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Stock-Based Compensation - Number of Shares Available for Issuance (Details) - USD ($)
 1 Months Ended 12 Months Ended
Mar. 31, 2014
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Number of shares available for issuance          
Number of shares available for issuance, beginning   3,563,000 7,435,000 12,495,000  
Addition (in shares)   10,000,000 0 0  
Granted (in shares)   (3,971,000) (4,642,000) (5,752,000)  
Cancelled/expired/forfeited (in shares)   351,000 770,000 692,000  
Number of shares available for issuance, ending   9,943,000 3,563,000 7,435,000 12,495,000
Aggregate Intrinsic Value          
Fair value per ordinary share (in dollars per share)     $ 21.15    
Cash received from the exercise of stock option   $ 1,000 $ 0 $ 1,313,000  
2014 Plan          
Number of shares available for issuance          
Addition (in shares) 1,000,000.0        
Employee and Non-Employee stock options          
Options Outstanding          
Outstanding at the beginning of the year (in shares)   3,019,000 387,000 551,000  
Granted (in shares)   2,187,000 2,750,000 0  
Exercised (in shares)       (105,000)  
Cancelled/expired/forfeited (in shares)   (98,000) (118,000) (59,000)  
Outstanding at the end of the year (in shares)   5,108,000 3,019,000 387,000 551,000
Vested and expected to vest at the end of the year (in shares)   4,686,000 2,752,000    
Exercisable at the end of the year (in shares)   1,226,000 172,000    
Weighted Average Exercise Price          
Outstanding at the beginning of the year (in dollars per share)   $ 22.51 $ 32.68 $ 28.85  
Granted (in dollars per share)   3.87 21.15    
Exercised (in dollars per share)       12.70  
Cancelled/expired/forfeited (in dollars per share)   22.07 24.12 32.68  
Outstanding at the end of the year (in dollars per share)   14.54 22.51 $ 32.68 $ 28.85
Vested and expected to vest at the end of the year (in dollars per share)   14.68 22.54    
Exercisable at the end of the year (in dollars per share)   $ 23.44 $ 32.68    
Weighted Average Remaining Contractual Life (In years)          
Outstanding at the end of the year   5 years 8 months 12 days 6 years 5 years 7 months 6 days 5 years 9 months 18 days
Vested and expected to vest at the end of the year   5 years 8 months 12 days 6 years    
Exercisable at the end of the year   4 years 10 months 24 days 4 years 7 months 6 days    
Aggregate Intrinsic Value          
Outstanding at the end of the year   $ 15,390,000     $ 6,683,000
Vested and expected to vest at the end of the year   13,905,000      
Total intrinsic value of options exercised   $ 0 $ 0 $ 4,000,000.0  
Fair value per ordinary share (in dollars per share)   $ 10.95 $ 19.12    
Cash received from the exercise of stock option   $ 0 $ 0 $ 1,300,000  
Unrecognized compensation cost   $ 30,500,000 $ 20,500,000    
Expected weighted-average recognition period for unrecognized compensation cost   3 years 1 month 6 days      
Restricted share units          
Aggregate Intrinsic Value          
Restricted shares units granted (in shares)   1,800,000 1,800,000 5,800,000