00-3c97-4137-9a6d-d86a8fbd0145" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesSingleMaturityDateAmortizedCostBasis_34371881-7040-44bc-b8c2-19675559f485" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesSingleMaturityDateAmortizedCostBasis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0bb0ab53-bf6b-4f87-9393-d53ca60b0b2b" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesSingleMaturityDateAmortizedCostBasis_34371881-7040-44bc-b8c2-19675559f485" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss_55adc171-f1b7-4bfa-927f-db83af2e0ebc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0bb0ab53-bf6b-4f87-9393-d53ca60b0b2b" xlink:to="loc_us-gaap_DebtSecuritiesHeldToMaturityExcludingAccruedInterestBeforeAllowanceForCreditLoss_55adc171-f1b7-4bfa-927f-db83af2e0ebc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearFairValue_288ee08a-5166-4515-93af-a8ea01e59cf9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearFairValue"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0bb0ab53-bf6b-4f87-9393-d53ca60b0b2b" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearFairValue_288ee08a-5166-4515-93af-a8ea01e59cf9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_bb90091c-704b-4ae7-888b-f198dab80aba" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0bb0ab53-bf6b-4f87-9393-d53ca60b0b2b" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_bb90091c-704b-4ae7-888b-f198dab80aba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_7911bbfd-b6b6-4537-8726-61fefba336e0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0bb0ab53-bf6b-4f87-9393-d53ca60b0b2b" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_7911bbfd-b6b6-4537-8726-61fefba336e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsFairValue_e3da0760-5829-402e-ac56-6ee284fd33c2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsFairValue"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0bb0ab53-bf6b-4f87-9393-d53ca60b0b2b" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsFairValue_e3da0760-5829-402e-ac56-6ee284fd33c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesSingleMaturityDateFairValue_a6cea271-5a23-4358-a8a8-e8766270ed0b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesSingleMaturityDateFairValue"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0bb0ab53-bf6b-4f87-9393-d53ca60b0b2b" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesSingleMaturityDateFairValue_a6cea271-5a23-4358-a8a8-e8766270ed0b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesFairValue_61593b27-a62a-4802-8b5e-0c1ed801681a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesFairValue"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0bb0ab53-bf6b-4f87-9393-d53ca60b0b2b" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesFairValue_61593b27-a62a-4802-8b5e-0c1ed801681a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_936e99d4-e182-44f4-9d20-55c00a413f76" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0bb0ab53-bf6b-4f87-9393-d53ca60b0b2b" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_936e99d4-e182-44f4-9d20-55c00a413f76" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost_f5143083-3c69-41e2-9b86-e8076288c671" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0bb0ab53-bf6b-4f87-9393-d53ca60b0b2b" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost_f5143083-3c69-41e2-9b86-e8076288c671" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost_10c23402-a5bf-4b2e-b606-d8067ed64d21" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0bb0ab53-bf6b-4f87-9393-d53ca60b0b2b" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost_10c23402-a5bf-4b2e-b606-d8067ed64d21" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsAmortizedCost_bdfc6a15-5c5d-4e63-8a17-9aa44154c5e4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsAmortizedCost"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0bb0ab53-bf6b-4f87-9393-d53ca60b0b2b" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsAmortizedCost_bdfc6a15-5c5d-4e63-8a17-9aa44154c5e4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesSingleMaturityDateAmortizedCostBasis_be46aaa6-7cde-4598-b8e3-4cf623fe8301" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesSingleMaturityDateAmortizedCostBasis"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0bb0ab53-bf6b-4f87-9393-d53ca60b0b2b" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesSingleMaturityDateAmortizedCostBasis_be46aaa6-7cde-4598-b8e3-4cf623fe8301" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateAmortizedCost_4b8c0d4c-3700-4269-b4cc-5c16fe98d098" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateAmortizedCost"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0bb0ab53-bf6b-4f87-9393-d53ca60b0b2b" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateAmortizedCost_4b8c0d4c-3700-4269-b4cc-5c16fe98d098" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_2a5a785b-4883-4d14-9d7e-5552f0a2a39d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0bb0ab53-bf6b-4f87-9393-d53ca60b0b2b" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_2a5a785b-4883-4d14-9d7e-5552f0a2a39d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_e8ac87a8-6677-4437-9c88-a4501c90e533" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0bb0ab53-bf6b-4f87-9393-d53ca60b0b2b" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_e8ac87a8-6677-4437-9c88-a4501c90e533" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_f184258f-2b63-4d68-ac42-86efa1b4e67a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0bb0ab53-bf6b-4f87-9393-d53ca60b0b2b" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_f184258f-2b63-4d68-ac42-86efa1b4e67a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_b0d16495-b05d-4562-a47f-125515f579b4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0bb0ab53-bf6b-4f87-9393-d53ca60b0b2b" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_b0d16495-b05d-4562-a47f-125515f579b4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue_998fca4b-2a81-4b52-90b8-6e0e6f194888" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0bb0ab53-bf6b-4f87-9393-d53ca60b0b2b" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue_998fca4b-2a81-4b52-90b8-6e0e6f194888" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesSingleMaturityDate_c18cacc4-f61f-42c5-b338-84cdfcbd3978" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesSingleMaturityDate"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0bb0ab53-bf6b-4f87-9393-d53ca60b0b2b" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesSingleMaturityDate_c18cacc4-f61f-42c5-b338-84cdfcbd3978" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateFairValue_505dc8d6-381e-450d-8058-39e168f18126" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateFairValue"/>
    <link:presentationArc order="25" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0bb0ab53-bf6b-4f87-9393-d53ca60b0b2b" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateFairValue_505dc8d6-381e-450d-8058-39e168f18126" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_41335ca4-597f-472b-aa77-cb0e5bd6a010" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:presentationArc order="26" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0bb0ab53-bf6b-4f87-9393-d53ca60b0b2b" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_41335ca4-597f-472b-aa77-cb0e5bd6a010" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/OtherLiabilitiesHeldforSale" xlink:type="simple" xlink:href="sfnc-20210930.xsd#OtherLiabilitiesHeldforSale"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/OtherLiabilitiesHeldforSale" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredCostsCapitalizedPrepaidAndOtherAssetsDisclosureAbstract_65da2815-0b95-45b5-a542-3b47f7248011" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredCostsCapitalizedPrepaidAndOtherAssetsDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsDisclosureTextBlock_1a469d21-539f-4b5f-90cb-9190c20c70c3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredCostsCapitalizedPrepaidAndOtherAssetsDisclosureAbstract_65da2815-0b95-45b5-a542-3b47f7248011" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsDisclosureTextBlock_1a469d21-539f-4b5f-90cb-9190c20c70c3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/OtherLiabilitiesHeldforSaleDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#OtherLiabilitiesHeldforSaleDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/OtherLiabilitiesHeldforSaleDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredCostsCapitalizedPrepaidAndOtherAssetsDisclosureAbstract_0e680108-7b69-428c-bb1d-276208bae7d3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredCostsCapitalizedPrepaidAndOtherAssetsDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_77909f61-518f-4576-9022-730d080fa51e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredCostsCapitalizedPrepaidAndOtherAssetsDisclosureAbstract_0e680108-7b69-428c-bb1d-276208bae7d3" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_77909f61-518f-4576-9022-730d080fa51e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationAxis_344f36d1-d0a4-4dc4-94f3-033cc2263b07" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisposalGroupClassificationAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_77909f61-518f-4576-9022-730d080fa51e" xlink:to="loc_us-gaap_DisposalGroupClassificationAxis_344f36d1-d0a4-4dc4-94f3-033cc2263b07" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_ce80a158-884f-406a-be9c-0f1db832b4d3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisposalGroupClassificationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_344f36d1-d0a4-4dc4-94f3-033cc2263b07" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_ce80a158-884f-406a-be9c-0f1db832b4d3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupHeldforsaleNotDiscontinuedOperationsMember_a7393c4a-4274-494a-aad3-aaaf210f85ef" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisposalGroupHeldforsaleNotDiscontinuedOperationsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisposalGroupClassificationDomain_ce80a158-884f-406a-be9c-0f1db832b4d3" xlink:to="loc_us-gaap_DisposalGroupHeldforsaleNotDiscontinuedOperationsMember_a7393c4a-4274-494a-aad3-aaaf210f85ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_0dd02958-adef-448f-bcab-454b6f86af89" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_77909f61-518f-4576-9022-730d080fa51e" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_0dd02958-adef-448f-bcab-454b6f86af89" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_80e12994-cd30-4fdd-90f2-9c46098ae4ad" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_0dd02958-adef-448f-bcab-454b6f86af89" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_80e12994-cd30-4fdd-90f2-9c46098ae4ad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_IllinoisBranchesMember_165410e9-c118-4e98-9d2a-b94a4b1097cf" xlink:href="sfnc-20210930.xsd#sfnc_IllinoisBranchesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_80e12994-cd30-4fdd-90f2-9c46098ae4ad" xlink:to="loc_sfnc_IllinoisBranchesMember_165410e9-c118-4e98-9d2a-b94a4b1097cf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_e03e86b0-d90a-4b9d-a790-a0433ee30692" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_77909f61-518f-4576-9022-730d080fa51e" xlink:to="loc_us-gaap_BusinessAcquisitionLineItems_e03e86b0-d90a-4b9d-a790-a0433ee30692" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_NumberOfBranchesSold_76f21031-d463-4f54-96d9-6e51cd47145b" xlink:href="sfnc-20210930.xsd#sfnc_NumberOfBranchesSold"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_e03e86b0-d90a-4b9d-a790-a0433ee30692" xlink:to="loc_sfnc_NumberOfBranchesSold_76f21031-d463-4f54-96d9-6e51cd47145b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansReceivableHeldForSaleAmount_986c3cf9-c615-4b6b-a347-49961449691c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoansReceivableHeldForSaleAmount"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_e03e86b0-d90a-4b9d-a790-a0433ee30692" xlink:to="loc_us-gaap_LoansReceivableHeldForSaleAmount_986c3cf9-c615-4b6b-a347-49961449691c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_DepositLiabilitiesHeldForSale_f3e11ac2-3893-4f4e-a299-1f0c8b116c8a" xlink:href="sfnc-20210930.xsd#sfnc_DepositLiabilitiesHeldForSale"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_e03e86b0-d90a-4b9d-a790-a0433ee30692" xlink:to="loc_sfnc_DepositLiabilitiesHeldForSale_f3e11ac2-3893-4f4e-a299-1f0c8b116c8a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfBusiness_8a405e40-0e0a-46b9-8577-0767e6c26b97" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainLossOnSaleOfBusiness"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_e03e86b0-d90a-4b9d-a790-a0433ee30692" xlink:to="loc_us-gaap_GainLossOnSaleOfBusiness_8a405e40-0e0a-46b9-8577-0767e6c26b97" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherLiabilities_866be746-6a30-4484-81e6-41081cf64138" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherLiabilities"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_e03e86b0-d90a-4b9d-a790-a0433ee30692" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherLiabilities_866be746-6a30-4484-81e6-41081cf64138" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/LoansandAllowanceforCreditLosses" xlink:type="simple" xlink:href="sfnc-20210930.xsd#LoansandAllowanceforCreditLosses"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/LoansandAllowanceforCreditLosses" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesAbstract_b71ce7f8-5969-43a5-8c58-ed725d3a89ab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivablesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansNotesTradeAndOtherReceivablesDisclosureTextBlock_f06d7cfa-4062-4b2d-b63d-394e1189fe0b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoansNotesTradeAndOtherReceivablesDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesAbstract_b71ce7f8-5969-43a5-8c58-ed725d3a89ab" xlink:to="loc_us-gaap_LoansNotesTradeAndOtherReceivablesDisclosureTextBlock_f06d7cfa-4062-4b2d-b63d-394e1189fe0b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/LoansandAllowanceforCreditLossesTables" xlink:type="simple" xlink:href="sfnc-20210930.xsd#LoansandAllowanceforCreditLossesTables"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/LoansandAllowanceforCreditLossesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesAbstract_3732baf6-a119-421b-89b6-d7fd4439e703" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivablesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTextBlock_6abff3a6-3718-4556-8082-469102133a59" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesAbstract_3732baf6-a119-421b-89b6-d7fd4439e703" xlink:to="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTextBlock_6abff3a6-3718-4556-8082-469102133a59" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFinancingReceivablesNonAccrualStatusTableTextBlock_b18ab87a-8204-4a62-b30e-768ca2cd9028" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfFinancingReceivablesNonAccrualStatusTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesAbstract_3732baf6-a119-421b-89b6-d7fd4439e703" xlink:to="loc_us-gaap_ScheduleOfFinancingReceivablesNonAccrualStatusTableTextBlock_b18ab87a-8204-4a62-b30e-768ca2cd9028" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PastDueFinancingReceivablesTableTextBlock_da69f588-3c85-4302-896b-679868373ca8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PastDueFinancingReceivablesTableTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesAbstract_3732baf6-a119-421b-89b6-d7fd4439e703" xlink:to="loc_us-gaap_PastDueFinancingReceivablesTableTextBlock_da69f588-3c85-4302-896b-679868373ca8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TroubledDebtRestructuringsOnFinancingReceivablesTableTextBlock_e8da75ea-fe1f-4784-9d09-6f634694c320" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TroubledDebtRestructuringsOnFinancingReceivablesTableTextBlock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesAbstract_3732baf6-a119-421b-89b6-d7fd4439e703" xlink:to="loc_us-gaap_TroubledDebtRestructuringsOnFinancingReceivablesTableTextBlock_e8da75ea-fe1f-4784-9d09-6f634694c320" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableCreditQualityIndicatorsTableTextBlock_658bc11d-b002-4057-b8bd-0600a6dbef99" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableCreditQualityIndicatorsTableTextBlock"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesAbstract_3732baf6-a119-421b-89b6-d7fd4439e703" xlink:to="loc_us-gaap_FinancingReceivableCreditQualityIndicatorsTableTextBlock_658bc11d-b002-4057-b8bd-0600a6dbef99" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForCreditLossesOnFinancingReceivablesTableTextBlock_340b9995-b122-4fb9-988f-ee1295fe016c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AllowanceForCreditLossesOnFinancingReceivablesTableTextBlock"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesAbstract_3732baf6-a119-421b-89b6-d7fd4439e703" xlink:to="loc_us-gaap_AllowanceForCreditLossesOnFinancingReceivablesTableTextBlock_340b9995-b122-4fb9-988f-ee1295fe016c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/LoansandAllowanceforCreditLossesTextualDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#LoansandAllowanceforCreditLossesTextualDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/LoansandAllowanceforCreditLossesTextualDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesAbstract_1eb8e4ac-d89d-4c83-b500-5aacbf22991b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivablesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_e409570e-cea6-4d86-af81-6ea2e5ece773" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesAbstract_1eb8e4ac-d89d-4c83-b500-5aacbf22991b" xlink:to="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_e409570e-cea6-4d86-af81-6ea2e5ece773" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_a2b3b82c-99f2-4c6d-bb75-b24513edea9c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_e409570e-cea6-4d86-af81-6ea2e5ece773" xlink:to="loc_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_a2b3b82c-99f2-4c6d-bb75-b24513edea9c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_022e1b39-277f-494c-a714-d6fbde93ae1f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_a2b3b82c-99f2-4c6d-bb75-b24513edea9c" xlink:to="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_022e1b39-277f-494c-a714-d6fbde93ae1f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SingleFamilyMember_e04bfc27-9f7a-478f-968c-ad8b92e86db3" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_SingleFamilyMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_022e1b39-277f-494c-a714-d6fbde93ae1f" xlink:to="loc_srt_SingleFamilyMember_e04bfc27-9f7a-478f-968c-ad8b92e86db3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialRealEstateMember_4484cbe0-5ddf-4efd-90ba-049167dea1f8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommercialRealEstateMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_022e1b39-277f-494c-a714-d6fbde93ae1f" xlink:to="loc_us-gaap_CommercialRealEstateMember_4484cbe0-5ddf-4efd-90ba-049167dea1f8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_OtherCommercialLoansMember_285f2f75-c8a2-43d1-9482-a489f70c1dce" xlink:href="sfnc-20210930.xsd#sfnc_OtherCommercialLoansMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_022e1b39-277f-494c-a714-d6fbde93ae1f" xlink:to="loc_sfnc_OtherCommercialLoansMember_285f2f75-c8a2-43d1-9482-a489f70c1dce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_PaycheckProtectionProgramLoansMember_87a9e164-d7d1-4006-89f2-fca81688d05a" xlink:href="sfnc-20210930.xsd#sfnc_PaycheckProtectionProgramLoansMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_022e1b39-277f-494c-a714-d6fbde93ae1f" xlink:to="loc_sfnc_PaycheckProtectionProgramLoansMember_87a9e164-d7d1-4006-89f2-fca81688d05a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivablePortfolioSegmentAxis_5a1896f1-1a7e-4f2f-b8ac-4b54649d240e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivablePortfolioSegmentAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_e409570e-cea6-4d86-af81-6ea2e5ece773" xlink:to="loc_us-gaap_FinancingReceivablePortfolioSegmentAxis_5a1896f1-1a7e-4f2f-b8ac-4b54649d240e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_5f586bcc-6164-4956-a8a7-e24313d55abb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentAxis_5a1896f1-1a7e-4f2f-b8ac-4b54649d240e" xlink:to="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_5f586bcc-6164-4956-a8a7-e24313d55abb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_RealEstatePortfolioSegmentMember_6ce9f761-6893-40a7-9c47-5dba360d9212" xlink:href="sfnc-20210930.xsd#sfnc_RealEstatePortfolioSegmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_5f586bcc-6164-4956-a8a7-e24313d55abb" xlink:to="loc_sfnc_RealEstatePortfolioSegmentMember_6ce9f761-6893-40a7-9c47-5dba360d9212" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_b7fd46c2-621c-4dcc-89ee-293c72717776" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_e409570e-cea6-4d86-af81-6ea2e5ece773" xlink:to="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_b7fd46c2-621c-4dcc-89ee-293c72717776" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivableTypeDomain_353b941f-2aef-46aa-a3f0-3fccccf93c1e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivableTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_b7fd46c2-621c-4dcc-89ee-293c72717776" xlink:to="loc_us-gaap_ReceivableTypeDomain_353b941f-2aef-46aa-a3f0-3fccccf93c1e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RealEstateAcquiredInSatisfactionOfDebtMember_4865565b-4c69-4cb2-a9d3-b63577b92ffe" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RealEstateAcquiredInSatisfactionOfDebtMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivableTypeDomain_353b941f-2aef-46aa-a3f0-3fccccf93c1e" xlink:to="loc_us-gaap_RealEstateAcquiredInSatisfactionOfDebtMember_4865565b-4c69-4cb2-a9d3-b63577b92ffe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollateralAxis_a829722a-a0b3-4f90-8042-4506ccde4d22" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CollateralAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_e409570e-cea6-4d86-af81-6ea2e5ece773" xlink:to="loc_us-gaap_CollateralAxis_a829722a-a0b3-4f90-8042-4506ccde4d22" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollateralDomain_d52c74da-ded5-4ba1-a86e-1a3fdae3eaf3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CollateralDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollateralAxis_a829722a-a0b3-4f90-8042-4506ccde4d22" xlink:to="loc_us-gaap_CollateralDomain_d52c74da-ded5-4ba1-a86e-1a3fdae3eaf3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResidentialRealEstateMember_9cebbacb-2aab-4a10-83ae-b3f85c0718c6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ResidentialRealEstateMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollateralDomain_d52c74da-ded5-4ba1-a86e-1a3fdae3eaf3" xlink:to="loc_us-gaap_ResidentialRealEstateMember_9cebbacb-2aab-4a10-83ae-b3f85c0718c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_SecuredEnergyProductionAssetsMember_eb71d485-65fb-40cf-8eff-2e13887f4743" xlink:href="sfnc-20210930.xsd#sfnc_SecuredEnergyProductionAssetsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollateralDomain_d52c74da-ded5-4ba1-a86e-1a3fdae3eaf3" xlink:to="loc_sfnc_SecuredEnergyProductionAssetsMember_eb71d485-65fb-40cf-8eff-2e13887f4743" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoanRestructuringModificationAxis_1f243b36-adb8-49f7-a3c4-658864a4ebc2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoanRestructuringModificationAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_e409570e-cea6-4d86-af81-6ea2e5ece773" xlink:to="loc_us-gaap_LoanRestructuringModificationAxis_1f243b36-adb8-49f7-a3c4-658864a4ebc2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoanRestructuringModificationDomain_1bf3730b-4647-4c36-932a-84ca89b2a24b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoanRestructuringModificationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LoanRestructuringModificationAxis_1f243b36-adb8-49f7-a3c4-658864a4ebc2" xlink:to="loc_us-gaap_LoanRestructuringModificationDomain_1bf3730b-4647-4c36-932a-84ca89b2a24b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_ExtendedMaturityandPaymentDeferralMember_8929c1ee-a5ba-45ce-afb0-6ba4027b3499" xlink:href="sfnc-20210930.xsd#sfnc_ExtendedMaturityandPaymentDeferralMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LoanRestructuringModificationDomain_1bf3730b-4647-4c36-932a-84ca89b2a24b" xlink:to="loc_sfnc_ExtendedMaturityandPaymentDeferralMember_8929c1ee-a5ba-45ce-afb0-6ba4027b3499" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemAxis_651619b2-8524-4da5-a753-46ca897fdd67" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UnusualOrInfrequentItemAxis"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_e409570e-cea6-4d86-af81-6ea2e5ece773" xlink:to="loc_us-gaap_UnusualOrInfrequentItemAxis_651619b2-8524-4da5-a753-46ca897fdd67" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemDomain_e6420377-80f6-4440-8bd1-7f9b32e5a9bf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UnusualOrInfrequentItemDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnusualOrInfrequentItemAxis_651619b2-8524-4da5-a753-46ca897fdd67" xlink:to="loc_us-gaap_UnusualOrInfrequentItemDomain_e6420377-80f6-4440-8bd1-7f9b32e5a9bf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_COVID19PandemicMember_0f116738-91ab-448b-b5b1-b08732f11505" xlink:href="sfnc-20210930.xsd#sfnc_COVID19PandemicMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnusualOrInfrequentItemDomain_e6420377-80f6-4440-8bd1-7f9b32e5a9bf" xlink:to="loc_sfnc_COVID19PandemicMember_0f116738-91ab-448b-b5b1-b08732f11505" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_bb5ec120-6469-41fe-8ca0-1be88bd87f21" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeAxis"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_e409570e-cea6-4d86-af81-6ea2e5ece773" xlink:to="loc_srt_RangeAxis_bb5ec120-6469-41fe-8ca0-1be88bd87f21" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_625ae6d4-5991-4975-a1ac-a4ed534d49c7" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_bb5ec120-6469-41fe-8ca0-1be88bd87f21" xlink:to="loc_srt_RangeMember_625ae6d4-5991-4975-a1ac-a4ed534d49c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_a455dcf0-902a-4458-83e5-c0358e06ae37" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MinimumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_625ae6d4-5991-4975-a1ac-a4ed534d49c7" xlink:to="loc_srt_MinimumMember_a455dcf0-902a-4458-83e5-c0358e06ae37" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_98c67fb3-1399-4cad-ac98-a69ed4216818" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MaximumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_625ae6d4-5991-4975-a1ac-a4ed534d49c7" xlink:to="loc_srt_MaximumMember_98c67fb3-1399-4cad-ac98-a69ed4216818" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_2b5f6bc3-45ac-491c-a79b-51d3da3d7b48" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_e409570e-cea6-4d86-af81-6ea2e5ece773" xlink:to="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_2b5f6bc3-45ac-491c-a79b-51d3da3d7b48" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_a54dc34b-bf91-4f04-8475-29ae2692064d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_2b5f6bc3-45ac-491c-a79b-51d3da3d7b48" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_a54dc34b-bf91-4f04-8475-29ae2692064d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivablePurchasedWithCreditDeteriorationDiscountPremium_5e8904c8-efc0-4b54-8448-d67672f7d64f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivablePurchasedWithCreditDeteriorationDiscountPremium"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_2b5f6bc3-45ac-491c-a79b-51d3da3d7b48" xlink:to="loc_us-gaap_FinancingReceivablePurchasedWithCreditDeteriorationDiscountPremium_5e8904c8-efc0-4b54-8448-d67672f7d64f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableAccruedInterestBeforeAllowanceForCreditLoss_4cfcf3b0-256d-45ba-ba51-78774a7e6546" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_2b5f6bc3-45ac-491c-a79b-51d3da3d7b48" xlink:to="loc_us-gaap_FinancingReceivableAccruedInterestBeforeAllowanceForCreditLoss_4cfcf3b0-256d-45ba-ba51-78774a7e6546" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_FinancingReceivableTermOfLoan_eca58b5a-a6db-43ad-9bd6-0747af2fcdac" xlink:href="sfnc-20210930.xsd#sfnc_FinancingReceivableTermOfLoan"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_2b5f6bc3-45ac-491c-a79b-51d3da3d7b48" xlink:to="loc_sfnc_FinancingReceivableTermOfLoan_eca58b5a-a6db-43ad-9bd6-0747af2fcdac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableNonaccrualNoAllowance_1fa58c66-05a4-45fa-ae7d-f353f8a2dfec" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableNonaccrualNoAllowance"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_2b5f6bc3-45ac-491c-a79b-51d3da3d7b48" xlink:to="loc_us-gaap_FinancingReceivableNonaccrualNoAllowance_1fa58c66-05a4-45fa-ae7d-f353f8a2dfec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableModificationsNumberOfContracts2_e76a688e-054b-42fa-b8f4-812ba47d3be8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableModificationsNumberOfContracts2"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_2b5f6bc3-45ac-491c-a79b-51d3da3d7b48" xlink:to="loc_us-gaap_FinancingReceivableModificationsNumberOfContracts2_e76a688e-054b-42fa-b8f4-812ba47d3be8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableModificationsRecordedInvestment_ee05b058-2a6c-43d6-b3e1-7146ad144f47" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableModificationsRecordedInvestment"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_2b5f6bc3-45ac-491c-a79b-51d3da3d7b48" xlink:to="loc_us-gaap_FinancingReceivableModificationsRecordedInvestment_ee05b058-2a6c-43d6-b3e1-7146ad144f47" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableModificationsPreModificationRecordedInvestment2_15974160-3d31-4184-90f6-8a94f4efcf67" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableModificationsPreModificationRecordedInvestment2"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_2b5f6bc3-45ac-491c-a79b-51d3da3d7b48" xlink:to="loc_us-gaap_FinancingReceivableModificationsPreModificationRecordedInvestment2_15974160-3d31-4184-90f6-8a94f4efcf67" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableAllowanceForCreditLosses_f2df405e-380d-434a-9e20-9d3132769f74" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableAllowanceForCreditLosses"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_2b5f6bc3-45ac-491c-a79b-51d3da3d7b48" xlink:to="loc_us-gaap_FinancingReceivableAllowanceForCreditLosses_f2df405e-380d-434a-9e20-9d3132769f74" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableModificationsSubsequentDefaultNumberOfContracts1_e12e6ff4-255d-4972-a97b-b3e5ede5c9e2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableModificationsSubsequentDefaultNumberOfContracts1"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_2b5f6bc3-45ac-491c-a79b-51d3da3d7b48" xlink:to="loc_us-gaap_FinancingReceivableModificationsSubsequentDefaultNumberOfContracts1_e12e6ff4-255d-4972-a97b-b3e5ede5c9e2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MortgageLoansInProcessOfForeclosureAmount_5f9071d1-b1cc-475a-94a5-a313e95f15a0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MortgageLoansInProcessOfForeclosureAmount"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_2b5f6bc3-45ac-491c-a79b-51d3da3d7b48" xlink:to="loc_us-gaap_MortgageLoansInProcessOfForeclosureAmount_5f9071d1-b1cc-475a-94a5-a313e95f15a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RealEstateAcquiredThroughForeclosure_0f189532-14c4-4bd7-9207-898639e02732" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RealEstateAcquiredThroughForeclosure"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_2b5f6bc3-45ac-491c-a79b-51d3da3d7b48" xlink:to="loc_us-gaap_RealEstateAcquiredThroughForeclosure_0f189532-14c4-4bd7-9207-898639e02732" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_FinancingReceivableCollateralDependentAmount_3e4b8442-7669-4577-8c12-483ac851623b" xlink:href="sfnc-20210930.xsd#sfnc_FinancingReceivableCollateralDependentAmount"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_2b5f6bc3-45ac-491c-a79b-51d3da3d7b48" xlink:to="loc_sfnc_FinancingReceivableCollateralDependentAmount_3e4b8442-7669-4577-8c12-483ac851623b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_NumberOfEnergyCredits_375cd0fc-8095-465f-8b16-68a75b98c121" xlink:href="sfnc-20210930.xsd#sfnc_NumberOfEnergyCredits"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_2b5f6bc3-45ac-491c-a79b-51d3da3d7b48" xlink:to="loc_sfnc_NumberOfEnergyCredits_375cd0fc-8095-465f-8b16-68a75b98c121" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableAllowanceForCreditLossesWriteOffs_d3142b89-e60b-4c61-ac0a-9ca350eeff7c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossesWriteOffs"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_2b5f6bc3-45ac-491c-a79b-51d3da3d7b48" xlink:to="loc_us-gaap_FinancingReceivableAllowanceForCreditLossesWriteOffs_d3142b89-e60b-4c61-ac0a-9ca350eeff7c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OffBalanceSheetCreditLossLiability_0c472722-ce56-4027-ba6f-bdf01e651fa8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OffBalanceSheetCreditLossLiability"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_2b5f6bc3-45ac-491c-a79b-51d3da3d7b48" xlink:to="loc_us-gaap_OffBalanceSheetCreditLossLiability_0c472722-ce56-4027-ba6f-bdf01e651fa8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OffBalanceSheetCreditLossLiabilityCreditLossExpenseReversal_2b762935-d494-4879-998d-fe45725ac639" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OffBalanceSheetCreditLossLiabilityCreditLossExpenseReversal"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_2b5f6bc3-45ac-491c-a79b-51d3da3d7b48" xlink:to="loc_us-gaap_OffBalanceSheetCreditLossLiabilityCreditLossExpenseReversal_2b762935-d494-4879-998d-fe45725ac639" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/LoansandAllowanceforCreditLossesLoanPortfoliobyCategoriesDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#LoansandAllowanceforCreditLossesLoanPortfoliobyCategoriesDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/LoansandAllowanceforCreditLossesLoanPortfoliobyCategoriesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesAbstract_f41eb9f2-d269-4a46-ad0d-13c8088bfe22" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivablesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansAndLeasesReceivableDisclosureTable_a127ccf0-cc7c-4249-a8d7-3e963586db77" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoansAndLeasesReceivableDisclosureTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesAbstract_f41eb9f2-d269-4a46-ad0d-13c8088bfe22" xlink:to="loc_us-gaap_LoansAndLeasesReceivableDisclosureTable_a127ccf0-cc7c-4249-a8d7-3e963586db77" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivablePortfolioSegmentAxis_033c7183-4cc9-4408-a37c-2fa22cf2e402" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivablePortfolioSegmentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LoansAndLeasesReceivableDisclosureTable_a127ccf0-cc7c-4249-a8d7-3e963586db77" xlink:to="loc_us-gaap_FinancingReceivablePortfolioSegmentAxis_033c7183-4cc9-4408-a37c-2fa22cf2e402" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_71c29212-788f-490f-be80-537bdd7e6b11" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentAxis_033c7183-4cc9-4408-a37c-2fa22cf2e402" xlink:to="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_71c29212-788f-490f-be80-537bdd7e6b11" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConsumerPortfolioSegmentMember_51247b75-2b4d-4d26-9586-ef395abec35f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConsumerPortfolioSegmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_71c29212-788f-490f-be80-537bdd7e6b11" xlink:to="loc_us-gaap_ConsumerPortfolioSegmentMember_51247b75-2b4d-4d26-9586-ef395abec35f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_RealEstatePortfolioSegmentMember_b89df3b4-ef95-4fec-bf3b-8d14ded1c8d9" xlink:href="sfnc-20210930.xsd#sfnc_RealEstatePortfolioSegmentMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_71c29212-788f-490f-be80-537bdd7e6b11" xlink:to="loc_sfnc_RealEstatePortfolioSegmentMember_b89df3b4-ef95-4fec-bf3b-8d14ded1c8d9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPortfolioSegmentMember_676d1f53-a20a-496c-b384-2395c69c06c5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommercialPortfolioSegmentMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_71c29212-788f-490f-be80-537bdd7e6b11" xlink:to="loc_us-gaap_CommercialPortfolioSegmentMember_676d1f53-a20a-496c-b384-2395c69c06c5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnallocatedFinancingReceivablesMember_cce812b9-eda8-445b-9bb2-1d28c50cb9b3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UnallocatedFinancingReceivablesMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_71c29212-788f-490f-be80-537bdd7e6b11" xlink:to="loc_us-gaap_UnallocatedFinancingReceivablesMember_cce812b9-eda8-445b-9bb2-1d28c50cb9b3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_deb13481-ed4f-407a-ab74-b318e9d3bce2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LoansAndLeasesReceivableDisclosureTable_a127ccf0-cc7c-4249-a8d7-3e963586db77" xlink:to="loc_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_deb13481-ed4f-407a-ab74-b318e9d3bce2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_fae69b87-9f0b-4957-a177-fdb9be448b82" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_deb13481-ed4f-407a-ab74-b318e9d3bce2" xlink:to="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_fae69b87-9f0b-4957-a177-fdb9be448b82" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditCardReceivablesMember_570a6b5b-1589-4f0e-a64d-31643b4793c6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CreditCardReceivablesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_fae69b87-9f0b-4957-a177-fdb9be448b82" xlink:to="loc_us-gaap_CreditCardReceivablesMember_570a6b5b-1589-4f0e-a64d-31643b4793c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_OtherConsumerLoansMember_fc4395ab-158f-42f5-a7f4-4498ce7d9f45" xlink:href="sfnc-20210930.xsd#sfnc_OtherConsumerLoansMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_fae69b87-9f0b-4957-a177-fdb9be448b82" xlink:to="loc_sfnc_OtherConsumerLoansMember_fc4395ab-158f-42f5-a7f4-4498ce7d9f45" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConstructionLoansMember_ea53f6e3-bdd3-4c43-8829-4585a64b6842" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConstructionLoansMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_fae69b87-9f0b-4957-a177-fdb9be448b82" xlink:to="loc_us-gaap_ConstructionLoansMember_ea53f6e3-bdd3-4c43-8829-4585a64b6842" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SingleFamilyMember_6a8dfc3f-2afe-4d27-a8d9-600f96b4ea06" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_SingleFamilyMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_fae69b87-9f0b-4957-a177-fdb9be448b82" xlink:to="loc_srt_SingleFamilyMember_6a8dfc3f-2afe-4d27-a8d9-600f96b4ea06" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_OtherCommercialLoansMember_11eeea4f-5923-491c-8393-69ba909ab4a1" xlink:href="sfnc-20210930.xsd#sfnc_OtherCommercialLoansMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_fae69b87-9f0b-4957-a177-fdb9be448b82" xlink:to="loc_sfnc_OtherCommercialLoansMember_11eeea4f-5923-491c-8393-69ba909ab4a1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_CommercialLoansMember_83285824-9974-415d-a57d-45208a73878c" xlink:href="sfnc-20210930.xsd#sfnc_CommercialLoansMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_fae69b87-9f0b-4957-a177-fdb9be448b82" xlink:to="loc_sfnc_CommercialLoansMember_83285824-9974-415d-a57d-45208a73878c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_AgriculturalLoansMember_ea610a74-cb99-497d-ae9a-edff92552891" xlink:href="sfnc-20210930.xsd#sfnc_AgriculturalLoansMember"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_fae69b87-9f0b-4957-a177-fdb9be448b82" xlink:to="loc_sfnc_AgriculturalLoansMember_ea610a74-cb99-497d-ae9a-edff92552891" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansAndLeasesReceivableDisclosureLineItems_4525f5a0-fabc-4001-837c-3520da12d4b6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoansAndLeasesReceivableDisclosureLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LoansAndLeasesReceivableDisclosureTable_a127ccf0-cc7c-4249-a8d7-3e963586db77" xlink:to="loc_us-gaap_LoansAndLeasesReceivableDisclosureLineItems_4525f5a0-fabc-4001-837c-3520da12d4b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_9a8d6de7-1701-4c50-83d4-0ff9a558172e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LoansAndLeasesReceivableDisclosureLineItems_4525f5a0-fabc-4001-837c-3520da12d4b6" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_9a8d6de7-1701-4c50-83d4-0ff9a558172e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/LoansandAllowanceforCreditLossesNonaccrualLoansExcludingLoansAcquiredSegregatedbyClassofLoansDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#LoansandAllowanceforCreditLossesNonaccrualLoansExcludingLoansAcquiredSegregatedbyClassofLoansDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/LoansandAllowanceforCreditLossesNonaccrualLoansExcludingLoansAcquiredSegregatedbyClassofLoansDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesAbstract_eb3ef0cd-f4b3-47a1-a4bf-d1b9bb611543" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivablesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFinancingReceivablesPastDueTable_8bc2f133-0ae2-4c60-adbe-a630f2b3f39a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfFinancingReceivablesPastDueTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesAbstract_eb3ef0cd-f4b3-47a1-a4bf-d1b9bb611543" xlink:to="loc_us-gaap_ScheduleOfFinancingReceivablesPastDueTable_8bc2f133-0ae2-4c60-adbe-a630f2b3f39a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivablePortfolioSegmentAxis_ef65de2d-86ee-494d-b9a6-b5456a7a72a3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivablePortfolioSegmentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFinancingReceivablesPastDueTable_8bc2f133-0ae2-4c60-adbe-a630f2b3f39a" xlink:to="loc_us-gaap_FinancingReceivablePortfolioSegmentAxis_ef65de2d-86ee-494d-b9a6-b5456a7a72a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_5d10a571-b51b-47a0-99a7-7279b31ff6bb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentAxis_ef65de2d-86ee-494d-b9a6-b5456a7a72a3" xlink:to="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_5d10a571-b51b-47a0-99a7-7279b31ff6bb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConsumerPortfolioSegmentMember_3f3a694a-7374-41e4-940c-7deb1f013e65" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConsumerPortfolioSegmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_5d10a571-b51b-47a0-99a7-7279b31ff6bb" xlink:to="loc_us-gaap_ConsumerPortfolioSegmentMember_3f3a694a-7374-41e4-940c-7deb1f013e65" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_RealEstatePortfolioSegmentMember_bd6b4961-42c4-4c72-bfb8-27289b6c3e9a" xlink:href="sfnc-20210930.xsd#sfnc_RealEstatePortfolioSegmentMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_5d10a571-b51b-47a0-99a7-7279b31ff6bb" xlink:to="loc_sfnc_RealEstatePortfolioSegmentMember_bd6b4961-42c4-4c72-bfb8-27289b6c3e9a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPortfolioSegmentMember_0b7a437c-270f-43a0-b9b8-fc81402a4cb6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommercialPortfolioSegmentMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_5d10a571-b51b-47a0-99a7-7279b31ff6bb" xlink:to="loc_us-gaap_CommercialPortfolioSegmentMember_0b7a437c-270f-43a0-b9b8-fc81402a4cb6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_d566f61e-d082-42b4-a879-017efe538805" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFinancingReceivablesPastDueTable_8bc2f133-0ae2-4c60-adbe-a630f2b3f39a" xlink:to="loc_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_d566f61e-d082-42b4-a879-017efe538805" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_1a627608-9291-4399-96b8-d2ddd7f0c9f8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_d566f61e-d082-42b4-a879-017efe538805" xlink:to="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_1a627608-9291-4399-96b8-d2ddd7f0c9f8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditCardReceivablesMember_3fe61875-e566-4f34-bf2f-5f4e6b2e0d7b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CreditCardReceivablesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_1a627608-9291-4399-96b8-d2ddd7f0c9f8" xlink:to="loc_us-gaap_CreditCardReceivablesMember_3fe61875-e566-4f34-bf2f-5f4e6b2e0d7b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_OtherConsumerLoansMember_4c21864b-02d0-4e28-b019-dcb81b31afdb" xlink:href="sfnc-20210930.xsd#sfnc_OtherConsumerLoansMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_1a627608-9291-4399-96b8-d2ddd7f0c9f8" xlink:to="loc_sfnc_OtherConsumerLoansMember_4c21864b-02d0-4e28-b019-dcb81b31afdb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConstructionLoansMember_1137a5f8-40bd-40e0-96d5-a12b1a535cd4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConstructionLoansMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_1a627608-9291-4399-96b8-d2ddd7f0c9f8" xlink:to="loc_us-gaap_ConstructionLoansMember_1137a5f8-40bd-40e0-96d5-a12b1a535cd4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SingleFamilyMember_0d473b3e-c9ca-4230-82dd-2fd62985e611" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_SingleFamilyMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_1a627608-9291-4399-96b8-d2ddd7f0c9f8" xlink:to="loc_srt_SingleFamilyMember_0d473b3e-c9ca-4230-82dd-2fd62985e611" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_OtherCommercialLoansMember_446df0ae-a367-4b22-ae58-65787587c63b" xlink:href="sfnc-20210930.xsd#sfnc_OtherCommercialLoansMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_1a627608-9291-4399-96b8-d2ddd7f0c9f8" xlink:to="loc_sfnc_OtherCommercialLoansMember_446df0ae-a367-4b22-ae58-65787587c63b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_CommercialLoansMember_af35067c-c93c-4451-b148-fef2fb6359e4" xlink:href="sfnc-20210930.xsd#sfnc_CommercialLoansMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_1a627608-9291-4399-96b8-d2ddd7f0c9f8" xlink:to="loc_sfnc_CommercialLoansMember_af35067c-c93c-4451-b148-fef2fb6359e4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_AgriculturalLoansMember_ce0d7bd2-649e-4012-a56c-b730e630b53f" xlink:href="sfnc-20210930.xsd#sfnc_AgriculturalLoansMember"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_1a627608-9291-4399-96b8-d2ddd7f0c9f8" xlink:to="loc_sfnc_AgriculturalLoansMember_ce0d7bd2-649e-4012-a56c-b730e630b53f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRecordedInvestmentPastDueLineItems_217d482c-ddf7-4d64-bb63-1301001cb112" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentPastDueLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFinancingReceivablesPastDueTable_8bc2f133-0ae2-4c60-adbe-a630f2b3f39a" xlink:to="loc_us-gaap_FinancingReceivableRecordedInvestmentPastDueLineItems_217d482c-ddf7-4d64-bb63-1301001cb112" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRecordedInvestmentNonaccrualStatus_3ae35157-5a9a-4763-a67c-abc94c5d5223" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentNonaccrualStatus"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentPastDueLineItems_217d482c-ddf7-4d64-bb63-1301001cb112" xlink:to="loc_us-gaap_FinancingReceivableRecordedInvestmentNonaccrualStatus_3ae35157-5a9a-4763-a67c-abc94c5d5223" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/LoansandAllowanceforCreditLossesAgeAnalysisofPastDueLoansExcludingLoansAcquiredSegregatedbyClassofLoansDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#LoansandAllowanceforCreditLossesAgeAnalysisofPastDueLoansExcludingLoansAcquiredSegregatedbyClassofLoansDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/LoansandAllowanceforCreditLossesAgeAnalysisofPastDueLoansExcludingLoansAcquiredSegregatedbyClassofLoansDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesAbstract_d1e40034-5296-44d3-b195-1856582aeba8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivablesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFinancingReceivablesPastDueTable_381ea3a4-198d-49d1-a303-e5450fa97306" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfFinancingReceivablesPastDueTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesAbstract_d1e40034-5296-44d3-b195-1856582aeba8" xlink:to="loc_us-gaap_ScheduleOfFinancingReceivablesPastDueTable_381ea3a4-198d-49d1-a303-e5450fa97306" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivablePortfolioSegmentAxis_04080819-8014-4153-9865-8afbf4d83d94" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivablePortfolioSegmentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFinancingReceivablesPastDueTable_381ea3a4-198d-49d1-a303-e5450fa97306" xlink:to="loc_us-gaap_FinancingReceivablePortfolioSegmentAxis_04080819-8014-4153-9865-8afbf4d83d94" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_5f21cd65-d78f-4709-be38-2c66011ba8ee" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentAxis_04080819-8014-4153-9865-8afbf4d83d94" xlink:to="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_5f21cd65-d78f-4709-be38-2c66011ba8ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConsumerPortfolioSegmentMember_949e9523-bb5c-4f5a-bb36-c19b2d5755db" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConsumerPortfolioSegmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_5f21cd65-d78f-4709-be38-2c66011ba8ee" xlink:to="loc_us-gaap_ConsumerPortfolioSegmentMember_949e9523-bb5c-4f5a-bb36-c19b2d5755db" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_RealEstatePortfolioSegmentMember_5ab1691b-e994-4306-beae-d60acf7d9ecd" xlink:href="sfnc-20210930.xsd#sfnc_RealEstatePortfolioSegmentMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_5f21cd65-d78f-4709-be38-2c66011ba8ee" xlink:to="loc_sfnc_RealEstatePortfolioSegmentMember_5ab1691b-e994-4306-beae-d60acf7d9ecd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPortfolioSegmentMember_ec8b42f0-8d06-4c07-b3e9-252fd73cd8b7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommercialPortfolioSegmentMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_5f21cd65-d78f-4709-be38-2c66011ba8ee" xlink:to="loc_us-gaap_CommercialPortfolioSegmentMember_ec8b42f0-8d06-4c07-b3e9-252fd73cd8b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnallocatedFinancingReceivablesMember_37dd424e-d406-4f2b-b639-0eff4a07ba10" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UnallocatedFinancingReceivablesMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_5f21cd65-d78f-4709-be38-2c66011ba8ee" xlink:to="loc_us-gaap_UnallocatedFinancingReceivablesMember_37dd424e-d406-4f2b-b639-0eff4a07ba10" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_c9ace89c-627f-421b-b123-68027772a3ab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFinancingReceivablesPastDueTable_381ea3a4-198d-49d1-a303-e5450fa97306" xlink:to="loc_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_c9ace89c-627f-421b-b123-68027772a3ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_8af37c8b-f736-4933-990c-90d29ca6a423" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_c9ace89c-627f-421b-b123-68027772a3ab" xlink:to="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_8af37c8b-f736-4933-990c-90d29ca6a423" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditCardReceivablesMember_47b5f577-1af6-4d71-a777-5eebbef272a8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CreditCardReceivablesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_8af37c8b-f736-4933-990c-90d29ca6a423" xlink:to="loc_us-gaap_CreditCardReceivablesMember_47b5f577-1af6-4d71-a777-5eebbef272a8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_OtherConsumerLoansMember_6e31cd63-cf7e-4f58-a3ae-d3df46a59e78" xlink:href="sfnc-20210930.xsd#sfnc_OtherConsumerLoansMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_8af37c8b-f736-4933-990c-90d29ca6a423" xlink:to="loc_sfnc_OtherConsumerLoansMember_6e31cd63-cf7e-4f58-a3ae-d3df46a59e78" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConstructionLoansMember_d28a7edb-62fc-43d7-883e-dbd3a97c1e14" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConstructionLoansMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_8af37c8b-f736-4933-990c-90d29ca6a423" xlink:to="loc_us-gaap_ConstructionLoansMember_d28a7edb-62fc-43d7-883e-dbd3a97c1e14" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SingleFamilyMember_8107d39a-2f09-4c3d-a61b-6f7d7e984a77" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_SingleFamilyMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_8af37c8b-f736-4933-990c-90d29ca6a423" xlink:to="loc_srt_SingleFamilyMember_8107d39a-2f09-4c3d-a61b-6f7d7e984a77" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_OtherCommercialLoansMember_85d169bc-c000-40f9-9754-d76356d89f8e" xlink:href="sfnc-20210930.xsd#sfnc_OtherCommercialLoansMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_8af37c8b-f736-4933-990c-90d29ca6a423" xlink:to="loc_sfnc_OtherCommercialLoansMember_85d169bc-c000-40f9-9754-d76356d89f8e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_CommercialLoansMember_6946521a-d28f-4d0b-ac08-b834bb49a571" xlink:href="sfnc-20210930.xsd#sfnc_CommercialLoansMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_8af37c8b-f736-4933-990c-90d29ca6a423" xlink:to="loc_sfnc_CommercialLoansMember_6946521a-d28f-4d0b-ac08-b834bb49a571" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_AgriculturalLoansMember_5e1df993-5dd9-48d2-81b5-45670386d8e5" xlink:href="sfnc-20210930.xsd#sfnc_AgriculturalLoansMember"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_8af37c8b-f736-4933-990c-90d29ca6a423" xlink:to="loc_sfnc_AgriculturalLoansMember_5e1df993-5dd9-48d2-81b5-45670386d8e5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivablesPeriodPastDueAxis_7dad2406-ef34-4f51-8d07-5e240db77453" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivablesPeriodPastDueAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFinancingReceivablesPastDueTable_381ea3a4-198d-49d1-a303-e5450fa97306" xlink:to="loc_us-gaap_FinancingReceivablesPeriodPastDueAxis_7dad2406-ef34-4f51-8d07-5e240db77453" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivablesPeriodPastDueDomain_f360ddd3-0009-46cc-b1d5-72579fe1b948" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivablesPeriodPastDueDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablesPeriodPastDueAxis_7dad2406-ef34-4f51-8d07-5e240db77453" xlink:to="loc_us-gaap_FinancingReceivablesPeriodPastDueDomain_f360ddd3-0009-46cc-b1d5-72579fe1b948" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_FinancingReceivables30To89DaysPastDueMember_3037fbe3-67b1-4746-a7a1-40370f54a41d" xlink:href="sfnc-20210930.xsd#sfnc_FinancingReceivables30To89DaysPastDueMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablesPeriodPastDueDomain_f360ddd3-0009-46cc-b1d5-72579fe1b948" xlink:to="loc_sfnc_FinancingReceivables30To89DaysPastDueMember_3037fbe3-67b1-4746-a7a1-40370f54a41d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivablesEqualToGreaterThan90DaysPastDueMember_b6978452-1814-42c5-89c0-703f6a3eff39" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivablesEqualToGreaterThan90DaysPastDueMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablesPeriodPastDueDomain_f360ddd3-0009-46cc-b1d5-72579fe1b948" xlink:to="loc_us-gaap_FinancingReceivablesEqualToGreaterThan90DaysPastDueMember_b6978452-1814-42c5-89c0-703f6a3eff39" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialAssetPastDueMember_fe936f4d-ab54-43a6-af2b-2cfc6e937b78" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialAssetPastDueMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablesPeriodPastDueDomain_f360ddd3-0009-46cc-b1d5-72579fe1b948" xlink:to="loc_us-gaap_FinancialAssetPastDueMember_fe936f4d-ab54-43a6-af2b-2cfc6e937b78" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialAssetNotPastDueMember_ac8e882a-00c7-438b-a2e2-6e50c6e38256" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialAssetNotPastDueMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablesPeriodPastDueDomain_f360ddd3-0009-46cc-b1d5-72579fe1b948" xlink:to="loc_us-gaap_FinancialAssetNotPastDueMember_ac8e882a-00c7-438b-a2e2-6e50c6e38256" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRecordedInvestmentPastDueLineItems_8f21c489-e0fc-4aad-9af7-9a0309bef15b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentPastDueLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFinancingReceivablesPastDueTable_381ea3a4-198d-49d1-a303-e5450fa97306" xlink:to="loc_us-gaap_FinancingReceivableRecordedInvestmentPastDueLineItems_8f21c489-e0fc-4aad-9af7-9a0309bef15b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_3301750e-1770-4f4e-9106-b617e9f6da99" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentPastDueLineItems_8f21c489-e0fc-4aad-9af7-9a0309bef15b" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_3301750e-1770-4f4e-9106-b617e9f6da99" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRecordedInvestment90DaysPastDueAndStillAccruing_d5d3db9b-3929-49e5-b1d1-554a01ba3cb6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestment90DaysPastDueAndStillAccruing"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentPastDueLineItems_8f21c489-e0fc-4aad-9af7-9a0309bef15b" xlink:to="loc_us-gaap_FinancingReceivableRecordedInvestment90DaysPastDueAndStillAccruing_d5d3db9b-3929-49e5-b1d1-554a01ba3cb6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/LoansandAllowanceforCreditLossesTroubledDebtRestructuringsExcludingLoansAcquiredSegregatedbyClassofLoansDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#LoansandAllowanceforCreditLossesTroubledDebtRestructuringsExcludingLoansAcquiredSegregatedbyClassofLoansDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/LoansandAllowanceforCreditLossesTroubledDebtRestructuringsExcludingLoansAcquiredSegregatedbyClassofLoansDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesAbstract_b61bc97a-6671-46d9-b86f-14e171207f3c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivablesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFinancingReceivableTroubledDebtRestructuringsTable_5e131820-97ce-434e-b3db-179dd0aa3bb9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfFinancingReceivableTroubledDebtRestructuringsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesAbstract_b61bc97a-6671-46d9-b86f-14e171207f3c" xlink:to="loc_us-gaap_ScheduleOfFinancingReceivableTroubledDebtRestructuringsTable_5e131820-97ce-434e-b3db-179dd0aa3bb9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivablePortfolioSegmentAxis_5d8a7157-0981-4cdb-a417-1c9ded33398e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivablePortfolioSegmentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFinancingReceivableTroubledDebtRestructuringsTable_5e131820-97ce-434e-b3db-179dd0aa3bb9" xlink:to="loc_us-gaap_FinancingReceivablePortfolioSegmentAxis_5d8a7157-0981-4cdb-a417-1c9ded33398e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_70c6592c-3fc4-4e3a-820a-8a379a43077e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentAxis_5d8a7157-0981-4cdb-a417-1c9ded33398e" xlink:to="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_70c6592c-3fc4-4e3a-820a-8a379a43077e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_RealEstatePortfolioSegmentMember_43406393-63ab-485f-817e-35c129d9d9cb" xlink:href="sfnc-20210930.xsd#sfnc_RealEstatePortfolioSegmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_70c6592c-3fc4-4e3a-820a-8a379a43077e" xlink:to="loc_sfnc_RealEstatePortfolioSegmentMember_43406393-63ab-485f-817e-35c129d9d9cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPortfolioSegmentMember_e49539cb-0ad0-4edc-b577-7f2c1bb82e57" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommercialPortfolioSegmentMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_70c6592c-3fc4-4e3a-820a-8a379a43077e" xlink:to="loc_us-gaap_CommercialPortfolioSegmentMember_e49539cb-0ad0-4edc-b577-7f2c1bb82e57" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_6eadd127-5286-4c81-b7fd-07962ebe4cf6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFinancingReceivableTroubledDebtRestructuringsTable_5e131820-97ce-434e-b3db-179dd0aa3bb9" xlink:to="loc_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_6eadd127-5286-4c81-b7fd-07962ebe4cf6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_9b410cbb-1756-4131-b03a-6e8e9abf226b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_6eadd127-5286-4c81-b7fd-07962ebe4cf6" xlink:to="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_9b410cbb-1756-4131-b03a-6e8e9abf226b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SingleFamilyMember_386e5689-dd7e-40fa-9f9e-9248301c95ee" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_SingleFamilyMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_9b410cbb-1756-4131-b03a-6e8e9abf226b" xlink:to="loc_srt_SingleFamilyMember_386e5689-dd7e-40fa-9f9e-9248301c95ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_OtherCommercialLoansMember_484ed08b-6870-4919-a651-4179edec9ec8" xlink:href="sfnc-20210930.xsd#sfnc_OtherCommercialLoansMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_9b410cbb-1756-4131-b03a-6e8e9abf226b" xlink:to="loc_sfnc_OtherCommercialLoansMember_484ed08b-6870-4919-a651-4179edec9ec8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_CommercialLoansMember_e6db76dc-d1ee-45e0-9d58-16614775779d" xlink:href="sfnc-20210930.xsd#sfnc_CommercialLoansMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_9b410cbb-1756-4131-b03a-6e8e9abf226b" xlink:to="loc_sfnc_CommercialLoansMember_e6db76dc-d1ee-45e0-9d58-16614775779d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_5c1b9835-fa66-419e-8680-bfe3811a6e98" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFinancingReceivableTroubledDebtRestructuringsTable_5e131820-97ce-434e-b3db-179dd0aa3bb9" xlink:to="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_5c1b9835-fa66-419e-8680-bfe3811a6e98" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivableTypeDomain_137d181d-a5ac-41e6-b5f8-7790f7ca55da" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivableTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_5c1b9835-fa66-419e-8680-bfe3811a6e98" xlink:to="loc_us-gaap_ReceivableTypeDomain_137d181d-a5ac-41e6-b5f8-7790f7ca55da" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_LoansExcludingAcquiredLoansMember_ba10422a-a099-46d0-bba6-4c1511dd48d2" xlink:href="sfnc-20210930.xsd#sfnc_LoansExcludingAcquiredLoansMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivableTypeDomain_137d181d-a5ac-41e6-b5f8-7790f7ca55da" xlink:to="loc_sfnc_LoansExcludingAcquiredLoansMember_ba10422a-a099-46d0-bba6-4c1511dd48d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentPerformanceStatusAxis_f9db4444-4596-4dc3-9d38-9a96a618f6f0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentPerformanceStatusAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFinancingReceivableTroubledDebtRestructuringsTable_5e131820-97ce-434e-b3db-179dd0aa3bb9" xlink:to="loc_us-gaap_FinancialInstrumentPerformanceStatusAxis_f9db4444-4596-4dc3-9d38-9a96a618f6f0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentPerformanceStatusDomain_7710cb49-b8b9-44ac-a4d3-97e211fbe75b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentPerformanceStatusDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentPerformanceStatusAxis_f9db4444-4596-4dc3-9d38-9a96a618f6f0" xlink:to="loc_us-gaap_FinancialInstrumentPerformanceStatusDomain_7710cb49-b8b9-44ac-a4d3-97e211fbe75b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PerformingFinancingReceivableMember_6e03b2cc-d983-40f3-af7c-062f851d48ac" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PerformingFinancingReceivableMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentPerformanceStatusDomain_7710cb49-b8b9-44ac-a4d3-97e211fbe75b" xlink:to="loc_us-gaap_PerformingFinancingReceivableMember_6e03b2cc-d983-40f3-af7c-062f851d48ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonperformingFinancingReceivableMember_e5f5b260-29eb-4440-a590-06a98a410eb3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NonperformingFinancingReceivableMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentPerformanceStatusDomain_7710cb49-b8b9-44ac-a4d3-97e211fbe75b" xlink:to="loc_us-gaap_NonperformingFinancingReceivableMember_e5f5b260-29eb-4440-a590-06a98a410eb3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoanRestructuringModificationAxis_649532a9-e152-4971-8374-a60ffa0953ac" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoanRestructuringModificationAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFinancingReceivableTroubledDebtRestructuringsTable_5e131820-97ce-434e-b3db-179dd0aa3bb9" xlink:to="loc_us-gaap_LoanRestructuringModificationAxis_649532a9-e152-4971-8374-a60ffa0953ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoanRestructuringModificationDomain_62a92f93-d5f5-4f3b-8916-9445c3b0d596" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoanRestructuringModificationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LoanRestructuringModificationAxis_649532a9-e152-4971-8374-a60ffa0953ac" xlink:to="loc_us-gaap_LoanRestructuringModificationDomain_62a92f93-d5f5-4f3b-8916-9445c3b0d596" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_ExtendedMaturityandPaymentDeferralMember_0a767241-d5f1-489c-acce-ea3f61633317" xlink:href="sfnc-20210930.xsd#sfnc_ExtendedMaturityandPaymentDeferralMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LoanRestructuringModificationDomain_62a92f93-d5f5-4f3b-8916-9445c3b0d596" xlink:to="loc_sfnc_ExtendedMaturityandPaymentDeferralMember_0a767241-d5f1-489c-acce-ea3f61633317" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemAxis_92288931-d410-48bc-bf5d-e9d90d1a22d3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UnusualOrInfrequentItemAxis"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFinancingReceivableTroubledDebtRestructuringsTable_5e131820-97ce-434e-b3db-179dd0aa3bb9" xlink:to="loc_us-gaap_UnusualOrInfrequentItemAxis_92288931-d410-48bc-bf5d-e9d90d1a22d3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemDomain_02d6d1db-e11a-4577-acd7-a001cc378bd4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UnusualOrInfrequentItemDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnusualOrInfrequentItemAxis_92288931-d410-48bc-bf5d-e9d90d1a22d3" xlink:to="loc_us-gaap_UnusualOrInfrequentItemDomain_02d6d1db-e11a-4577-acd7-a001cc378bd4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_COVID19PandemicMember_e4238350-5f2f-46f3-9490-fcd0b5bc2779" xlink:href="sfnc-20210930.xsd#sfnc_COVID19PandemicMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_UnusualOrInfrequentItemDomain_02d6d1db-e11a-4577-acd7-a001cc378bd4" xlink:to="loc_sfnc_COVID19PandemicMember_e4238350-5f2f-46f3-9490-fcd0b5bc2779" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableModificationsLineItems_cf010ca9-a4b7-4e2e-8a0f-b55ded083a1f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableModificationsLineItems"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFinancingReceivableTroubledDebtRestructuringsTable_5e131820-97ce-434e-b3db-179dd0aa3bb9" xlink:to="loc_us-gaap_FinancingReceivableModificationsLineItems_cf010ca9-a4b7-4e2e-8a0f-b55ded083a1f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableModificationsNumberOfContracts2_28df27f4-16fd-44b8-9031-c749a63faea8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableModificationsNumberOfContracts2"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableModificationsLineItems_cf010ca9-a4b7-4e2e-8a0f-b55ded083a1f" xlink:to="loc_us-gaap_FinancingReceivableModificationsNumberOfContracts2_28df27f4-16fd-44b8-9031-c749a63faea8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableModificationsRecordedInvestment_230d3409-50ee-431a-9dda-7728d943b61c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableModificationsRecordedInvestment"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableModificationsLineItems_cf010ca9-a4b7-4e2e-8a0f-b55ded083a1f" xlink:to="loc_us-gaap_FinancingReceivableModificationsRecordedInvestment_230d3409-50ee-431a-9dda-7728d943b61c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/LoansandAllowanceforCreditLossesLoansRestructuredasTDRsExcludingLoansAcquiredSegregatedbyClassofLoansDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#LoansandAllowanceforCreditLossesLoansRestructuredasTDRsExcludingLoansAcquiredSegregatedbyClassofLoansDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/LoansandAllowanceforCreditLossesLoansRestructuredasTDRsExcludingLoansAcquiredSegregatedbyClassofLoansDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesAbstract_bc06606a-352c-4dd3-aa84-7d5f63fa6dbb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivablesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFinancingReceivableTroubledDebtRestructuringsTable_082433a9-cdc1-4453-9b15-590f5b430aca" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfFinancingReceivableTroubledDebtRestructuringsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesAbstract_bc06606a-352c-4dd3-aa84-7d5f63fa6dbb" xlink:to="loc_us-gaap_ScheduleOfFinancingReceivableTroubledDebtRestructuringsTable_082433a9-cdc1-4453-9b15-590f5b430aca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivablePortfolioSegmentAxis_d34aa10e-d452-4751-afca-2f51d6bb9088" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivablePortfolioSegmentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFinancingReceivableTroubledDebtRestructuringsTable_082433a9-cdc1-4453-9b15-590f5b430aca" xlink:to="loc_us-gaap_FinancingReceivablePortfolioSegmentAxis_d34aa10e-d452-4751-afca-2f51d6bb9088" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_63097791-c5cf-450f-85e8-3ff06f1b2739" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentAxis_d34aa10e-d452-4751-afca-2f51d6bb9088" xlink:to="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_63097791-c5cf-450f-85e8-3ff06f1b2739" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_RealEstatePortfolioSegmentMember_e19ed7d2-c088-45f5-b78f-d408452fbcb0" xlink:href="sfnc-20210930.xsd#sfnc_RealEstatePortfolioSegmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_63097791-c5cf-450f-85e8-3ff06f1b2739" xlink:to="loc_sfnc_RealEstatePortfolioSegmentMember_e19ed7d2-c088-45f5-b78f-d408452fbcb0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_87012351-6b02-4dc7-bf75-f9114ed3b876" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFinancingReceivableTroubledDebtRestructuringsTable_082433a9-cdc1-4453-9b15-590f5b430aca" xlink:to="loc_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_87012351-6b02-4dc7-bf75-f9114ed3b876" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_6689d036-7998-4e30-8f86-b31c39562a15" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_87012351-6b02-4dc7-bf75-f9114ed3b876" xlink:to="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_6689d036-7998-4e30-8f86-b31c39562a15" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_OtherCommercialLoansMember_1e264d92-5af5-4e87-b5c2-d9e4c65b073c" xlink:href="sfnc-20210930.xsd#sfnc_OtherCommercialLoansMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_6689d036-7998-4e30-8f86-b31c39562a15" xlink:to="loc_sfnc_OtherCommercialLoansMember_1e264d92-5af5-4e87-b5c2-d9e4c65b073c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SingleFamilyMember_275cd498-dd9b-4b95-b85c-884c5eb75f6f" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_SingleFamilyMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_6689d036-7998-4e30-8f86-b31c39562a15" xlink:to="loc_srt_SingleFamilyMember_275cd498-dd9b-4b95-b85c-884c5eb75f6f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoanRestructuringModificationAxis_b3ebfd89-97f1-4bf9-a94d-00983a183bff" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoanRestructuringModificationAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFinancingReceivableTroubledDebtRestructuringsTable_082433a9-cdc1-4453-9b15-590f5b430aca" xlink:to="loc_us-gaap_LoanRestructuringModificationAxis_b3ebfd89-97f1-4bf9-a94d-00983a183bff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoanRestructuringModificationDomain_fafd7541-e74f-476a-8150-42d3bb29938a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoanRestructuringModificationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LoanRestructuringModificationAxis_b3ebfd89-97f1-4bf9-a94d-00983a183bff" xlink:to="loc_us-gaap_LoanRestructuringModificationDomain_fafd7541-e74f-476a-8150-42d3bb29938a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ExtendedMaturityMember_1df69cc6-c5a9-4153-b5ab-add184e76234" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ExtendedMaturityMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LoanRestructuringModificationDomain_fafd7541-e74f-476a-8150-42d3bb29938a" xlink:to="loc_us-gaap_ExtendedMaturityMember_1df69cc6-c5a9-4153-b5ab-add184e76234" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractualInterestRateReductionMember_adab53ae-15b5-4e7f-bd5c-fbb745e1b577" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ContractualInterestRateReductionMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LoanRestructuringModificationDomain_fafd7541-e74f-476a-8150-42d3bb29938a" xlink:to="loc_us-gaap_ContractualInterestRateReductionMember_adab53ae-15b5-4e7f-bd5c-fbb745e1b577" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableModificationsLineItems_dfb79684-822d-4541-a3a9-5c0244cbbd78" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableModificationsLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFinancingReceivableTroubledDebtRestructuringsTable_082433a9-cdc1-4453-9b15-590f5b430aca" xlink:to="loc_us-gaap_FinancingReceivableModificationsLineItems_dfb79684-822d-4541-a3a9-5c0244cbbd78" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableModificationsNumberOfContracts2_4c5ba492-ab27-40d9-95bf-20c0477c5a93" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableModificationsNumberOfContracts2"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableModificationsLineItems_dfb79684-822d-4541-a3a9-5c0244cbbd78" xlink:to="loc_us-gaap_FinancingReceivableModificationsNumberOfContracts2_4c5ba492-ab27-40d9-95bf-20c0477c5a93" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableModificationsPreModificationRecordedInvestment2_17826b49-6dac-40fd-bc8c-a495fc3654d6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableModificationsPreModificationRecordedInvestment2"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableModificationsLineItems_dfb79684-822d-4541-a3a9-5c0244cbbd78" xlink:to="loc_us-gaap_FinancingReceivableModificationsPreModificationRecordedInvestment2_17826b49-6dac-40fd-bc8c-a495fc3654d6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableModificationsPostModificationRecordedInvestment2_df51a815-f3ce-49ff-b17a-f5876f4c440d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableModificationsPostModificationRecordedInvestment2"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableModificationsLineItems_dfb79684-822d-4541-a3a9-5c0244cbbd78" xlink:to="loc_us-gaap_FinancingReceivableModificationsPostModificationRecordedInvestment2_df51a815-f3ce-49ff-b17a-f5876f4c440d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_FinancialImpactOnDateOfRestructure_2c2dff2a-fccf-479c-b226-f5a19ab41c8a" xlink:href="sfnc-20210930.xsd#sfnc_FinancialImpactOnDateOfRestructure"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableModificationsLineItems_dfb79684-822d-4541-a3a9-5c0244cbbd78" xlink:to="loc_sfnc_FinancialImpactOnDateOfRestructure_2c2dff2a-fccf-479c-b226-f5a19ab41c8a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/LoansandAllowanceforCreditLossesLoansbyCreditRiskRatingSegregatedbyClassofLoansDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#LoansandAllowanceforCreditLossesLoansbyCreditRiskRatingSegregatedbyClassofLoansDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/LoansandAllowanceforCreditLossesLoansbyCreditRiskRatingSegregatedbyClassofLoansDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesAbstract_da2a1be8-ae11-425e-a664-8a1a93001744" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivablesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFinancingReceivableRecordedInvestmentCreditQualityIndicatorTable_c6a15e9e-09c8-4bcc-9048-9d01fa80d8be" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfFinancingReceivableRecordedInvestmentCreditQualityIndicatorTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesAbstract_da2a1be8-ae11-425e-a664-8a1a93001744" xlink:to="loc_us-gaap_ScheduleOfFinancingReceivableRecordedInvestmentCreditQualityIndicatorTable_c6a15e9e-09c8-4bcc-9048-9d01fa80d8be" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivablesPeriodPastDueAxis_3a0f3357-207f-4a1d-bcb1-dc9e6a54aa72" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivablesPeriodPastDueAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFinancingReceivableRecordedInvestmentCreditQualityIndicatorTable_c6a15e9e-09c8-4bcc-9048-9d01fa80d8be" xlink:to="loc_us-gaap_FinancingReceivablesPeriodPastDueAxis_3a0f3357-207f-4a1d-bcb1-dc9e6a54aa72" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivablesPeriodPastDueDomain_eda28d1b-18ae-4ffe-9b0b-c38012d3dbef" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivablesPeriodPastDueDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablesPeriodPastDueAxis_3a0f3357-207f-4a1d-bcb1-dc9e6a54aa72" xlink:to="loc_us-gaap_FinancingReceivablesPeriodPastDueDomain_eda28d1b-18ae-4ffe-9b0b-c38012d3dbef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialAssetNotPastDueMember_06206d67-795b-4602-9557-f61e8b0d3b15" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialAssetNotPastDueMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablesPeriodPastDueDomain_eda28d1b-18ae-4ffe-9b0b-c38012d3dbef" xlink:to="loc_us-gaap_FinancialAssetNotPastDueMember_06206d67-795b-4602-9557-f61e8b0d3b15" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_FinancialAsset30to89DaysPastDueMember_c983faaf-5e40-49e6-837b-c02dc99dcb9c" xlink:href="sfnc-20210930.xsd#sfnc_FinancialAsset30to89DaysPastDueMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablesPeriodPastDueDomain_eda28d1b-18ae-4ffe-9b0b-c38012d3dbef" xlink:to="loc_sfnc_FinancialAsset30to89DaysPastDueMember_c983faaf-5e40-49e6-837b-c02dc99dcb9c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivablesEqualToGreaterThan90DaysPastDueMember_8ce1ea12-79d1-45cb-859e-5d31b7e5fb54" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivablesEqualToGreaterThan90DaysPastDueMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablesPeriodPastDueDomain_eda28d1b-18ae-4ffe-9b0b-c38012d3dbef" xlink:to="loc_us-gaap_FinancingReceivablesEqualToGreaterThan90DaysPastDueMember_8ce1ea12-79d1-45cb-859e-5d31b7e5fb54" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_FinancingReceivablesEqualToGreaterThan30DaysPastDueMember_db78a179-e6d8-4cad-a1f1-0f0c8e7ea9e1" xlink:href="sfnc-20210930.xsd#sfnc_FinancingReceivablesEqualToGreaterThan30DaysPastDueMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablesPeriodPastDueDomain_eda28d1b-18ae-4ffe-9b0b-c38012d3dbef" xlink:to="loc_sfnc_FinancingReceivablesEqualToGreaterThan30DaysPastDueMember_db78a179-e6d8-4cad-a1f1-0f0c8e7ea9e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivablePortfolioSegmentAxis_88468305-604c-4bf8-a98d-6d6335321931" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivablePortfolioSegmentAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFinancingReceivableRecordedInvestmentCreditQualityIndicatorTable_c6a15e9e-09c8-4bcc-9048-9d01fa80d8be" xlink:to="loc_us-gaap_FinancingReceivablePortfolioSegmentAxis_88468305-604c-4bf8-a98d-6d6335321931" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_c8e5e7c6-e441-454d-b5cb-53a41c3dfac3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentAxis_88468305-604c-4bf8-a98d-6d6335321931" xlink:to="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_c8e5e7c6-e441-454d-b5cb-53a41c3dfac3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConsumerPortfolioSegmentMember_8db0f86b-d88e-42d7-a79b-a5b2c2869be2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConsumerPortfolioSegmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_c8e5e7c6-e441-454d-b5cb-53a41c3dfac3" xlink:to="loc_us-gaap_ConsumerPortfolioSegmentMember_8db0f86b-d88e-42d7-a79b-a5b2c2869be2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_RealEstatePortfolioSegmentMember_66c44c3c-0240-4a2c-8ca0-68a189ff14bf" xlink:href="sfnc-20210930.xsd#sfnc_RealEstatePortfolioSegmentMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_c8e5e7c6-e441-454d-b5cb-53a41c3dfac3" xlink:to="loc_sfnc_RealEstatePortfolioSegmentMember_66c44c3c-0240-4a2c-8ca0-68a189ff14bf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPortfolioSegmentMember_a492919b-56a7-4b1b-ba2f-0c9a65edb24f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommercialPortfolioSegmentMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_c8e5e7c6-e441-454d-b5cb-53a41c3dfac3" xlink:to="loc_us-gaap_CommercialPortfolioSegmentMember_a492919b-56a7-4b1b-ba2f-0c9a65edb24f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnallocatedFinancingReceivablesMember_1c566437-1249-40bd-971f-a8b2906a99d0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UnallocatedFinancingReceivablesMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_c8e5e7c6-e441-454d-b5cb-53a41c3dfac3" xlink:to="loc_us-gaap_UnallocatedFinancingReceivablesMember_1c566437-1249-40bd-971f-a8b2906a99d0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_d2ca8671-2fbe-4546-a3a6-4125b397581c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFinancingReceivableRecordedInvestmentCreditQualityIndicatorTable_c6a15e9e-09c8-4bcc-9048-9d01fa80d8be" xlink:to="loc_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_d2ca8671-2fbe-4546-a3a6-4125b397581c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_4018ddac-2242-460e-8158-60ca5a2f481e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_d2ca8671-2fbe-4546-a3a6-4125b397581c" xlink:to="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_4018ddac-2242-460e-8158-60ca5a2f481e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditCardReceivablesMember_cd2d5d1a-dc73-4fc2-b009-c6a76c542ca5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CreditCardReceivablesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_4018ddac-2242-460e-8158-60ca5a2f481e" xlink:to="loc_us-gaap_CreditCardReceivablesMember_cd2d5d1a-dc73-4fc2-b009-c6a76c542ca5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_OtherConsumerLoansMember_739499c2-2a18-481f-b8e7-f474f9e89cde" xlink:href="sfnc-20210930.xsd#sfnc_OtherConsumerLoansMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_4018ddac-2242-460e-8158-60ca5a2f481e" xlink:to="loc_sfnc_OtherConsumerLoansMember_739499c2-2a18-481f-b8e7-f474f9e89cde" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConstructionLoansMember_b76383da-bb4d-496e-8cb9-91724336daa2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConstructionLoansMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_4018ddac-2242-460e-8158-60ca5a2f481e" xlink:to="loc_us-gaap_ConstructionLoansMember_b76383da-bb4d-496e-8cb9-91724336daa2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SingleFamilyMember_5d29f8fe-709b-453c-9ff3-830da4af8bdc" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_SingleFamilyMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_4018ddac-2242-460e-8158-60ca5a2f481e" xlink:to="loc_srt_SingleFamilyMember_5d29f8fe-709b-453c-9ff3-830da4af8bdc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_OtherCommercialLoansMember_b55edd04-b4b4-43ca-9d80-cd4ee89d94c7" xlink:href="sfnc-20210930.xsd#sfnc_OtherCommercialLoansMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_4018ddac-2242-460e-8158-60ca5a2f481e" xlink:to="loc_sfnc_OtherCommercialLoansMember_b55edd04-b4b4-43ca-9d80-cd4ee89d94c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_CommercialLoansMember_d5b37e3f-cd49-4a6d-8382-6691632e88d6" xlink:href="sfnc-20210930.xsd#sfnc_CommercialLoansMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_4018ddac-2242-460e-8158-60ca5a2f481e" xlink:to="loc_sfnc_CommercialLoansMember_d5b37e3f-cd49-4a6d-8382-6691632e88d6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_AgriculturalLoansMember_9ca41e0e-534b-4c32-82ff-0fa74f45b257" xlink:href="sfnc-20210930.xsd#sfnc_AgriculturalLoansMember"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_4018ddac-2242-460e-8158-60ca5a2f481e" xlink:to="loc_sfnc_AgriculturalLoansMember_9ca41e0e-534b-4c32-82ff-0fa74f45b257" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InternalCreditAssessmentAxis_d8530cce-5c02-4336-a37b-8e28fbba31ab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InternalCreditAssessmentAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFinancingReceivableRecordedInvestmentCreditQualityIndicatorTable_c6a15e9e-09c8-4bcc-9048-9d01fa80d8be" xlink:to="loc_us-gaap_InternalCreditAssessmentAxis_d8530cce-5c02-4336-a37b-8e28fbba31ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InternalCreditAssessmentDomain_6e8d3105-1267-42b4-abd5-c55c7df191b9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InternalCreditAssessmentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InternalCreditAssessmentAxis_d8530cce-5c02-4336-a37b-8e28fbba31ab" xlink:to="loc_us-gaap_InternalCreditAssessmentDomain_6e8d3105-1267-42b4-abd5-c55c7df191b9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PassMember_75a50c48-0eaf-43f9-adff-3afa2faf16f0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PassMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InternalCreditAssessmentDomain_6e8d3105-1267-42b4-abd5-c55c7df191b9" xlink:to="loc_us-gaap_PassMember_75a50c48-0eaf-43f9-adff-3afa2faf16f0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SpecialMentionMember_de90fde1-ea60-46b7-84b5-d54baf0e892d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SpecialMentionMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InternalCreditAssessmentDomain_6e8d3105-1267-42b4-abd5-c55c7df191b9" xlink:to="loc_us-gaap_SpecialMentionMember_de90fde1-ea60-46b7-84b5-d54baf0e892d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubstandardMember_dbb8604f-67b7-46ec-9312-639edbabf282" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubstandardMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InternalCreditAssessmentDomain_6e8d3105-1267-42b4-abd5-c55c7df191b9" xlink:to="loc_us-gaap_SubstandardMember_dbb8604f-67b7-46ec-9312-639edbabf282" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DoubtfulMember_8ccbd9eb-7ef5-4dad-a597-6cc4bf622b57" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DoubtfulMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InternalCreditAssessmentDomain_6e8d3105-1267-42b4-abd5-c55c7df191b9" xlink:to="loc_us-gaap_DoubtfulMember_8ccbd9eb-7ef5-4dad-a597-6cc4bf622b57" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CriticizedMember_f20d15f6-afd6-41f8-b7ec-5de6da49644f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CriticizedMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InternalCreditAssessmentDomain_6e8d3105-1267-42b4-abd5-c55c7df191b9" xlink:to="loc_us-gaap_CriticizedMember_f20d15f6-afd6-41f8-b7ec-5de6da49644f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_CriticizedAndPastDueMember_e25fbdd8-58b0-4992-bef2-ca0a790975d2" xlink:href="sfnc-20210930.xsd#sfnc_CriticizedAndPastDueMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InternalCreditAssessmentDomain_6e8d3105-1267-42b4-abd5-c55c7df191b9" xlink:to="loc_sfnc_CriticizedAndPastDueMember_e25fbdd8-58b0-4992-bef2-ca0a790975d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRecordedInvestmentLineItems_ea60ff2c-5317-45e6-a997-f32a913f1da3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFinancingReceivableRecordedInvestmentCreditQualityIndicatorTable_c6a15e9e-09c8-4bcc-9048-9d01fa80d8be" xlink:to="loc_us-gaap_FinancingReceivableRecordedInvestmentLineItems_ea60ff2c-5317-45e6-a997-f32a913f1da3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearOneOriginatedCurrentFiscalYear_ee48971e-9a01-4d9c-855f-0724f91e7fd0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestYearOneOriginatedCurrentFiscalYear"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentLineItems_ea60ff2c-5317-45e6-a997-f32a913f1da3" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearOneOriginatedCurrentFiscalYear_ee48971e-9a01-4d9c-855f-0724f91e7fd0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearTwoOriginatedFiscalYearBeforeCurrentFiscalYear_378a49ae-ec36-46bb-87b1-bb554f9c8d23" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestYearTwoOriginatedFiscalYearBeforeCurrentFiscalYear"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentLineItems_ea60ff2c-5317-45e6-a997-f32a913f1da3" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearTwoOriginatedFiscalYearBeforeCurrentFiscalYear_378a49ae-ec36-46bb-87b1-bb554f9c8d23" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearThreeOriginatedTwoYearsBeforeCurrentFiscalYear_781691d7-fe04-4c88-909a-448cc8270a07" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestYearThreeOriginatedTwoYearsBeforeCurrentFiscalYear"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentLineItems_ea60ff2c-5317-45e6-a997-f32a913f1da3" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearThreeOriginatedTwoYearsBeforeCurrentFiscalYear_781691d7-fe04-4c88-909a-448cc8270a07" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearFourOriginatedThreeYearsBeforeCurrentFiscalYear_733dd70a-9a7c-4fe7-aa23-fd91c72cdc98" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestYearFourOriginatedThreeYearsBeforeCurrentFiscalYear"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentLineItems_ea60ff2c-5317-45e6-a997-f32a913f1da3" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearFourOriginatedThreeYearsBeforeCurrentFiscalYear_733dd70a-9a7c-4fe7-aa23-fd91c72cdc98" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearFiveOriginatedFourYearsBeforeCurrentFiscalYear_6fac49d2-2f6a-4f9f-9a76-53edf21e8cc3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestYearFiveOriginatedFourYearsBeforeCurrentFiscalYear"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentLineItems_ea60ff2c-5317-45e6-a997-f32a913f1da3" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestYearFiveOriginatedFourYearsBeforeCurrentFiscalYear_6fac49d2-2f6a-4f9f-9a76-53edf21e8cc3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestOriginatedMoreThanFiveYearsBeforeCurrentFiscalYear_2e1999e4-2600-494a-a783-0cdab56a3c29" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestOriginatedMoreThanFiveYearsBeforeCurrentFiscalYear"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentLineItems_ea60ff2c-5317-45e6-a997-f32a913f1da3" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestOriginatedMoreThanFiveYearsBeforeCurrentFiscalYear_2e1999e4-2600-494a-a783-0cdab56a3c29" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestRevolving_89bace1e-5faa-4cd9-9a80-f02e15e9eda4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestRevolving"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentLineItems_ea60ff2c-5317-45e6-a997-f32a913f1da3" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestRevolving_89bace1e-5faa-4cd9-9a80-f02e15e9eda4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestRevolvingConvertedToTermLoan_ae20ba1d-bf46-4d22-b774-aa98f9dbb719" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestRevolvingConvertedToTermLoan"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentLineItems_ea60ff2c-5317-45e6-a997-f32a913f1da3" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestRevolvingConvertedToTermLoan_ae20ba1d-bf46-4d22-b774-aa98f9dbb719" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_d2fca3da-9ec7-43f1-aedb-5b142a8c3098" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentLineItems_ea60ff2c-5317-45e6-a997-f32a913f1da3" xlink:to="loc_us-gaap_FinancingReceivableExcludingAccruedInterestBeforeAllowanceForCreditLoss_d2fca3da-9ec7-43f1-aedb-5b142a8c3098" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/LoansandAllowanceforCreditLossesCollateralDependentLoansDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#LoansandAllowanceforCreditLossesCollateralDependentLoansDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/LoansandAllowanceforCreditLossesCollateralDependentLoansDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesAbstract_a3b15fae-a9de-4727-9b2e-ad990f014296" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivablesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansAndLeasesReceivableDisclosureTable_c20c8dea-dd00-4a59-bf00-2f8e9599db29" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoansAndLeasesReceivableDisclosureTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesAbstract_a3b15fae-a9de-4727-9b2e-ad990f014296" xlink:to="loc_us-gaap_LoansAndLeasesReceivableDisclosureTable_c20c8dea-dd00-4a59-bf00-2f8e9599db29" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivablePortfolioSegmentAxis_fdf90ff8-c9f6-4d05-b072-b97b8bc4ec7c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivablePortfolioSegmentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LoansAndLeasesReceivableDisclosureTable_c20c8dea-dd00-4a59-bf00-2f8e9599db29" xlink:to="loc_us-gaap_FinancingReceivablePortfolioSegmentAxis_fdf90ff8-c9f6-4d05-b072-b97b8bc4ec7c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_ee1b7713-339f-4c6a-94d1-e7af8ce6dbe5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentAxis_fdf90ff8-c9f6-4d05-b072-b97b8bc4ec7c" xlink:to="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_ee1b7713-339f-4c6a-94d1-e7af8ce6dbe5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_RealEstatePortfolioSegmentMember_47404bf6-3800-4ab2-81f4-0c8dd7bec8c0" xlink:href="sfnc-20210930.xsd#sfnc_RealEstatePortfolioSegmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_ee1b7713-339f-4c6a-94d1-e7af8ce6dbe5" xlink:to="loc_sfnc_RealEstatePortfolioSegmentMember_47404bf6-3800-4ab2-81f4-0c8dd7bec8c0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPortfolioSegmentMember_7f0d82d6-d10c-4bfe-b292-a113f0cfe308" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommercialPortfolioSegmentMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_ee1b7713-339f-4c6a-94d1-e7af8ce6dbe5" xlink:to="loc_us-gaap_CommercialPortfolioSegmentMember_7f0d82d6-d10c-4bfe-b292-a113f0cfe308" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_77b8426e-8744-486b-bb3c-491c1be0f460" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LoansAndLeasesReceivableDisclosureTable_c20c8dea-dd00-4a59-bf00-2f8e9599db29" xlink:to="loc_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_77b8426e-8744-486b-bb3c-491c1be0f460" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_632393e7-2336-48fd-a1ae-1cf4b59216a2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_77b8426e-8744-486b-bb3c-491c1be0f460" xlink:to="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_632393e7-2336-48fd-a1ae-1cf4b59216a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConstructionLoansMember_4a91c59f-9b2a-4a9b-a7de-4567c28128b8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConstructionLoansMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_632393e7-2336-48fd-a1ae-1cf4b59216a2" xlink:to="loc_us-gaap_ConstructionLoansMember_4a91c59f-9b2a-4a9b-a7de-4567c28128b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SingleFamilyMember_c2e82ee6-503f-4adb-a89f-938c3c79edf8" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_SingleFamilyMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_632393e7-2336-48fd-a1ae-1cf4b59216a2" xlink:to="loc_srt_SingleFamilyMember_c2e82ee6-503f-4adb-a89f-938c3c79edf8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_OtherCommercialLoansMember_77d70639-56ba-4a90-b03e-f1a78874debc" xlink:href="sfnc-20210930.xsd#sfnc_OtherCommercialLoansMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_632393e7-2336-48fd-a1ae-1cf4b59216a2" xlink:to="loc_sfnc_OtherCommercialLoansMember_77d70639-56ba-4a90-b03e-f1a78874debc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_CommercialLoansMember_8565867c-cc02-4f57-a867-ead127033b8b" xlink:href="sfnc-20210930.xsd#sfnc_CommercialLoansMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_632393e7-2336-48fd-a1ae-1cf4b59216a2" xlink:to="loc_sfnc_CommercialLoansMember_8565867c-cc02-4f57-a867-ead127033b8b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollateralAxis_65ad865b-410b-4dc7-bccd-099937e1ba41" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CollateralAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LoansAndLeasesReceivableDisclosureTable_c20c8dea-dd00-4a59-bf00-2f8e9599db29" xlink:to="loc_us-gaap_CollateralAxis_65ad865b-410b-4dc7-bccd-099937e1ba41" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollateralDomain_85df86b5-ac5c-438c-a69c-ed76f118a3c7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CollateralDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollateralAxis_65ad865b-410b-4dc7-bccd-099937e1ba41" xlink:to="loc_us-gaap_CollateralDomain_85df86b5-ac5c-438c-a69c-ed76f118a3c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RealEstateMember_3f489bfc-9897-4e3a-9e3a-431f72ed76e8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RealEstateMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollateralDomain_85df86b5-ac5c-438c-a69c-ed76f118a3c7" xlink:to="loc_us-gaap_RealEstateMember_3f489bfc-9897-4e3a-9e3a-431f72ed76e8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_SecuredEnergyProductionAssetsMember_6bf4c516-2a22-40b5-b8d2-b38dabc2fbf2" xlink:href="sfnc-20210930.xsd#sfnc_SecuredEnergyProductionAssetsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollateralDomain_85df86b5-ac5c-438c-a69c-ed76f118a3c7" xlink:to="loc_sfnc_SecuredEnergyProductionAssetsMember_6bf4c516-2a22-40b5-b8d2-b38dabc2fbf2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_OtherBusinessAssetsMember_5402b340-9519-4d50-9561-f057f659d6e5" xlink:href="sfnc-20210930.xsd#sfnc_OtherBusinessAssetsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollateralDomain_85df86b5-ac5c-438c-a69c-ed76f118a3c7" xlink:to="loc_sfnc_OtherBusinessAssetsMember_5402b340-9519-4d50-9561-f057f659d6e5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansAndLeasesReceivableDisclosureLineItems_fd4624d8-ab94-4383-b257-67843d703004" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoansAndLeasesReceivableDisclosureLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LoansAndLeasesReceivableDisclosureTable_c20c8dea-dd00-4a59-bf00-2f8e9599db29" xlink:to="loc_us-gaap_LoansAndLeasesReceivableDisclosureLineItems_fd4624d8-ab94-4383-b257-67843d703004" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_FinancingReceivableCollateralDependentAmount_734299b2-0e9c-4f9f-8d08-679d8b7033e0" xlink:href="sfnc-20210930.xsd#sfnc_FinancingReceivableCollateralDependentAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LoansAndLeasesReceivableDisclosureLineItems_fd4624d8-ab94-4383-b257-67843d703004" xlink:to="loc_sfnc_FinancingReceivableCollateralDependentAmount_734299b2-0e9c-4f9f-8d08-679d8b7033e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/LoansandAllowanceforCreditLossesActivityintheAllowanceforLoanLossesbyPortfolioSegmentfortheCurrentYearDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#LoansandAllowanceforCreditLossesActivityintheAllowanceforLoanLossesbyPortfolioSegmentfortheCurrentYearDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/LoansandAllowanceforCreditLossesActivityintheAllowanceforLoanLossesbyPortfolioSegmentfortheCurrentYearDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesAbstract_a03022c3-e891-4c32-9018-6dc07269cd1f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivablesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansAndLeasesReceivableDisclosureTable_06564098-d171-450c-bcbe-14ad58723384" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoansAndLeasesReceivableDisclosureTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesAbstract_a03022c3-e891-4c32-9018-6dc07269cd1f" xlink:to="loc_us-gaap_LoansAndLeasesReceivableDisclosureTable_06564098-d171-450c-bcbe-14ad58723384" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_d47b117f-45fd-4bb6-a57b-8c0576b17c3c" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CumulativeEffectPeriodOfAdoptionAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LoansAndLeasesReceivableDisclosureTable_06564098-d171-450c-bcbe-14ad58723384" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_d47b117f-45fd-4bb6-a57b-8c0576b17c3c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_88f267a1-9a47-4d9b-a5be-a6affcc6464d" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CumulativeEffectPeriodOfAdoptionDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_d47b117f-45fd-4bb6-a57b-8c0576b17c3c" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_88f267a1-9a47-4d9b-a5be-a6affcc6464d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember_0dbe3771-e59f-412e-bc01-0a84037e95cb" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_88f267a1-9a47-4d9b-a5be-a6affcc6464d" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember_0dbe3771-e59f-412e-bc01-0a84037e95cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_4f45016e-0144-4fe8-a5c2-bccc1b731e2e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LoansAndLeasesReceivableDisclosureTable_06564098-d171-450c-bcbe-14ad58723384" xlink:to="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_4f45016e-0144-4fe8-a5c2-bccc1b731e2e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivableTypeDomain_3945b758-7f31-461a-b1f7-480764b112c5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivableTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_4f45016e-0144-4fe8-a5c2-bccc1b731e2e" xlink:to="loc_us-gaap_ReceivableTypeDomain_3945b758-7f31-461a-b1f7-480764b112c5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_LoansExcludingAcquiredLoansMember_372c9c9e-90ab-4469-ba22-b3adb9e8daaa" xlink:href="sfnc-20210930.xsd#sfnc_LoansExcludingAcquiredLoansMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivableTypeDomain_3945b758-7f31-461a-b1f7-480764b112c5" xlink:to="loc_sfnc_LoansExcludingAcquiredLoansMember_372c9c9e-90ab-4469-ba22-b3adb9e8daaa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivablePortfolioSegmentAxis_6d844f26-8f92-45b1-bc8e-b0f79dc016c1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivablePortfolioSegmentAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LoansAndLeasesReceivableDisclosureTable_06564098-d171-450c-bcbe-14ad58723384" xlink:to="loc_us-gaap_FinancingReceivablePortfolioSegmentAxis_6d844f26-8f92-45b1-bc8e-b0f79dc016c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_87cc35ca-07d5-4582-9602-493b4f008e85" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentAxis_6d844f26-8f92-45b1-bc8e-b0f79dc016c1" xlink:to="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_87cc35ca-07d5-4582-9602-493b4f008e85" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPortfolioSegmentMember_748a7dda-3f83-4660-91ee-723160312c6b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommercialPortfolioSegmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_87cc35ca-07d5-4582-9602-493b4f008e85" xlink:to="loc_us-gaap_CommercialPortfolioSegmentMember_748a7dda-3f83-4660-91ee-723160312c6b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_RealEstatePortfolioSegmentMember_58dcb34a-9623-4651-97cf-dc110ce61acb" xlink:href="sfnc-20210930.xsd#sfnc_RealEstatePortfolioSegmentMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_87cc35ca-07d5-4582-9602-493b4f008e85" xlink:to="loc_sfnc_RealEstatePortfolioSegmentMember_58dcb34a-9623-4651-97cf-dc110ce61acb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConsumerPortfolioSegmentMember_2344e51e-f139-4d59-96fc-89b535c5f83f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConsumerPortfolioSegmentMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain_87cc35ca-07d5-4582-9602-493b4f008e85" xlink:to="loc_us-gaap_ConsumerPortfolioSegmentMember_2344e51e-f139-4d59-96fc-89b535c5f83f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_3c622a86-24c4-466f-a44c-368b36dbe322" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LoansAndLeasesReceivableDisclosureTable_06564098-d171-450c-bcbe-14ad58723384" xlink:to="loc_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_3c622a86-24c4-466f-a44c-368b36dbe322" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_f496e26f-bb97-4f0c-b652-c793772703af" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_3c622a86-24c4-466f-a44c-368b36dbe322" xlink:to="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_f496e26f-bb97-4f0c-b652-c793772703af" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditCardReceivablesMember_cb189174-b358-4b4d-b5c8-8caa4c7437fa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CreditCardReceivablesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_f496e26f-bb97-4f0c-b652-c793772703af" xlink:to="loc_us-gaap_CreditCardReceivablesMember_cb189174-b358-4b4d-b5c8-8caa4c7437fa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_OtherLoansMember_92a3baab-fbde-4b1c-9ff6-e7767f53cf06" xlink:href="sfnc-20210930.xsd#sfnc_OtherLoansMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_f496e26f-bb97-4f0c-b652-c793772703af" xlink:to="loc_sfnc_OtherLoansMember_92a3baab-fbde-4b1c-9ff6-e7767f53cf06" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansAndLeasesReceivableDisclosureLineItems_3ddebc25-2423-4a74-a92c-a70fe35d8c9c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoansAndLeasesReceivableDisclosureLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LoansAndLeasesReceivableDisclosureTable_06564098-d171-450c-bcbe-14ad58723384" xlink:to="loc_us-gaap_LoansAndLeasesReceivableDisclosureLineItems_3ddebc25-2423-4a74-a92c-a70fe35d8c9c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForLoanAndLeaseLossesRollForward_437931e1-3d85-4154-aa23-c65150ca0845" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AllowanceForLoanAndLeaseLossesRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LoansAndLeasesReceivableDisclosureLineItems_3ddebc25-2423-4a74-a92c-a70fe35d8c9c" xlink:to="loc_us-gaap_AllowanceForLoanAndLeaseLossesRollForward_437931e1-3d85-4154-aa23-c65150ca0845" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableAllowanceForCreditLossExcludingAccruedInterest_02b3ab49-a89b-4069-bd65-308944333e07" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossExcludingAccruedInterest"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AllowanceForLoanAndLeaseLossesRollForward_437931e1-3d85-4154-aa23-c65150ca0845" xlink:to="loc_us-gaap_FinancingReceivableAllowanceForCreditLossExcludingAccruedInterest_02b3ab49-a89b-4069-bd65-308944333e07" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForLoanLossesExpensed_bec0de47-f830-4d58-87d7-ad22fa99f592" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProvisionForLoanLossesExpensed"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AllowanceForLoanAndLeaseLossesRollForward_437931e1-3d85-4154-aa23-c65150ca0845" xlink:to="loc_us-gaap_ProvisionForLoanLossesExpensed_bec0de47-f830-4d58-87d7-ad22fa99f592" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableAllowanceForCreditLossesWriteOffs_52acf89c-3f5a-4cc1-adf4-1ac6116742cb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossesWriteOffs"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AllowanceForLoanAndLeaseLossesRollForward_437931e1-3d85-4154-aa23-c65150ca0845" xlink:to="loc_us-gaap_FinancingReceivableAllowanceForCreditLossesWriteOffs_52acf89c-3f5a-4cc1-adf4-1ac6116742cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableAllowanceForCreditLossesRecovery_7a828aee-6dc0-48a6-aa26-8f71b6ace651" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossesRecovery"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AllowanceForLoanAndLeaseLossesRollForward_437931e1-3d85-4154-aa23-c65150ca0845" xlink:to="loc_us-gaap_FinancingReceivableAllowanceForCreditLossesRecovery_7a828aee-6dc0-48a6-aa26-8f71b6ace651" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableAllowanceForCreditLossWriteoffAfterRecovery_452fbb68-e951-4900-bf22-7581f1cb8722" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossWriteoffAfterRecovery"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AllowanceForLoanAndLeaseLossesRollForward_437931e1-3d85-4154-aa23-c65150ca0845" xlink:to="loc_us-gaap_FinancingReceivableAllowanceForCreditLossWriteoffAfterRecovery_452fbb68-e951-4900-bf22-7581f1cb8722" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTotalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableAllowanceForCreditLossExcludingAccruedInterest_185225fd-d087-485c-84de-e73a226d9f06" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossExcludingAccruedInterest"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AllowanceForLoanAndLeaseLossesRollForward_437931e1-3d85-4154-aa23-c65150ca0845" xlink:to="loc_us-gaap_FinancingReceivableAllowanceForCreditLossExcludingAccruedInterest_185225fd-d087-485c-84de-e73a226d9f06" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/LoansandAllowanceforCreditLossesProvisionforCreditLossesDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#LoansandAllowanceforCreditLossesProvisionforCreditLossesDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/LoansandAllowanceforCreditLossesProvisionforCreditLossesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesAbstract_6a8e4adb-e468-4b7d-86b8-fd38236e3379" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivablesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForLoanAndLeaseLosses_2cc477b5-0570-448b-850a-399d58a3ac2d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProvisionForLoanAndLeaseLosses"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesAbstract_6a8e4adb-e468-4b7d-86b8-fd38236e3379" xlink:to="loc_us-gaap_ProvisionForLoanAndLeaseLosses_2cc477b5-0570-448b-850a-399d58a3ac2d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_ProvisionForUnfundedCommitments_8df4e0cd-4d88-452e-b095-ec1478507289" xlink:href="sfnc-20210930.xsd#sfnc_ProvisionForUnfundedCommitments"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesAbstract_6a8e4adb-e468-4b7d-86b8-fd38236e3379" xlink:to="loc_sfnc_ProvisionForUnfundedCommitments_8df4e0cd-4d88-452e-b095-ec1478507289" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesHeldToMaturityCreditLossExpenseReversal_594eb1d5-57dd-471a-a8d5-dcb80246f549" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesHeldToMaturityCreditLossExpenseReversal"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesAbstract_6a8e4adb-e468-4b7d-86b8-fd38236e3379" xlink:to="loc_us-gaap_DebtSecuritiesHeldToMaturityCreditLossExpenseReversal_594eb1d5-57dd-471a-a8d5-dcb80246f549" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleChangeInPresentValueExpenseReversal_01a551a8-e4a4-4fae-a50c-a4835c65619f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleChangeInPresentValueExpenseReversal"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesAbstract_6a8e4adb-e468-4b7d-86b8-fd38236e3379" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleChangeInPresentValueExpenseReversal_01a551a8-e4a4-4fae-a50c-a4835c65619f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForLoanLeaseAndOtherLosses_45d0ae0c-0977-4326-9306-0e7af1a92e6e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProvisionForLoanLeaseAndOtherLosses"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesAbstract_6a8e4adb-e468-4b7d-86b8-fd38236e3379" xlink:to="loc_us-gaap_ProvisionForLoanLeaseAndOtherLosses_45d0ae0c-0977-4326-9306-0e7af1a92e6e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/RightOfUseLeaseAssetsandLeaseLiabilities" xlink:type="simple" xlink:href="sfnc-20210930.xsd#RightOfUseLeaseAssetsandLeaseLiabilities"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/RightOfUseLeaseAssetsandLeaseLiabilities" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_9c7fa113-48b1-4c5c-a31a-42542d5d4c0b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeasesTextBlock_62cbd771-60fa-4753-84cd-5772745f4901" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeasesTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_9c7fa113-48b1-4c5c-a31a-42542d5d4c0b" xlink:to="loc_us-gaap_LesseeOperatingLeasesTextBlock_62cbd771-60fa-4753-84cd-5772745f4901" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/RightOfUseLeaseAssetsandLeaseLiabilitiesTables" xlink:type="simple" xlink:href="sfnc-20210930.xsd#RightOfUseLeaseAssetsandLeaseLiabilitiesTables"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/RightOfUseLeaseAssetsandLeaseLiabilitiesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_165cdd79-756e-4548-b8ed-df816fd84189" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCostTableTextBlock_639eb4f3-f1f1-4f2f-b98c-fd8333ad61d3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LeaseCostTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_165cdd79-756e-4548-b8ed-df816fd84189" xlink:to="loc_us-gaap_LeaseCostTableTextBlock_639eb4f3-f1f1-4f2f-b98c-fd8333ad61d3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/RightOfUseLeaseAssetsandLeaseLiabilitiesLeaseExpenseandSupplementalInformationDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#RightOfUseLeaseAssetsandLeaseLiabilitiesLeaseExpenseandSupplementalInformationDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/RightOfUseLeaseAssetsandLeaseLiabilitiesLeaseExpenseandSupplementalInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_92d9903e-8ecf-48c9-ac80-6e91f2fcd56a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_4b71d6a5-1d12-40a2-bca4-d174405166da" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_92d9903e-8ecf-48c9-ac80-6e91f2fcd56a" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_4b71d6a5-1d12-40a2-bca4-d174405166da" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_0cf305a5-8424-4289-9e21-5e802525b437" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_92d9903e-8ecf-48c9-ac80-6e91f2fcd56a" xlink:to="loc_us-gaap_OperatingLeaseLiability_0cf305a5-8424-4289-9e21-5e802525b437" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1_ddeca171-44c3-4d51-aa80-909a605139b5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_92d9903e-8ecf-48c9-ac80-6e91f2fcd56a" xlink:to="loc_us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1_ddeca171-44c3-4d51-aa80-909a605139b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent_21c9b6c2-b2a1-449c-8530-019841bc36d8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_92d9903e-8ecf-48c9-ac80-6e91f2fcd56a" xlink:to="loc_us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent_21c9b6c2-b2a1-449c-8530-019841bc36d8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAssetStatementOfFinancialPositionExtensibleList_990a085d-adfa-49ec-a4b9-95d83e321a27" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAssetStatementOfFinancialPositionExtensibleList"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_92d9903e-8ecf-48c9-ac80-6e91f2fcd56a" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAssetStatementOfFinancialPositionExtensibleList_990a085d-adfa-49ec-a4b9-95d83e321a27" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrentStatementOfFinancialPositionExtensibleList_7dd507ca-0e44-4df6-b694-fac831b4a3c7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrentStatementOfFinancialPositionExtensibleList"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_92d9903e-8ecf-48c9-ac80-6e91f2fcd56a" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrentStatementOfFinancialPositionExtensibleList_7dd507ca-0e44-4df6-b694-fac831b4a3c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/RightOfUseLeaseAssetsandLeaseLiabilitiesDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#RightOfUseLeaseAssetsandLeaseLiabilitiesDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/RightOfUseLeaseAssetsandLeaseLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_6c667857-d36b-46ee-89a2-6730b8ee00d9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseExpense_78614a54-dbf7-4aaf-b8dd-67eb33f46219" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseExpense"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_6c667857-d36b-46ee-89a2-6730b8ee00d9" xlink:to="loc_us-gaap_OperatingLeaseExpense_78614a54-dbf7-4aaf-b8dd-67eb33f46219" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/PremisesandEquipment" xlink:type="simple" xlink:href="sfnc-20210930.xsd#PremisesandEquipment"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/PremisesandEquipment" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAbstract_4394038a-7308-4478-ab7f-a25a643a5566" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock_8893d87e-1c0f-42d9-8db2-4d22d55f2f56" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_4394038a-7308-4478-ab7f-a25a643a5566" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock_8893d87e-1c0f-42d9-8db2-4d22d55f2f56" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/PremisesandEquipmentTables" xlink:type="simple" xlink:href="sfnc-20210930.xsd#PremisesandEquipmentTables"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/PremisesandEquipmentTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAbstract_1562742b-8abe-4867-8d90-565609dc5136" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTextBlock_5626b2e2-b73d-4554-9682-0733239323d2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_1562742b-8abe-4867-8d90-565609dc5136" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTextBlock_5626b2e2-b73d-4554-9682-0733239323d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/PremisesandEquipmentDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#PremisesandEquipmentDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/PremisesandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAbstract_7c8bacd6-2857-426a-aede-deacae7b64ba" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_451b47e8-2ee5-47c5-90b6-b5b094dba789" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_7c8bacd6-2857-426a-aede-deacae7b64ba" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_451b47e8-2ee5-47c5-90b6-b5b094dba789" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_9d1df749-7ff5-4bdd-8043-7293da2ff37f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_451b47e8-2ee5-47c5-90b6-b5b094dba789" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_9d1df749-7ff5-4bdd-8043-7293da2ff37f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_7cd58334-653c-4dae-952a-27cb6b1cf3da" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_9d1df749-7ff5-4bdd-8043-7293da2ff37f" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_7cd58334-653c-4dae-952a-27cb6b1cf3da" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LandMember_58882095-1982-40cc-b0db-dc0e78c6252c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LandMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_7cd58334-653c-4dae-952a-27cb6b1cf3da" xlink:to="loc_us-gaap_LandMember_58882095-1982-40cc-b0db-dc0e78c6252c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BuildingAndBuildingImprovementsMember_73de3b8b-3470-413f-99cd-25283282bd45" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BuildingAndBuildingImprovementsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_7cd58334-653c-4dae-952a-27cb6b1cf3da" xlink:to="loc_us-gaap_BuildingAndBuildingImprovementsMember_73de3b8b-3470-413f-99cd-25283282bd45" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_83cb79e4-058b-4bb2-9320-d6e39c861593" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FurnitureAndFixturesMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_7cd58334-653c-4dae-952a-27cb6b1cf3da" xlink:to="loc_us-gaap_FurnitureAndFixturesMember_83cb79e4-058b-4bb2-9320-d6e39c861593" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_SoftwareMember_52303082-a9b4-4787-97f5-3c5194a6947d" xlink:href="sfnc-20210930.xsd#sfnc_SoftwareMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_7cd58334-653c-4dae-952a-27cb6b1cf3da" xlink:to="loc_sfnc_SoftwareMember_52303082-a9b4-4787-97f5-3c5194a6947d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConstructionInProgressMember_c2d3179e-dfc5-4247-94ec-9051feb5fe84" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConstructionInProgressMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_7cd58334-653c-4dae-952a-27cb6b1cf3da" xlink:to="loc_us-gaap_ConstructionInProgressMember_c2d3179e-dfc5-4247-94ec-9051feb5fe84" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3b0ad9ef-312f-440f-bd72-098f634a75e4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_451b47e8-2ee5-47c5-90b6-b5b094dba789" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3b0ad9ef-312f-440f-bd72-098f634a75e4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_025c4236-3390-4daf-83cb-c60865e08d5c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3b0ad9ef-312f-440f-bd72-098f634a75e4" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_025c4236-3390-4daf-83cb-c60865e08d5c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAssetStatementOfFinancialPositionExtensibleList_c990b507-9cf6-4dcd-8724-4a33d31d737a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAssetStatementOfFinancialPositionExtensibleList"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3b0ad9ef-312f-440f-bd72-098f634a75e4" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAssetStatementOfFinancialPositionExtensibleList_c990b507-9cf6-4dcd-8724-4a33d31d737a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_bebec84b-3d06-46b4-a135-bd528e9c0c7e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3b0ad9ef-312f-440f-bd72-098f634a75e4" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_bebec84b-3d06-46b4-a135-bd528e9c0c7e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_PropertyPlantandEquipmentandRightofUseAssetAccumulatedDepreciationandAmortization_25cbacdc-e78e-4c76-9111-4e20d6776fba" xlink:href="sfnc-20210930.xsd#sfnc_PropertyPlantandEquipmentandRightofUseAssetAccumulatedDepreciationandAmortization"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3b0ad9ef-312f-440f-bd72-098f634a75e4" xlink:to="loc_sfnc_PropertyPlantandEquipmentandRightofUseAssetAccumulatedDepreciationandAmortization_25cbacdc-e78e-4c76-9111-4e20d6776fba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_PropertyPlantandEquipmentandRightofUseAssetafterAccumulatedDepreciationandAmortization_acbf3d70-68e9-4540-942b-3ecd71a8ff64" xlink:href="sfnc-20210930.xsd#sfnc_PropertyPlantandEquipmentandRightofUseAssetafterAccumulatedDepreciationandAmortization"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3b0ad9ef-312f-440f-bd72-098f634a75e4" xlink:to="loc_sfnc_PropertyPlantandEquipmentandRightofUseAssetafterAccumulatedDepreciationandAmortization_acbf3d70-68e9-4540-942b-3ecd71a8ff64" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/GoodwillandOtherIntangibleAssets" xlink:type="simple" xlink:href="sfnc-20210930.xsd#GoodwillandOtherIntangibleAssets"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/GoodwillandOtherIntangibleAssets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_47dad14c-fbbd-404b-8108-3dfdb8dd6719" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureTextBlock_5a2aee05-31a9-450a-ae8e-948eedafd5d7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_47dad14c-fbbd-404b-8108-3dfdb8dd6719" xlink:to="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureTextBlock_5a2aee05-31a9-450a-ae8e-948eedafd5d7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/GoodwillandOtherIntangibleAssetsTables" xlink:type="simple" xlink:href="sfnc-20210930.xsd#GoodwillandOtherIntangibleAssetsTables"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/GoodwillandOtherIntangibleAssetsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_ab01ed5c-c989-457d-9f7b-1a2dbfc252b1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock_84d177b1-e67b-468e-8595-10077758c2ff" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_ab01ed5c-c989-457d-9f7b-1a2dbfc252b1" xlink:to="loc_us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock_84d177b1-e67b-468e-8595-10077758c2ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleofFiniteLivedIntangibleAssetsFutureAmortizationExpenseTableTextBlock_3960b10a-2fa0-41e7-b8cc-c0521ab5ee66" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleofFiniteLivedIntangibleAssetsFutureAmortizationExpenseTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_ab01ed5c-c989-457d-9f7b-1a2dbfc252b1" xlink:to="loc_us-gaap_ScheduleofFiniteLivedIntangibleAssetsFutureAmortizationExpenseTableTextBlock_3960b10a-2fa0-41e7-b8cc-c0521ab5ee66" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/GoodwillandOtherIntangibleAssetsTextualDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#GoodwillandOtherIntangibleAssetsTextualDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/GoodwillandOtherIntangibleAssetsTextualDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_12e038af-74f6-4e6a-8078-42c9923b33cb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_ecd660ad-bf3f-436f-ac6e-67ec8dcd326e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_12e038af-74f6-4e6a-8078-42c9923b33cb" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_ecd660ad-bf3f-436f-ac6e-67ec8dcd326e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_a14d717f-9bb3-46c1-99be-d904399d4c04" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_ecd660ad-bf3f-436f-ac6e-67ec8dcd326e" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_a14d717f-9bb3-46c1-99be-d904399d4c04" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_e6859201-c170-4a33-a14a-8da4c94e89aa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_a14d717f-9bb3-46c1-99be-d904399d4c04" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_e6859201-c170-4a33-a14a-8da4c94e89aa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_CoreDepositPremiumMember_7cdc314c-6667-416f-8414-a8a4c011b841" xlink:href="sfnc-20210930.xsd#sfnc_CoreDepositPremiumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_e6859201-c170-4a33-a14a-8da4c94e89aa" xlink:to="loc_sfnc_CoreDepositPremiumMember_7cdc314c-6667-416f-8414-a8a4c011b841" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_692ca147-f6a7-48fd-9e4d-0199bd6f2087" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_ecd660ad-bf3f-436f-ac6e-67ec8dcd326e" xlink:to="loc_srt_RangeAxis_692ca147-f6a7-48fd-9e4d-0199bd6f2087" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_bcf58c15-a83a-42f5-8db8-80a20e7d1d80" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_692ca147-f6a7-48fd-9e4d-0199bd6f2087" xlink:to="loc_srt_RangeMember_bcf58c15-a83a-42f5-8db8-80a20e7d1d80" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_ecee99ab-6ff4-45ee-be4c-f0da1c194370" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MinimumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_bcf58c15-a83a-42f5-8db8-80a20e7d1d80" xlink:to="loc_srt_MinimumMember_ecee99ab-6ff4-45ee-be4c-f0da1c194370" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_c9fa301b-d434-4220-88be-a2adb7b2e133" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MaximumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_bcf58c15-a83a-42f5-8db8-80a20e7d1d80" xlink:to="loc_srt_MaximumMember_c9fa301b-d434-4220-88be-a2adb7b2e133" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_d9e6c78b-4ce6-40a1-83d8-90df3908ce91" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_ecd660ad-bf3f-436f-ac6e-67ec8dcd326e" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_d9e6c78b-4ce6-40a1-83d8-90df3908ce91" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_029fab45-30ed-43a1-8b66-6c6e006a44a8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Goodwill"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_d9e6c78b-4ce6-40a1-83d8-90df3908ce91" xlink:to="loc_us-gaap_Goodwill_029fab45-30ed-43a1-8b66-6c6e006a44a8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_50a2137a-6d6f-407d-84e1-6a48ccab1d6f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillImpairmentLoss"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_d9e6c78b-4ce6-40a1-83d8-90df3908ce91" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_50a2137a-6d6f-407d-84e1-6a48ccab1d6f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_bb98ffad-f196-4b8a-8df7-35980310d9e6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_d9e6c78b-4ce6-40a1-83d8-90df3908ce91" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_bb98ffad-f196-4b8a-8df7-35980310d9e6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/GoodwillandOtherIntangibleAssetsChangesinGoodwillandOtherIntangiblesDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#GoodwillandOtherIntangibleAssetsChangesinGoodwillandOtherIntangiblesDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/GoodwillandOtherIntangibleAssetsChangesinGoodwillandOtherIntangiblesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_23d56547-5be9-4006-80c6-8cef58699c50" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_44551db5-bb58-469b-903a-005c8dafbc83" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_23d56547-5be9-4006-80c6-8cef58699c50" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_44551db5-bb58-469b-903a-005c8dafbc83" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_17c15bc2-ea97-49b3-8d67-39ac27459562" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_44551db5-bb58-469b-903a-005c8dafbc83" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_17c15bc2-ea97-49b3-8d67-39ac27459562" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_45c41582-859a-46b8-a08a-80e37b209f8b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_17c15bc2-ea97-49b3-8d67-39ac27459562" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_45c41582-859a-46b8-a08a-80e37b209f8b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_CoreDepositPremiumMember_82fbda29-a27e-4340-af02-d90d6fd864ae" xlink:href="sfnc-20210930.xsd#sfnc_CoreDepositPremiumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_45c41582-859a-46b8-a08a-80e37b209f8b" xlink:to="loc_sfnc_CoreDepositPremiumMember_82fbda29-a27e-4340-af02-d90d6fd864ae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_BooksOfBusinessIntangibleMember_b4756353-79c1-4db8-b93a-7ba39be71cd3" xlink:href="sfnc-20210930.xsd#sfnc_BooksOfBusinessIntangibleMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_45c41582-859a-46b8-a08a-80e37b209f8b" xlink:to="loc_sfnc_BooksOfBusinessIntangibleMember_b4756353-79c1-4db8-b93a-7ba39be71cd3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_da239cac-3d9e-4132-ac67-d5d3b18a895a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_44551db5-bb58-469b-903a-005c8dafbc83" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_da239cac-3d9e-4132-ac67-d5d3b18a895a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsRollForward_2d5e532d-974d-4ada-941c-14d597213611" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_da239cac-3d9e-4132-ac67-d5d3b18a895a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsRollForward_2d5e532d-974d-4ada-941c-14d597213611" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_bda8393e-5cc6-4635-a89a-d274910c190b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsRollForward_2d5e532d-974d-4ada-941c-14d597213611" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_bda8393e-5cc6-4635-a89a-d274910c190b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_FinitelivedIntangibleAssetsDisposition_67e33088-86fc-414f-a5fe-18d77a40f23a" xlink:href="sfnc-20210930.xsd#sfnc_FinitelivedIntangibleAssetsDisposition"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsRollForward_2d5e532d-974d-4ada-941c-14d597213611" xlink:to="loc_sfnc_FinitelivedIntangibleAssetsDisposition_67e33088-86fc-414f-a5fe-18d77a40f23a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_aded7dae-8c26-4529-9073-2583d4355623" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsRollForward_2d5e532d-974d-4ada-941c-14d597213611" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_aded7dae-8c26-4529-9073-2583d4355623" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_ee58f51f-2c5d-4a53-92e4-cc5d0d9c29d2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsRollForward_2d5e532d-974d-4ada-941c-14d597213611" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_ee58f51f-2c5d-4a53-92e4-cc5d0d9c29d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_e548e633-fe10-4798-b4f8-2da7cb2c7893" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsRollForward_2d5e532d-974d-4ada-941c-14d597213611" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_e548e633-fe10-4798-b4f8-2da7cb2c7893" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/GoodwillandOtherIntangibleAssetsGoodwillandOtherIntangiblesDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#GoodwillandOtherIntangibleAssetsGoodwillandOtherIntangiblesDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/GoodwillandOtherIntangibleAssetsGoodwillandOtherIntangiblesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_12d34ef0-7e89-4d6c-add9-a8aff47c7529" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_8484f2ad-1874-4f7e-b8dc-ffa653aea10a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_12d34ef0-7e89-4d6c-add9-a8aff47c7529" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_8484f2ad-1874-4f7e-b8dc-ffa653aea10a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_accf21bb-4e7e-444b-bd58-f078f7c2ac6b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_8484f2ad-1874-4f7e-b8dc-ffa653aea10a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_accf21bb-4e7e-444b-bd58-f078f7c2ac6b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_f4df01ab-ea20-48a0-b286-59f3d6354b91" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_accf21bb-4e7e-444b-bd58-f078f7c2ac6b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_f4df01ab-ea20-48a0-b286-59f3d6354b91" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_CoreDepositPremiumMember_6a98fc6f-eca4-4c07-88f3-44803157bc55" xlink:href="sfnc-20210930.xsd#sfnc_CoreDepositPremiumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_f4df01ab-ea20-48a0-b286-59f3d6354b91" xlink:to="loc_sfnc_CoreDepositPremiumMember_6a98fc6f-eca4-4c07-88f3-44803157bc55" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_BooksOfBusinessIntangibleMember_1c3dd225-6c81-48ed-975d-a2ac97626490" xlink:href="sfnc-20210930.xsd#sfnc_BooksOfBusinessIntangibleMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_f4df01ab-ea20-48a0-b286-59f3d6354b91" xlink:to="loc_sfnc_BooksOfBusinessIntangibleMember_1c3dd225-6c81-48ed-975d-a2ac97626490" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_59744c52-e01c-4ce9-bbaa-71fff39cc943" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_8484f2ad-1874-4f7e-b8dc-ffa653aea10a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_59744c52-e01c-4ce9-bbaa-71fff39cc943" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_652e6635-8649-4977-a22d-aa5b175452ca" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_59744c52-e01c-4ce9-bbaa-71fff39cc943" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_652e6635-8649-4977-a22d-aa5b175452ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_13ac0199-9550-44e8-bd89-17ef3a5a9ac4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_59744c52-e01c-4ce9-bbaa-71fff39cc943" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_13ac0199-9550-44e8-bd89-17ef3a5a9ac4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_fc719189-3a24-42c7-8fb3-1dd6d444e62c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_59744c52-e01c-4ce9-bbaa-71fff39cc943" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_fc719189-3a24-42c7-8fb3-1dd6d444e62c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/GoodwillandOtherIntangibleAssetsAmortizationExpenseDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#GoodwillandOtherIntangibleAssetsAmortizationExpenseDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/GoodwillandOtherIntangibleAssetsAmortizationExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_aa9dfb56-1d29-41b2-985f-7e361827564b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_6ddaef6f-f036-4851-b40b-b4a5cabef0c6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_aa9dfb56-1d29-41b2-985f-7e361827564b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_6ddaef6f-f036-4851-b40b-b4a5cabef0c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_a049b7bd-c319-44f0-87ef-e8fe0cf6a7cb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_aa9dfb56-1d29-41b2-985f-7e361827564b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_a049b7bd-c319-44f0-87ef-e8fe0cf6a7cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_52b0ca87-64b0-496b-96d8-4ef8acb30cc4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_aa9dfb56-1d29-41b2-985f-7e361827564b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_52b0ca87-64b0-496b-96d8-4ef8acb30cc4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_5648acfc-7550-41ca-9da0-e1557bbef3ea" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_aa9dfb56-1d29-41b2-985f-7e361827564b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_5648acfc-7550-41ca-9da0-e1557bbef3ea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_5b1edf21-a09b-4dc0-a0a9-a74ddc40c75a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_aa9dfb56-1d29-41b2-985f-7e361827564b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_5b1edf21-a09b-4dc0-a0a9-a74ddc40c75a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour_08e4aaaa-c9fb-4626-8616-3b2507a25fb2" xlink:href="sfnc-20210930.xsd#sfnc_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_aa9dfb56-1d29-41b2-985f-7e361827564b" xlink:to="loc_sfnc_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour_08e4aaaa-c9fb-4626-8616-3b2507a25fb2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_29b41375-2f48-4840-947a-cb97ad41da6b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract_aa9dfb56-1d29-41b2-985f-7e361827564b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_29b41375-2f48-4840-947a-cb97ad41da6b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/TimeDeposits" xlink:type="simple" xlink:href="sfnc-20210930.xsd#TimeDeposits"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/TimeDeposits" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankingAndThriftOtherDisclosuresAbstract_7c08de37-23a6-4206-807e-9b76e720f6a2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BankingAndThriftOtherDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepositLiabilitiesDisclosuresTextBlock_0d8a13e5-17df-4114-a651-9d999c7218aa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DepositLiabilitiesDisclosuresTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BankingAndThriftOtherDisclosuresAbstract_7c08de37-23a6-4206-807e-9b76e720f6a2" xlink:to="loc_us-gaap_DepositLiabilitiesDisclosuresTextBlock_0d8a13e5-17df-4114-a651-9d999c7218aa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/TimeDepositsTextualDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#TimeDepositsTextualDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/TimeDepositsTextualDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankingAndThriftOtherDisclosuresAbstract_c35deaba-dede-4394-910e-7bc91bf71a34" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BankingAndThriftOtherDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDeposits100000OrMore_830cfc74-7700-4f54-aeaf-d140ae1e1199" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TimeDeposits100000OrMore"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BankingAndThriftOtherDisclosuresAbstract_c35deaba-dede-4394-910e-7bc91bf71a34" xlink:to="loc_us-gaap_TimeDeposits100000OrMore_830cfc74-7700-4f54-aeaf-d140ae1e1199" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositsAtOrAboveFDICInsuranceLimit_90de7dc3-89e8-4f4b-800b-bb7b47fe5941" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TimeDepositsAtOrAboveFDICInsuranceLimit"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BankingAndThriftOtherDisclosuresAbstract_c35deaba-dede-4394-910e-7bc91bf71a34" xlink:to="loc_us-gaap_TimeDepositsAtOrAboveFDICInsuranceLimit_90de7dc3-89e8-4f4b-800b-bb7b47fe5941" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/IncomeTaxes" xlink:type="simple" xlink:href="sfnc-20210930.xsd#IncomeTaxes"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/IncomeTaxes" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_a523c03c-ea80-4d93-9fd0-561e244987a6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureTextBlock_e875e414-97a9-4b04-8937-a3ee343ce355" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_a523c03c-ea80-4d93-9fd0-561e244987a6" xlink:to="loc_us-gaap_IncomeTaxDisclosureTextBlock_e875e414-97a9-4b04-8937-a3ee343ce355" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/IncomeTaxesTables" xlink:type="simple" xlink:href="sfnc-20210930.xsd#IncomeTaxesTables"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/IncomeTaxesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_431392ae-f65f-4923-8b1b-431dbe4f7d7b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock_9ea00d03-0602-431d-9efa-2aa8fe154972" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_431392ae-f65f-4923-8b1b-431dbe4f7d7b" xlink:to="loc_us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock_9ea00d03-0602-431d-9efa-2aa8fe154972" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock_e6df159c-2840-445a-893d-6186ae28d6fc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_431392ae-f65f-4923-8b1b-431dbe4f7d7b" xlink:to="loc_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock_e6df159c-2840-445a-893d-6186ae28d6fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock_490cc62f-edf5-4f6c-8d6e-e78ca2cd3373" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_431392ae-f65f-4923-8b1b-431dbe4f7d7b" xlink:to="loc_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock_490cc62f-edf5-4f6c-8d6e-e78ca2cd3373" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/IncomeTaxesProvisionforIncomeTaxesDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#IncomeTaxesProvisionforIncomeTaxesDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/IncomeTaxesProvisionforIncomeTaxesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_d49301af-368b-4207-a74b-a68596279b44" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_7f2f8749-fbdd-4290-800e-80c9b4fde156" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_d49301af-368b-4207-a74b-a68596279b44" xlink:to="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_7f2f8749-fbdd-4290-800e-80c9b4fde156" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_e90d112c-7d55-4da8-a2b4-008835bdc1d5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_d49301af-368b-4207-a74b-a68596279b44" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_e90d112c-7d55-4da8-a2b4-008835bdc1d5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_1717c90d-cdba-472d-99ff-0202794ec53f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_d49301af-368b-4207-a74b-a68596279b44" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_1717c90d-cdba-472d-99ff-0202794ec53f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/IncomeTaxesTaxEffectsofTemporaryDifferencesRelatedtoDeferredTaxesIncludedinOtherLiabilitiesDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#IncomeTaxesTaxEffectsofTemporaryDifferencesRelatedtoDeferredTaxesIncludedinOtherLiabilitiesDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/IncomeTaxesTaxEffectsofTemporaryDifferencesRelatedtoDeferredTaxesIncludedinOtherLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_22b09c3d-90d2-457b-b0bd-3cdef0c4d2fd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGrossAbstract_79005bf0-55c1-4064-90b3-6bac32be9e75" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsGrossAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_22b09c3d-90d2-457b-b0bd-3cdef0c4d2fd" xlink:to="loc_us-gaap_DeferredTaxAssetsGrossAbstract_79005bf0-55c1-4064-90b3-6bac32be9e75" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_DeferredTaxAssetsLoansAcquired_e9bdda23-52d5-49e8-a92a-cbefa1d3ea8b" xlink:href="sfnc-20210930.xsd#sfnc_DeferredTaxAssetsLoansAcquired"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsGrossAbstract_79005bf0-55c1-4064-90b3-6bac32be9e75" xlink:to="loc_sfnc_DeferredTaxAssetsLoansAcquired_e9bdda23-52d5-49e8-a92a-cbefa1d3ea8b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsProvisionForLoanLosses_761f51e5-187e-4862-b6ef-4f18108974d7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsProvisionForLoanLosses"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsGrossAbstract_79005bf0-55c1-4064-90b3-6bac32be9e75" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsProvisionForLoanLosses_761f51e5-187e-4862-b6ef-4f18108974d7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_DeferredTaxAssetsOnForeclosedAssets_b8401eae-ef42-4fd3-b6c6-44110cc003f0" xlink:href="sfnc-20210930.xsd#sfnc_DeferredTaxAssetsOnForeclosedAssets"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsGrossAbstract_79005bf0-55c1-4064-90b3-6bac32be9e75" xlink:to="loc_sfnc_DeferredTaxAssetsOnForeclosedAssets_b8401eae-ef42-4fd3-b6c6-44110cc003f0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOtherLossCarryforwards_45cf3c5b-6047-4776-beac-b349c8b213d3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsOtherLossCarryforwards"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsGrossAbstract_79005bf0-55c1-4064-90b3-6bac32be9e75" xlink:to="loc_us-gaap_DeferredTaxAssetsOtherLossCarryforwards_45cf3c5b-6047-4776-beac-b349c8b213d3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeCompensation_9bc98033-780e-42b1-bcd5-2b5b30cd862c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeCompensation"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsGrossAbstract_79005bf0-55c1-4064-90b3-6bac32be9e75" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeCompensation_9bc98033-780e-42b1-bcd5-2b5b30cd862c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsOther_569f9bad-cc48-44ec-8b69-4d52d7ab3a93" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsOther"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsGrossAbstract_79005bf0-55c1-4064-90b3-6bac32be9e75" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsOther_569f9bad-cc48-44ec-8b69-4d52d7ab3a93" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_DeferredTaxAssetsAcquiredSecurities_ee363543-99ae-4101-b929-0675846d5a4d" xlink:href="sfnc-20210930.xsd#sfnc_DeferredTaxAssetsAcquiredSecurities"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsGrossAbstract_79005bf0-55c1-4064-90b3-6bac32be9e75" xlink:to="loc_sfnc_DeferredTaxAssetsAcquiredSecurities_ee363543-99ae-4101-b929-0675846d5a4d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_DeferredTaxAssetsOperatingLeaseLiabilities_aaf5d178-18bb-4801-bc95-ef20e5f96fb4" xlink:href="sfnc-20210930.xsd#sfnc_DeferredTaxAssetsOperatingLeaseLiabilities"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsGrossAbstract_79005bf0-55c1-4064-90b3-6bac32be9e75" xlink:to="loc_sfnc_DeferredTaxAssetsOperatingLeaseLiabilities_aaf5d178-18bb-4801-bc95-ef20e5f96fb4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsUnrealizedLossesOnAvailableforSaleSecuritiesGross_67191cd1-6528-4e62-bef1-a19b6032dc99" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsUnrealizedLossesOnAvailableforSaleSecuritiesGross"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsGrossAbstract_79005bf0-55c1-4064-90b3-6bac32be9e75" xlink:to="loc_us-gaap_DeferredTaxAssetsUnrealizedLossesOnAvailableforSaleSecuritiesGross_67191cd1-6528-4e62-bef1-a19b6032dc99" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_DeferredTaxAssetsTaxDeferredExpenseReservesandAccrualsUnfundedCommitments_40614333-b177-4b09-902f-0516ba01e33a" xlink:href="sfnc-20210930.xsd#sfnc_DeferredTaxAssetsTaxDeferredExpenseReservesandAccrualsUnfundedCommitments"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsGrossAbstract_79005bf0-55c1-4064-90b3-6bac32be9e75" xlink:to="loc_sfnc_DeferredTaxAssetsTaxDeferredExpenseReservesandAccrualsUnfundedCommitments_40614333-b177-4b09-902f-0516ba01e33a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOther_a63be936-b1b6-421c-87e4-ffe8273448b5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsOther"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsGrossAbstract_79005bf0-55c1-4064-90b3-6bac32be9e75" xlink:to="loc_us-gaap_DeferredTaxAssetsOther_a63be936-b1b6-421c-87e4-ffe8273448b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_e6845399-7c5b-4cfc-9e99-bc015694d276" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsGrossAbstract_79005bf0-55c1-4064-90b3-6bac32be9e75" xlink:to="loc_us-gaap_DeferredTaxAssetsGross_e6845399-7c5b-4cfc-9e99-bc015694d276" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesAbstract_a8dfd67f-273a-4a2a-9135-95c68acd1c89" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxLiabilitiesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_22b09c3d-90d2-457b-b0bd-3cdef0c4d2fd" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesAbstract_a8dfd67f-273a-4a2a-9135-95c68acd1c89" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssets_560f20e7-f10b-4755-970d-936fbcaeb151" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssets"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxLiabilitiesAbstract_a8dfd67f-273a-4a2a-9135-95c68acd1c89" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssets_560f20e7-f10b-4755-970d-936fbcaeb151" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_4a6c1d58-544b-4ef0-9458-a043e465c2bb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxLiabilitiesAbstract_a8dfd67f-273a-4a2a-9135-95c68acd1c89" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_4a6c1d58-544b-4ef0-9458-a043e465c2bb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_DeferredTaxLiabilitiesOperatingRightOfUseAssets_783c16dd-dfb4-4bdc-9788-79f3110e07ba" xlink:href="sfnc-20210930.xsd#sfnc_DeferredTaxLiabilitiesOperatingRightOfUseAssets"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxLiabilitiesAbstract_a8dfd67f-273a-4a2a-9135-95c68acd1c89" xlink:to="loc_sfnc_DeferredTaxLiabilitiesOperatingRightOfUseAssets_783c16dd-dfb4-4bdc-9788-79f3110e07ba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_DeferredTaxLiabilitiesUnrealizedGainsonAvailableforSaleSecuritiesGross_612fa5f5-9a74-4320-8aed-108bc37d52f3" xlink:href="sfnc-20210930.xsd#sfnc_DeferredTaxLiabilitiesUnrealizedGainsonAvailableforSaleSecuritiesGross"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxLiabilitiesAbstract_a8dfd67f-273a-4a2a-9135-95c68acd1c89" xlink:to="loc_sfnc_DeferredTaxLiabilitiesUnrealizedGainsonAvailableforSaleSecuritiesGross_612fa5f5-9a74-4320-8aed-108bc37d52f3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesOther_39b1afe2-6f3a-403a-b404-52ea3c12df05" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxLiabilitiesOther"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxLiabilitiesAbstract_a8dfd67f-273a-4a2a-9135-95c68acd1c89" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesOther_39b1afe2-6f3a-403a-b404-52ea3c12df05" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_c4ed0b44-3611-43e9-b60b-adaecd40da1b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxLiabilitiesAbstract_a8dfd67f-273a-4a2a-9135-95c68acd1c89" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilities_c4ed0b44-3611-43e9-b60b-adaecd40da1b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTotalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_ef88ebfe-52fc-4bfe-88f0-8b206b86830c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsLiabilitiesNet"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_22b09c3d-90d2-457b-b0bd-3cdef0c4d2fd" xlink:to="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_ef88ebfe-52fc-4bfe-88f0-8b206b86830c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#IncomeTaxesReconciliationofIncomeTaxExpenseDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_b844d6f5-3b76-4ad6-9b16-a3f28b303d4f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_77c0ab50-a982-4632-972a-7320d5252899" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_b844d6f5-3b76-4ad6-9b16-a3f28b303d4f" xlink:to="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_77c0ab50-a982-4632-972a-7320d5252899" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_692261e0-596f-4127-8b68-d42fa370c1ed" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_b844d6f5-3b76-4ad6-9b16-a3f28b303d4f" xlink:to="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_692261e0-596f-4127-8b68-d42fa370c1ed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost_94588883-4574-46b1-89c9-2d309f35871d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_b844d6f5-3b76-4ad6-9b16-a3f28b303d4f" xlink:to="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost_94588883-4574-46b1-89c9-2d309f35871d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_IncomeTaxRateReconciliationTaxExemptInterestIncome_dd5fdb77-fc02-47d5-8e30-66d30431b8d3" xlink:href="sfnc-20210930.xsd#sfnc_IncomeTaxRateReconciliationTaxExemptInterestIncome"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_b844d6f5-3b76-4ad6-9b16-a3f28b303d4f" xlink:to="loc_sfnc_IncomeTaxRateReconciliationTaxExemptInterestIncome_dd5fdb77-fc02-47d5-8e30-66d30431b8d3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_IncomeTaxReconciliationBankOwnedLifeInsurance_e046a92c-98f9-4767-8aca-24a49d71d075" xlink:href="sfnc-20210930.xsd#sfnc_IncomeTaxReconciliationBankOwnedLifeInsurance"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_b844d6f5-3b76-4ad6-9b16-a3f28b303d4f" xlink:to="loc_sfnc_IncomeTaxReconciliationBankOwnedLifeInsurance_e046a92c-98f9-4767-8aca-24a49d71d075" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxCredits_ff60582e-54b6-4d72-8871-591673476499" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxReconciliationTaxCredits"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_b844d6f5-3b76-4ad6-9b16-a3f28b303d4f" xlink:to="loc_us-gaap_IncomeTaxReconciliationTaxCredits_ff60582e-54b6-4d72-8871-591673476499" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_583cef2d-affc-4221-a98d-e8a95b0df21f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxReconciliationOtherAdjustments"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_b844d6f5-3b76-4ad6-9b16-a3f28b303d4f" xlink:to="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_583cef2d-affc-4221-a98d-e8a95b0df21f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_6f62dfee-4ed3-40d5-82ff-96e14f702a98" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_b844d6f5-3b76-4ad6-9b16-a3f28b303d4f" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_6f62dfee-4ed3-40d5-82ff-96e14f702a98" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/IncomeTaxesTextualDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#IncomeTaxesTextualDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/IncomeTaxesTextualDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_339b397d-51e9-4808-aaaa-480d6545e28f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLossCarryforwardsTable_8dc6d12d-ddf2-41e4-b19b-c3562422dfdb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLossCarryforwardsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_339b397d-51e9-4808-aaaa-480d6545e28f" xlink:to="loc_us-gaap_OperatingLossCarryforwardsTable_8dc6d12d-ddf2-41e4-b19b-c3562422dfdb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_e19cab1e-5588-456d-ae04-1e0cf6c6d6ed" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_8dc6d12d-ddf2-41e4-b19b-c3562422dfdb" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_e19cab1e-5588-456d-ae04-1e0cf6c6d6ed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_0af0a326-b20e-42df-961e-15ae534858ec" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_e19cab1e-5588-456d-ae04-1e0cf6c6d6ed" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_0af0a326-b20e-42df-961e-15ae534858ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_MetropolitanMember_233a47bc-bb7e-4ff6-9699-fbb483918678" xlink:href="sfnc-20210930.xsd#sfnc_MetropolitanMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_0af0a326-b20e-42df-961e-15ae534858ec" xlink:to="loc_sfnc_MetropolitanMember_233a47bc-bb7e-4ff6-9699-fbb483918678" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityAxis_b5817b60-6d61-4071-969e-c44447ff8ada" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxAuthorityAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_8dc6d12d-ddf2-41e4-b19b-c3562422dfdb" xlink:to="loc_us-gaap_IncomeTaxAuthorityAxis_b5817b60-6d61-4071-969e-c44447ff8ada" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_05f81df5-f6d0-4178-af38-697919125daf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_b5817b60-6d61-4071-969e-c44447ff8ada" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_05f81df5-f6d0-4178-af38-697919125daf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DomesticCountryMember_35aaddce-b05f-49fb-a682-ad6b7513c613" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DomesticCountryMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_05f81df5-f6d0-4178-af38-697919125daf" xlink:to="loc_us-gaap_DomesticCountryMember_35aaddce-b05f-49fb-a682-ad6b7513c613" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StateAndLocalJurisdictionMember_bc6a8d46-c468-4c8f-a320-1c3be411ad1c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StateAndLocalJurisdictionMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_05f81df5-f6d0-4178-af38-697919125daf" xlink:to="loc_us-gaap_StateAndLocalJurisdictionMember_bc6a8d46-c468-4c8f-a320-1c3be411ad1c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxPeriodAxis_d8334cbc-4efd-4ba4-ad63-fec4b8bca469" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TaxPeriodAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_8dc6d12d-ddf2-41e4-b19b-c3562422dfdb" xlink:to="loc_us-gaap_TaxPeriodAxis_d8334cbc-4efd-4ba4-ad63-fec4b8bca469" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxPeriodDomain_53b1b1b5-f9fd-4dba-a5d8-8303d804ab5c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TaxPeriodDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TaxPeriodAxis_d8334cbc-4efd-4ba4-ad63-fec4b8bca469" xlink:to="loc_us-gaap_TaxPeriodDomain_53b1b1b5-f9fd-4dba-a5d8-8303d804ab5c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarliestTaxYearMember_d8df4495-94d1-479f-beb3-27cb2a64a485" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarliestTaxYearMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TaxPeriodDomain_53b1b1b5-f9fd-4dba-a5d8-8303d804ab5c" xlink:to="loc_us-gaap_EarliestTaxYearMember_d8df4495-94d1-479f-beb3-27cb2a64a485" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLossCarryforwardsLineItems_87a10ffa-461e-4d43-b779-f92340450a76" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLossCarryforwardsLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_8dc6d12d-ddf2-41e4-b19b-c3562422dfdb" xlink:to="loc_us-gaap_OperatingLossCarryforwardsLineItems_87a10ffa-461e-4d43-b779-f92340450a76" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLossCarryforwards_c0dc4655-a1a7-4d62-9902-8f66e2bd4409" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLossCarryforwards"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_87a10ffa-461e-4d43-b779-f92340450a76" xlink:to="loc_us-gaap_OperatingLossCarryforwards_c0dc4655-a1a7-4d62-9902-8f66e2bd4409" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OpenTaxYear_f40a2397-a82e-4791-94f2-ad43d800dab3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OpenTaxYear"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_87a10ffa-461e-4d43-b779-f92340450a76" xlink:to="loc_us-gaap_OpenTaxYear_f40a2397-a82e-4791-94f2-ad43d800dab3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/SecuritiesSoldUnderAgreementstoRepurchase" xlink:type="simple" xlink:href="sfnc-20210930.xsd#SecuritiesSoldUnderAgreementstoRepurchase"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/SecuritiesSoldUnderAgreementstoRepurchase" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_9fbf47d1-b61a-43f7-b125-ac716ee5b405" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisclosureOfRepurchaseAgreementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepurchaseAgreementsResaleAgreementsSecuritiesBorrowedAndSecuritiesLoanedDisclosureTextBlock_a7021674-0020-4bf6-ae69-b84c4abe9d44" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepurchaseAgreementsResaleAgreementsSecuritiesBorrowedAndSecuritiesLoanedDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_9fbf47d1-b61a-43f7-b125-ac716ee5b405" xlink:to="loc_us-gaap_RepurchaseAgreementsResaleAgreementsSecuritiesBorrowedAndSecuritiesLoanedDisclosureTextBlock_a7021674-0020-4bf6-ae69-b84c4abe9d44" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/SecuritiesSoldUnderAgreementstoRepurchaseTables" xlink:type="simple" xlink:href="sfnc-20210930.xsd#SecuritiesSoldUnderAgreementstoRepurchaseTables"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/SecuritiesSoldUnderAgreementstoRepurchaseTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_e80d0423-7ab2-40f9-869c-db00c00ea870" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisclosureOfRepurchaseAgreementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRepurchaseAgreements_bcb1a36c-4843-46bb-89fa-ec1708c842fc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfRepurchaseAgreements"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_e80d0423-7ab2-40f9-869c-db00c00ea870" xlink:to="loc_us-gaap_ScheduleOfRepurchaseAgreements_bcb1a36c-4843-46bb-89fa-ec1708c842fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/SecuritiesSoldUnderAgreementstoRepurchaseTextualDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#SecuritiesSoldUnderAgreementstoRepurchaseTextualDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/SecuritiesSoldUnderAgreementstoRepurchaseTextualDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_bc958216-839e-4b59-bf35-e7ea85e74469" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisclosureOfRepurchaseAgreementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialAssetsSoldUnderAgreementsToRepurchaseGrossIncludingNotSubjectToMasterNettingArrangement_a9eaf9d5-42fb-4d81-91e8-7d77ff4d7472" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialAssetsSoldUnderAgreementsToRepurchaseGrossIncludingNotSubjectToMasterNettingArrangement"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_bc958216-839e-4b59-bf35-e7ea85e74469" xlink:to="loc_us-gaap_FinancialAssetsSoldUnderAgreementsToRepurchaseGrossIncludingNotSubjectToMasterNettingArrangement_a9eaf9d5-42fb-4d81-91e8-7d77ff4d7472" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/SecuritiesSoldUnderAgreementstoRepurchaseContractualMaturityoftheAgreementsDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#SecuritiesSoldUnderAgreementstoRepurchaseContractualMaturityoftheAgreementsDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/SecuritiesSoldUnderAgreementstoRepurchaseContractualMaturityoftheAgreementsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_93929cf5-ea71-4cd4-8d90-ff90a0f716fa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisclosureOfRepurchaseAgreementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransferOfCertainFinancialAssetsAccountedForAsSecuredBorrowingsTable_ec743817-97a3-4cce-9df3-7ac1b56a0d5e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransferOfCertainFinancialAssetsAccountedForAsSecuredBorrowingsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfRepurchaseAgreementsAbstract_93929cf5-ea71-4cd4-8d90-ff90a0f716fa" xlink:to="loc_us-gaap_TransferOfCertainFinancialAssetsAccountedForAsSecuredBorrowingsTable_ec743817-97a3-4cce-9df3-7ac1b56a0d5e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_062530c4-eba9-466a-a406-d1add139d655" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransferOfCertainFinancialAssetsAccountedForAsSecuredBorrowingsTable_ec743817-97a3-4cce-9df3-7ac1b56a0d5e" xlink:to="loc_us-gaap_FinancialInstrumentAxis_062530c4-eba9-466a-a406-d1add139d655" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_b7dd2a33-6ced-4789-882c-ab00ad21b045" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_062530c4-eba9-466a-a406-d1add139d655" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_b7dd2a33-6ced-4789-882c-ab00ad21b045" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_d440a74d-ce12-48f1-aac2-be9f3f4a5356" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_b7dd2a33-6ced-4789-882c-ab00ad21b045" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_d440a74d-ce12-48f1-aac2-be9f3f4a5356" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_226ef892-c9f6-4c44-a110-1d961a1f1343" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransferOfCertainFinancialAssetsAccountedForAsSecuredBorrowingsTable_ec743817-97a3-4cce-9df3-7ac1b56a0d5e" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_226ef892-c9f6-4c44-a110-1d961a1f1343" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_b0e29bba-5c87-484b-af68-b829e4113557" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodsAxis_226ef892-c9f6-4c44-a110-1d961a1f1343" xlink:to="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_b0e29bba-5c87-484b-af68-b829e4113557" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MaturityOvernightMember_04cfa4f8-f392-4632-badf-cff0636a6a22" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MaturityOvernightMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_b0e29bba-5c87-484b-af68-b829e4113557" xlink:to="loc_us-gaap_MaturityOvernightMember_04cfa4f8-f392-4632-badf-cff0636a6a22" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MaturityUpTo30DaysMember_25e7a08c-5b7c-496a-883b-36bd778fec6a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MaturityUpTo30DaysMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_b0e29bba-5c87-484b-af68-b829e4113557" xlink:to="loc_us-gaap_MaturityUpTo30DaysMember_25e7a08c-5b7c-496a-883b-36bd778fec6a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Maturity30To90DaysMember_c98cea1a-0182-4d4d-a3f5-7cecc4c2c779" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Maturity30To90DaysMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_b0e29bba-5c87-484b-af68-b829e4113557" xlink:to="loc_us-gaap_Maturity30To90DaysMember_c98cea1a-0182-4d4d-a3f5-7cecc4c2c779" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MaturityOver90DaysMember_00ceac9f-73e9-4767-bf0a-9a605a76918e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MaturityOver90DaysMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsSoldUnderAgreementsToRepurchaseMaturityPeriodDomain_b0e29bba-5c87-484b-af68-b829e4113557" xlink:to="loc_us-gaap_MaturityOver90DaysMember_00ceac9f-73e9-4767-bf0a-9a605a76918e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransferOfCertainFinancialAssetsAccountedForAsSecuredBorrowingsLineItems_150eb0e9-76d9-4bfe-9c9a-ef7ba9442602" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransferOfCertainFinancialAssetsAccountedForAsSecuredBorrowingsLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransferOfCertainFinancialAssetsAccountedForAsSecuredBorrowingsTable_ec743817-97a3-4cce-9df3-7ac1b56a0d5e" xlink:to="loc_us-gaap_TransferOfCertainFinancialAssetsAccountedForAsSecuredBorrowingsLineItems_150eb0e9-76d9-4bfe-9c9a-ef7ba9442602" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialAssetsSoldUnderAgreementsToRepurchaseGrossIncludingNotSubjectToMasterNettingArrangement_3f3ec502-632d-4a10-9367-4461754295c2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialAssetsSoldUnderAgreementsToRepurchaseGrossIncludingNotSubjectToMasterNettingArrangement"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransferOfCertainFinancialAssetsAccountedForAsSecuredBorrowingsLineItems_150eb0e9-76d9-4bfe-9c9a-ef7ba9442602" xlink:to="loc_us-gaap_FinancialAssetsSoldUnderAgreementsToRepurchaseGrossIncludingNotSubjectToMasterNettingArrangement_3f3ec502-632d-4a10-9367-4461754295c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/OtherBorrowingsandSubordinatedNotesandDebentures" xlink:type="simple" xlink:href="sfnc-20210930.xsd#OtherBorrowingsandSubordinatedNotesandDebentures"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/OtherBorrowingsandSubordinatedNotesandDebentures" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_6bced35f-d628-46ed-918a-63344ad80614" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureTextBlock_0ef9b5b7-c5cc-4db4-903d-c5fbc6ff2ee0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_6bced35f-d628-46ed-918a-63344ad80614" xlink:to="loc_us-gaap_DebtDisclosureTextBlock_0ef9b5b7-c5cc-4db4-903d-c5fbc6ff2ee0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/OtherBorrowingsandSubordinatedNotesandDebenturesTables" xlink:type="simple" xlink:href="sfnc-20210930.xsd#OtherBorrowingsandSubordinatedNotesandDebenturesTables"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/OtherBorrowingsandSubordinatedNotesandDebenturesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_e7e4c3c3-c3be-4354-8593-87f605a36a54" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDebtTableTextBlock_99454f77-5d02-493f-927b-8305438fafe5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfDebtTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_e7e4c3c3-c3be-4354-8593-87f605a36a54" xlink:to="loc_us-gaap_ScheduleOfDebtTableTextBlock_99454f77-5d02-493f-927b-8305438fafe5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfMaturitiesOfLongTermDebtTableTextBlock_5e8ba63f-c610-4cc7-9cb2-ac65562af08c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfMaturitiesOfLongTermDebtTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_e7e4c3c3-c3be-4354-8593-87f605a36a54" xlink:to="loc_us-gaap_ScheduleOfMaturitiesOfLongTermDebtTableTextBlock_5e8ba63f-c610-4cc7-9cb2-ac65562af08c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/OtherBorrowingsandSubordinatedNotesandDebenturesDebtComponentsDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#OtherBorrowingsandSubordinatedNotesandDebenturesDebtComponentsDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/OtherBorrowingsandSubordinatedNotesandDebenturesDebtComponentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_0e6b68ee-60d0-4aa5-897c-f3beca9c4e23" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_48408dfa-8ad7-4ec2-aa89-8ff6c400e422" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_0e6b68ee-60d0-4aa5-897c-f3beca9c4e23" xlink:to="loc_us-gaap_DebtInstrumentTable_48408dfa-8ad7-4ec2-aa89-8ff6c400e422" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_605150d2-3119-4c2d-a49e-279f029dac94" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_48408dfa-8ad7-4ec2-aa89-8ff6c400e422" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_605150d2-3119-4c2d-a49e-279f029dac94" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_2f5b4251-80a9-451b-adeb-a0e7a0736769" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_605150d2-3119-4c2d-a49e-279f029dac94" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_2f5b4251-80a9-451b-adeb-a0e7a0736769" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankAdvancesMember_7220930a-4e19-4813-aa05-120462fd955a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_2f5b4251-80a9-451b-adeb-a0e7a0736769" xlink:to="loc_us-gaap_FederalHomeLoanBankAdvancesMember_7220930a-4e19-4813-aa05-120462fd955a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_OtherLongTermDebtMember_6cc67d14-dfb6-4557-883b-e969c21b7395" xlink:href="sfnc-20210930.xsd#sfnc_OtherLongTermDebtMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_2f5b4251-80a9-451b-adeb-a0e7a0736769" xlink:to="loc_sfnc_OtherLongTermDebtMember_6cc67d14-dfb6-4557-883b-e969c21b7395" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_FederalHomeLoanBankAdvanceandOtherLongTermDebtMember_c567d400-4052-4302-9229-bc2e37ac8f04" xlink:href="sfnc-20210930.xsd#sfnc_FederalHomeLoanBankAdvanceandOtherLongTermDebtMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_2f5b4251-80a9-451b-adeb-a0e7a0736769" xlink:to="loc_sfnc_FederalHomeLoanBankAdvanceandOtherLongTermDebtMember_c567d400-4052-4302-9229-bc2e37ac8f04" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubordinatedDebtMember_60f868f5-eab8-4760-b0d7-b54fe2f6c5be" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubordinatedDebtMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_2f5b4251-80a9-451b-adeb-a0e7a0736769" xlink:to="loc_us-gaap_SubordinatedDebtMember_60f868f5-eab8-4760-b0d7-b54fe2f6c5be" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_SubordinatedDebtandUnsecuredDebtMember_4281d441-54ae-4808-9cdf-4f259afe55fe" xlink:href="sfnc-20210930.xsd#sfnc_SubordinatedDebtandUnsecuredDebtMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_2f5b4251-80a9-451b-adeb-a0e7a0736769" xlink:to="loc_sfnc_SubordinatedDebtandUnsecuredDebtMember_4281d441-54ae-4808-9cdf-4f259afe55fe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_e28fc640-7a10-49c6-a1ed-07a2af8d43bc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_48408dfa-8ad7-4ec2-aa89-8ff6c400e422" xlink:to="loc_us-gaap_DebtInstrumentAxis_e28fc640-7a10-49c6-a1ed-07a2af8d43bc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_1beb72c8-82db-4e23-8d30-0e5c68950b9e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_e28fc640-7a10-49c6-a1ed-07a2af8d43bc" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_1beb72c8-82db-4e23-8d30-0e5c68950b9e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_SubordinatedNotesPayableDue04012028Member_8b9afed4-432a-41c5-b34e-40971ca35ac9" xlink:href="sfnc-20210930.xsd#sfnc_SubordinatedNotesPayableDue04012028Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_1beb72c8-82db-4e23-8d30-0e5c68950b9e" xlink:to="loc_sfnc_SubordinatedNotesPayableDue04012028Member_8b9afed4-432a-41c5-b34e-40971ca35ac9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_TrustPreferredSecuritiesDue9152037Member_2452ed8d-ac62-4b98-97c3-de4a5c5d6607" xlink:href="sfnc-20210930.xsd#sfnc_TrustPreferredSecuritiesDue9152037Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_1beb72c8-82db-4e23-8d30-0e5c68950b9e" xlink:to="loc_sfnc_TrustPreferredSecuritiesDue9152037Member_2452ed8d-ac62-4b98-97c3-de4a5c5d6607" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_TrustPreferredSecuritiesDue662037Member_ee86ad56-6ee6-45a2-9280-9ba8f079bfa0" xlink:href="sfnc-20210930.xsd#sfnc_TrustPreferredSecuritiesDue662037Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_1beb72c8-82db-4e23-8d30-0e5c68950b9e" xlink:to="loc_sfnc_TrustPreferredSecuritiesDue662037Member_ee86ad56-6ee6-45a2-9280-9ba8f079bfa0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_TrustPreferredSecuritiesDue12152035Member_44f1cf4e-7244-48ed-ac3f-be587a9ceea9" xlink:href="sfnc-20210930.xsd#sfnc_TrustPreferredSecuritiesDue12152035Member"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_1beb72c8-82db-4e23-8d30-0e5c68950b9e" xlink:to="loc_sfnc_TrustPreferredSecuritiesDue12152035Member_44f1cf4e-7244-48ed-ac3f-be587a9ceea9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_TrustPreferredSecuritiesDue6152037Member_734ada18-96b7-4246-95eb-29c232a1532b" xlink:href="sfnc-20210930.xsd#sfnc_TrustPreferredSecuritiesDue6152037Member"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_1beb72c8-82db-4e23-8d30-0e5c68950b9e" xlink:to="loc_sfnc_TrustPreferredSecuritiesDue6152037Member_734ada18-96b7-4246-95eb-29c232a1532b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_TrustPreferredSecuritiesDue12152036Member_98c4a75a-b3ab-47ee-8fb9-6ce81e6af790" xlink:href="sfnc-20210930.xsd#sfnc_TrustPreferredSecuritiesDue12152036Member"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_1beb72c8-82db-4e23-8d30-0e5c68950b9e" xlink:to="loc_sfnc_TrustPreferredSecuritiesDue12152036Member_98c4a75a-b3ab-47ee-8fb9-6ce81e6af790" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateAxis_b9ae877f-6eb1-46d2-aaee-c370c95e4c2b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_VariableRateAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_48408dfa-8ad7-4ec2-aa89-8ff6c400e422" xlink:to="loc_us-gaap_VariableRateAxis_b9ae877f-6eb1-46d2-aaee-c370c95e4c2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_5d6df00b-45f5-46e0-b7f7-725c8bafdbd0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_VariableRateDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateAxis_b9ae877f-6eb1-46d2-aaee-c370c95e4c2b" xlink:to="loc_us-gaap_VariableRateDomain_5d6df00b-45f5-46e0-b7f7-725c8bafdbd0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LondonInterbankOfferedRateLIBORMember_1fc6cf27-fc6f-439c-8dfb-deff7d45545b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LondonInterbankOfferedRateLIBORMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateDomain_5d6df00b-45f5-46e0-b7f7-725c8bafdbd0" xlink:to="loc_us-gaap_LondonInterbankOfferedRateLIBORMember_1fc6cf27-fc6f-439c-8dfb-deff7d45545b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_73608185-95f2-49af-baae-63840b12d37b" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_48408dfa-8ad7-4ec2-aa89-8ff6c400e422" xlink:to="loc_srt_RangeAxis_73608185-95f2-49af-baae-63840b12d37b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_5cb482f0-d813-4a24-a25b-dc389a773e07" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_73608185-95f2-49af-baae-63840b12d37b" xlink:to="loc_srt_RangeMember_5cb482f0-d813-4a24-a25b-dc389a773e07" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_436a1b0d-496f-4e06-8110-e8ac1c629791" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MinimumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_5cb482f0-d813-4a24-a25b-dc389a773e07" xlink:to="loc_srt_MinimumMember_436a1b0d-496f-4e06-8110-e8ac1c629791" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_a236a7d2-7c36-4ab0-8cf5-529827c909a5" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MaximumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_5cb482f0-d813-4a24-a25b-dc389a773e07" xlink:to="loc_srt_MaximumMember_a236a7d2-7c36-4ab0-8cf5-529827c909a5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_0fa53643-62d1-4621-804e-4455528bd7e0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_48408dfa-8ad7-4ec2-aa89-8ff6c400e422" xlink:to="loc_us-gaap_DebtInstrumentLineItems_0fa53643-62d1-4621-804e-4455528bd7e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_b486fba3-954f-436f-bc94-8e79485b5270" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0fa53643-62d1-4621-804e-4455528bd7e0" xlink:to="loc_us-gaap_LongTermDebt_b486fba3-954f-436f-bc94-8e79485b5270" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_292c3a0b-e080-4121-bf91-096eb027411c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0fa53643-62d1-4621-804e-4455528bd7e0" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_292c3a0b-e080-4121-bf91-096eb027411c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_ba028b38-c4de-4319-aa99-ac57238e086d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0fa53643-62d1-4621-804e-4455528bd7e0" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_ba028b38-c4de-4319-aa99-ac57238e086d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_421f6862-87c1-4355-bb18-e652d4ffeb35" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0fa53643-62d1-4621-804e-4455528bd7e0" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_421f6862-87c1-4355-bb18-e652d4ffeb35" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_25632732-c438-4501-be49-34c9064fe231" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0fa53643-62d1-4621-804e-4455528bd7e0" xlink:to="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_25632732-c438-4501-be49-34c9064fe231" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/OtherBorrowingsandSubordinatedNotesandDebenturesTextualDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#OtherBorrowingsandSubordinatedNotesandDebenturesTextualDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/OtherBorrowingsandSubordinatedNotesandDebenturesTextualDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_7d78bf47-edda-402f-adab-ec7f4589bc8e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_f6304532-d3da-4c1f-a368-d52ceee84a0a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_7d78bf47-edda-402f-adab-ec7f4589bc8e" xlink:to="loc_us-gaap_DebtInstrumentTable_f6304532-d3da-4c1f-a368-d52ceee84a0a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_930fc9b1-d9e4-401c-9cab-ed05925df757" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_f6304532-d3da-4c1f-a368-d52ceee84a0a" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_930fc9b1-d9e4-401c-9cab-ed05925df757" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_d187f75b-f8ea-47ef-99a5-a907f64ef207" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_930fc9b1-d9e4-401c-9cab-ed05925df757" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_d187f75b-f8ea-47ef-99a5-a907f64ef207" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubordinatedDebtMember_f4f6ca7a-3d6e-44c4-b79a-1b383af17896" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubordinatedDebtMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_d187f75b-f8ea-47ef-99a5-a907f64ef207" xlink:to="loc_us-gaap_SubordinatedDebtMember_f4f6ca7a-3d6e-44c4-b79a-1b383af17896" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_e371f615-fe47-4078-a131-a75e00c29c2b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_f6304532-d3da-4c1f-a368-d52ceee84a0a" xlink:to="loc_us-gaap_DebtInstrumentAxis_e371f615-fe47-4078-a131-a75e00c29c2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_01e43608-625b-4f53-b26b-c1545d3115e9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_e371f615-fe47-4078-a131-a75e00c29c2b" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_01e43608-625b-4f53-b26b-c1545d3115e9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_FederalHomeLoanBankOwnstheOptionsFOTOAdvancesMember_0bca7e01-66da-498a-ad72-d3b252b0d432" xlink:href="sfnc-20210930.xsd#sfnc_FederalHomeLoanBankOwnstheOptionsFOTOAdvancesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_01e43608-625b-4f53-b26b-c1545d3115e9" xlink:to="loc_sfnc_FederalHomeLoanBankOwnstheOptionsFOTOAdvancesMember_0bca7e01-66da-498a-ad72-d3b252b0d432" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_b6c91af3-e1cb-4fa3-b862-8345dfa5bbdb" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_f6304532-d3da-4c1f-a368-d52ceee84a0a" xlink:to="loc_srt_RangeAxis_b6c91af3-e1cb-4fa3-b862-8345dfa5bbdb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_452fcdf5-f60b-45a0-86e4-ddb85a4e3a23" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_b6c91af3-e1cb-4fa3-b862-8345dfa5bbdb" xlink:to="loc_srt_RangeMember_452fcdf5-f60b-45a0-86e4-ddb85a4e3a23" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_7b83e77a-8b7e-4d12-80bf-b81aab021ad1" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MinimumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_452fcdf5-f60b-45a0-86e4-ddb85a4e3a23" xlink:to="loc_srt_MinimumMember_7b83e77a-8b7e-4d12-80bf-b81aab021ad1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_aa0524f6-b692-4b0e-a148-b87e36763541" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MaximumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_452fcdf5-f60b-45a0-86e4-ddb85a4e3a23" xlink:to="loc_srt_MaximumMember_aa0524f6-b692-4b0e-a148-b87e36763541" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateAxis_829d75ac-7fb0-48e1-bbbe-eb4d01be47cf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_VariableRateAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_f6304532-d3da-4c1f-a368-d52ceee84a0a" xlink:to="loc_us-gaap_VariableRateAxis_829d75ac-7fb0-48e1-bbbe-eb4d01be47cf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_7d4ada76-9c2a-48cd-94e0-f54212f84c1f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_VariableRateDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateAxis_829d75ac-7fb0-48e1-bbbe-eb4d01be47cf" xlink:to="loc_us-gaap_VariableRateDomain_7d4ada76-9c2a-48cd-94e0-f54212f84c1f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LondonInterbankOfferedRateLIBORMember_1ab0827e-a940-42ad-853f-522492019beb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LondonInterbankOfferedRateLIBORMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateDomain_7d4ada76-9c2a-48cd-94e0-f54212f84c1f" xlink:to="loc_us-gaap_LondonInterbankOfferedRateLIBORMember_1ab0827e-a940-42ad-853f-522492019beb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_23176eb4-c4e4-415a-87dd-000356c04a9a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_f6304532-d3da-4c1f-a368-d52ceee84a0a" xlink:to="loc_us-gaap_DebtInstrumentLineItems_23176eb4-c4e4-415a-87dd-000356c04a9a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_a02949e3-2d22-4673-b5ce-e501d444f588" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_23176eb4-c4e4-415a-87dd-000356c04a9a" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_a02949e3-2d22-4673-b5ce-e501d444f588" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_18639949-d0f2-4a61-9d4f-d52abb23b020" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_23176eb4-c4e4-415a-87dd-000356c04a9a" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_18639949-d0f2-4a61-9d4f-d52abb23b020" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_8e090622-d959-41e0-b268-164f36162e7d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_23176eb4-c4e4-415a-87dd-000356c04a9a" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_8e090622-d959-41e0-b268-164f36162e7d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_002fffbc-cd32-46aa-85b2-a08548d085c3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_23176eb4-c4e4-415a-87dd-000356c04a9a" xlink:to="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_002fffbc-cd32-46aa-85b2-a08548d085c3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_a0182b0f-8cf8-4e3e-a292-9f3a418bbdf7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdvancesFromFederalHomeLoanBanks"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_23176eb4-c4e4-415a-87dd-000356c04a9a" xlink:to="loc_us-gaap_AdvancesFromFederalHomeLoanBanks_a0182b0f-8cf8-4e3e-a292-9f3a418bbdf7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueWithinOneYearOfBalanceSheetDate_203a2939-0801-481a-b836-7c500862db4d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueWithinOneYearOfBalanceSheetDate"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_23176eb4-c4e4-415a-87dd-000356c04a9a" xlink:to="loc_us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryDueWithinOneYearOfBalanceSheetDate_203a2939-0801-481a-b836-7c500862db4d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTerm_3a6f1504-21c4-4380-a8e7-6b2a3b96704c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentTerm"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_23176eb4-c4e4-415a-87dd-000356c04a9a" xlink:to="loc_us-gaap_DebtInstrumentTerm_3a6f1504-21c4-4380-a8e7-6b2a3b96704c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankAdvancesGeneralDebtObligationsDisclosuresCollateralPledged1_91ce0b26-c756-4e0b-8775-f31930c7c523" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesGeneralDebtObligationsDisclosuresCollateralPledged1"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_23176eb4-c4e4-415a-87dd-000356c04a9a" xlink:to="loc_us-gaap_FederalHomeLoanBankAdvancesGeneralDebtObligationsDisclosuresCollateralPledged1_91ce0b26-c756-4e0b-8775-f31930c7c523" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_AdvancesFromFederalHomeLoanBankAvailable_80f3ca57-f56c-4408-b73d-e6691fd5d47e" xlink:href="sfnc-20210930.xsd#sfnc_AdvancesFromFederalHomeLoanBankAvailable"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_23176eb4-c4e4-415a-87dd-000356c04a9a" xlink:to="loc_sfnc_AdvancesFromFederalHomeLoanBankAvailable_80f3ca57-f56c-4408-b73d-e6691fd5d47e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/OtherBorrowingsandSubordinatedNotesandDebenturesAggregateAnnualMaturitiesofLongtermDebtDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#OtherBorrowingsandSubordinatedNotesandDebenturesAggregateAnnualMaturitiesofLongtermDebtDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/OtherBorrowingsandSubordinatedNotesandDebenturesAggregateAnnualMaturitiesofLongtermDebtDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_e5f1978e-b880-4f04-8eb8-5120f832a26d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_085a8b3a-6db3-4867-90eb-4fc94427b16f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_e5f1978e-b880-4f04-8eb8-5120f832a26d" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_085a8b3a-6db3-4867-90eb-4fc94427b16f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_e50eefe4-ba41-4846-be39-33aa3b7fa29b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_e5f1978e-b880-4f04-8eb8-5120f832a26d" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_e50eefe4-ba41-4846-be39-33aa3b7fa29b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_638c06ac-3462-4dbd-98d9-3533948e0ef8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_e5f1978e-b880-4f04-8eb8-5120f832a26d" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_638c06ac-3462-4dbd-98d9-3533948e0ef8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_98afb03f-ed04-43e2-a562-bdae668dead7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_e5f1978e-b880-4f04-8eb8-5120f832a26d" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_98afb03f-ed04-43e2-a562-bdae668dead7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_0d5823f3-c1e6-4c96-88f2-c74de6367899" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_e5f1978e-b880-4f04-8eb8-5120f832a26d" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_0d5823f3-c1e6-4c96-88f2-c74de6367899" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_LongTermDebtMaturityAfterYearFour_2d05578e-aaf8-40b4-9775-72ad036ef60b" xlink:href="sfnc-20210930.xsd#sfnc_LongTermDebtMaturityAfterYearFour"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_e5f1978e-b880-4f04-8eb8-5120f832a26d" xlink:to="loc_sfnc_LongTermDebtMaturityAfterYearFour_2d05578e-aaf8-40b4-9775-72ad036ef60b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_34a7a2c1-23ee-4494-b18b-72b0193eeaa4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_e5f1978e-b880-4f04-8eb8-5120f832a26d" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_34a7a2c1-23ee-4494-b18b-72b0193eeaa4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/ContingentLiabilities" xlink:type="simple" xlink:href="sfnc-20210930.xsd#ContingentLiabilities"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/ContingentLiabilities" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_ae14b4ab-06be-46bb-a4ad-ff5ee05882a9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_ae38b775-09f6-45a1-b3f9-7f7371293f00" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_ae14b4ab-06be-46bb-a4ad-ff5ee05882a9" xlink:to="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_ae38b775-09f6-45a1-b3f9-7f7371293f00" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/CapitalStock" xlink:type="simple" xlink:href="sfnc-20210930.xsd#CapitalStock"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/CapitalStock" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_db0c20d6-bd76-49af-a1e6-9ca4028f47ab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_CapitalStockDisclosureTextBlock_fdf1b52d-3600-4b07-8247-ea6e661e48ac" xlink:href="sfnc-20210930.xsd#sfnc_CapitalStockDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_db0c20d6-bd76-49af-a1e6-9ca4028f47ab" xlink:to="loc_sfnc_CapitalStockDisclosureTextBlock_fdf1b52d-3600-4b07-8247-ea6e661e48ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/CapitalStockTextualDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#CapitalStockTextualDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/CapitalStockTextualDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_da0b7049-9e60-4b09-a266-703f52f2fde3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_bccfc0ad-2138-4248-bdd0-d58412b80722" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_da0b7049-9e60-4b09-a266-703f52f2fde3" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_bccfc0ad-2138-4248-bdd0-d58412b80722" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_fd119479-22b0-4d09-bf2b-7563e6083210" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_bccfc0ad-2138-4248-bdd0-d58412b80722" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_fd119479-22b0-4d09-bf2b-7563e6083210" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_21e9de4a-f2ea-4dc1-9e5c-ad3b3963c957" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_fd119479-22b0-4d09-bf2b-7563e6083210" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_21e9de4a-f2ea-4dc1-9e5c-ad3b3963c957" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_RelianceBancsharesInc.Member_6cf29d17-e30e-435d-be9f-cc2eeaefb1e3" xlink:href="sfnc-20210930.xsd#sfnc_RelianceBancsharesInc.Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_21e9de4a-f2ea-4dc1-9e5c-ad3b3963c957" xlink:to="loc_sfnc_RelianceBancsharesInc.Member_6cf29d17-e30e-435d-be9f-cc2eeaefb1e3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_07245944-8f46-4358-a0f4-c74c4b0c9450" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_bccfc0ad-2138-4248-bdd0-d58412b80722" xlink:to="loc_srt_RangeAxis_07245944-8f46-4358-a0f4-c74c4b0c9450" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_eda2f855-b6bd-46f6-8b84-5f78ee00b09d" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_07245944-8f46-4358-a0f4-c74c4b0c9450" xlink:to="loc_srt_RangeMember_eda2f855-b6bd-46f6-8b84-5f78ee00b09d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_79c2b178-6c6f-4f8e-bde9-477eaee9aeab" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MaximumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_eda2f855-b6bd-46f6-8b84-5f78ee00b09d" xlink:to="loc_srt_MaximumMember_79c2b178-6c6f-4f8e-bde9-477eaee9aeab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_eaca6884-f7c4-4002-937a-b6f5c5f3cb7e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_bccfc0ad-2138-4248-bdd0-d58412b80722" xlink:to="loc_us-gaap_StatementClassOfStockAxis_eaca6884-f7c4-4002-937a-b6f5c5f3cb7e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_0b6e32b0-2b36-4129-918e-3adb13ffe9e1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_eaca6884-f7c4-4002-937a-b6f5c5f3cb7e" xlink:to="loc_us-gaap_ClassOfStockDomain_0b6e32b0-2b36-4129-918e-3adb13ffe9e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesDPreferredStockMember_a0d6f7af-14a9-4d29-811d-2de5ce1477d3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeriesDPreferredStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_0b6e32b0-2b36-4129-918e-3adb13ffe9e1" xlink:to="loc_us-gaap_SeriesDPreferredStockMember_a0d6f7af-14a9-4d29-811d-2de5ce1477d3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_27a9d0f2-f854-452e-a7d7-b9da091a2f44" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_bccfc0ad-2138-4248-bdd0-d58412b80722" xlink:to="loc_us-gaap_ClassOfStockLineItems_27a9d0f2-f854-452e-a7d7-b9da091a2f44" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_f8e90a5c-f1c7-4e20-9198-9378b4dbd2fd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockSharesAuthorized"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_27a9d0f2-f854-452e-a7d7-b9da091a2f44" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_f8e90a5c-f1c7-4e20-9198-9378b4dbd2fd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockParOrStatedValuePerShare_bbc39c9e-91f0-4060-8ef1-3be370e97abe" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockParOrStatedValuePerShare"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_27a9d0f2-f854-452e-a7d7-b9da091a2f44" xlink:to="loc_us-gaap_PreferredStockParOrStatedValuePerShare_bbc39c9e-91f0-4060-8ef1-3be370e97abe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockLiquidationPreferenceValue_03225964-a14d-467d-8b1c-eef7d27ff22c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockLiquidationPreferenceValue"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_27a9d0f2-f854-452e-a7d7-b9da091a2f44" xlink:to="loc_us-gaap_PreferredStockLiquidationPreferenceValue_03225964-a14d-467d-8b1c-eef7d27ff22c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramNumberOfSharesAuthorizedToBeRepurchased_cd6c0133-2fd0-4440-8d75-73ff37277b2e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockRepurchaseProgramNumberOfSharesAuthorizedToBeRepurchased"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_27a9d0f2-f854-452e-a7d7-b9da091a2f44" xlink:to="loc_us-gaap_StockRepurchaseProgramNumberOfSharesAuthorizedToBeRepurchased_cd6c0133-2fd0-4440-8d75-73ff37277b2e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodShares_52d304e6-3154-403c-9e4c-2c4d16cdc153" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodShares"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_27a9d0f2-f854-452e-a7d7-b9da091a2f44" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodShares_52d304e6-3154-403c-9e4c-2c4d16cdc153" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_StockRepurchasedDuringPeriodValueAverage_a49cbae9-7b61-4aea-b875-46637a2e946c" xlink:href="sfnc-20210930.xsd#sfnc_StockRepurchasedDuringPeriodValueAverage"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_27a9d0f2-f854-452e-a7d7-b9da091a2f44" xlink:to="loc_sfnc_StockRepurchasedDuringPeriodValueAverage_a49cbae9-7b61-4aea-b875-46637a2e946c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/UndividedProfits" xlink:type="simple" xlink:href="sfnc-20210930.xsd#UndividedProfits"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/UndividedProfits" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_47147a78-c5f1-4c45-acba-f0754d9bd357" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictionsOnDividendsLoansAndAdvancesTextBlock_08156fec-9a0a-4125-8f78-9db8be884876" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictionsOnDividendsLoansAndAdvancesTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_47147a78-c5f1-4c45-acba-f0754d9bd357" xlink:to="loc_us-gaap_RestrictionsOnDividendsLoansAndAdvancesTextBlock_08156fec-9a0a-4125-8f78-9db8be884876" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/UndividedProfitsTextualDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#UndividedProfitsTextualDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/UndividedProfitsTextualDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_efd3262d-b37f-45de-b944-a0147d49b1e4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_ThresholdPercentageOfNetProfitsExceededByDividendsDeclaredAnyCalendarYear_d835af0e-3e04-40c1-8af3-6bebfbdaeff2" xlink:href="sfnc-20210930.xsd#sfnc_ThresholdPercentageOfNetProfitsExceededByDividendsDeclaredAnyCalendarYear"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_efd3262d-b37f-45de-b944-a0147d49b1e4" xlink:to="loc_sfnc_ThresholdPercentageOfNetProfitsExceededByDividendsDeclaredAnyCalendarYear_d835af0e-3e04-40c1-8af3-6bebfbdaeff2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_ThresholdPercentageOfNetProfitsExceededByDividendsDeclaredCombinedWithPrecedingYear_1be0e0c6-2a90-4e06-925d-6b776ddfa8a9" xlink:href="sfnc-20210930.xsd#sfnc_ThresholdPercentageOfNetProfitsExceededByDividendsDeclaredCombinedWithPrecedingYear"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_efd3262d-b37f-45de-b944-a0147d49b1e4" xlink:to="loc_sfnc_ThresholdPercentageOfNetProfitsExceededByDividendsDeclaredCombinedWithPrecedingYear_1be0e0c6-2a90-4e06-925d-6b776ddfa8a9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatutoryAccountingPracticesStatutoryAmountAvailableForDividendPaymentsWithoutRegulatoryApproval_255327bb-72c5-479e-a741-a47c59f0a140" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatutoryAccountingPracticesStatutoryAmountAvailableForDividendPaymentsWithoutRegulatoryApproval"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_efd3262d-b37f-45de-b944-a0147d49b1e4" xlink:to="loc_us-gaap_StatutoryAccountingPracticesStatutoryAmountAvailableForDividendPaymentsWithoutRegulatoryApproval_255327bb-72c5-479e-a741-a47c59f0a140" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TierOneLeverageCapitalRequiredToBeWellCapitalizedToAverageAssets_d3700e51-07f6-4fff-9104-546ab5578a70" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TierOneLeverageCapitalRequiredToBeWellCapitalizedToAverageAssets"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_efd3262d-b37f-45de-b944-a0147d49b1e4" xlink:to="loc_us-gaap_TierOneLeverageCapitalRequiredToBeWellCapitalizedToAverageAssets_d3700e51-07f6-4fff-9104-546ab5578a70" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TierOneRiskBasedCapitalRequiredToBeWellCapitalizedToRiskWeightedAssets_43edfb3e-217d-40cd-9738-9f3e25483742" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TierOneRiskBasedCapitalRequiredToBeWellCapitalizedToRiskWeightedAssets"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_efd3262d-b37f-45de-b944-a0147d49b1e4" xlink:to="loc_us-gaap_TierOneRiskBasedCapitalRequiredToBeWellCapitalizedToRiskWeightedAssets_43edfb3e-217d-40cd-9738-9f3e25483742" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CapitalRequiredToBeWellCapitalizedToRiskWeightedAssets_814dd315-324b-45af-9ee2-fbd266257ceb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CapitalRequiredToBeWellCapitalizedToRiskWeightedAssets"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_efd3262d-b37f-45de-b944-a0147d49b1e4" xlink:to="loc_us-gaap_CapitalRequiredToBeWellCapitalizedToRiskWeightedAssets_814dd315-324b-45af-9ee2-fbd266257ceb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_CommonEquityTier1RatioRequiredToBeWellCapitalized_c75b270e-78ca-4bff-adb1-7a7e4563568c" xlink:href="sfnc-20210930.xsd#sfnc_CommonEquityTier1RatioRequiredToBeWellCapitalized"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_efd3262d-b37f-45de-b944-a0147d49b1e4" xlink:to="loc_sfnc_CommonEquityTier1RatioRequiredToBeWellCapitalized_c75b270e-78ca-4bff-adb1-7a7e4563568c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_CapitalConservationBuffer_01a6f150-1310-470f-8255-a410e97dea11" xlink:href="sfnc-20210930.xsd#sfnc_CapitalConservationBuffer"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_efd3262d-b37f-45de-b944-a0147d49b1e4" xlink:to="loc_sfnc_CapitalConservationBuffer_01a6f150-1310-470f-8255-a410e97dea11" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CapitalToRiskWeightedAssets_e3e83e24-2dfd-4f71-a887-c6513fc94884" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CapitalToRiskWeightedAssets"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_efd3262d-b37f-45de-b944-a0147d49b1e4" xlink:to="loc_us-gaap_CapitalToRiskWeightedAssets_e3e83e24-2dfd-4f71-a887-c6513fc94884" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/StockBasedCompensation" xlink:type="simple" xlink:href="sfnc-20210930.xsd#StockBasedCompensation"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/StockBasedCompensation" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_1afd2a2a-e8f5-4245-b349-5f7fd21aa935" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_b67c5b84-8030-4164-833a-82d9bbdefa64" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_1afd2a2a-e8f5-4245-b349-5f7fd21aa935" xlink:to="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_b67c5b84-8030-4164-833a-82d9bbdefa64" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/StockBasedCompensationTables" xlink:type="simple" xlink:href="sfnc-20210930.xsd#StockBasedCompensationTables"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/StockBasedCompensationTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_ba1cc33e-e4cb-42fd-b3f7-ecd950f1dfc7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock_0a5ab022-f784-4a62-a189-3986d98ae40f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_ba1cc33e-e4cb-42fd-b3f7-ecd950f1dfc7" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock_0a5ab022-f784-4a62-a189-3986d98ae40f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTextBlock_e1872280-2a00-4557-8f9e-4170abccb6f6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_ba1cc33e-e4cb-42fd-b3f7-ecd950f1dfc7" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTextBlock_e1872280-2a00-4557-8f9e-4170abccb6f6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfNonvestedRestrictedStockUnitsActivityTableTextBlock_d285a869-060f-4b40-aa6b-d498b36a419b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfNonvestedRestrictedStockUnitsActivityTableTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_ba1cc33e-e4cb-42fd-b3f7-ecd950f1dfc7" xlink:to="loc_us-gaap_ScheduleOfNonvestedRestrictedStockUnitsActivityTableTextBlock_d285a869-060f-4b40-aa6b-d498b36a419b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/StockBasedCompensationStockCompensationPlansDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#StockBasedCompensationStockCompensationPlansDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/StockBasedCompensationStockCompensationPlansDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_fa780678-ecbc-449e-9e74-a41157d52287" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_42ad4104-cd88-414d-83a9-967d6265904c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_fa780678-ecbc-449e-9e74-a41157d52287" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_42ad4104-cd88-414d-83a9-967d6265904c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_1bcace1d-29c7-402d-b630-b95f55fc8188" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_42ad4104-cd88-414d-83a9-967d6265904c" xlink:to="loc_us-gaap_AwardTypeAxis_1bcace1d-29c7-402d-b630-b95f55fc8188" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_46a91d9c-ffa5-4308-b8d0-e6b383da1eb4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_1bcace1d-29c7-402d-b630-b95f55fc8188" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_46a91d9c-ffa5-4308-b8d0-e6b383da1eb4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockMember_398af832-1eaf-4836-986c-3fee05c99fed" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_46a91d9c-ffa5-4308-b8d0-e6b383da1eb4" xlink:to="loc_us-gaap_RestrictedStockMember_398af832-1eaf-4836-986c-3fee05c99fed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_StockUnitsMember_9392714a-e2aa-48aa-aa83-c9e424e3f51f" xlink:href="sfnc-20210930.xsd#sfnc_StockUnitsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_46a91d9c-ffa5-4308-b8d0-e6b383da1eb4" xlink:to="loc_sfnc_StockUnitsMember_9392714a-e2aa-48aa-aa83-c9e424e3f51f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4f946dd9-0b35-48c2-90d0-c34f14a58b61" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_42ad4104-cd88-414d-83a9-967d6265904c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4f946dd9-0b35-48c2-90d0-c34f14a58b61" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_fde52a98-9ebb-401e-96b7-c7203e57006a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4f946dd9-0b35-48c2-90d0-c34f14a58b61" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_fde52a98-9ebb-401e-96b7-c7203e57006a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_0fc89c46-8a8e-49fd-a75c-5e5bcca6c96d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_fde52a98-9ebb-401e-96b7-c7203e57006a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_0fc89c46-8a8e-49fd-a75c-5e5bcca6c96d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_c7643554-7b8d-4cde-9efb-2a8cc7eacb27" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_fde52a98-9ebb-401e-96b7-c7203e57006a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_c7643554-7b8d-4cde-9efb-2a8cc7eacb27" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_d0087f6f-6912-4a34-b3ff-f326b366f069" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_fde52a98-9ebb-401e-96b7-c7203e57006a" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_d0087f6f-6912-4a34-b3ff-f326b366f069" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriod_22652a2b-17cf-4e22-ac4a-9f17bd3d02e4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriod"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_fde52a98-9ebb-401e-96b7-c7203e57006a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriod_22652a2b-17cf-4e22-ac4a-9f17bd3d02e4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_443430b4-6c20-4fda-aa80-e261cd4a32ef" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_fde52a98-9ebb-401e-96b7-c7203e57006a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_443430b4-6c20-4fda-aa80-e261cd4a32ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_1f8c3de9-2417-4ad1-9301-03446d7f2767" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4f946dd9-0b35-48c2-90d0-c34f14a58b61" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_1f8c3de9-2417-4ad1-9301-03446d7f2767" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_fd6cbee5-b7bf-4a9b-bdc2-f9c31fabc967" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4f946dd9-0b35-48c2-90d0-c34f14a58b61" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_fd6cbee5-b7bf-4a9b-bdc2-f9c31fabc967" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_cf499456-33fc-4efe-9275-21271f700abb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_fd6cbee5-b7bf-4a9b-bdc2-f9c31fabc967" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_cf499456-33fc-4efe-9275-21271f700abb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_60ecfb9c-c3ac-4a6a-8052-690f9d2675e0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_fd6cbee5-b7bf-4a9b-bdc2-f9c31fabc967" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_60ecfb9c-c3ac-4a6a-8052-690f9d2675e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_ea1c64f2-992c-4220-9e4a-12bb1e3a7ccf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_fd6cbee5-b7bf-4a9b-bdc2-f9c31fabc967" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_ea1c64f2-992c-4220-9e4a-12bb1e3a7ccf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriodWeightedAverageExercisePrice_83c71dfe-72e3-4d86-b4c9-1ea78b9c4e71" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriodWeightedAverageExercisePrice"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_fd6cbee5-b7bf-4a9b-bdc2-f9c31fabc967" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriodWeightedAverageExercisePrice_83c71dfe-72e3-4d86-b4c9-1ea78b9c4e71" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_e45089c8-8821-4e0d-b11d-2b88bb32aaad" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_fd6cbee5-b7bf-4a9b-bdc2-f9c31fabc967" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_e45089c8-8821-4e0d-b11d-2b88bb32aaad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_5f48f3e3-e92b-4604-8d31-836d797d1465" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4f946dd9-0b35-48c2-90d0-c34f14a58b61" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_5f48f3e3-e92b-4604-8d31-836d797d1465" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_4e8bf1c8-b6f9-4bf5-b990-c9fb593fc7cf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4f946dd9-0b35-48c2-90d0-c34f14a58b61" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_4e8bf1c8-b6f9-4bf5-b990-c9fb593fc7cf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_97479b35-17ab-4eb0-a866-c241010c90ce" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_4e8bf1c8-b6f9-4bf5-b990-c9fb593fc7cf" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_97479b35-17ab-4eb0-a866-c241010c90ce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_01fc70de-5133-46f8-b2df-71fe4e66112d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_4e8bf1c8-b6f9-4bf5-b990-c9fb593fc7cf" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_01fc70de-5133-46f8-b2df-71fe4e66112d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_e9403a85-2124-4020-a5c1-b370bc3d9876" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_4e8bf1c8-b6f9-4bf5-b990-c9fb593fc7cf" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_e9403a85-2124-4020-a5c1-b370bc3d9876" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_96fd6fb2-c0a8-486b-8177-8919cd96b3d1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_4e8bf1c8-b6f9-4bf5-b990-c9fb593fc7cf" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_96fd6fb2-c0a8-486b-8177-8919cd96b3d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_72e920d7-ebd4-4f80-8907-27adc93bf5c8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_4e8bf1c8-b6f9-4bf5-b990-c9fb593fc7cf" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_72e920d7-ebd4-4f80-8907-27adc93bf5c8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_8020f703-bbdb-4797-b195-f56e3598a7ca" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4f946dd9-0b35-48c2-90d0-c34f14a58b61" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_8020f703-bbdb-4797-b195-f56e3598a7ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_38de76af-a467-499d-bf44-2f95ba12dd74" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_8020f703-bbdb-4797-b195-f56e3598a7ca" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_38de76af-a467-499d-bf44-2f95ba12dd74" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_609e7a46-8640-43c2-a84f-048b3b23638f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_8020f703-bbdb-4797-b195-f56e3598a7ca" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_609e7a46-8640-43c2-a84f-048b3b23638f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_1aaad622-aa07-4772-a1cf-9e706d75a754" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_8020f703-bbdb-4797-b195-f56e3598a7ca" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_1aaad622-aa07-4772-a1cf-9e706d75a754" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_8ce86a2e-8706-4935-9e25-f1df60283d09" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_8020f703-bbdb-4797-b195-f56e3598a7ca" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_8ce86a2e-8706-4935-9e25-f1df60283d09" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_81a5e5f9-4f70-4d1e-8429-cb2651aebd83" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_8020f703-bbdb-4797-b195-f56e3598a7ca" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_81a5e5f9-4f70-4d1e-8429-cb2651aebd83" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/StockBasedCompensationStockOptionsDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#StockBasedCompensationStockOptionsDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/StockBasedCompensationStockOptionsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_a3fed867-ee2d-4ac4-9f8b-ad527dd5b809" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTable_33fdbcd0-5076-4b46-b49e-67935c60ddc0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_a3fed867-ee2d-4ac4-9f8b-ad527dd5b809" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTable_33fdbcd0-5076-4b46-b49e-67935c60ddc0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis_dd6bdad4-50e1-42d2-b449-3f704dddc348" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTable_33fdbcd0-5076-4b46-b49e-67935c60ddc0" xlink:to="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis_dd6bdad4-50e1-42d2-b449-3f704dddc348" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain_5acf99b0-7363-4c19-aee7-e63099ad3fd5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis_dd6bdad4-50e1-42d2-b449-3f704dddc348" xlink:to="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain_5acf99b0-7363-4c19-aee7-e63099ad3fd5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_Range01Member_f533c681-0744-4de4-8a8f-e4508c741c0d" xlink:href="sfnc-20210930.xsd#sfnc_Range01Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain_5acf99b0-7363-4c19-aee7-e63099ad3fd5" xlink:to="loc_sfnc_Range01Member_f533c681-0744-4de4-8a8f-e4508c741c0d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_Range02Member_c8513239-e8a2-4917-989d-81eea7c755b3" xlink:href="sfnc-20210930.xsd#sfnc_Range02Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain_5acf99b0-7363-4c19-aee7-e63099ad3fd5" xlink:to="loc_sfnc_Range02Member_c8513239-e8a2-4917-989d-81eea7c755b3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_Range03Member_de57d633-51fa-4076-b4ed-d3e418fb7b01" xlink:href="sfnc-20210930.xsd#sfnc_Range03Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain_5acf99b0-7363-4c19-aee7-e63099ad3fd5" xlink:to="loc_sfnc_Range03Member_de57d633-51fa-4076-b4ed-d3e418fb7b01" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_Range04Member_0e72bf1b-b866-4128-a94c-30ea01a34738" xlink:href="sfnc-20210930.xsd#sfnc_Range04Member"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain_5acf99b0-7363-4c19-aee7-e63099ad3fd5" xlink:to="loc_sfnc_Range04Member_0e72bf1b-b866-4128-a94c-30ea01a34738" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_Range05Member_97e1d32a-a504-429d-968d-f26be0a7e1a8" xlink:href="sfnc-20210930.xsd#sfnc_Range05Member"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain_5acf99b0-7363-4c19-aee7-e63099ad3fd5" xlink:to="loc_sfnc_Range05Member_97e1d32a-a504-429d-968d-f26be0a7e1a8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_Range06Member_a69bb78f-ddfd-4432-b983-ec5c2c903899" xlink:href="sfnc-20210930.xsd#sfnc_Range06Member"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain_5acf99b0-7363-4c19-aee7-e63099ad3fd5" xlink:to="loc_sfnc_Range06Member_a69bb78f-ddfd-4432-b983-ec5c2c903899" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_Range07Member_f1a33a26-21e7-419c-9260-a1998ddf6019" xlink:href="sfnc-20210930.xsd#sfnc_Range07Member"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain_5acf99b0-7363-4c19-aee7-e63099ad3fd5" xlink:to="loc_sfnc_Range07Member_f1a33a26-21e7-419c-9260-a1998ddf6019" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_Range08Member_bc09f99e-e3a0-4a4e-95f5-0efcd311d896" xlink:href="sfnc-20210930.xsd#sfnc_Range08Member"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain_5acf99b0-7363-4c19-aee7-e63099ad3fd5" xlink:to="loc_sfnc_Range08Member_bc09f99e-e3a0-4a4e-95f5-0efcd311d896" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLineItems_083d7060-bf5c-4aa8-92bb-bb9be341ec2d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTable_33fdbcd0-5076-4b46-b49e-67935c60ddc0" xlink:to="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLineItems_083d7060-bf5c-4aa8-92bb-bb9be341ec2d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit_3821232e-fa81-4552-8b0b-70632a06858d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLineItems_083d7060-bf5c-4aa8-92bb-bb9be341ec2d" xlink:to="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit_3821232e-fa81-4552-8b0b-70632a06858d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit_fb74f665-cc51-4255-91dc-57acf9ec9257" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLineItems_083d7060-bf5c-4aa8-92bb-bb9be341ec2d" xlink:to="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit_fb74f665-cc51-4255-91dc-57acf9ec9257" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions_a2c5c2e9-2721-47f2-8eeb-1ea2b97f9edf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLineItems_083d7060-bf5c-4aa8-92bb-bb9be341ec2d" xlink:to="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions_a2c5c2e9-2721-47f2-8eeb-1ea2b97f9edf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2_237e1c81-5842-4542-aac4-47c94c5a6f88" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLineItems_083d7060-bf5c-4aa8-92bb-bb9be341ec2d" xlink:to="loc_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2_237e1c81-5842-4542-aac4-47c94c5a6f88" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1_25ba999b-9ebf-498c-9dda-0e9239f26b37" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLineItems_083d7060-bf5c-4aa8-92bb-bb9be341ec2d" xlink:to="loc_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1_25ba999b-9ebf-498c-9dda-0e9239f26b37" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions_9a7b0cb5-e998-41bc-84ea-225d9e839e56" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLineItems_083d7060-bf5c-4aa8-92bb-bb9be341ec2d" xlink:to="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions_9a7b0cb5-e998-41bc-84ea-225d9e839e56" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1_ac1c7fea-c3a6-4d80-b846-6b5073c18ff1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLineItems_083d7060-bf5c-4aa8-92bb-bb9be341ec2d" xlink:to="loc_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1_ac1c7fea-c3a6-4d80-b846-6b5073c18ff1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/StockBasedCompensationSummaryofCompanysRestrictedPerformanceStockUnitActivityDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#StockBasedCompensationSummaryofCompanysRestrictedPerformanceStockUnitActivityDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/StockBasedCompensationSummaryofCompanysRestrictedPerformanceStockUnitActivityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_0765cba5-18d9-4173-a5bb-1fba1cb0e7ff" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_29934521-ac64-4013-b022-5e6a7409e818" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_0765cba5-18d9-4173-a5bb-1fba1cb0e7ff" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_29934521-ac64-4013-b022-5e6a7409e818" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_9fec2538-88f5-4f61-b1f7-85dc36282375" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_29934521-ac64-4013-b022-5e6a7409e818" xlink:to="loc_us-gaap_AwardTypeAxis_9fec2538-88f5-4f61-b1f7-85dc36282375" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_406b2ba3-102d-4969-9b4a-330e0568da4b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_9fec2538-88f5-4f61-b1f7-85dc36282375" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_406b2ba3-102d-4969-9b4a-330e0568da4b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_eb36169b-485e-4011-a7cd-9b1236707340" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_406b2ba3-102d-4969-9b4a-330e0568da4b" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_eb36169b-485e-4011-a7cd-9b1236707340" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_359007c5-69c5-4967-a0b0-bc910a166c0b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_29934521-ac64-4013-b022-5e6a7409e818" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_359007c5-69c5-4967-a0b0-bc910a166c0b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_0194cc6e-0686-4b00-8709-e5a250236b91" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_359007c5-69c5-4967-a0b0-bc910a166c0b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_0194cc6e-0686-4b00-8709-e5a250236b91" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_b8eb9b8a-a5ea-44bc-b1f5-1a965b6912d5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_359007c5-69c5-4967-a0b0-bc910a166c0b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_b8eb9b8a-a5ea-44bc-b1f5-1a965b6912d5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_a9716d4c-7623-47a7-8475-3d8c4c98e8bc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_359007c5-69c5-4967-a0b0-bc910a166c0b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_a9716d4c-7623-47a7-8475-3d8c4c98e8bc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_7f0d908d-8e01-4820-809c-a7ff05eb9104" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_359007c5-69c5-4967-a0b0-bc910a166c0b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_7f0d908d-8e01-4820-809c-a7ff05eb9104" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_92f8841e-950e-44fd-8944-3c2a225061b5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_359007c5-69c5-4967-a0b0-bc910a166c0b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_92f8841e-950e-44fd-8944-3c2a225061b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/StockBasedCompensationTextualDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#StockBasedCompensationTextualDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/StockBasedCompensationTextualDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_daf7783c-3a4a-43c9-8002-3bf8bcf2159b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_d13fbc56-c4ef-43b1-a7c9-f0a3563f5dd9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_daf7783c-3a4a-43c9-8002-3bf8bcf2159b" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_d13fbc56-c4ef-43b1-a7c9-f0a3563f5dd9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_62a5e6ab-800f-41ed-b81c-7f337a0dc8a3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_daf7783c-3a4a-43c9-8002-3bf8bcf2159b" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_62a5e6ab-800f-41ed-b81c-7f337a0dc8a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions_7696c075-ff8c-4d87-98e8-0f8cea385b0b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_daf7783c-3a4a-43c9-8002-3bf8bcf2159b" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions_7696c075-ff8c-4d87-98e8-0f8cea385b0b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_6383b1d3-5201-4b2d-b4e6-22590ecfe2b6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_daf7783c-3a4a-43c9-8002-3bf8bcf2159b" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_6383b1d3-5201-4b2d-b4e6-22590ecfe2b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_7b4dae9a-40ec-4441-ba7f-dc356b11de70" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_daf7783c-3a4a-43c9-8002-3bf8bcf2159b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_7b4dae9a-40ec-4441-ba7f-dc356b11de70" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_852acf8a-ca05-4cb2-99d6-428612bdce03" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_daf7783c-3a4a-43c9-8002-3bf8bcf2159b" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_852acf8a-ca05-4cb2-99d6-428612bdce03" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharePrice_d3edcba1-7f09-4207-8fa5-3f9ff90c1d5c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharePrice"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_daf7783c-3a4a-43c9-8002-3bf8bcf2159b" xlink:to="loc_us-gaap_SharePrice_d3edcba1-7f09-4207-8fa5-3f9ff90c1d5c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_502c0e07-fa2b-4f94-8b0c-1f29aa323409" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_daf7783c-3a4a-43c9-8002-3bf8bcf2159b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_502c0e07-fa2b-4f94-8b0c-1f29aa323409" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_b4f68098-0591-43dc-87a8-5d1dfa4e6312" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_daf7783c-3a4a-43c9-8002-3bf8bcf2159b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_b4f68098-0591-43dc-87a8-5d1dfa4e6312" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/EarningsPerShareEPS" xlink:type="simple" xlink:href="sfnc-20210930.xsd#EarningsPerShareEPS"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/EarningsPerShareEPS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_7f60a664-c2e7-4a34-8a97-45e0a0f8cdc1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareTextBlock_4d449f6f-b0f1-45fc-be4d-b936b2608617" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_7f60a664-c2e7-4a34-8a97-45e0a0f8cdc1" xlink:to="loc_us-gaap_EarningsPerShareTextBlock_4d449f6f-b0f1-45fc-be4d-b936b2608617" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/EarningsPerShareEPSTables" xlink:type="simple" xlink:href="sfnc-20210930.xsd#EarningsPerShareEPSTables"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/EarningsPerShareEPSTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_95675a50-2970-40f1-ba4b-ab9da75adccd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_858484b3-ca1f-4532-a253-44b51ee98cdb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_95675a50-2970-40f1-ba4b-ab9da75adccd" xlink:to="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_858484b3-ca1f-4532-a253-44b51ee98cdb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/EarningsPerShareEPSDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#EarningsPerShareEPSDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/EarningsPerShareEPSDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_f34ca554-d83b-470d-8c2a-6407c93ff33f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_7ead6c59-ca6c-4176-bf95-0a2fe88f95cb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_f34ca554-d83b-470d-8c2a-6407c93ff33f" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_7ead6c59-ca6c-4176-bf95-0a2fe88f95cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_151f3aaf-cde0-48ef-8351-2d92985bbdc5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_f34ca554-d83b-470d-8c2a-6407c93ff33f" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_151f3aaf-cde0-48ef-8351-2d92985bbdc5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_c79a1771-30ce-4cf2-8ebf-6ab055da19cf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_f34ca554-d83b-470d-8c2a-6407c93ff33f" xlink:to="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_c79a1771-30ce-4cf2-8ebf-6ab055da19cf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_a332738b-686b-4cd1-b05e-d6be8eb0c1b8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_f34ca554-d83b-470d-8c2a-6407c93ff33f" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_a332738b-686b-4cd1-b05e-d6be8eb0c1b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_d959ac13-fb8b-4527-932f-c0bd6174aee5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_f34ca554-d83b-470d-8c2a-6407c93ff33f" xlink:to="loc_us-gaap_EarningsPerShareBasic_d959ac13-fb8b-4527-932f-c0bd6174aee5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_27119bcc-4e5f-4a50-a2a3-d52412aef548" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_f34ca554-d83b-470d-8c2a-6407c93ff33f" xlink:to="loc_us-gaap_EarningsPerShareDiluted_27119bcc-4e5f-4a50-a2a3-d52412aef548" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/EarningsPerShareEPSTextualDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#EarningsPerShareEPSTextualDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/EarningsPerShareEPSTextualDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_619425f3-9d4e-4790-a02c-d67cb9be4158" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_6161fc2a-967c-4fde-87b0-cbb1b31b4f7b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_619425f3-9d4e-4790-a02c-d67cb9be4158" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_6161fc2a-967c-4fde-87b0-cbb1b31b4f7b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_b9d082bd-623c-4964-9256-a452ed7d32e0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_6161fc2a-967c-4fde-87b0-cbb1b31b4f7b" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_b9d082bd-623c-4964-9256-a452ed7d32e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_edc6ccd2-aea6-490e-b65f-bf50bb508e40" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_b9d082bd-623c-4964-9256-a452ed7d32e0" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_edc6ccd2-aea6-490e-b65f-bf50bb508e40" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_9cd1b668-38ea-4b9f-81aa-5ed11504628e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_edc6ccd2-aea6-490e-b65f-bf50bb508e40" xlink:to="loc_us-gaap_EmployeeStockOptionMember_9cd1b668-38ea-4b9f-81aa-5ed11504628e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_aa6697c1-ad2a-4b3f-9cb6-0ce5db13173e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_6161fc2a-967c-4fde-87b0-cbb1b31b4f7b" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_aa6697c1-ad2a-4b3f-9cb6-0ce5db13173e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_3cda7c12-edfa-4ac1-88c6-9d081e5db71b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_aa6697c1-ad2a-4b3f-9cb6-0ce5db13173e" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_3cda7c12-edfa-4ac1-88c6-9d081e5db71b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/AdditionalCashFlowInformation" xlink:type="simple" xlink:href="sfnc-20210930.xsd#AdditionalCashFlowInformation"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/AdditionalCashFlowInformation" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SupplementalCashFlowInformationAbstract_50fae0f5-f5d1-4fd2-9693-3466e435c2c2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SupplementalCashFlowInformationAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowSupplementalDisclosuresTextBlock_793e8e9d-214f-4a64-95c9-93ad6a4e7a08" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashFlowSupplementalDisclosuresTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_50fae0f5-f5d1-4fd2-9693-3466e435c2c2" xlink:to="loc_us-gaap_CashFlowSupplementalDisclosuresTextBlock_793e8e9d-214f-4a64-95c9-93ad6a4e7a08" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/AdditionalCashFlowInformationTables" xlink:type="simple" xlink:href="sfnc-20210930.xsd#AdditionalCashFlowInformationTables"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/AdditionalCashFlowInformationTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SupplementalCashFlowInformationAbstract_13bab0f8-9c01-4862-83aa-4fea1b5f5970" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SupplementalCashFlowInformationAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCashFlowSupplementalDisclosuresTableTextBlock_de90f519-b43a-4ead-a8e2-c202808187bb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfCashFlowSupplementalDisclosuresTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_13bab0f8-9c01-4862-83aa-4fea1b5f5970" xlink:to="loc_us-gaap_ScheduleOfCashFlowSupplementalDisclosuresTableTextBlock_de90f519-b43a-4ead-a8e2-c202808187bb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/AdditionalCashFlowInformationDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#AdditionalCashFlowInformationDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/AdditionalCashFlowInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SupplementalCashFlowInformationAbstract_cb5ac0e8-791a-4526-a690-3c224988d35b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SupplementalCashFlowInformationAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherSignificantNoncashTransactionsTable_256e170c-fc5b-4829-8f19-056a986abae2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherSignificantNoncashTransactionsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_cb5ac0e8-791a-4526-a690-3c224988d35b" xlink:to="loc_us-gaap_OtherSignificantNoncashTransactionsTable_256e170c-fc5b-4829-8f19-056a986abae2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherSignificantNoncashTransactionsByUniqueDescriptionAxis_fcf9e782-2adf-41a8-99d1-1ca7d6536f33" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherSignificantNoncashTransactionsByUniqueDescriptionAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherSignificantNoncashTransactionsTable_256e170c-fc5b-4829-8f19-056a986abae2" xlink:to="loc_us-gaap_OtherSignificantNoncashTransactionsByUniqueDescriptionAxis_fcf9e782-2adf-41a8-99d1-1ca7d6536f33" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherSignificantNoncashTransactionNameDomain_2f6d38e6-3f56-461c-83fa-104add92de3a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherSignificantNoncashTransactionNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherSignificantNoncashTransactionsByUniqueDescriptionAxis_fcf9e782-2adf-41a8-99d1-1ca7d6536f33" xlink:to="loc_us-gaap_OtherSignificantNoncashTransactionNameDomain_2f6d38e6-3f56-461c-83fa-104add92de3a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_TransfersofLoanstoForeclosedAssetsHeldforSaleMember_667e1d88-a471-409e-b64b-c425133cc1f9" xlink:href="sfnc-20210930.xsd#sfnc_TransfersofLoanstoForeclosedAssetsHeldforSaleMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherSignificantNoncashTransactionNameDomain_2f6d38e6-3f56-461c-83fa-104add92de3a" xlink:to="loc_sfnc_TransfersofLoanstoForeclosedAssetsHeldforSaleMember_667e1d88-a471-409e-b64b-c425133cc1f9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_TransferOfPremisesToForeclosedAssetsAndOtherRealEstateOwnedMember_5d5b554e-10a4-46be-b8e6-0d7428aa941f" xlink:href="sfnc-20210930.xsd#sfnc_TransferOfPremisesToForeclosedAssetsAndOtherRealEstateOwnedMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherSignificantNoncashTransactionNameDomain_2f6d38e6-3f56-461c-83fa-104add92de3a" xlink:to="loc_sfnc_TransferOfPremisesToForeclosedAssetsAndOtherRealEstateOwnedMember_5d5b554e-10a4-46be-b8e6-0d7428aa941f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherSignificantNoncashTransactionsLineItems_c2e307a4-3c8f-463c-8b50-8d47af48deba" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherSignificantNoncashTransactionsLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherSignificantNoncashTransactionsTable_256e170c-fc5b-4829-8f19-056a986abae2" xlink:to="loc_us-gaap_OtherSignificantNoncashTransactionsLineItems_c2e307a4-3c8f-463c-8b50-8d47af48deba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPaidNet_3e16cdfa-34b6-4c7e-a26a-8c6f92941a1e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestPaidNet"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherSignificantNoncashTransactionsLineItems_c2e307a4-3c8f-463c-8b50-8d47af48deba" xlink:to="loc_us-gaap_InterestPaidNet_3e16cdfa-34b6-4c7e-a26a-8c6f92941a1e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxesPaidNet_8a40fdf5-969f-481a-9aa9-ee92a23e3b18" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxesPaidNet"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherSignificantNoncashTransactionsLineItems_c2e307a4-3c8f-463c-8b50-8d47af48deba" xlink:to="loc_us-gaap_IncomeTaxesPaidNet_8a40fdf5-969f-481a-9aa9-ee92a23e3b18" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransferToOtherRealEstate_cbecaf3c-58f3-42a0-bf53-b828c50d78e1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransferToOtherRealEstate"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherSignificantNoncashTransactionsLineItems_c2e307a4-3c8f-463c-8b50-8d47af48deba" xlink:to="loc_us-gaap_TransferToOtherRealEstate_cbecaf3c-58f3-42a0-bf53-b828c50d78e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_TransferOfPropertyToHeldForSale_560c8ef0-e05c-4b26-9f2a-efae7c5c1cae" xlink:href="sfnc-20210930.xsd#sfnc_TransferOfPropertyToHeldForSale"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherSignificantNoncashTransactionsLineItems_c2e307a4-3c8f-463c-8b50-8d47af48deba" xlink:to="loc_sfnc_TransferOfPropertyToHeldForSale_560c8ef0-e05c-4b26-9f2a-efae7c5c1cae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_TransfersOfOtherRealEstateOwnedToPremisesHeldForSale_e6958455-6172-40ca-90fe-9a561ae4cf1e" xlink:href="sfnc-20210930.xsd#sfnc_TransfersOfOtherRealEstateOwnedToPremisesHeldForSale"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherSignificantNoncashTransactionsLineItems_c2e307a4-3c8f-463c-8b50-8d47af48deba" xlink:to="loc_sfnc_TransfersOfOtherRealEstateOwnedToPremisesHeldForSale_e6958455-6172-40ca-90fe-9a561ae4cf1e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransferOfOtherRealEstate_661b73b7-00dd-4b29-9f4f-a0ab764d57d0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransferOfOtherRealEstate"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherSignificantNoncashTransactionsLineItems_c2e307a4-3c8f-463c-8b50-8d47af48deba" xlink:to="loc_us-gaap_TransferOfOtherRealEstate_661b73b7-00dd-4b29-9f4f-a0ab764d57d0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_TransfersOfPremisesHeldForSaleToPremises_a3d7a76e-ba7e-4930-95d1-9498e590a408" xlink:href="sfnc-20210930.xsd#sfnc_TransfersOfPremisesHeldForSaleToPremises"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherSignificantNoncashTransactionsLineItems_c2e307a4-3c8f-463c-8b50-8d47af48deba" xlink:to="loc_sfnc_TransfersOfPremisesHeldForSaleToPremises_a3d7a76e-ba7e-4930-95d1-9498e590a408" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableReclassificationToHeldForSale_f0c0b695-f070-42eb-a929-ac365e15dbec" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableReclassificationToHeldForSale"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherSignificantNoncashTransactionsLineItems_c2e307a4-3c8f-463c-8b50-8d47af48deba" xlink:to="loc_us-gaap_FinancingReceivableReclassificationToHeldForSale_f0c0b695-f070-42eb-a929-ac365e15dbec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_TransferofDepositstoOtherLiabilitiesHeldforsale_68b2f5cb-4f41-4e60-ba52-1674a98d567b" xlink:href="sfnc-20210930.xsd#sfnc_TransferofDepositstoOtherLiabilitiesHeldforsale"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherSignificantNoncashTransactionsLineItems_c2e307a4-3c8f-463c-8b50-8d47af48deba" xlink:to="loc_sfnc_TransferofDepositstoOtherLiabilitiesHeldforsale_68b2f5cb-4f41-4e60-ba52-1674a98d567b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/OtherIncomeandOtherOperatingExpenses" xlink:type="simple" xlink:href="sfnc-20210930.xsd#OtherIncomeandOtherOperatingExpenses"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/OtherIncomeandOtherOperatingExpenses" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherIncomeAndExpensesAbstract_444f0dd6-fe53-49bc-9262-ef40f4a9761c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherIncomeAndExpensesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherIncomeAndOtherExpenseDisclosureTextBlock_7a47fade-c512-4886-94ac-f66e049cc99a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherIncomeAndOtherExpenseDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherIncomeAndExpensesAbstract_444f0dd6-fe53-49bc-9262-ef40f4a9761c" xlink:to="loc_us-gaap_OtherIncomeAndOtherExpenseDisclosureTextBlock_7a47fade-c512-4886-94ac-f66e049cc99a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/OtherIncomeandOtherOperatingExpensesTables" xlink:type="simple" xlink:href="sfnc-20210930.xsd#OtherIncomeandOtherOperatingExpensesTables"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/OtherIncomeandOtherOperatingExpensesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherIncomeAndExpensesAbstract_61aa2880-9a2f-46dd-a495-0c1cbe62d2a4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherIncomeAndExpensesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfOtherOperatingCostAndExpenseByComponentTextBlock_54ebe2b5-8f92-4e9a-93ed-04c942b697c1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfOtherOperatingCostAndExpenseByComponentTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherIncomeAndExpensesAbstract_61aa2880-9a2f-46dd-a495-0c1cbe62d2a4" xlink:to="loc_us-gaap_ScheduleOfOtherOperatingCostAndExpenseByComponentTextBlock_54ebe2b5-8f92-4e9a-93ed-04c942b697c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/OtherIncomeandOtherOperatingExpensesTextualDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#OtherIncomeandOtherOperatingExpensesTextualDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/OtherIncomeandOtherOperatingExpensesTextualDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherIncomeAndExpensesAbstract_1abf13d5-c4e0-4ecb-b4a1-3f61d30195bc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherIncomeAndExpensesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncomeOtherOperatingIncome_9fa6f6b4-8609-42b9-9e80-06a70eddbdc3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoninterestIncomeOtherOperatingIncome"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherIncomeAndExpensesAbstract_1abf13d5-c4e0-4ecb-b4a1-3f61d30195bc" xlink:to="loc_us-gaap_NoninterestIncomeOtherOperatingIncome_9fa6f6b4-8609-42b9-9e80-06a70eddbdc3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfBusiness_b68725b7-6e75-48b4-a2d0-2f721ec7ee15" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainLossOnSaleOfBusiness"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherIncomeAndExpensesAbstract_1abf13d5-c4e0-4ecb-b4a1-3f61d30195bc" xlink:to="loc_us-gaap_GainLossOnSaleOfBusiness_b68725b7-6e75-48b4-a2d0-2f721ec7ee15" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/OtherIncomeandOtherOperatingExpensesDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#OtherIncomeandOtherOperatingExpensesDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/OtherIncomeandOtherOperatingExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherIncomeAndExpensesAbstract_8a7b614c-0beb-4f62-b0f4-30374a047073" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherIncomeAndExpensesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfessionalFees_0670f807-763d-443d-9291-8ec8d990ff0e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfessionalFees"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherIncomeAndExpensesAbstract_8a7b614c-0beb-4f62-b0f4-30374a047073" xlink:to="loc_us-gaap_ProfessionalFees_0670f807-763d-443d-9291-8ec8d990ff0e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PostageExpense_006dd346-d3c7-45d0-a6d5-2d33e2579b51" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PostageExpense"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherIncomeAndExpensesAbstract_8a7b614c-0beb-4f62-b0f4-30374a047073" xlink:to="loc_us-gaap_PostageExpense_006dd346-d3c7-45d0-a6d5-2d33e2579b51" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Communication_ff4ff995-e21f-4de4-bf01-8bf96cc3b4cd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Communication"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherIncomeAndExpensesAbstract_8a7b614c-0beb-4f62-b0f4-30374a047073" xlink:to="loc_us-gaap_Communication_ff4ff995-e21f-4de4-bf01-8bf96cc3b4cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_CreditCardExpense_0374e56f-9343-4120-9816-2b0f9f2e78a4" xlink:href="sfnc-20210930.xsd#sfnc_CreditCardExpense"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherIncomeAndExpensesAbstract_8a7b614c-0beb-4f62-b0f4-30374a047073" xlink:to="loc_sfnc_CreditCardExpense_0374e56f-9343-4120-9816-2b0f9f2e78a4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketingExpense_9059b36c-1ddb-463f-b8e4-a549804efabf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MarketingExpense"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherIncomeAndExpensesAbstract_8a7b614c-0beb-4f62-b0f4-30374a047073" xlink:to="loc_us-gaap_MarketingExpense_9059b36c-1ddb-463f-b8e4-a549804efabf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_SoftwareandTechnologyExpense_45d3eb08-0bd9-4740-b607-dd71a438d8be" xlink:href="sfnc-20210930.xsd#sfnc_SoftwareandTechnologyExpense"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherIncomeAndExpensesAbstract_8a7b614c-0beb-4f62-b0f4-30374a047073" xlink:to="loc_sfnc_SoftwareandTechnologyExpense_45d3eb08-0bd9-4740-b607-dd71a438d8be" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SuppliesExpense_168e318a-0e6c-48dc-9253-faeab28fb3ad" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SuppliesExpense"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherIncomeAndExpensesAbstract_8a7b614c-0beb-4f62-b0f4-30374a047073" xlink:to="loc_us-gaap_SuppliesExpense_168e318a-0e6c-48dc-9253-faeab28fb3ad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_9d158e71-c758-44b9-a30e-860a6a320b39" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherIncomeAndExpensesAbstract_8a7b614c-0beb-4f62-b0f4-30374a047073" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_9d158e71-c758-44b9-a30e-860a6a320b39" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_BranchRightSizingExpense_6c97eb1f-ec6a-4f36-8d45-34eeb38a45d3" xlink:href="sfnc-20210930.xsd#sfnc_BranchRightSizingExpense"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherIncomeAndExpensesAbstract_8a7b614c-0beb-4f62-b0f4-30374a047073" xlink:to="loc_sfnc_BranchRightSizingExpense_6c97eb1f-ec6a-4f36-8d45-34eeb38a45d3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherGeneralExpense_da26bd74-0e43-4cf9-aa9e-8e21c772d29b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherGeneralExpense"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherIncomeAndExpensesAbstract_8a7b614c-0beb-4f62-b0f4-30374a047073" xlink:to="loc_us-gaap_OtherGeneralExpense_da26bd74-0e43-4cf9-aa9e-8e21c772d29b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoninterestExpense_972d855e-e8a3-4e17-baa0-511b20367072" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherNoninterestExpense"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherIncomeAndExpensesAbstract_8a7b614c-0beb-4f62-b0f4-30374a047073" xlink:to="loc_us-gaap_OtherNoninterestExpense_972d855e-e8a3-4e17-baa0-511b20367072" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/CertainTransactions" xlink:type="simple" xlink:href="sfnc-20210930.xsd#CertainTransactions"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/CertainTransactions" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsAbstract_e2181790-6628-4c44-b6e9-24ca40275498" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RelatedPartyTransactionsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsDisclosureTextBlock_ddf94f23-5f46-4b26-be3e-4e8f5bfea24c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RelatedPartyTransactionsDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionsAbstract_e2181790-6628-4c44-b6e9-24ca40275498" xlink:to="loc_us-gaap_RelatedPartyTransactionsDisclosureTextBlock_ddf94f23-5f46-4b26-be3e-4e8f5bfea24c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/CommitmentsandCreditRisk" xlink:type="simple" xlink:href="sfnc-20210930.xsd#CommitmentsandCreditRisk"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/CommitmentsandCreditRisk" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_f4beb578-c219-419b-83b6-177248e1de2c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsDisclosureTextBlock_3455669b-bb45-4228-9dfe-379b3a853bdb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommitmentsDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_f4beb578-c219-419b-83b6-177248e1de2c" xlink:to="loc_us-gaap_CommitmentsDisclosureTextBlock_3455669b-bb45-4228-9dfe-379b3a853bdb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/CommitmentsandCreditRiskTextualDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#CommitmentsandCreditRiskTextualDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/CommitmentsandCreditRiskTextualDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_d83bee09-3dfe-4b63-a4f6-ed07c18ed77b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCommitmentsTable_3c4a23d1-c37a-42a9-8e21-eeb138578328" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherCommitmentsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_d83bee09-3dfe-4b63-a4f6-ed07c18ed77b" xlink:to="loc_us-gaap_OtherCommitmentsTable_3c4a23d1-c37a-42a9-8e21-eeb138578328" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_6aa70014-64d9-4854-bd31-5074a9bfe86c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherCommitmentsTable_3c4a23d1-c37a-42a9-8e21-eeb138578328" xlink:to="loc_us-gaap_FinancialInstrumentAxis_6aa70014-64d9-4854-bd31-5074a9bfe86c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_e98cfb46-b15e-42c2-9fb1-9443dfc8f7d3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_6aa70014-64d9-4854-bd31-5074a9bfe86c" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_e98cfb46-b15e-42c2-9fb1-9443dfc8f7d3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_CreditCardCommitmentsToExtendCreditMember_b6c7684b-ac74-4739-b38a-f5fe0a4ab11f" xlink:href="sfnc-20210930.xsd#sfnc_CreditCardCommitmentsToExtendCreditMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_e98cfb46-b15e-42c2-9fb1-9443dfc8f7d3" xlink:to="loc_sfnc_CreditCardCommitmentsToExtendCreditMember_b6c7684b-ac74-4739-b38a-f5fe0a4ab11f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_OtherLoanCommitmentsToExtendCreditMember_82d9b055-5046-488e-943f-cb6f3818183f" xlink:href="sfnc-20210930.xsd#sfnc_OtherLoanCommitmentsToExtendCreditMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_e98cfb46-b15e-42c2-9fb1-9443dfc8f7d3" xlink:to="loc_sfnc_OtherLoanCommitmentsToExtendCreditMember_82d9b055-5046-488e-943f-cb6f3818183f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_FixedRateMortgageLoansMember_7fe38ab3-48ae-4535-bbd1-2dcee32604b4" xlink:href="sfnc-20210930.xsd#sfnc_FixedRateMortgageLoansMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_e98cfb46-b15e-42c2-9fb1-9443dfc8f7d3" xlink:to="loc_sfnc_FixedRateMortgageLoansMember_7fe38ab3-48ae-4535-bbd1-2dcee32604b4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_f20778d5-d9a6-4e0a-bf09-5b69f8dfe64c" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherCommitmentsTable_3c4a23d1-c37a-42a9-8e21-eeb138578328" xlink:to="loc_srt_RangeAxis_f20778d5-d9a6-4e0a-bf09-5b69f8dfe64c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_2e20b028-244c-4100-bf9e-ec0c19ee6f1e" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_f20778d5-d9a6-4e0a-bf09-5b69f8dfe64c" xlink:to="loc_srt_RangeMember_2e20b028-244c-4100-bf9e-ec0c19ee6f1e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_0449a35b-10b1-4382-87a1-e2de8eb4b9e9" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MinimumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_2e20b028-244c-4100-bf9e-ec0c19ee6f1e" xlink:to="loc_srt_MinimumMember_0449a35b-10b1-4382-87a1-e2de8eb4b9e9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_6d1e6e99-9133-474a-9df5-74372cd43bd6" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MaximumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_2e20b028-244c-4100-bf9e-ec0c19ee6f1e" xlink:to="loc_srt_MaximumMember_6d1e6e99-9133-474a-9df5-74372cd43bd6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredRevenueArrangementTypeAxis_06cabb09-12ba-4f2a-9ce2-01a5ba3673aa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredRevenueArrangementTypeAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherCommitmentsTable_3c4a23d1-c37a-42a9-8e21-eeb138578328" xlink:to="loc_us-gaap_DeferredRevenueArrangementTypeAxis_06cabb09-12ba-4f2a-9ce2-01a5ba3673aa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredRevenueArrangementTypeDomain_267b4e90-5e03-4e6c-869a-a9dbe363fc32" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredRevenueArrangementTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueArrangementTypeAxis_06cabb09-12ba-4f2a-9ce2-01a5ba3673aa" xlink:to="loc_us-gaap_DeferredRevenueArrangementTypeDomain_267b4e90-5e03-4e6c-869a-a9dbe363fc32" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_StandbyLettersOfCredit1Member_7884e872-8123-4cea-9d99-ef3683d2b034" xlink:href="sfnc-20210930.xsd#sfnc_StandbyLettersOfCredit1Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueArrangementTypeDomain_267b4e90-5e03-4e6c-869a-a9dbe363fc32" xlink:to="loc_sfnc_StandbyLettersOfCredit1Member_7884e872-8123-4cea-9d99-ef3683d2b034" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeAxis_0190fa7c-3f81-467e-899b-98f6b1013914" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherCommitmentsTable_3c4a23d1-c37a-42a9-8e21-eeb138578328" xlink:to="loc_us-gaap_InvestmentTypeAxis_0190fa7c-3f81-467e-899b-98f6b1013914" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_b58fc1fc-dbcd-4294-aa17-2524b3f105ba" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_0190fa7c-3f81-467e-899b-98f6b1013914" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_b58fc1fc-dbcd-4294-aa17-2524b3f105ba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankCertificatesAndObligationsFHLBMember_70993653-90e8-4430-93d3-c5b2d77f1916" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FederalHomeLoanBankCertificatesAndObligationsFHLBMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_b58fc1fc-dbcd-4294-aa17-2524b3f105ba" xlink:to="loc_us-gaap_FederalHomeLoanBankCertificatesAndObligationsFHLBMember_70993653-90e8-4430-93d3-c5b2d77f1916" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCommitmentsLineItems_634466cd-a8a8-4496-a678-533252e50a59" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherCommitmentsLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherCommitmentsTable_3c4a23d1-c37a-42a9-8e21-eeb138578328" xlink:to="loc_us-gaap_OtherCommitmentsLineItems_634466cd-a8a8-4496-a678-533252e50a59" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusedCommitmentsToExtendCredit_f56aabb5-149a-4391-9a4e-ff2d42766555" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UnusedCommitmentsToExtendCredit"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherCommitmentsLineItems_634466cd-a8a8-4496-a678-533252e50a59" xlink:to="loc_us-gaap_UnusedCommitmentsToExtendCredit_f56aabb5-149a-4391-9a4e-ff2d42766555" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LettersOfCreditOutstandingAmount_aeedba19-c875-460d-91c0-52ff25900ce0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LettersOfCreditOutstandingAmount"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherCommitmentsLineItems_634466cd-a8a8-4496-a678-533252e50a59" xlink:to="loc_us-gaap_LettersOfCreditOutstandingAmount_aeedba19-c875-460d-91c0-52ff25900ce0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_LettersOfCreditTerm_a5a0e846-7e52-4af0-985c-45584d07e3e6" xlink:href="sfnc-20210930.xsd#sfnc_LettersOfCreditTerm"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherCommitmentsLineItems_634466cd-a8a8-4496-a678-533252e50a59" xlink:to="loc_sfnc_LettersOfCreditTerm_a5a0e846-7e52-4af0-985c-45584d07e3e6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiability_76cdb785-b9b4-4e9e-87fa-2f1f627d5b99" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ContractWithCustomerLiability"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherCommitmentsLineItems_634466cd-a8a8-4496-a678-533252e50a59" xlink:to="loc_us-gaap_ContractWithCustomerLiability_76cdb785-b9b4-4e9e-87fa-2f1f627d5b99" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/FairValueMeasurements" xlink:type="simple" xlink:href="sfnc-20210930.xsd#FairValueMeasurements"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/FairValueMeasurements" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_f3ce8712-75dc-48aa-b8be-d2943aa98a91" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresTextBlock_af37b1ed-93c0-45ab-85c2-2de2e5abe317" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueDisclosuresTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_f3ce8712-75dc-48aa-b8be-d2943aa98a91" xlink:to="loc_us-gaap_FairValueDisclosuresTextBlock_af37b1ed-93c0-45ab-85c2-2de2e5abe317" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/FairValueMeasurementsTables" xlink:type="simple" xlink:href="sfnc-20210930.xsd#FairValueMeasurementsTables"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/FairValueMeasurementsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_29703bf2-8bd8-400c-b823-eff265b558c9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisTextBlock_a3f4d2e6-29d8-4245-943c-b3c743aa2863" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_29703bf2-8bd8-400c-b823-eff265b558c9" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisTextBlock_a3f4d2e6-29d8-4245-943c-b3c743aa2863" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnNonrecurringBasisTextBlock_85da3c9a-f1c3-466b-8cd6-31abbe40e45b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnNonrecurringBasisTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_29703bf2-8bd8-400c-b823-eff265b558c9" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnNonrecurringBasisTextBlock_85da3c9a-f1c3-466b-8cd6-31abbe40e45b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByBalanceSheetGroupingTextBlock_208a9d2a-7183-4731-a5c1-25f1d4b9d528" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByBalanceSheetGroupingTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_29703bf2-8bd8-400c-b823-eff265b558c9" xlink:to="loc_us-gaap_FairValueByBalanceSheetGroupingTextBlock_208a9d2a-7183-4731-a5c1-25f1d4b9d528" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/FairValueMeasurementsFairValueofFinancialAssetsMeasureonaRecurringBasisDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#FairValueMeasurementsFairValueofFinancialAssetsMeasureonaRecurringBasisDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/FairValueMeasurementsFairValueofFinancialAssetsMeasureonaRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_d8f6585f-2d30-4b1e-9b8e-56497e9e463f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_98f00a3c-6320-48e2-9e83-d2769a4c1ee1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_d8f6585f-2d30-4b1e-9b8e-56497e9e463f" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_98f00a3c-6320-48e2-9e83-d2769a4c1ee1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_92cfa789-2b2e-42ed-b806-3dd970836242" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_98f00a3c-6320-48e2-9e83-d2769a4c1ee1" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_92cfa789-2b2e-42ed-b806-3dd970836242" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_9c9d4945-1bf6-4734-9290-78b09866bfdc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_92cfa789-2b2e-42ed-b806-3dd970836242" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_9c9d4945-1bf6-4734-9290-78b09866bfdc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_c5381bb6-b3d0-47a3-a0b5-67098576a81f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementsRecurringMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_9c9d4945-1bf6-4734-9290-78b09866bfdc" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_c5381bb6-b3d0-47a3-a0b5-67098576a81f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_238e0fc2-7c1f-4b28-bf2f-e409a67d2dfb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_98f00a3c-6320-48e2-9e83-d2769a4c1ee1" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_238e0fc2-7c1f-4b28-bf2f-e409a67d2dfb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3ce6e762-1d13-4f6c-90af-431e508b19bf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_238e0fc2-7c1f-4b28-bf2f-e409a67d2dfb" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3ce6e762-1d13-4f6c-90af-431e508b19bf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_06bf9a6e-6376-411f-bea0-7b3e172b757d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3ce6e762-1d13-4f6c-90af-431e508b19bf" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_06bf9a6e-6376-411f-bea0-7b3e172b757d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_7de699b2-1786-4075-98f9-72b1b3f68f4d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3ce6e762-1d13-4f6c-90af-431e508b19bf" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_7de699b2-1786-4075-98f9-72b1b3f68f4d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_ab1d3199-d2e6-4a0b-a576-9d7a50a13d1c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3ce6e762-1d13-4f6c-90af-431e508b19bf" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_ab1d3199-d2e6-4a0b-a576-9d7a50a13d1c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_4c0b33bf-224c-4b97-8d86-f7c6018fd17a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_98f00a3c-6320-48e2-9e83-d2769a4c1ee1" xlink:to="loc_us-gaap_FinancialInstrumentAxis_4c0b33bf-224c-4b97-8d86-f7c6018fd17a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_3f2b969e-1603-493d-a2a8-e49994ef2449" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_4c0b33bf-224c-4b97-8d86-f7c6018fd17a" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_3f2b969e-1603-493d-a2a8-e49994ef2449" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_378d3e4b-75cb-4fba-b447-953cd85f8d33" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_3f2b969e-1603-493d-a2a8-e49994ef2449" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_378d3e4b-75cb-4fba-b447-953cd85f8d33" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_b63e452e-4399-4e99-99aa-ccc78fa0cbd9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_3f2b969e-1603-493d-a2a8-e49994ef2449" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_b63e452e-4399-4e99-99aa-ccc78fa0cbd9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_46dc8909-2bf4-4c14-bb31-e5bd68d87999" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_3f2b969e-1603-493d-a2a8-e49994ef2449" xlink:to="loc_us-gaap_MortgageBackedSecuritiesIssuedByPrivateEnterprisesMember_46dc8909-2bf4-4c14-bb31-e5bd68d87999" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USStatesAndPoliticalSubdivisionsMember_ee0653ec-32b5-4e5d-80d0-3c1ecfcdaf56" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USStatesAndPoliticalSubdivisionsMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_3f2b969e-1603-493d-a2a8-e49994ef2449" xlink:to="loc_us-gaap_USStatesAndPoliticalSubdivisionsMember_ee0653ec-32b5-4e5d-80d0-3c1ecfcdaf56" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_OtherSecuritiesMember_13b48b39-50ef-491d-8c22-f9af4d84351b" xlink:href="sfnc-20210930.xsd#sfnc_OtherSecuritiesMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_3f2b969e-1603-493d-a2a8-e49994ef2449" xlink:to="loc_sfnc_OtherSecuritiesMember_13b48b39-50ef-491d-8c22-f9af4d84351b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_1bfa9f54-8ae6-4afe-816b-ff79c0279fb9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_98f00a3c-6320-48e2-9e83-d2769a4c1ee1" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_1bfa9f54-8ae6-4afe-816b-ff79c0279fb9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_dfe112d2-6770-452f-9cb5-24b6cbf88585" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_1bfa9f54-8ae6-4afe-816b-ff79c0279fb9" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_dfe112d2-6770-452f-9cb5-24b6cbf88585" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MortgagesHeldForSaleFairValueDisclosure_41144f82-1b4a-44a2-bc09-0e49b24a3f97" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MortgagesHeldForSaleFairValueDisclosure"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_1bfa9f54-8ae6-4afe-816b-ff79c0279fb9" xlink:to="loc_us-gaap_MortgagesHeldForSaleFairValueDisclosure_41144f82-1b4a-44a2-bc09-0e49b24a3f97" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_1f2b920c-c863-47c5-9b50-0325e5a6dc60" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeAssets"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_1bfa9f54-8ae6-4afe-816b-ff79c0279fb9" xlink:to="loc_us-gaap_DerivativeAssets_1f2b920c-c863-47c5-9b50-0325e5a6dc60" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_OtherLiabilitiesHeldForSaleFairValueDisclosure_a842502a-3dbc-4b9c-a8bc-cf5c687b7145" xlink:href="sfnc-20210930.xsd#sfnc_OtherLiabilitiesHeldForSaleFairValueDisclosure"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_1bfa9f54-8ae6-4afe-816b-ff79c0279fb9" xlink:to="loc_sfnc_OtherLiabilitiesHeldForSaleFairValueDisclosure_a842502a-3dbc-4b9c-a8bc-cf5c687b7145" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_1499d44c-fce0-4df4-97bf-00fb45b9c81d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLiabilities"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_1bfa9f54-8ae6-4afe-816b-ff79c0279fb9" xlink:to="loc_us-gaap_DerivativeLiabilities_1499d44c-fce0-4df4-97bf-00fb45b9c81d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/FairValueMeasurementsFairValueofFinancialAssetsMeasuredonaNonrecurringBasisDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#FairValueMeasurementsFairValueofFinancialAssetsMeasuredonaNonrecurringBasisDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/FairValueMeasurementsFairValueofFinancialAssetsMeasuredonaNonrecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_19c5c3bd-6c0f-4354-b8ee-c43ddf41467f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_af3f49b8-8506-49c8-9ee9-6b2b4379fa7b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_19c5c3bd-6c0f-4354-b8ee-c43ddf41467f" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_af3f49b8-8506-49c8-9ee9-6b2b4379fa7b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollateralAxis_4b2345f9-92b5-49dd-b54f-f6c086fc7b57" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CollateralAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_af3f49b8-8506-49c8-9ee9-6b2b4379fa7b" xlink:to="loc_us-gaap_CollateralAxis_4b2345f9-92b5-49dd-b54f-f6c086fc7b57" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollateralDomain_4f77447e-94e6-4d4b-bc82-f519429a0b2c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CollateralDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollateralAxis_4b2345f9-92b5-49dd-b54f-f6c086fc7b57" xlink:to="loc_us-gaap_CollateralDomain_4f77447e-94e6-4d4b-bc82-f519429a0b2c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollateralPledgedMember_53e794c8-62ff-4ddd-b46e-e30afbf8c339" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CollateralPledgedMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollateralDomain_4f77447e-94e6-4d4b-bc82-f519429a0b2c" xlink:to="loc_us-gaap_CollateralPledgedMember_53e794c8-62ff-4ddd-b46e-e30afbf8c339" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_44677bc0-8345-4f42-983f-371de8277152" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_af3f49b8-8506-49c8-9ee9-6b2b4379fa7b" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_44677bc0-8345-4f42-983f-371de8277152" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_1ba4ccc7-237c-4473-8a0f-dbd8a8b9e23f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_44677bc0-8345-4f42-983f-371de8277152" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_1ba4ccc7-237c-4473-8a0f-dbd8a8b9e23f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_8e9ec390-8ec9-4074-9149-35fa7d067cec" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_1ba4ccc7-237c-4473-8a0f-dbd8a8b9e23f" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_8e9ec390-8ec9-4074-9149-35fa7d067cec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_28e31097-3711-46cf-9f48-c6f3c84af83b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_1ba4ccc7-237c-4473-8a0f-dbd8a8b9e23f" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_28e31097-3711-46cf-9f48-c6f3c84af83b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_95030c95-dec3-4c28-998c-69f9b8fd29e1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_1ba4ccc7-237c-4473-8a0f-dbd8a8b9e23f" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_95030c95-dec3-4c28-998c-69f9b8fd29e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_078e41e3-d521-4b7a-8cc6-75d417b35540" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_af3f49b8-8506-49c8-9ee9-6b2b4379fa7b" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_078e41e3-d521-4b7a-8cc6-75d417b35540" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_a9f463fc-eeae-4ca4-b39c-1955b7c226b8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_078e41e3-d521-4b7a-8cc6-75d417b35540" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_a9f463fc-eeae-4ca4-b39c-1955b7c226b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsNonrecurringMember_3a3cdfa8-3ada-414c-a1c8-0def154212f4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementsNonrecurringMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_a9f463fc-eeae-4ca4-b39c-1955b7c226b8" xlink:to="loc_us-gaap_FairValueMeasurementsNonrecurringMember_3a3cdfa8-3ada-414c-a1c8-0def154212f4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_e8ab17d5-61a4-4272-b92c-867254a6529f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_af3f49b8-8506-49c8-9ee9-6b2b4379fa7b" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_e8ab17d5-61a4-4272-b92c-867254a6529f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_ImpairedFinancingReceivableRecordedInvestmentFairValueDisclosure_8725e28b-fcef-4fdd-ad97-b33a769bcdf3" xlink:href="sfnc-20210930.xsd#sfnc_ImpairedFinancingReceivableRecordedInvestmentFairValueDisclosure"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_e8ab17d5-61a4-4272-b92c-867254a6529f" xlink:to="loc_sfnc_ImpairedFinancingReceivableRecordedInvestmentFairValueDisclosure_8725e28b-fcef-4fdd-ad97-b33a769bcdf3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsHeldForSaleLongLivedFairValueDisclosure_d07cbeb3-4f00-46c4-81cc-ef86a76180b9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsHeldForSaleLongLivedFairValueDisclosure"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_e8ab17d5-61a4-4272-b92c-867254a6529f" xlink:to="loc_us-gaap_AssetsHeldForSaleLongLivedFairValueDisclosure_d07cbeb3-4f00-46c4-81cc-ef86a76180b9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairedFinancingReceivableRelatedAllowance_7cc30320-3ccd-4019-89b9-88a610f52ed4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ImpairedFinancingReceivableRelatedAllowance"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_e8ab17d5-61a4-4272-b92c-867254a6529f" xlink:to="loc_us-gaap_ImpairedFinancingReceivableRelatedAllowance_7cc30320-3ccd-4019-89b9-88a610f52ed4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/FairValueMeasurementsEstimatedFairValuesandRelatedCarryingAmountsofFinancialInstrumentsDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#FairValueMeasurementsEstimatedFairValuesandRelatedCarryingAmountsofFinancialInstrumentsDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/FairValueMeasurementsEstimatedFairValuesandRelatedCarryingAmountsofFinancialInstrumentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_315d0d4a-e2f2-4c48-bb0d-d1d2ae1475d4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByBalanceSheetGroupingTable_29a5e3e5-ff82-472e-926e-56fd6843849e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByBalanceSheetGroupingTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_315d0d4a-e2f2-4c48-bb0d-d1d2ae1475d4" xlink:to="loc_us-gaap_FairValueByBalanceSheetGroupingTable_29a5e3e5-ff82-472e-926e-56fd6843849e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_d19a936e-763a-4815-8fc9-7918f0541943" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByMeasurementBasisAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_29a5e3e5-ff82-472e-926e-56fd6843849e" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_d19a936e-763a-4815-8fc9-7918f0541943" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_2a99db9f-c033-4b51-9580-4f06ab8dd038" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueDisclosureItemAmountsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_d19a936e-763a-4815-8fc9-7918f0541943" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_2a99db9f-c033-4b51-9580-4f06ab8dd038" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_2dd3d6dd-b209-4505-8e51-8e2c1b25890c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_2a99db9f-c033-4b51-9580-4f06ab8dd038" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_2dd3d6dd-b209-4505-8e51-8e2c1b25890c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_cceac18f-5085-4a2b-ae2c-6b8a3e50b4b6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CarryingReportedAmountFairValueDisclosureMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_2a99db9f-c033-4b51-9580-4f06ab8dd038" xlink:to="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_cceac18f-5085-4a2b-ae2c-6b8a3e50b4b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_8a00bf72-4b67-456c-ba55-84d883d71359" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EstimateOfFairValueFairValueDisclosureMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_2a99db9f-c033-4b51-9580-4f06ab8dd038" xlink:to="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_8a00bf72-4b67-456c-ba55-84d883d71359" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_ff4a91da-ec29-4572-98dc-df8ad02a8754" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_29a5e3e5-ff82-472e-926e-56fd6843849e" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_ff4a91da-ec29-4572-98dc-df8ad02a8754" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_9c788c6a-d25e-4b57-acb9-c930bc9dfa19" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_ff4a91da-ec29-4572-98dc-df8ad02a8754" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_9c788c6a-d25e-4b57-acb9-c930bc9dfa19" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_dd99cf2b-bfc7-4fe6-8758-5b62065d4e21" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_9c788c6a-d25e-4b57-acb9-c930bc9dfa19" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_dd99cf2b-bfc7-4fe6-8758-5b62065d4e21" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_109d46c4-955f-479b-a771-6f1ef4122cb7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_9c788c6a-d25e-4b57-acb9-c930bc9dfa19" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_109d46c4-955f-479b-a771-6f1ef4122cb7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_b5e6702c-cf84-4401-97c1-691902206817" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_9c788c6a-d25e-4b57-acb9-c930bc9dfa19" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_b5e6702c-cf84-4401-97c1-691902206817" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByLiabilityClassAxis_abeec19a-92fe-4caa-add1-21ec15cfc74f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByLiabilityClassAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_29a5e3e5-ff82-472e-926e-56fd6843849e" xlink:to="loc_us-gaap_FairValueByLiabilityClassAxis_abeec19a-92fe-4caa-add1-21ec15cfc74f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_3f49879e-6e5d-4936-b91f-be93ec540d1d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis_abeec19a-92fe-4caa-add1-21ec15cfc74f" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_3f49879e-6e5d-4936-b91f-be93ec540d1d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_NonInterestBearingTransactionAccountsMember_d7638d5e-fc45-4c0a-a9f1-1758b0c80615" xlink:href="sfnc-20210930.xsd#sfnc_NonInterestBearingTransactionAccountsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_3f49879e-6e5d-4936-b91f-be93ec540d1d" xlink:to="loc_sfnc_NonInterestBearingTransactionAccountsMember_d7638d5e-fc45-4c0a-a9f1-1758b0c80615" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_InterestBearingTransactionAccountsAndSavingsDepositsMember_3f10f990-d7ae-4b11-b459-31a78eaed5aa" xlink:href="sfnc-20210930.xsd#sfnc_InterestBearingTransactionAccountsAndSavingsDepositsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_3f49879e-6e5d-4936-b91f-be93ec540d1d" xlink:to="loc_sfnc_InterestBearingTransactionAccountsAndSavingsDepositsMember_3f10f990-d7ae-4b11-b459-31a78eaed5aa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_TimeDepositsMember_6bb899bd-5881-48a1-bb16-aac922eacb2d" xlink:href="sfnc-20210930.xsd#sfnc_TimeDepositsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_3f49879e-6e5d-4936-b91f-be93ec540d1d" xlink:to="loc_sfnc_TimeDepositsMember_6bb899bd-5881-48a1-bb16-aac922eacb2d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_be644148-4b7d-49f4-a36d-ee5865ceac7b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_29a5e3e5-ff82-472e-926e-56fd6843849e" xlink:to="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_be644148-4b7d-49f4-a36d-ee5865ceac7b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_1198c7fb-b221-42ce-a737-ae52cbd6ea8b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_be644148-4b7d-49f4-a36d-ee5865ceac7b" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_1198c7fb-b221-42ce-a737-ae52cbd6ea8b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_InterestBearingBalancesDueFromBanksTimeFairValueDisclosure_0ab8c694-6df9-4887-8c87-ca0079989ce9" xlink:href="sfnc-20210930.xsd#sfnc_InterestBearingBalancesDueFromBanksTimeFairValueDisclosure"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_be644148-4b7d-49f4-a36d-ee5865ceac7b" xlink:to="loc_sfnc_InterestBearingBalancesDueFromBanksTimeFairValueDisclosure_0ab8c694-6df9-4887-8c87-ca0079989ce9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesFairValue_3be0dbac-db86-4856-9b17-55f19dc09700" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesFairValue"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_be644148-4b7d-49f4-a36d-ee5865ceac7b" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesFairValue_3be0dbac-db86-4856-9b17-55f19dc09700" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_InterestReceivableFairValueDisclosure_17997e9a-7906-45f3-87df-1c23e084906d" xlink:href="sfnc-20210930.xsd#sfnc_InterestReceivableFairValueDisclosure"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_be644148-4b7d-49f4-a36d-ee5865ceac7b" xlink:to="loc_sfnc_InterestReceivableFairValueDisclosure_17997e9a-7906-45f3-87df-1c23e084906d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansReceivableFairValueDisclosure_4e1361ef-e951-42b5-a7cb-7341781f588b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoansReceivableFairValueDisclosure"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_be644148-4b7d-49f4-a36d-ee5865ceac7b" xlink:to="loc_us-gaap_LoansReceivableFairValueDisclosure_4e1361ef-e951-42b5-a7cb-7341781f588b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepositsFairValueDisclosure_e53de7ed-c218-49a9-b6ff-617d829d5f97" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DepositsFairValueDisclosure"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_be644148-4b7d-49f4-a36d-ee5865ceac7b" xlink:to="loc_us-gaap_DepositsFairValueDisclosure_e53de7ed-c218-49a9-b6ff-617d829d5f97" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalFundsPurchasedAndSecuritiesLoanedOrSoldUnderAgreementsToRepurchaseFairValueDisclosure_bc191258-cd65-4f27-a749-209228180f89" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FederalFundsPurchasedAndSecuritiesLoanedOrSoldUnderAgreementsToRepurchaseFairValueDisclosure"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_be644148-4b7d-49f4-a36d-ee5865ceac7b" xlink:to="loc_us-gaap_FederalFundsPurchasedAndSecuritiesLoanedOrSoldUnderAgreementsToRepurchaseFairValueDisclosure_bc191258-cd65-4f27-a749-209228180f89" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_OtherBorrowingsFairValueDisclosure_ec6d6744-b450-4e62-bdeb-c6c547f76a31" xlink:href="sfnc-20210930.xsd#sfnc_OtherBorrowingsFairValueDisclosure"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_be644148-4b7d-49f4-a36d-ee5865ceac7b" xlink:to="loc_sfnc_OtherBorrowingsFairValueDisclosure_ec6d6744-b450-4e62-bdeb-c6c547f76a31" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisSubordinatedDebtObligations_e0a146a8-c9e0-4907-af12-e23404bfd084" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisSubordinatedDebtObligations"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_be644148-4b7d-49f4-a36d-ee5865ceac7b" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisSubordinatedDebtObligations_e0a146a8-c9e0-4907-af12-e23404bfd084" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_InterestPayableFairValueDisclosure_c6313d76-5c7d-44cf-ada2-af941ed81f42" xlink:href="sfnc-20210930.xsd#sfnc_InterestPayableFairValueDisclosure"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_be644148-4b7d-49f4-a36d-ee5865ceac7b" xlink:to="loc_sfnc_InterestPayableFairValueDisclosure_c6313d76-5c7d-44cf-ada2-af941ed81f42" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/DerivativeInstruments" xlink:type="simple" xlink:href="sfnc-20210930.xsd#DerivativeInstruments"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/DerivativeInstruments" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_28a7f263-60e7-4434-a62e-22584a62b4cf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_78d04356-a4b6-41f4-a2e3-873308189e18" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_28a7f263-60e7-4434-a62e-22584a62b4cf" xlink:to="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_78d04356-a4b6-41f4-a2e3-873308189e18" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/DerivativeInstrumentsTables" xlink:type="simple" xlink:href="sfnc-20210930.xsd#DerivativeInstrumentsTables"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/DerivativeInstrumentsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_756019ce-e430-41c3-b47f-5fe00c9cf236" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDerivativeInstrumentsInStatementOfFinancialPositionFairValueTextBlock_aea4676e-41f2-4d77-848c-6b68a791ee9c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfDerivativeInstrumentsInStatementOfFinancialPositionFairValueTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_756019ce-e430-41c3-b47f-5fe00c9cf236" xlink:to="loc_us-gaap_ScheduleOfDerivativeInstrumentsInStatementOfFinancialPositionFairValueTextBlock_aea4676e-41f2-4d77-848c-6b68a791ee9c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/DerivativeInstrumentsDerivativeInstrumentsNotionalandFairValueAmountsofDerivativeInstrumentsDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#DerivativeInstrumentsDerivativeInstrumentsNotionalandFairValueAmountsofDerivativeInstrumentsDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/DerivativeInstrumentsDerivativeInstrumentsNotionalandFairValueAmountsofDerivativeInstrumentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_65372b6e-30b6-463b-a700-be2ce8cc71df" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_f004da75-b7be-479b-a052-8ff9cb096fa3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_65372b6e-30b6-463b-a700-be2ce8cc71df" xlink:to="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_f004da75-b7be-479b-a052-8ff9cb096fa3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_b1a4b99c-3b31-47a5-8fc1-99a4ba2d417b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_f004da75-b7be-479b-a052-8ff9cb096fa3" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_b1a4b99c-3b31-47a5-8fc1-99a4ba2d417b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_600f38ed-ccbb-45fc-8036-e51b52b2eb9a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_b1a4b99c-3b31-47a5-8fc1-99a4ba2d417b" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_600f38ed-ccbb-45fc-8036-e51b52b2eb9a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueHedgingMember_642047b3-22bc-498c-9140-766f87fda3db" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueHedgingMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_600f38ed-ccbb-45fc-8036-e51b52b2eb9a" xlink:to="loc_us-gaap_FairValueHedgingMember_642047b3-22bc-498c-9140-766f87fda3db" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_6082e735-ad4c-4f33-a373-fc58b218d514" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateSwapMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_600f38ed-ccbb-45fc-8036-e51b52b2eb9a" xlink:to="loc_us-gaap_InterestRateSwapMember_6082e735-ad4c-4f33-a373-fc58b218d514" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativesFairValueLineItems_93dd8d67-3a8c-40cc-bd7a-cee5f50e20f5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativesFairValueLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_f004da75-b7be-479b-a052-8ff9cb096fa3" xlink:to="loc_us-gaap_DerivativesFairValueLineItems_93dd8d67-3a8c-40cc-bd7a-cee5f50e20f5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAverageVariableInterestRate_74f05ac2-0314-4a9c-8b09-1331fc1b83fe" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeAverageVariableInterestRate"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_93dd8d67-3a8c-40cc-bd7a-cee5f50e20f5" xlink:to="loc_us-gaap_DerivativeAverageVariableInterestRate_74f05ac2-0314-4a9c-8b09-1331fc1b83fe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetNotionalAmount_421e8028-5388-4936-8ec4-cd56fc472bdd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeAssetNotionalAmount"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_93dd8d67-3a8c-40cc-bd7a-cee5f50e20f5" xlink:to="loc_us-gaap_DerivativeAssetNotionalAmount_421e8028-5388-4936-8ec4-cd56fc472bdd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_1005d2f8-dc5e-47a7-9719-4fca47c07158" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeAssets"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_93dd8d67-3a8c-40cc-bd7a-cee5f50e20f5" xlink:to="loc_us-gaap_DerivativeAssets_1005d2f8-dc5e-47a7-9719-4fca47c07158" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_94e74466-53b7-4b03-8e7a-e88b7a4bc332" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLiabilityNotionalAmount"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_93dd8d67-3a8c-40cc-bd7a-cee5f50e20f5" xlink:to="loc_us-gaap_DerivativeLiabilityNotionalAmount_94e74466-53b7-4b03-8e7a-e88b7a4bc332" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_57f0f7e5-2fe9-47ec-b813-12e8cdaf3d23" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLiabilities"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_93dd8d67-3a8c-40cc-bd7a-cee5f50e20f5" xlink:to="loc_us-gaap_DerivativeLiabilities_57f0f7e5-2fe9-47ec-b813-12e8cdaf3d23" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://simmonsbank.com/role/DerivativeInstrumentsNarrativeDetails" xlink:type="simple" xlink:href="sfnc-20210930.xsd#DerivativeInstrumentsNarrativeDetails"/>
  <link:presentationLink xlink:role="http://simmonsbank.com/role/DerivativeInstrumentsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_4e784335-2e10-4da3-9aa6-a637b7185f9a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_761e2b26-6864-418d-8fbb-ad969877c138" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_4e784335-2e10-4da3-9aa6-a637b7185f9a" xlink:to="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_761e2b26-6864-418d-8fbb-ad969877c138" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_bde6559b-3739-47d6-a816-6e99e7cc5045" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_761e2b26-6864-418d-8fbb-ad969877c138" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_bde6559b-3739-47d6-a816-6e99e7cc5045" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_5509dbc1-8db2-4579-9741-436686256036" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_bde6559b-3739-47d6-a816-6e99e7cc5045" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_5509dbc1-8db2-4579-9741-436686256036" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_RiskParticipationAgreementsMember_59107843-eaac-42e1-ad1f-d09da50bd9bf" xlink:href="sfnc-20210930.xsd#sfnc_RiskParticipationAgreementsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_5509dbc1-8db2-4579-9741-436686256036" xlink:to="loc_sfnc_RiskParticipationAgreementsMember_59107843-eaac-42e1-ad1f-d09da50bd9bf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EnergyRelatedDerivativeMember_63cc28c6-bc97-4540-ac67-b68403649945" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EnergyRelatedDerivativeMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_5509dbc1-8db2-4579-9741-436686256036" xlink:to="loc_us-gaap_EnergyRelatedDerivativeMember_63cc28c6-bc97-4540-ac67-b68403649945" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativesFairValueLineItems_a88c8ab9-7d0c-433f-b969-86a72941801f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativesFairValueLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_761e2b26-6864-418d-8fbb-ad969877c138" xlink:to="loc_us-gaap_DerivativesFairValueLineItems_a88c8ab9-7d0c-433f-b969-86a72941801f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_sfnc_DerivativeInstrumentCovenantMaximumOutstandingNotionalContractAmountPercentOfAssets_620143e3-edea-4ee2-a26c-82976d81af02" xlink:href="sfnc-20210930.xsd#sfnc_DerivativeInstrumentCovenantMaximumOutstandingNotionalContractAmountPercentOfAssets"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_a88c8ab9-7d0c-433f-b969-86a72941801f" xlink:to="loc_sfnc_DerivativeInstrumentCovenantMaximumOutstandingNotionalContractAmountPercentOfAssets_620143e3-edea-4ee2-a26c-82976d81af02" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeNotionalAmount_da30a84d-eac1-4e70-bedc-2493a659333a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeNotionalAmount"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_a88c8ab9-7d0c-433f-b969-86a72941801f" xlink:to="loc_us-gaap_DerivativeNotionalAmount_da30a84d-eac1-4e70-bedc-2493a659333a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetNotionalAmount_d4686990-84d4-4bcf-b09f-53adf3016885" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeAssetNotionalAmount"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_a88c8ab9-7d0c-433f-b969-86a72941801f" xlink:to="loc_us-gaap_DerivativeAssetNotionalAmount_d4686990-84d4-4bcf-b09f-53adf3016885" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_a355b771-e9bf-4dee-9c69-5d3629746ecc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLiabilityNotionalAmount"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_a88c8ab9-7d0c-433f-b969-86a72941801f" xlink:to="loc_us-gaap_DerivativeLiabilityNotionalAmount_a355b771-e9bf-4dee-9c69-5d3629746ecc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeNet_a9964803-c16f-4afb-b100-353ebb57a691" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeNet"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_a88c8ab9-7d0c-433f-b969-86a72941801f" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeNet_a9964803-c16f-4afb-b100-353ebb57a691" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
