Exhibit 21

SIMMONS FIRST NATIONAL CORPORATION

DIRECT AND INDIRECT SUBSIDIARIES

AS OF DECEMBER 31, 2022

Name of Direct or Indirect Subsidiary			State of Incorporation or Organization
Simmons Bank			AR
Simmons First Investment Group, Inc.			AR
Simmons First Insurance Services, Inc.			AR
Simmons First Properties, Inc.			TN
Simmons First Insurance Services of TN, LLC			TN
FS Providence PCC of Grenada, LLC			TN
Providence PCC of Grenada, LLC			MS
Simmons First Special Assets, Inc.			TN
PSH LLC			MO
Simmons First Auto, Inc.			TN
Simmons First Investments, Inc.			NV
Simmons First REIT of MO, LLC			MO
Simmons First SW REIT, Inc.			DE
Simmons First REIT of TN, Inc.			MD
Harob, Inc.			TX
Heartland Insurance, LLC			AR
Simmons NMTC Holding, LLC			AR
Stillwater NMTC, LLC			OK
Stillwater NMTC Investment Fund II, LLC			OK
AAC Investment Fund, LLC			AR
Santa Ana Holdings, LLC			MO
SWC PPR, LLC			AZ
Venture Holding Company, LLC			TN
Heartland Bank Liquidating Trust			AR
Cradduck LMB Investment Fund 2, LLC			MO
REI Subsidiary CDE 12, LLC			OK
SWB Recovery Corp.			TX
Simmons First Risk Management, Inc.			NV
SF Real Estate Holdings, Inc.			AR
Beacon Village Tax Credit Fund, L.L.C.			MO

Beacon Village, LP			MO
Capital Partners Series SB II, LLC			MO
Capital Partners Series SB III, LLC			MO
Capital Partners Series SB IV, LLC			MO
Capital Partners Series SB, LLC			MO
Gateway Neighborhood Fund I, LLC			MO
Raintree LMB, LLC			MO
Stockton Community Development Corporation			MO
Tax Credit Holdings – Vandeventer, LLC			MO
Vandeventer Place, LP			MO
The Successful Investors, LLC			MO
Tax Credit Holdings Woodbury II, LLC			MO
Woodbury Place II, LP			MO
Tax Credit Holding Jennings II, LLC			MO
Jennings Place II, LP			MO
Capital Partners Series SB V, LLC			MO
Capital Partners Series SB VI, LLC			MO
PR RT, LLC			MO