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Summary of Unaudited Quarterly financial data (in thousands, except per share data) (Details) (USD $)	3 Months Ended
	Dec. 31, 2013	Sep. 30, 2013	Jun. 30, 2013	Mar. 31, 2013	Dec. 31, 2012	Sep. 30, 2012	Jun. 30, 2012	Mar. 31, 2012
Summary of Unaudited Quarterly financial data
Product revenue	$ 5,658	$ 2,535	$ 5,581	$ 4,672	$ 4,558	$ 3,418	$ 6,244	$ 6,572
Research and development contract revenue	267	462	368	400	226	502	458	515
Net loss attributable to common shareholders	$ (28,929)	$ (15,948)	$ (9,338)	$ (8,576)	$ (8,474)	$ (10,325)	$ (6,480)	$ (6,583)
Basic and Diluted	$ (0.28)	$ (0.19)	$ (0.14)	$ (0.18)	$ (0.22)	$ (0.27)	$ (0.17)	$ (0.28)

X

- Definition

The amount of net income or loss for the period per each share in instances when basic and diluted earnings per share are the same amount and reported as a single line item on the face of the financial statements. Basic earnings per share is the amount of net income or loss for the period per each share of common stock or unit outstanding during the reporting period. Diluted earnings per share includes the amount of net income or loss for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period.

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X

- Definition

The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

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- Definition

Aggregate revenue during the period from the sale of goods in the normal course of business, after deducting returns, allowances and discounts.

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- Definition

Aggregate revenue during the period from services rendered in the normal course of business, after deducting allowances and discounts.

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No definition available.

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