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Stock-Based Compensation - Number of Shares Available for Issuance (Details) - USD ($) | 1 Months Ended | 12 Months Ended
--- | --- | ---
Mar. 31, 2014 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Number of shares available for issuance |  |  |  |  |
Number of shares available for issuance, beginning |  | 3,563,000 | 7,435,000 | 12,495,000 |
Addition (in shares) |  | 10,000,000 | 0 | 0 |
Granted (in shares) |  | (3,971,000) | (4,642,000) | (5,752,000) |
Cancelled/expired/forfeited (in shares) |  | 351,000 | 770,000 | 692,000 |
Number of shares available for issuance, ending |  | 9,943,000 | 3,563,000 | 7,435,000 | 12,495,000
Aggregate Intrinsic Value |  |  |  |  |
Fair value per ordinary share (in dollars per share) |  |  | $ 21.15 |  |
Cash received from the exercise of stock option |  | $ 1,000 | $ 0 | $ 1,313,000 |
2014 Plan |  |  |  |  |
Number of shares available for issuance |  |  |  |  |
Addition (in shares) | 1,000,000.0 |  |  |  |
Employee and Non-Employee stock options |  |  |  |  |
Options Outstanding |  |  |  |  |
Outstanding at the beginning of the year (in shares) |  | 3,019,000 | 387,000 | 551,000 |
Granted (in shares) |  | 2,187,000 | 2,750,000 | 0 |
Exercised (in shares) |  |  |  | (105,000) |
Cancelled/expired/forfeited (in shares) |  | (98,000) | (118,000) | (59,000) |
Outstanding at the end of the year (in shares) |  | 5,108,000 | 3,019,000 | 387,000 | 551,000
Vested and expected to vest at the end of the year (in shares) |  | 4,686,000 | 2,752,000 |  |
Exercisable at the end of the year (in shares) |  | 1,226,000 | 172,000 |  |
Weighted Average Exercise Price |  |  |  |  |
Outstanding at the beginning of the year (in dollars per share) |  | $ 22.51 | $ 32.68 | $ 28.85 |
Granted (in dollars per share) |  | 3.87 | 21.15 |  |
Exercised (in dollars per share) |  |  |  | 12.70 |
Cancelled/expired/forfeited (in dollars per share) |  | 22.07 | 24.12 | 32.68 |
Outstanding at the end of the year (in dollars per share) |  | 14.54 | 22.51 | $ 32.68 | $ 28.85
Vested and expected to vest at the end of the year (in dollars per share) |  | 14.68 | 22.54 |  |
Exercisable at the end of the year (in dollars per share) |  | $ 23.44 | $ 32.68 |  |
Weighted Average Remaining Contractual Life (In years) |  |  |  |  |
Outstanding at the end of the year |  | 5 years 8 months 12 days | 6 years | 5 years 7 months 6 days | 5 years 9 months 18 days
Vested and expected to vest at the end of the year |  | 5 years 8 months 12 days | 6 years |  |
Exercisable at the end of the year |  | 4 years 10 months 24 days | 4 years 7 months 6 days |  |
Aggregate Intrinsic Value |  |  |  |  |
Outstanding at the end of the year |  | $ 15,390,000 |  |  | $ 6,683,000
Vested and expected to vest at the end of the year |  | 13,905,000 |  |  |
Total intrinsic value of options exercised |  | $ 0 | $ 0 | $ 4,000,000.0 |
Fair value per ordinary share (in dollars per share) |  | $ 10.95 | $ 19.12 |  |
Cash received from the exercise of stock option |  | $ 0 | $ 0 | $ 1,300,000 |
Unrecognized compensation cost |  | $ 30,500,000 | $ 20,500,000 |  |
Expected weighted-average recognition period for unrecognized compensation cost |  | 3 years 1 month 6 days |  |  |
Restricted share units |  |  |  |  |
Aggregate Intrinsic Value |  |  |  |  |
Restricted shares units granted (in shares) |  | 1,800,000 | 1,800,000 | 5,800,000 |

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