<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:1fa3f0dc-5d20-4078-a471-dcd2f510d4a8,g:6b5f679b-ef13-4122-bc21-f3428ace9bfe-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.energyfuels.com/role/Cover" xlink:type="simple" xlink:href="efr-20220630.xsd#Cover"/>
  <link:definitionLink xlink:role="http://www.energyfuels.com/role/Cover" xlink:type="extended" id="ibee621700ee8458ab195306d0e502be6_Cover">
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_2434d54d-277d-4901-9884-01a46a7f292e" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentType"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_DocumentType_2434d54d-277d-4901-9884-01a46a7f292e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentQuarterlyReport_261bf3a0-1e84-46e2-8e8d-4b91e0515ddd" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentQuarterlyReport"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_DocumentQuarterlyReport_261bf3a0-1e84-46e2-8e8d-4b91e0515ddd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_c2f106b7-295f-4288-85be-5f78da4f82c0" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentPeriodEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_DocumentPeriodEndDate_c2f106b7-295f-4288-85be-5f78da4f82c0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentTransitionReport_5dc909cf-3bcf-42ca-b414-5106279157f9" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentTransitionReport"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_DocumentTransitionReport_5dc909cf-3bcf-42ca-b414-5106279157f9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_4c1aa222-f97a-4d47-b755-723bc281de3b" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityFileNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_EntityFileNumber_4c1aa222-f97a-4d47-b755-723bc281de3b" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_71b5fae1-a740-4bbf-a1f4-8514bd9c27c2" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityRegistrantName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_EntityRegistrantName_71b5fae1-a740-4bbf-a1f4-8514bd9c27c2" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_8e3d38ef-948f-48ca-93ef-1bcd371f2091" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_EntityIncorporationStateCountryCode_8e3d38ef-948f-48ca-93ef-1bcd371f2091" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_4b21cdee-3774-4be3-a0c3-77df6f283bf8" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_EntityTaxIdentificationNumber_4b21cdee-3774-4be3-a0c3-77df6f283bf8" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_9dac6a9d-fb4e-473e-aa09-4938a47091fa" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressAddressLine1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_EntityAddressAddressLine1_9dac6a9d-fb4e-473e-aa09-4938a47091fa" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_ab4a6e1b-3e68-4a05-af2f-d59765e8bcde" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressAddressLine2"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_EntityAddressAddressLine2_ab4a6e1b-3e68-4a05-af2f-d59765e8bcde" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_eac158f6-8eb6-471e-a376-2c548e265393" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressCityOrTown"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_EntityAddressCityOrTown_eac158f6-8eb6-471e-a376-2c548e265393" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_d00e6f2a-56e8-4606-ba6c-2206bc530355" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressStateOrProvince"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_EntityAddressStateOrProvince_d00e6f2a-56e8-4606-ba6c-2206bc530355" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_e1065bfc-88c2-42ae-a386-ee467933d254" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressPostalZipCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_EntityAddressPostalZipCode_e1065bfc-88c2-42ae-a386-ee467933d254" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_6234aa1d-963d-475d-8686-2937715a2bee" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_CityAreaCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_CityAreaCode_6234aa1d-963d-475d-8686-2937715a2bee" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_a10e2888-b6c6-4593-854e-74ad20dcc528" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_LocalPhoneNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_LocalPhoneNumber_a10e2888-b6c6-4593-854e-74ad20dcc528" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_d177e4df-2706-4c3a-b6b9-0c721c003c1e" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_Security12bTitle"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_Security12bTitle_d177e4df-2706-4c3a-b6b9-0c721c003c1e" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_effb95da-09f8-48b3-8452-5ee75b5ac10c" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_TradingSymbol"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_TradingSymbol_effb95da-09f8-48b3-8452-5ee75b5ac10c" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_c2c5d549-d859-4112-ac6f-ae17345f6e2e" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_SecurityExchangeName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_SecurityExchangeName_c2c5d549-d859-4112-ac6f-ae17345f6e2e" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCurrentReportingStatus_7e8068ad-339c-4bb5-8ac8-2ebce203c6eb" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityCurrentReportingStatus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_EntityCurrentReportingStatus_7e8068ad-339c-4bb5-8ac8-2ebce203c6eb" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInteractiveDataCurrent_a602826e-2ce5-4ab2-b2f5-71d65972a08b" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityInteractiveDataCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_EntityInteractiveDataCurrent_a602826e-2ce5-4ab2-b2f5-71d65972a08b" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFilerCategory_868376bb-f038-4f0a-b4a9-e0ccd173f234" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityFilerCategory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_EntityFilerCategory_868376bb-f038-4f0a-b4a9-e0ccd173f234" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitySmallBusiness_a67b2ef2-2aca-4529-aefc-4f6b47a1f1ef" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntitySmallBusiness"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_EntitySmallBusiness_a67b2ef2-2aca-4529-aefc-4f6b47a1f1ef" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_9b452159-8a50-4c13-b1b5-d8327f2ea3dd" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_EntityEmergingGrowthCompany_9b452159-8a50-4c13-b1b5-d8327f2ea3dd" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityShellCompany_f4ddcc60-ea13-403f-9e2e-db93d713a910" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityShellCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_EntityShellCompany_f4ddcc60-ea13-403f-9e2e-db93d713a910" xlink:type="arc" order="23"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_eb0e65ca-d289-4028-b203-0c60ee3566dd" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityCommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_eb0e65ca-d289-4028-b203-0c60ee3566dd" xlink:type="arc" order="24"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_1f883176-27bf-4ffb-b19c-a1079d074513" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_AmendmentFlag"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_AmendmentFlag_1f883176-27bf-4ffb-b19c-a1079d074513" xlink:type="arc" order="25"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_2bc23970-4638-4813-bc13-30b23760267b" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityCentralIndexKey"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_EntityCentralIndexKey_2bc23970-4638-4813-bc13-30b23760267b" xlink:type="arc" order="26"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_2ab86b4d-d46e-4c48-aacf-66673785af8e" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_CurrentFiscalYearEndDate_2ab86b4d-d46e-4c48-aacf-66673785af8e" xlink:type="arc" order="27"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus_3d40443a-dccf-4415-9915-961c78db6ae3" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentFiscalYearFocus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_DocumentFiscalYearFocus_3d40443a-dccf-4415-9915-961c78db6ae3" xlink:type="arc" order="28"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus_bf723652-8631-48cb-a4d1-59cf13ceb0b3" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentFiscalPeriodFocus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_DocumentFiscalPeriodFocus_bf723652-8631-48cb-a4d1-59cf13ceb0b3" xlink:type="arc" order="29"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitiesTable_45997de2-fc24-404c-b9c8-8c5281fbcf91" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntitiesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_dei_EntityInformationLineItems_0deb997d-8786-4055-a192-c4927d42c905" xlink:to="loc_dei_EntitiesTable_45997de2-fc24-404c-b9c8-8c5281fbcf91" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityListingsExchangeAxis_0532357e-e1a9-4cd8-a262-df849e99caa3" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityListingsExchangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dei_EntitiesTable_45997de2-fc24-404c-b9c8-8c5281fbcf91" xlink:to="loc_dei_EntityListingsExchangeAxis_0532357e-e1a9-4cd8-a262-df849e99caa3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_ExchangeDomain_0532357e-e1a9-4cd8-a262-df849e99caa3_default" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_ExchangeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_EntityListingsExchangeAxis_0532357e-e1a9-4cd8-a262-df849e99caa3" xlink:to="loc_dei_ExchangeDomain_0532357e-e1a9-4cd8-a262-df849e99caa3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_ExchangeDomain_ecc6e183-28cd-47f9-8d4d-ea21bae69ce0" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_ExchangeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_EntityListingsExchangeAxis_0532357e-e1a9-4cd8-a262-df849e99caa3" xlink:to="loc_dei_ExchangeDomain_ecc6e183-28cd-47f9-8d4d-ea21bae69ce0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_exch_XNYS_1df754b0-d712-4496-80fc-e2b6ca4b27ab" xlink:href="https://xbrl.sec.gov/exch/2021/exch-2021.xsd#exch_XNYS"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_ExchangeDomain_ecc6e183-28cd-47f9-8d4d-ea21bae69ce0" xlink:to="loc_exch_XNYS_1df754b0-d712-4496-80fc-e2b6ca4b27ab" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_exch_XTSE_5b2844c2-9f39-41cb-94ed-c6ef710f5a45" xlink:href="https://xbrl.sec.gov/exch/2021/exch-2021.xsd#exch_XTSE"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_ExchangeDomain_ecc6e183-28cd-47f9-8d4d-ea21bae69ce0" xlink:to="loc_exch_XTSE_5b2844c2-9f39-41cb-94ed-c6ef710f5a45" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.energyfuels.com/role/ConsolidatedStatementsofChangesinEquity" xlink:type="simple" xlink:href="efr-20220630.xsd#ConsolidatedStatementsofChangesinEquity"/>
  <link:definitionLink xlink:role="http://www.energyfuels.com/role/ConsolidatedStatementsofChangesinEquity" xlink:type="extended" id="i3f82829f2777441cbd1260a195d63347_ConsolidatedStatementsofChangesinEquity">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_d3c441a2-74a8-4608-93db-20583c0af92c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6123617b-e3dc-4897-88ff-d1a6b9d76d61" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_d3c441a2-74a8-4608-93db-20583c0af92c" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6123617b-e3dc-4897-88ff-d1a6b9d76d61" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesIssued_bdb8daa7-0abb-4bbf-9240-c5576a3008d7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6123617b-e3dc-4897-88ff-d1a6b9d76d61" xlink:to="loc_us-gaap_SharesIssued_bdb8daa7-0abb-4bbf-9240-c5576a3008d7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_c2308bef-f7a4-4fb0-9a3f-864a7980497f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6123617b-e3dc-4897-88ff-d1a6b9d76d61" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_c2308bef-f7a4-4fb0-9a3f-864a7980497f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_4649285b-36a6-460c-95e8-b867a5dd9042" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6123617b-e3dc-4897-88ff-d1a6b9d76d61" xlink:to="loc_us-gaap_NetIncomeLoss_4649285b-36a6-460c-95e8-b867a5dd9042" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_7b578631-ee31-4267-b751-9f3605cd9e12" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6123617b-e3dc-4897-88ff-d1a6b9d76d61" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_7b578631-ee31-4267-b751-9f3605cd9e12" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_SharesIssuedForCashByAtTheMarketOfferingShares_6f7bc109-5a11-4310-82f4-f0039178f0e2" xlink:href="efr-20220630.xsd#efr_SharesIssuedForCashByAtTheMarketOfferingShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6123617b-e3dc-4897-88ff-d1a6b9d76d61" xlink:to="loc_efr_SharesIssuedForCashByAtTheMarketOfferingShares_6f7bc109-5a11-4310-82f4-f0039178f0e2" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_SharesIssuedForCashByAtTheMarketOffering_c6325197-78b7-418c-b617-3824decc3c09" xlink:href="efr-20220630.xsd#efr_SharesIssuedForCashByAtTheMarketOffering"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6123617b-e3dc-4897-88ff-d1a6b9d76d61" xlink:to="loc_efr_SharesIssuedForCashByAtTheMarketOffering_c6325197-78b7-418c-b617-3824decc3c09" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalStockIssuedIssuanceCosts_f3636b45-a403-45a3-b592-427fcafbe328" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalStockIssuedIssuanceCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6123617b-e3dc-4897-88ff-d1a6b9d76d61" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalStockIssuedIssuanceCosts_f3636b45-a403-45a3-b592-427fcafbe328" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_0fbdcbcd-bac8-449b-bb34-d3ea5266e46e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6123617b-e3dc-4897-88ff-d1a6b9d76d61" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_0fbdcbcd-bac8-449b-bb34-d3ea5266e46e" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_f174c9c6-96b2-484f-b4df-7be5abcb3896" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6123617b-e3dc-4897-88ff-d1a6b9d76d61" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_f174c9c6-96b2-484f-b4df-7be5abcb3896" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_96367a29-df9d-44f0-bb0a-c2ab3ae00c2f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6123617b-e3dc-4897-88ff-d1a6b9d76d61" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_96367a29-df9d-44f0-bb0a-c2ab3ae00c2f" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_SharesIssuedForTheVestingOfRestrictedStockUnitsShares_8cc481a9-83cc-48ef-bf02-cb347513fc33" xlink:href="efr-20220630.xsd#efr_SharesIssuedForTheVestingOfRestrictedStockUnitsShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6123617b-e3dc-4897-88ff-d1a6b9d76d61" xlink:to="loc_efr_SharesIssuedForTheVestingOfRestrictedStockUnitsShares_8cc481a9-83cc-48ef-bf02-cb347513fc33" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_StockIssuedDuringPeriodValueCashPaymentforTaxWithholding_5d0fb0bf-4d07-4616-a042-47fd7894398d" xlink:href="efr-20220630.xsd#efr_StockIssuedDuringPeriodValueCashPaymentforTaxWithholding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6123617b-e3dc-4897-88ff-d1a6b9d76d61" xlink:to="loc_efr_StockIssuedDuringPeriodValueCashPaymentforTaxWithholding_5d0fb0bf-4d07-4616-a042-47fd7894398d" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_StockIssuedForExerciseOfWarrants_4340d492-ea30-4f16-8eaf-45f1f1efa34a" xlink:href="efr-20220630.xsd#efr_StockIssuedForExerciseOfWarrants"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6123617b-e3dc-4897-88ff-d1a6b9d76d61" xlink:to="loc_efr_StockIssuedForExerciseOfWarrants_4340d492-ea30-4f16-8eaf-45f1f1efa34a" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued_dafa2291-c58d-40c2-8e1a-06e155b19bab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6123617b-e3dc-4897-88ff-d1a6b9d76d61" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued_dafa2291-c58d-40c2-8e1a-06e155b19bab" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_SharesIssuedforConsultingServices_c4d9251a-0bbc-4cfb-905d-607fe2ae0d50" xlink:href="efr-20220630.xsd#efr_SharesIssuedforConsultingServices"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6123617b-e3dc-4897-88ff-d1a6b9d76d61" xlink:to="loc_efr_SharesIssuedforConsultingServices_c4d9251a-0bbc-4cfb-905d-607fe2ae0d50" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_AdjustmentstoAdditionalPaidinCapitalSharesIssuedForConsultingServices_f7a27152-07c5-4325-8f69-efa9f18e29cd" xlink:href="efr-20220630.xsd#efr_AdjustmentstoAdditionalPaidinCapitalSharesIssuedForConsultingServices"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6123617b-e3dc-4897-88ff-d1a6b9d76d61" xlink:to="loc_efr_AdjustmentstoAdditionalPaidinCapitalSharesIssuedForConsultingServices_f7a27152-07c5-4325-8f69-efa9f18e29cd" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross_ca403518-ca69-4a70-87bb-aff305eb5634" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6123617b-e3dc-4897-88ff-d1a6b9d76d61" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross_ca403518-ca69-4a70-87bb-aff305eb5634" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncontrollingInterestIncreaseFromSubsidiaryEquityIssuance_03d4549e-16b3-4c64-aad4-97effc01bd04" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoncontrollingInterestIncreaseFromSubsidiaryEquityIssuance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6123617b-e3dc-4897-88ff-d1a6b9d76d61" xlink:to="loc_us-gaap_NoncontrollingInterestIncreaseFromSubsidiaryEquityIssuance_03d4549e-16b3-4c64-aad4-97effc01bd04" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesIssued_9bcb43eb-89a4-45bf-8b83-67a69b1f8327" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharesIssued"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_67028583-2943-44af-9389-43d372735598" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_f7376815-8aad-4598-b130-48bf58d5de22" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_d3c441a2-74a8-4608-93db-20583c0af92c" xlink:to="loc_us-gaap_StatementTable_f7376815-8aad-4598-b130-48bf58d5de22" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_da531cc8-652d-45fa-a5df-0ab9b41be584" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_f7376815-8aad-4598-b130-48bf58d5de22" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_da531cc8-652d-45fa-a5df-0ab9b41be584" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_da531cc8-652d-45fa-a5df-0ab9b41be584_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_da531cc8-652d-45fa-a5df-0ab9b41be584" xlink:to="loc_us-gaap_EquityComponentDomain_da531cc8-652d-45fa-a5df-0ab9b41be584_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_568c5688-4268-401e-bf67-aee4791b6c37" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_da531cc8-652d-45fa-a5df-0ab9b41be584" xlink:to="loc_us-gaap_EquityComponentDomain_568c5688-4268-401e-bf67-aee4791b6c37" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_1aa75a3e-fde8-4edb-a11c-bfb929b6d6cb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_568c5688-4268-401e-bf67-aee4791b6c37" xlink:to="loc_us-gaap_CommonStockMember_1aa75a3e-fde8-4edb-a11c-bfb929b6d6cb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_c0904f55-9694-4e70-a313-f7e402ceecb5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_568c5688-4268-401e-bf67-aee4791b6c37" xlink:to="loc_us-gaap_RetainedEarningsMember_c0904f55-9694-4e70-a313-f7e402ceecb5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_ca6d1db9-ee3b-43c1-bbbe-224e5de0b4e4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_568c5688-4268-401e-bf67-aee4791b6c37" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_ca6d1db9-ee3b-43c1-bbbe-224e5de0b4e4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ParentMember_ef576035-606e-41a9-8553-3ef475b6b169" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ParentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_568c5688-4268-401e-bf67-aee4791b6c37" xlink:to="loc_us-gaap_ParentMember_ef576035-606e-41a9-8553-3ef475b6b169" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncontrollingInterestMember_5fce2591-c351-4ebb-9447-3d0f8255ef44" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_568c5688-4268-401e-bf67-aee4791b6c37" xlink:to="loc_us-gaap_NoncontrollingInterestMember_5fce2591-c351-4ebb-9447-3d0f8255ef44" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.energyfuels.com/role/INVENTORIESScheduleofInventoryCurrentDetails" xlink:type="simple" xlink:href="efr-20220630.xsd#INVENTORIESScheduleofInventoryCurrentDetails"/>
  <link:definitionLink xlink:role="http://www.energyfuels.com/role/INVENTORIESScheduleofInventoryCurrentDetails" xlink:type="extended" id="i2cde10b0641645058d1d1f593b7342f7_INVENTORIESScheduleofInventoryCurrentDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryLineItems_8c0432dd-6354-433c-9e75-794d53a477ca" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcess_d04cccd1-63be-48be-afc8-76d3eaa78e69" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryWorkInProcess"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InventoryLineItems_8c0432dd-6354-433c-9e75-794d53a477ca" xlink:to="loc_us-gaap_InventoryWorkInProcess_d04cccd1-63be-48be-afc8-76d3eaa78e69" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_InventoryOfOreInStockpiles_30262da7-fbb9-44cc-b1fd-f61b2a77389e" xlink:href="efr-20220630.xsd#efr_InventoryOfOreInStockpiles"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InventoryLineItems_8c0432dd-6354-433c-9e75-794d53a477ca" xlink:to="loc_efr_InventoryOfOreInStockpiles_30262da7-fbb9-44cc-b1fd-f61b2a77389e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterials_5e3b8ecb-9e35-4638-bc61-06cc14fc23df" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryRawMaterials"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InventoryLineItems_8c0432dd-6354-433c-9e75-794d53a477ca" xlink:to="loc_us-gaap_InventoryRawMaterials_5e3b8ecb-9e35-4638-bc61-06cc14fc23df" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_60667f3b-ee02-4f0e-bad2-3801e2ad880f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InventoryLineItems_8c0432dd-6354-433c-9e75-794d53a477ca" xlink:to="loc_us-gaap_InventoryNet_60667f3b-ee02-4f0e-bad2-3801e2ad880f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_InventoryCurrent_d868e4ae-fe81-4495-a502-44c8db479ef3" xlink:href="efr-20220630.xsd#efr_InventoryCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InventoryLineItems_8c0432dd-6354-433c-9e75-794d53a477ca" xlink:to="loc_efr_InventoryCurrent_d868e4ae-fe81-4495-a502-44c8db479ef3" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNoncurrent_1e5d06fa-2a68-4655-81c3-e3bccedf8f0e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InventoryLineItems_8c0432dd-6354-433c-9e75-794d53a477ca" xlink:to="loc_us-gaap_InventoryNoncurrent_1e5d06fa-2a68-4655-81c3-e3bccedf8f0e" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryCurrentTable_483ade67-a6ce-4222-884c-579e5aa54a5f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryCurrentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_InventoryLineItems_8c0432dd-6354-433c-9e75-794d53a477ca" xlink:to="loc_us-gaap_InventoryCurrentTable_483ade67-a6ce-4222-884c-579e5aa54a5f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PublicUtilitiesInventoryAxis_64f10cdf-7438-48b9-a00e-d4702ced2dfe" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PublicUtilitiesInventoryAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_InventoryCurrentTable_483ade67-a6ce-4222-884c-579e5aa54a5f" xlink:to="loc_us-gaap_PublicUtilitiesInventoryAxis_64f10cdf-7438-48b9-a00e-d4702ced2dfe" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PublicUtilitiesInventoryTypeDomain_64f10cdf-7438-48b9-a00e-d4702ced2dfe_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PublicUtilitiesInventoryTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PublicUtilitiesInventoryAxis_64f10cdf-7438-48b9-a00e-d4702ced2dfe" xlink:to="loc_us-gaap_PublicUtilitiesInventoryTypeDomain_64f10cdf-7438-48b9-a00e-d4702ced2dfe_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PublicUtilitiesInventoryTypeDomain_caf9f7a4-b136-4b51-ba04-8cdc0faa245c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PublicUtilitiesInventoryTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PublicUtilitiesInventoryAxis_64f10cdf-7438-48b9-a00e-d4702ced2dfe" xlink:to="loc_us-gaap_PublicUtilitiesInventoryTypeDomain_caf9f7a4-b136-4b51-ba04-8cdc0faa245c" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.energyfuels.com/role/PLANTANDEQUIPMENTANDMINERALPROPERTIESScheduleofPropertyPlantandEquipmentDetails" xlink:type="simple" xlink:href="efr-20220630.xsd#PLANTANDEQUIPMENTANDMINERALPROPERTIESScheduleofPropertyPlantandEquipmentDetails"/>
  <link:definitionLink xlink:role="http://www.energyfuels.com/role/PLANTANDEQUIPMENTANDMINERALPROPERTIESScheduleofPropertyPlantandEquipmentDetails" xlink:type="extended" id="idf336f998483425cb37600af4a52937e_PLANTANDEQUIPMENTANDMINERALPROPERTIESScheduleofPropertyPlantandEquipmentDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_dc4b81ba-ecca-4606-82a7-629787747f3a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_afb054a9-79bc-4096-af62-615878d7afff" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_dc4b81ba-ecca-4606-82a7-629787747f3a" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_afb054a9-79bc-4096-af62-615878d7afff" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_7944d55a-530d-49d5-88e4-5743e6be13ec" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_dc4b81ba-ecca-4606-82a7-629787747f3a" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_7944d55a-530d-49d5-88e4-5743e6be13ec" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_edde75c2-d122-45e8-b98f-f475039273e2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_dc4b81ba-ecca-4606-82a7-629787747f3a" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_edde75c2-d122-45e8-b98f-f475039273e2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_07efd5e6-966e-4a6c-9166-1433b553f423" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_dc4b81ba-ecca-4606-82a7-629787747f3a" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_07efd5e6-966e-4a6c-9166-1433b553f423" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_6bf563f1-1d61-4569-b9e0-dfc5c06ec641" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_07efd5e6-966e-4a6c-9166-1433b553f423" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_6bf563f1-1d61-4569-b9e0-dfc5c06ec641" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_6bf563f1-1d61-4569-b9e0-dfc5c06ec641_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_6bf563f1-1d61-4569-b9e0-dfc5c06ec641" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_6bf563f1-1d61-4569-b9e0-dfc5c06ec641_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_0a717e27-afca-4a74-92d3-6f69273b52d1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_6bf563f1-1d61-4569-b9e0-dfc5c06ec641" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_0a717e27-afca-4a74-92d3-6f69273b52d1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_NicholsRanchMember_aee46392-709d-4128-b113-a10b6fc82d85" xlink:href="efr-20220630.xsd#efr_NicholsRanchMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_0a717e27-afca-4a74-92d3-6f69273b52d1" xlink:to="loc_efr_NicholsRanchMember_aee46392-709d-4128-b113-a10b6fc82d85" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_AltaMesaMember_f078fb0f-a4b8-4522-8a07-185f6baf3c54" xlink:href="efr-20220630.xsd#efr_AltaMesaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_0a717e27-afca-4a74-92d3-6f69273b52d1" xlink:to="loc_efr_AltaMesaMember_f078fb0f-a4b8-4522-8a07-185f6baf3c54" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_EquipmentAndOtherMember_80289887-618a-43b2-bfa3-ae8c7c83827a" xlink:href="efr-20220630.xsd#efr_EquipmentAndOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_0a717e27-afca-4a74-92d3-6f69273b52d1" xlink:to="loc_efr_EquipmentAndOtherMember_80289887-618a-43b2-bfa3-ae8c7c83827a" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.energyfuels.com/role/PLANTANDEQUIPMENTANDMINERALPROPERTIESScheduleofSummaryofMineralPropertiesDetails" xlink:type="simple" xlink:href="efr-20220630.xsd#PLANTANDEQUIPMENTANDMINERALPROPERTIESScheduleofSummaryofMineralPropertiesDetails"/>
  <link:definitionLink xlink:role="http://www.energyfuels.com/role/PLANTANDEQUIPMENTANDMINERALPROPERTIESScheduleofSummaryofMineralPropertiesDetails" xlink:type="extended" id="i33341eb79382477a81f697859b923b35_PLANTANDEQUIPMENTANDMINERALPROPERTIESScheduleofSummaryofMineralPropertiesDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_c99a308a-4be6-4142-b87b-6c75a36d9dbd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MineralPropertiesNet_c081bd67-d730-44dc-a924-d0384124bb56" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MineralPropertiesNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_c99a308a-4be6-4142-b87b-6c75a36d9dbd" xlink:to="loc_us-gaap_MineralPropertiesNet_c081bd67-d730-44dc-a924-d0384124bb56" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_2004f55e-4c46-40ad-925c-702eb6e353e4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_c99a308a-4be6-4142-b87b-6c75a36d9dbd" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_2004f55e-4c46-40ad-925c-702eb6e353e4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_MineralPropertiesAxis_7e99e5f1-38ea-40ef-8a88-a36e2f13157a" xlink:href="efr-20220630.xsd#efr_MineralPropertiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_2004f55e-4c46-40ad-925c-702eb6e353e4" xlink:to="loc_efr_MineralPropertiesAxis_7e99e5f1-38ea-40ef-8a88-a36e2f13157a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_MineralPropertiesDomain_7e99e5f1-38ea-40ef-8a88-a36e2f13157a_default" xlink:href="efr-20220630.xsd#efr_MineralPropertiesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_efr_MineralPropertiesAxis_7e99e5f1-38ea-40ef-8a88-a36e2f13157a" xlink:to="loc_efr_MineralPropertiesDomain_7e99e5f1-38ea-40ef-8a88-a36e2f13157a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_MineralPropertiesDomain_8a1e3b71-6885-45a9-a1df-91b1e7b2e319" xlink:href="efr-20220630.xsd#efr_MineralPropertiesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_efr_MineralPropertiesAxis_7e99e5f1-38ea-40ef-8a88-a36e2f13157a" xlink:to="loc_efr_MineralPropertiesDomain_8a1e3b71-6885-45a9-a1df-91b1e7b2e319" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_UranerzISRPropertiesMember_9d4dfb11-ba2e-403b-8b8d-b09fbe026fd9" xlink:href="efr-20220630.xsd#efr_UranerzISRPropertiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_efr_MineralPropertiesDomain_8a1e3b71-6885-45a9-a1df-91b1e7b2e319" xlink:to="loc_efr_UranerzISRPropertiesMember_9d4dfb11-ba2e-403b-8b8d-b09fbe026fd9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_SheepMountainMember_7c6e35c5-de7b-44f4-b695-4db61548e4e5" xlink:href="efr-20220630.xsd#efr_SheepMountainMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_efr_MineralPropertiesDomain_8a1e3b71-6885-45a9-a1df-91b1e7b2e319" xlink:to="loc_efr_SheepMountainMember_7c6e35c5-de7b-44f4-b695-4db61548e4e5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_RocaHondaMember_a1ae918f-c67e-4d01-a673-ac0d2e90515f" xlink:href="efr-20220630.xsd#efr_RocaHondaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_efr_MineralPropertiesDomain_8a1e3b71-6885-45a9-a1df-91b1e7b2e319" xlink:to="loc_efr_RocaHondaMember_a1ae918f-c67e-4d01-a673-ac0d2e90515f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_OtherMember_8eca08ae-d45d-4ef8-abf2-dda9b1874066" xlink:href="efr-20220630.xsd#efr_OtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_efr_MineralPropertiesDomain_8a1e3b71-6885-45a9-a1df-91b1e7b2e319" xlink:to="loc_efr_OtherMember_8eca08ae-d45d-4ef8-abf2-dda9b1874066" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.energyfuels.com/role/ASSETRETIREMENTOBLIGATIONSANDRESTRICTEDCASHNarrativeDetails" xlink:type="simple" xlink:href="efr-20220630.xsd#ASSETRETIREMENTOBLIGATIONSANDRESTRICTEDCASHNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.energyfuels.com/role/ASSETRETIREMENTOBLIGATIONSANDRESTRICTEDCASHNarrativeDetails" xlink:type="extended" id="i1f1022870edb459e8a93042b902497b6_ASSETRETIREMENTOBLIGATIONSANDRESTRICTEDCASHNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_efr_ScheduleofAssetRetirementObligationsLineItems_4a9aff3f-f749-4e5d-9f25-d8a3e5844707" xlink:href="efr-20220630.xsd#efr_ScheduleofAssetRetirementObligationsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_RiskFreeRate_b642c90d-4324-4901-a997-7e999df864ab" xlink:href="efr-20220630.xsd#efr_RiskFreeRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_efr_ScheduleofAssetRetirementObligationsLineItems_4a9aff3f-f749-4e5d-9f25-d8a3e5844707" xlink:to="loc_efr_RiskFreeRate_b642c90d-4324-4901-a997-7e999df864ab" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_InflationRate_64f194c9-9430-4456-b8ed-49a42cf31390" xlink:href="efr-20220630.xsd#efr_InflationRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_efr_ScheduleofAssetRetirementObligationsLineItems_4a9aff3f-f749-4e5d-9f25-d8a3e5844707" xlink:to="loc_efr_InflationRate_64f194c9-9430-4456-b8ed-49a42cf31390" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetRetirementObligation_96962fba-9cc0-4328-8ecc-b8d1296fbbab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetRetirementObligation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_efr_ScheduleofAssetRetirementObligationsLineItems_4a9aff3f-f749-4e5d-9f25-d8a3e5844707" xlink:to="loc_us-gaap_AssetRetirementObligation_96962fba-9cc0-4328-8ecc-b8d1296fbbab" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_ScheduleofAssetRetirementObligationsTable_f062c283-e176-4b0d-81e0-1808e11b799f" xlink:href="efr-20220630.xsd#efr_ScheduleofAssetRetirementObligationsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_efr_ScheduleofAssetRetirementObligationsLineItems_4a9aff3f-f749-4e5d-9f25-d8a3e5844707" xlink:to="loc_efr_ScheduleofAssetRetirementObligationsTable_f062c283-e176-4b0d-81e0-1808e11b799f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_96c589b7-969a-438a-a40a-da73622d8cbd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingenciesByNatureOfContingencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_efr_ScheduleofAssetRetirementObligationsTable_f062c283-e176-4b0d-81e0-1808e11b799f" xlink:to="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_96c589b7-969a-438a-a40a-da73622d8cbd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNatureDomain_96c589b7-969a-438a-a40a-da73622d8cbd_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_96c589b7-969a-438a-a40a-da73622d8cbd" xlink:to="loc_us-gaap_LossContingencyNatureDomain_96c589b7-969a-438a-a40a-da73622d8cbd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNatureDomain_d294a0d3-2a97-4ed6-9a86-5eb5f8bdf9a4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_96c589b7-969a-438a-a40a-da73622d8cbd" xlink:to="loc_us-gaap_LossContingencyNatureDomain_d294a0d3-2a97-4ed6-9a86-5eb5f8bdf9a4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_CanyonProjectMember_f8271eba-6fe3-4b74-aa75-715b0352c1ea" xlink:href="efr-20220630.xsd#efr_CanyonProjectMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingencyNatureDomain_d294a0d3-2a97-4ed6-9a86-5eb5f8bdf9a4" xlink:to="loc_efr_CanyonProjectMember_f8271eba-6fe3-4b74-aa75-715b0352c1ea" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_c0e94103-ed82-4bc2-8660-b725260a8f34" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_efr_ScheduleofAssetRetirementObligationsTable_f062c283-e176-4b0d-81e0-1808e11b799f" xlink:to="loc_srt_RangeAxis_c0e94103-ed82-4bc2-8660-b725260a8f34" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_c0e94103-ed82-4bc2-8660-b725260a8f34_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_c0e94103-ed82-4bc2-8660-b725260a8f34" xlink:to="loc_srt_RangeMember_c0e94103-ed82-4bc2-8660-b725260a8f34_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_23e399b6-79bf-44e5-8696-7fa078a35395" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_c0e94103-ed82-4bc2-8660-b725260a8f34" xlink:to="loc_srt_RangeMember_23e399b6-79bf-44e5-8696-7fa078a35395" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_350537df-a4a3-42a4-9204-1186b390ae74" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_23e399b6-79bf-44e5-8696-7fa078a35395" xlink:to="loc_srt_MinimumMember_350537df-a4a3-42a4-9204-1186b390ae74" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_0993d6b2-1dc2-41ca-8394-3502392ec384" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_23e399b6-79bf-44e5-8696-7fa078a35395" xlink:to="loc_srt_MaximumMember_0993d6b2-1dc2-41ca-8394-3502392ec384" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_AssetRetirementObligationAxis_7a7cc3cf-c95b-43b9-bdd7-6684409f902c" xlink:href="efr-20220630.xsd#efr_AssetRetirementObligationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_efr_ScheduleofAssetRetirementObligationsTable_f062c283-e176-4b0d-81e0-1808e11b799f" xlink:to="loc_efr_AssetRetirementObligationAxis_7a7cc3cf-c95b-43b9-bdd7-6684409f902c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_AssetRetirementObligationDomain_7a7cc3cf-c95b-43b9-bdd7-6684409f902c_default" xlink:href="efr-20220630.xsd#efr_AssetRetirementObligationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_efr_AssetRetirementObligationAxis_7a7cc3cf-c95b-43b9-bdd7-6684409f902c" xlink:to="loc_efr_AssetRetirementObligationDomain_7a7cc3cf-c95b-43b9-bdd7-6684409f902c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_AssetRetirementObligationDomain_df655398-ceb7-4a70-a14d-bb5ad490c5d8" xlink:href="efr-20220630.xsd#efr_AssetRetirementObligationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_efr_AssetRetirementObligationAxis_7a7cc3cf-c95b-43b9-bdd7-6684409f902c" xlink:to="loc_efr_AssetRetirementObligationDomain_df655398-ceb7-4a70-a14d-bb5ad490c5d8" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.energyfuels.com/role/LEASESNarrativeDetails" xlink:type="simple" xlink:href="efr-20220630.xsd#LEASESNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.energyfuels.com/role/LEASESNarrativeDetails" xlink:type="extended" id="i974863dd9dfc48c696146a43e087c669_LEASESNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasedAssetsLineItems_ffc8e18e-beb8-41c4-a12b-70d708564213" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeasedAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_a5965b66-c5b1-47ac-9209-7deee59abd37" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_ffc8e18e-beb8-41c4-a12b-70d708564213" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_a5965b66-c5b1-47ac-9209-7deee59abd37" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_043ddb08-43b6-496f-a1a2-59dd4d059a6c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_ffc8e18e-beb8-41c4-a12b-70d708564213" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_043ddb08-43b6-496f-a1a2-59dd4d059a6c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_042c322b-217b-45c1-8e84-423404e0fa07" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_ffc8e18e-beb8-41c4-a12b-70d708564213" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_042c322b-217b-45c1-8e84-423404e0fa07" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCost_4ca2d329-061b-4b05-95d1-033078920371" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LeaseCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_ffc8e18e-beb8-41c4-a12b-70d708564213" xlink:to="loc_us-gaap_LeaseCost_4ca2d329-061b-4b05-95d1-033078920371" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseTermOfContract_025b0e98-2082-4d60-8e70-4b5ae06d2ff2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseTermOfContract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_ffc8e18e-beb8-41c4-a12b-70d708564213" xlink:to="loc_us-gaap_LesseeOperatingLeaseTermOfContract_025b0e98-2082-4d60-8e70-4b5ae06d2ff2" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_6f8ce75b-b806-4b8c-beaa-8e941216213b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseRenewalTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_ffc8e18e-beb8-41c4-a12b-70d708564213" xlink:to="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_6f8ce75b-b806-4b8c-beaa-8e941216213b" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_682e1a47-de90-4b00-a2e4-7d5f4c85d979" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfOperatingLeasedAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_ffc8e18e-beb8-41c4-a12b-70d708564213" xlink:to="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_682e1a47-de90-4b00-a2e4-7d5f4c85d979" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_902ad22b-9bcc-463a-8b64-5709b45e1e6d" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_682e1a47-de90-4b00-a2e4-7d5f4c85d979" xlink:to="loc_srt_RangeAxis_902ad22b-9bcc-463a-8b64-5709b45e1e6d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_902ad22b-9bcc-463a-8b64-5709b45e1e6d_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_902ad22b-9bcc-463a-8b64-5709b45e1e6d" xlink:to="loc_srt_RangeMember_902ad22b-9bcc-463a-8b64-5709b45e1e6d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_0df2bfc6-2a36-4e48-b035-0a9550d3a26c" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_902ad22b-9bcc-463a-8b64-5709b45e1e6d" xlink:to="loc_srt_RangeMember_0df2bfc6-2a36-4e48-b035-0a9550d3a26c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_d390fd21-84b4-4695-931b-7216aa057b08" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_0df2bfc6-2a36-4e48-b035-0a9550d3a26c" xlink:to="loc_srt_MinimumMember_d390fd21-84b4-4695-931b-7216aa057b08" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_a3266ed6-509f-4b4f-9e70-c026b138334a" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_0df2bfc6-2a36-4e48-b035-0a9550d3a26c" xlink:to="loc_srt_MaximumMember_a3266ed6-509f-4b4f-9e70-c026b138334a" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.energyfuels.com/role/CAPITALSTOCKNarrativeDetails" xlink:type="simple" xlink:href="efr-20220630.xsd#CAPITALSTOCKNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.energyfuels.com/role/CAPITALSTOCKNarrativeDetails" xlink:type="extended" id="id604451c404d4a62b010a78923c44cba_CAPITALSTOCKNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightLineItems_68a99be0-5298-4a6c-a987-eb9fe028803c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfWarrantOrRightLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_b610a14f-0ad0-470a-823a-cdb39abf97d9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_68a99be0-5298-4a6c-a987-eb9fe028803c" xlink:to="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_b610a14f-0ad0-470a-823a-cdb39abf97d9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_52a8191b-e403-4130-9311-78991aec7303" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SaleOfStockConsiderationReceivedOnTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_68a99be0-5298-4a6c-a987-eb9fe028803c" xlink:to="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_52a8191b-e403-4130-9311-78991aec7303" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightTable_f05cc8ae-017a-4efa-87da-97c0039e1043" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfWarrantOrRightTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_68a99be0-5298-4a6c-a987-eb9fe028803c" xlink:to="loc_us-gaap_ClassOfWarrantOrRightTable_f05cc8ae-017a-4efa-87da-97c0039e1043" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_974e2ce7-a850-4d67-9a28-b7b1fa624317" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_f05cc8ae-017a-4efa-87da-97c0039e1043" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_974e2ce7-a850-4d67-9a28-b7b1fa624317" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_974e2ce7-a850-4d67-9a28-b7b1fa624317_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_974e2ce7-a850-4d67-9a28-b7b1fa624317" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_974e2ce7-a850-4d67-9a28-b7b1fa624317_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_14cb48ec-77cf-4fa4-8bcb-ef9a333342ef" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_974e2ce7-a850-4d67-9a28-b7b1fa624317" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_14cb48ec-77cf-4fa4-8bcb-ef9a333342ef" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_AtTheMarketSaleOfStockMember_d1b190de-62ee-43e1-a3ff-8fec82782a60" xlink:href="efr-20220630.xsd#efr_AtTheMarketSaleOfStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_14cb48ec-77cf-4fa4-8bcb-ef9a333342ef" xlink:to="loc_efr_AtTheMarketSaleOfStockMember_d1b190de-62ee-43e1-a3ff-8fec82782a60" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.energyfuels.com/role/SHAREBASEDPAYMENTSNarrativeDetails" xlink:type="simple" xlink:href="efr-20220630.xsd#SHAREBASEDPAYMENTSNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.energyfuels.com/role/SHAREBASEDPAYMENTSNarrativeDetails" xlink:type="extended" id="i1c34c2fe85814ebb9d38d11830e4edae_SHAREBASEDPAYMENTSNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6a9d27f4-d802-45d1-8487-6c746f6120dd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_f4b554d2-cc7a-4af0-9343-605e5a5db036" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6a9d27f4-d802-45d1-8487-6c746f6120dd" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_f4b554d2-cc7a-4af0-9343-605e5a5db036" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_c1712f49-e35b-453f-9103-8209c844b35a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6a9d27f4-d802-45d1-8487-6c746f6120dd" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_c1712f49-e35b-453f-9103-8209c844b35a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_3d2e5212-5a98-45ad-91dd-a09020ee48c1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6a9d27f4-d802-45d1-8487-6c746f6120dd" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_3d2e5212-5a98-45ad-91dd-a09020ee48c1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_SharebasedCompensationArrangementbySharebasedPaymentAwardOptionsExercisablePeriod_18365e5e-ed0c-4db8-859d-fae7d9ad5c0a" xlink:href="efr-20220630.xsd#efr_SharebasedCompensationArrangementbySharebasedPaymentAwardOptionsExercisablePeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6a9d27f4-d802-45d1-8487-6c746f6120dd" xlink:to="loc_efr_SharebasedCompensationArrangementbySharebasedPaymentAwardOptionsExercisablePeriod_18365e5e-ed0c-4db8-859d-fae7d9ad5c0a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTermInstant_47bbc705-c739-46fd-9ea8-b2c7fdd47532" xlink:href="efr-20220630.xsd#efr_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTermInstant"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6a9d27f4-d802-45d1-8487-6c746f6120dd" xlink:to="loc_efr_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTermInstant_47bbc705-c739-46fd-9ea8-b2c7fdd47532" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_c58a4c23-f212-4d0a-9337-11d782de88e0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6a9d27f4-d802-45d1-8487-6c746f6120dd" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_c58a4c23-f212-4d0a-9337-11d782de88e0" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_8cbeb193-03ea-4952-86c6-a86b94e687fd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6a9d27f4-d802-45d1-8487-6c746f6120dd" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_8cbeb193-03ea-4952-86c6-a86b94e687fd" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_SharebasedCompensationArrangementbySharebasedPaymentAwardPeriodOfExercisePrice_9b58cba3-f853-48e6-90a4-be6b8c0c94d6" xlink:href="efr-20220630.xsd#efr_SharebasedCompensationArrangementbySharebasedPaymentAwardPeriodOfExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6a9d27f4-d802-45d1-8487-6c746f6120dd" xlink:to="loc_efr_SharebasedCompensationArrangementbySharebasedPaymentAwardPeriodOfExercisePrice_9b58cba3-f853-48e6-90a4-be6b8c0c94d6" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_e26afc42-a7c5-4ea8-b2f5-cde88a382b0c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6a9d27f4-d802-45d1-8487-6c746f6120dd" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_e26afc42-a7c5-4ea8-b2f5-cde88a382b0c" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_167d7a92-fe9f-49dd-88b9-82aa87cd9117" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6a9d27f4-d802-45d1-8487-6c746f6120dd" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_167d7a92-fe9f-49dd-88b9-82aa87cd9117" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_ea6f5169-11ac-48f9-bb6e-f7c383cb7ed2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6a9d27f4-d802-45d1-8487-6c746f6120dd" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_ea6f5169-11ac-48f9-bb6e-f7c383cb7ed2" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_77c91237-a1c7-4289-a790-bf8f3f4a7d9e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6a9d27f4-d802-45d1-8487-6c746f6120dd" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_77c91237-a1c7-4289-a790-bf8f3f4a7d9e" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue_8b665248-6030-4daa-ae05-149d7804b656" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6a9d27f4-d802-45d1-8487-6c746f6120dd" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue_8b665248-6030-4daa-ae05-149d7804b656" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_24158b91-7ec5-4c6d-a9f5-e39bbd5dd9a1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6a9d27f4-d802-45d1-8487-6c746f6120dd" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_24158b91-7ec5-4c6d-a9f5-e39bbd5dd9a1" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrantDateIntrinsicValue_6a4b2e1a-a4f7-46ed-81f2-d72e78babbb1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrantDateIntrinsicValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6a9d27f4-d802-45d1-8487-6c746f6120dd" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrantDateIntrinsicValue_6a4b2e1a-a4f7-46ed-81f2-d72e78babbb1" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_d46e6792-c98d-4a8c-971d-3fa9ef956aa9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6a9d27f4-d802-45d1-8487-6c746f6120dd" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_d46e6792-c98d-4a8c-971d-3fa9ef956aa9" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_UnrecognizedCompensationCostsRelatedToUnvestedStockOptions_26c022cd-6304-4c38-a86d-68c3956e5f18" xlink:href="efr-20220630.xsd#efr_UnrecognizedCompensationCostsRelatedToUnvestedStockOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6a9d27f4-d802-45d1-8487-6c746f6120dd" xlink:to="loc_efr_UnrecognizedCompensationCostsRelatedToUnvestedStockOptions_26c022cd-6304-4c38-a86d-68c3956e5f18" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_UnrecognizedCompensationCostsRelatedToRSUAwards_fbf09606-751b-42c0-8ac6-841666a7bf13" xlink:href="efr-20220630.xsd#efr_UnrecognizedCompensationCostsRelatedToRSUAwards"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6a9d27f4-d802-45d1-8487-6c746f6120dd" xlink:to="loc_efr_UnrecognizedCompensationCostsRelatedToRSUAwards_fbf09606-751b-42c0-8ac6-841666a7bf13" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_0cd45fdb-8ef5-4b01-8737-42c7db44c808" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6a9d27f4-d802-45d1-8487-6c746f6120dd" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_0cd45fdb-8ef5-4b01-8737-42c7db44c808" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_4555a2df-4125-4291-a419-d1d56144b0f1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6a9d27f4-d802-45d1-8487-6c746f6120dd" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_4555a2df-4125-4291-a419-d1d56144b0f1" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGranted_98122786-13c0-43b0-92d2-7c6173d1a834" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGranted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6a9d27f4-d802-45d1-8487-6c746f6120dd" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGranted_98122786-13c0-43b0-92d2-7c6173d1a834" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsIssuedNumber_57fc645d-2c91-44cd-9c02-441ce71b177f" xlink:href="efr-20220630.xsd#efr_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsIssuedNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6a9d27f4-d802-45d1-8487-6c746f6120dd" xlink:to="loc_efr_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsIssuedNumber_57fc645d-2c91-44cd-9c02-441ce71b177f" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_01414fd4-2c56-4cbd-bef7-c562b49f646a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6a9d27f4-d802-45d1-8487-6c746f6120dd" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_01414fd4-2c56-4cbd-bef7-c562b49f646a" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_14fa4b99-dcc5-4255-878f-8577c68068d6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6a9d27f4-d802-45d1-8487-6c746f6120dd" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_14fa4b99-dcc5-4255-878f-8577c68068d6" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_6b009ff8-66c7-4d64-a7b5-17b3a0cfabc4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_14fa4b99-dcc5-4255-878f-8577c68068d6" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_6b009ff8-66c7-4d64-a7b5-17b3a0cfabc4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_6b009ff8-66c7-4d64-a7b5-17b3a0cfabc4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_6b009ff8-66c7-4d64-a7b5-17b3a0cfabc4" xlink:to="loc_us-gaap_EquityComponentDomain_6b009ff8-66c7-4d64-a7b5-17b3a0cfabc4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_5c8fbfd7-0e31-4cae-866c-7913dc53e610" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_6b009ff8-66c7-4d64-a7b5-17b3a0cfabc4" xlink:to="loc_us-gaap_EquityComponentDomain_5c8fbfd7-0e31-4cae-866c-7913dc53e610" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_d8c616bd-5366-4760-b1ad-02482ac34490" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_5c8fbfd7-0e31-4cae-866c-7913dc53e610" xlink:to="loc_us-gaap_CommonStockMember_d8c616bd-5366-4760-b1ad-02482ac34490" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VestingAxis_ad0099c8-a4ff-478d-80ba-5cf08635246c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_VestingAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_14fa4b99-dcc5-4255-878f-8577c68068d6" xlink:to="loc_us-gaap_VestingAxis_ad0099c8-a4ff-478d-80ba-5cf08635246c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VestingDomain_ad0099c8-a4ff-478d-80ba-5cf08635246c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_VestingDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_VestingAxis_ad0099c8-a4ff-478d-80ba-5cf08635246c" xlink:to="loc_us-gaap_VestingDomain_ad0099c8-a4ff-478d-80ba-5cf08635246c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VestingDomain_9dd9f2a8-2ef2-4769-a22d-ddb2ba0b9542" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_VestingDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_VestingAxis_ad0099c8-a4ff-478d-80ba-5cf08635246c" xlink:to="loc_us-gaap_VestingDomain_9dd9f2a8-2ef2-4769-a22d-ddb2ba0b9542" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationAwardTrancheOneMember_61cce03d-7d9a-4e27-a6e2-628a05c27f55" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationAwardTrancheOneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VestingDomain_9dd9f2a8-2ef2-4769-a22d-ddb2ba0b9542" xlink:to="loc_us-gaap_ShareBasedCompensationAwardTrancheOneMember_61cce03d-7d9a-4e27-a6e2-628a05c27f55" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationAwardTrancheTwoMember_63675c81-9ff4-4f20-8c13-58470b1cc9ce" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationAwardTrancheTwoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VestingDomain_9dd9f2a8-2ef2-4769-a22d-ddb2ba0b9542" xlink:to="loc_us-gaap_ShareBasedCompensationAwardTrancheTwoMember_63675c81-9ff4-4f20-8c13-58470b1cc9ce" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationAwardTrancheThreeMember_ea694d51-c81b-414b-83d0-c1c5cf20fc89" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationAwardTrancheThreeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VestingDomain_9dd9f2a8-2ef2-4769-a22d-ddb2ba0b9542" xlink:to="loc_us-gaap_ShareBasedCompensationAwardTrancheThreeMember_ea694d51-c81b-414b-83d0-c1c5cf20fc89" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_d0848184-7f88-44e4-a7e0-91b86b40d0fb" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_14fa4b99-dcc5-4255-878f-8577c68068d6" xlink:to="loc_srt_RangeAxis_d0848184-7f88-44e4-a7e0-91b86b40d0fb" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_d0848184-7f88-44e4-a7e0-91b86b40d0fb_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_d0848184-7f88-44e4-a7e0-91b86b40d0fb" xlink:to="loc_srt_RangeMember_d0848184-7f88-44e4-a7e0-91b86b40d0fb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_8b3cbd30-4aaa-4605-9949-868274da68e0" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_d0848184-7f88-44e4-a7e0-91b86b40d0fb" xlink:to="loc_srt_RangeMember_8b3cbd30-4aaa-4605-9949-868274da68e0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_f104fcd5-24b4-4131-a224-63723579d99e" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_8b3cbd30-4aaa-4605-9949-868274da68e0" xlink:to="loc_srt_MaximumMember_f104fcd5-24b4-4131-a224-63723579d99e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_c4941c1b-8d2a-4484-9140-379184540f40" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_14fa4b99-dcc5-4255-878f-8577c68068d6" xlink:to="loc_us-gaap_AwardTypeAxis_c4941c1b-8d2a-4484-9140-379184540f40" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_c4941c1b-8d2a-4484-9140-379184540f40_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_c4941c1b-8d2a-4484-9140-379184540f40" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_c4941c1b-8d2a-4484-9140-379184540f40_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_b63def6b-c2b1-4d24-ae6d-368d07c630ed" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_c4941c1b-8d2a-4484-9140-379184540f40" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_b63def6b-c2b1-4d24-ae6d-368d07c630ed" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_StockIncentivePlanMember_2bb5b7d6-3004-41e7-9189-7770f102b351" xlink:href="efr-20220630.xsd#efr_StockIncentivePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_b63def6b-c2b1-4d24-ae6d-368d07c630ed" xlink:to="loc_efr_StockIncentivePlanMember_2bb5b7d6-3004-41e7-9189-7770f102b351" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_cb50fd7f-0c2a-4899-99ef-90ca961de077" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_b63def6b-c2b1-4d24-ae6d-368d07c630ed" xlink:to="loc_us-gaap_EmployeeStockOptionMember_cb50fd7f-0c2a-4899-99ef-90ca961de077" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_b3768e69-2fa6-4eee-a81e-0446924ac0ba" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_b63def6b-c2b1-4d24-ae6d-368d07c630ed" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_b3768e69-2fa6-4eee-a81e-0446924ac0ba" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockAppreciationRightsSARSMember_effc81f9-1e49-4efc-af03-124cff71a479" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockAppreciationRightsSARSMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_b63def6b-c2b1-4d24-ae6d-368d07c630ed" xlink:to="loc_us-gaap_StockAppreciationRightsSARSMember_effc81f9-1e49-4efc-af03-124cff71a479" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.energyfuels.com/role/SHAREBASEDPAYMENTSScheduleofSharebasedPaymentAwardStockOptionsValuationAssumptionsDetails" xlink:type="simple" xlink:href="efr-20220630.xsd#SHAREBASEDPAYMENTSScheduleofSharebasedPaymentAwardStockOptionsValuationAssumptionsDetails"/>
  <link:definitionLink xlink:role="http://www.energyfuels.com/role/SHAREBASEDPAYMENTSScheduleofSharebasedPaymentAwardStockOptionsValuationAssumptionsDetails" xlink:type="extended" id="ie7c560885de340879db5c23a203d249b_SHAREBASEDPAYMENTSScheduleofSharebasedPaymentAwardStockOptionsValuationAssumptionsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_827873a6-5f8a-490b-b609-80d5fc480c77" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_02f5aacb-8c98-4e3d-b85f-02808046f65c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_827873a6-5f8a-490b-b609-80d5fc480c77" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_02f5aacb-8c98-4e3d-b85f-02808046f65c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_ccc1fc76-1fbc-4032-96e2-e46eed5ffe9a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_827873a6-5f8a-490b-b609-80d5fc480c77" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_ccc1fc76-1fbc-4032-96e2-e46eed5ffe9a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_6c72e4da-ef65-497f-af08-5c2007abfba8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_827873a6-5f8a-490b-b609-80d5fc480c77" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_6c72e4da-ef65-497f-af08-5c2007abfba8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_cdf5ae90-3073-457e-8e44-e5bc0b12cf4e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_827873a6-5f8a-490b-b609-80d5fc480c77" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_cdf5ae90-3073-457e-8e44-e5bc0b12cf4e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_4a95f5d0-9d9d-4d23-bf6d-6dfb1ad011bd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_827873a6-5f8a-490b-b609-80d5fc480c77" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_4a95f5d0-9d9d-4d23-bf6d-6dfb1ad011bd" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_517e319f-bdd0-4b0c-9d57-a9c2441094aa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_827873a6-5f8a-490b-b609-80d5fc480c77" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_517e319f-bdd0-4b0c-9d57-a9c2441094aa" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_007d54c1-90d8-476c-9c4e-c6a57720d608" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_517e319f-bdd0-4b0c-9d57-a9c2441094aa" xlink:to="loc_us-gaap_AwardTypeAxis_007d54c1-90d8-476c-9c4e-c6a57720d608" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_007d54c1-90d8-476c-9c4e-c6a57720d608_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_007d54c1-90d8-476c-9c4e-c6a57720d608" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_007d54c1-90d8-476c-9c4e-c6a57720d608_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_c346bd07-993d-4a3f-a861-368183cda849" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_007d54c1-90d8-476c-9c4e-c6a57720d608" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_c346bd07-993d-4a3f-a861-368183cda849" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_5b795587-f30b-4fb5-90f3-a5e2d82894f6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_c346bd07-993d-4a3f-a861-368183cda849" xlink:to="loc_us-gaap_EmployeeStockOptionMember_5b795587-f30b-4fb5-90f3-a5e2d82894f6" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.energyfuels.com/role/SHAREBASEDPAYMENTSScheduleofSharebasedCompensationStockOptionsActivityDetails" xlink:type="simple" xlink:href="efr-20220630.xsd#SHAREBASEDPAYMENTSScheduleofSharebasedCompensationStockOptionsActivityDetails"/>
  <link:definitionLink xlink:role="http://www.energyfuels.com/role/SHAREBASEDPAYMENTSScheduleofSharebasedCompensationStockOptionsActivityDetails" xlink:type="extended" id="i34dd51210de34f34bcefe191d4b93125_SHAREBASEDPAYMENTSScheduleofSharebasedCompensationStockOptionsActivityDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_acb4a076-4b19-40e3-aeed-d7c803d13be6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_f2fae5f5-f813-4302-8d8f-0d013174dd68" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_acb4a076-4b19-40e3-aeed-d7c803d13be6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_f2fae5f5-f813-4302-8d8f-0d013174dd68" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_352aa4e2-643e-4484-97ef-2561d2483ec1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_f2fae5f5-f813-4302-8d8f-0d013174dd68" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_352aa4e2-643e-4484-97ef-2561d2483ec1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_f1401e0a-13f5-4745-900f-f9c088e3fa71" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_f2fae5f5-f813-4302-8d8f-0d013174dd68" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_f1401e0a-13f5-4745-900f-f9c088e3fa71" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_546da25e-6d63-4ea9-bbed-80d94010f2a7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_f2fae5f5-f813-4302-8d8f-0d013174dd68" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_546da25e-6d63-4ea9-bbed-80d94010f2a7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_dbac7d8e-a705-46ca-a704-2f1b895ca4c4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_f2fae5f5-f813-4302-8d8f-0d013174dd68" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_dbac7d8e-a705-46ca-a704-2f1b895ca4c4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice_9bb9cb8d-e61f-4afa-b1ba-460030a5fdf9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_f2fae5f5-f813-4302-8d8f-0d013174dd68" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice_9bb9cb8d-e61f-4afa-b1ba-460030a5fdf9" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_4176df21-1365-48e7-8715-d402339ab835" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_f3f27ba0-943b-406e-a8cc-abe8defa2a39" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_f2fae5f5-f813-4302-8d8f-0d013174dd68" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_f3f27ba0-943b-406e-a8cc-abe8defa2a39" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_0423b3fd-c849-4125-9cca-c00f999ab63f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_acb4a076-4b19-40e3-aeed-d7c803d13be6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_0423b3fd-c849-4125-9cca-c00f999ab63f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_5d30800e-32c9-4038-8066-7a7352f86382" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_0423b3fd-c849-4125-9cca-c00f999ab63f" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_5d30800e-32c9-4038-8066-7a7352f86382" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod_9e43a67f-98d9-4eee-9ee1-f26c8b89f8ee" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_0423b3fd-c849-4125-9cca-c00f999ab63f" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod_9e43a67f-98d9-4eee-9ee1-f26c8b89f8ee" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_56c62b2f-3027-4e7c-95b7-9af2d6625f84" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_0423b3fd-c849-4125-9cca-c00f999ab63f" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_56c62b2f-3027-4e7c-95b7-9af2d6625f84" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod_e70315c2-3956-4c49-9302-6ffeb0ba3650" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_0423b3fd-c849-4125-9cca-c00f999ab63f" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod_e70315c2-3956-4c49-9302-6ffeb0ba3650" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_b3dbee20-6a90-4da3-bda7-1a3cbe59745a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_6133e841-60f3-4f97-adf4-74c7aee6a0b2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_0423b3fd-c849-4125-9cca-c00f999ab63f" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_6133e841-60f3-4f97-adf4-74c7aee6a0b2" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_1e83f826-0cfe-4869-bc34-08cfe98c3b74" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_acb4a076-4b19-40e3-aeed-d7c803d13be6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_1e83f826-0cfe-4869-bc34-08cfe98c3b74" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_608b80ab-4a0e-467b-aa07-525a5bca872b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_1e83f826-0cfe-4869-bc34-08cfe98c3b74" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_608b80ab-4a0e-467b-aa07-525a5bca872b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTermInstant_326228c9-05f6-4595-ba46-09f4394d5535" xlink:href="efr-20220630.xsd#efr_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTermInstant"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_1e83f826-0cfe-4869-bc34-08cfe98c3b74" xlink:to="loc_efr_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTermInstant_326228c9-05f6-4595-ba46-09f4394d5535" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue_1b8a02ae-aaac-4fa8-a592-af6714e3dbd6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_1e83f826-0cfe-4869-bc34-08cfe98c3b74" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue_1b8a02ae-aaac-4fa8-a592-af6714e3dbd6" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_427aa8cc-e819-452b-9d12-58814254e749" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_1e83f826-0cfe-4869-bc34-08cfe98c3b74" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_427aa8cc-e819-452b-9d12-58814254e749" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedNumberOfSharesRollForward_ecd75fc3-af37-4efa-9223-c961fc216005" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedNumberOfSharesRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_acb4a076-4b19-40e3-aeed-d7c803d13be6" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedNumberOfSharesRollForward_ecd75fc3-af37-4efa-9223-c961fc216005" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedNumberOfShares_29b1bdf0-f2d1-463a-8034-7e890c5a85a5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedNumberOfShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedNumberOfSharesRollForward_ecd75fc3-af37-4efa-9223-c961fc216005" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedNumberOfShares_29b1bdf0-f2d1-463a-8034-7e890c5a85a5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_ShareBasedCompensationArrangementByShareBasedPaymentAwardGrantedNonvestedNumberOfShares_7998cbb1-33d2-4eda-bf15-5f00a5a9b8da" xlink:href="efr-20220630.xsd#efr_ShareBasedCompensationArrangementByShareBasedPaymentAwardGrantedNonvestedNumberOfShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedNumberOfSharesRollForward_ecd75fc3-af37-4efa-9223-c961fc216005" xlink:to="loc_efr_ShareBasedCompensationArrangementByShareBasedPaymentAwardGrantedNonvestedNumberOfShares_7998cbb1-33d2-4eda-bf15-5f00a5a9b8da" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedNumberOfShares_8e8a7a82-abd0-43b1-bece-21c094fed3c2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedNumberOfShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedNumberOfSharesRollForward_ecd75fc3-af37-4efa-9223-c961fc216005" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedNumberOfShares_8e8a7a82-abd0-43b1-bece-21c094fed3c2" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedOptionsForfeitedNumberOfShares_7ac75765-43bc-4ed4-b55c-c8f3ffdef944" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedOptionsForfeitedNumberOfShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedNumberOfSharesRollForward_ecd75fc3-af37-4efa-9223-c961fc216005" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedOptionsForfeitedNumberOfShares_7ac75765-43bc-4ed4-b55c-c8f3ffdef944" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedNumberOfShares_cf968ac0-8f86-4b13-8d2c-aa82a40e226d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedNumberOfShares"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedWeightedAverageGrantDateFairValueAbstract_fbf2ae56-08ed-4751-80a7-2e065468d6d2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedWeightedAverageGrantDateFairValueAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_acb4a076-4b19-40e3-aeed-d7c803d13be6" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedWeightedAverageGrantDateFairValueAbstract_fbf2ae56-08ed-4751-80a7-2e065468d6d2" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_b208c45b-f7b7-442e-bdb3-ef45f4f161a9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedWeightedAverageGrantDateFairValueAbstract_fbf2ae56-08ed-4751-80a7-2e065468d6d2" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_b208c45b-f7b7-442e-bdb3-ef45f4f161a9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_ShareBasedCompensationArrangementByShareBasedPaymentAwardGrantedNonvestedWeightedAverageGrantDateFairValue_e249c41c-07a2-437a-bef8-6fff8c3e9e33" xlink:href="efr-20220630.xsd#efr_ShareBasedCompensationArrangementByShareBasedPaymentAwardGrantedNonvestedWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedWeightedAverageGrantDateFairValueAbstract_fbf2ae56-08ed-4751-80a7-2e065468d6d2" xlink:to="loc_efr_ShareBasedCompensationArrangementByShareBasedPaymentAwardGrantedNonvestedWeightedAverageGrantDateFairValue_e249c41c-07a2-437a-bef8-6fff8c3e9e33" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedWeightedAverageGrantDateFairValue_56c29541-d8ae-4abf-b81b-3efbbcb11665" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedWeightedAverageGrantDateFairValueAbstract_fbf2ae56-08ed-4751-80a7-2e065468d6d2" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedWeightedAverageGrantDateFairValue_56c29541-d8ae-4abf-b81b-3efbbcb11665" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedOptionsForfeitedWeightedAverageGrantDateFairValue_5c16ff95-1d73-4fb4-86ee-b8a11b1f3010" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedOptionsForfeitedWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedWeightedAverageGrantDateFairValueAbstract_fbf2ae56-08ed-4751-80a7-2e065468d6d2" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedOptionsForfeitedWeightedAverageGrantDateFairValue_5c16ff95-1d73-4fb4-86ee-b8a11b1f3010" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_9be2fb93-cf00-4384-a0b7-02ab592429c0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_9ebaa197-c52e-4150-a2af-eea0f7f0775f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_acb4a076-4b19-40e3-aeed-d7c803d13be6" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_9ebaa197-c52e-4150-a2af-eea0f7f0775f" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_3fb1dc0d-d05f-4894-af58-40f688bd6fc8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_acb4a076-4b19-40e3-aeed-d7c803d13be6" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_3fb1dc0d-d05f-4894-af58-40f688bd6fc8" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_5081e30d-3e6e-42a6-9889-94d93521526f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_3fb1dc0d-d05f-4894-af58-40f688bd6fc8" xlink:to="loc_us-gaap_StatementClassOfStockAxis_5081e30d-3e6e-42a6-9889-94d93521526f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_5081e30d-3e6e-42a6-9889-94d93521526f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_5081e30d-3e6e-42a6-9889-94d93521526f" xlink:to="loc_us-gaap_ClassOfStockDomain_5081e30d-3e6e-42a6-9889-94d93521526f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_b339c787-0beb-4d43-96a9-a2613e4e0186" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_5081e30d-3e6e-42a6-9889-94d93521526f" xlink:to="loc_us-gaap_ClassOfStockDomain_b339c787-0beb-4d43-96a9-a2613e4e0186" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockOptionMember_b184a7c8-da6b-4214-8f96-1af99a4f67ab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_b339c787-0beb-4d43-96a9-a2613e4e0186" xlink:to="loc_us-gaap_StockOptionMember_b184a7c8-da6b-4214-8f96-1af99a4f67ab" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_f3a41e01-810a-4b12-a1ec-985386cb5cb3" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_3fb1dc0d-d05f-4894-af58-40f688bd6fc8" xlink:to="loc_srt_RangeAxis_f3a41e01-810a-4b12-a1ec-985386cb5cb3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_f3a41e01-810a-4b12-a1ec-985386cb5cb3_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_f3a41e01-810a-4b12-a1ec-985386cb5cb3" xlink:to="loc_srt_RangeMember_f3a41e01-810a-4b12-a1ec-985386cb5cb3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_54ff8fcf-7120-4a2d-9831-f3dddcc3e815" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_f3a41e01-810a-4b12-a1ec-985386cb5cb3" xlink:to="loc_srt_RangeMember_54ff8fcf-7120-4a2d-9831-f3dddcc3e815" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_8089a076-7ed5-429e-9f11-df29b1b02dcc" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_54ff8fcf-7120-4a2d-9831-f3dddcc3e815" xlink:to="loc_srt_MinimumMember_8089a076-7ed5-429e-9f11-df29b1b02dcc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_0c50521d-cac7-46df-ab17-e08e4c2f885f" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_54ff8fcf-7120-4a2d-9831-f3dddcc3e815" xlink:to="loc_srt_MaximumMember_0c50521d-cac7-46df-ab17-e08e4c2f885f" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.energyfuels.com/role/SHAREBASEDPAYMENTSScheduleofSharebasedCompensationRestrictedStockRestrictedStockUnitsActivityandSARsDetails" xlink:type="simple" xlink:href="efr-20220630.xsd#SHAREBASEDPAYMENTSScheduleofSharebasedCompensationRestrictedStockRestrictedStockUnitsActivityandSARsDetails"/>
  <link:definitionLink xlink:role="http://www.energyfuels.com/role/SHAREBASEDPAYMENTSScheduleofSharebasedCompensationRestrictedStockRestrictedStockUnitsActivityandSARsDetails" xlink:type="extended" id="iac932187f79648e7b82e5c8ae29a1324_SHAREBASEDPAYMENTSScheduleofSharebasedCompensationRestrictedStockRestrictedStockUnitsActivityandSARsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d666039d-8a00-428a-b033-74272aca94f1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_bd336118-1a66-4d06-9619-24178b5bc80d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d666039d-8a00-428a-b033-74272aca94f1" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_bd336118-1a66-4d06-9619-24178b5bc80d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedNumberOfSharesRollForward_b500b0de-3738-41e1-b9ae-31af56737439" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedNumberOfSharesRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d666039d-8a00-428a-b033-74272aca94f1" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedNumberOfSharesRollForward_b500b0de-3738-41e1-b9ae-31af56737439" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber_298c1b9c-4566-4b39-b650-30e307c8f96f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedNumberOfSharesRollForward_b500b0de-3738-41e1-b9ae-31af56737439" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber_298c1b9c-4566-4b39-b650-30e307c8f96f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_5ac395cd-1a2d-4fd8-b690-aaac43901efc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedNumberOfSharesRollForward_b500b0de-3738-41e1-b9ae-31af56737439" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_5ac395cd-1a2d-4fd8-b690-aaac43901efc" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_e6eb413d-282f-4f68-b692-32c61c5ce4a5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedNumberOfSharesRollForward_b500b0de-3738-41e1-b9ae-31af56737439" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_e6eb413d-282f-4f68-b692-32c61c5ce4a5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercised_73c35f97-243c-4a68-ae59-8b3cef45151a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedNumberOfSharesRollForward_b500b0de-3738-41e1-b9ae-31af56737439" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercised_73c35f97-243c-4a68-ae59-8b3cef45151a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_23573eb1-1c88-41ef-aff3-20ad65e8ebe9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedNumberOfSharesRollForward_b500b0de-3738-41e1-b9ae-31af56737439" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_23573eb1-1c88-41ef-aff3-20ad65e8ebe9" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber_e4fe0f1c-b77b-47d0-8f2e-ccb6d4edcb1f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedWeightedAverageGrantDateFairValueAbstract_17fc150c-3544-46d9-9d3e-d88417be7489" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedWeightedAverageGrantDateFairValueAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d666039d-8a00-428a-b033-74272aca94f1" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedWeightedAverageGrantDateFairValueAbstract_17fc150c-3544-46d9-9d3e-d88417be7489" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_2a970b2e-0e48-4ffb-9033-5c3eee596987" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedWeightedAverageGrantDateFairValueAbstract_17fc150c-3544-46d9-9d3e-d88417be7489" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_2a970b2e-0e48-4ffb-9033-5c3eee596987" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_2f2dd68f-31e4-4691-8227-2877ef552aab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedWeightedAverageGrantDateFairValueAbstract_17fc150c-3544-46d9-9d3e-d88417be7489" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_2f2dd68f-31e4-4691-8227-2877ef552aab" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisedWeightedAverageExercisePrice_a20e633a-f5c9-488d-90c3-0db2a87dc3d7" xlink:href="efr-20220630.xsd#efr_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisedWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedWeightedAverageGrantDateFairValueAbstract_17fc150c-3544-46d9-9d3e-d88417be7489" xlink:to="loc_efr_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisedWeightedAverageExercisePrice_a20e633a-f5c9-488d-90c3-0db2a87dc3d7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_3d543f52-7ed9-4bed-8c19-c8b87494fa09" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedWeightedAverageGrantDateFairValueAbstract_17fc150c-3544-46d9-9d3e-d88417be7489" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_3d543f52-7ed9-4bed-8c19-c8b87494fa09" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_fe306fb8-4f34-4908-9dcb-dbb935d9bd53" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedWeightedAverageGrantDateFairValueAbstract_17fc150c-3544-46d9-9d3e-d88417be7489" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_fe306fb8-4f34-4908-9dcb-dbb935d9bd53" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_fb674600-3d16-4c81-972a-a3cd39b677bc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_UnrecognizedCompensationCostsRelatedToUnvestedStockOptions_decc2605-a067-44ab-ab11-0b02fce5f07a" xlink:href="efr-20220630.xsd#efr_UnrecognizedCompensationCostsRelatedToUnvestedStockOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d666039d-8a00-428a-b033-74272aca94f1" xlink:to="loc_efr_UnrecognizedCompensationCostsRelatedToUnvestedStockOptions_decc2605-a067-44ab-ab11-0b02fce5f07a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_UnrecognizedCompensationCostsRelatedToRSUAwards_8c9c2534-db65-4c9d-8c4b-91d7195a33e9" xlink:href="efr-20220630.xsd#efr_UnrecognizedCompensationCostsRelatedToRSUAwards"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d666039d-8a00-428a-b033-74272aca94f1" xlink:to="loc_efr_UnrecognizedCompensationCostsRelatedToRSUAwards_8c9c2534-db65-4c9d-8c4b-91d7195a33e9" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercisableNumber_6b37a6e6-599c-4192-a090-3036d3d28583" xlink:href="efr-20220630.xsd#efr_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercisableNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d666039d-8a00-428a-b033-74272aca94f1" xlink:to="loc_efr_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercisableNumber_6b37a6e6-599c-4192-a090-3036d3d28583" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercisableWeightedAverageExercisePrice_126c09ff-dc14-4558-a8bc-e521a233adf2" xlink:href="efr-20220630.xsd#efr_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercisableWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d666039d-8a00-428a-b033-74272aca94f1" xlink:to="loc_efr_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercisableWeightedAverageExercisePrice_126c09ff-dc14-4558-a8bc-e521a233adf2" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsOutstandingWeightedAverageRemainingContractualTerms_36c7a899-c69a-44fc-be61-63cbcb0219b1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsOutstandingWeightedAverageRemainingContractualTerms"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d666039d-8a00-428a-b033-74272aca94f1" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsOutstandingWeightedAverageRemainingContractualTerms_36c7a899-c69a-44fc-be61-63cbcb0219b1" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercisableWeightedAverageRemainingContractualTerm_717f4c78-3323-4f39-9c37-be68a57cd844" xlink:href="efr-20220630.xsd#efr_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercisableWeightedAverageRemainingContractualTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d666039d-8a00-428a-b033-74272aca94f1" xlink:to="loc_efr_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercisableWeightedAverageRemainingContractualTerm_717f4c78-3323-4f39-9c37-be68a57cd844" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueOutstanding_59c90747-59e2-4c5f-b98f-90e9b1694642" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d666039d-8a00-428a-b033-74272aca94f1" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueOutstanding_59c90747-59e2-4c5f-b98f-90e9b1694642" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercisableAggregateIntrinsicValue_9851c276-a0f1-4a0d-8b61-261bf9dea54d" xlink:href="efr-20220630.xsd#efr_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercisableAggregateIntrinsicValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d666039d-8a00-428a-b033-74272aca94f1" xlink:to="loc_efr_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercisableAggregateIntrinsicValue_9851c276-a0f1-4a0d-8b61-261bf9dea54d" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_989a3d47-08cb-4410-bdf4-629b414245d3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d666039d-8a00-428a-b033-74272aca94f1" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_989a3d47-08cb-4410-bdf4-629b414245d3" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_88b8eeb3-6da1-4b5d-a41d-0a6272c09c4f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d666039d-8a00-428a-b033-74272aca94f1" xlink:to="loc_us-gaap_CommonStockSharesIssued_88b8eeb3-6da1-4b5d-a41d-0a6272c09c4f" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_d8cecb1e-59e0-47c6-ba79-e346c7ee620a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d666039d-8a00-428a-b033-74272aca94f1" xlink:to="loc_us-gaap_CommonStockValue_d8cecb1e-59e0-47c6-ba79-e346c7ee620a" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_f0f48fc3-06a9-48ce-9698-29e0092b6790" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d666039d-8a00-428a-b033-74272aca94f1" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_f0f48fc3-06a9-48ce-9698-29e0092b6790" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_ed8b9920-15b8-456c-a9b7-f46a0f84efaf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_f0f48fc3-06a9-48ce-9698-29e0092b6790" xlink:to="loc_us-gaap_AwardTypeAxis_ed8b9920-15b8-456c-a9b7-f46a0f84efaf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_ed8b9920-15b8-456c-a9b7-f46a0f84efaf_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_ed8b9920-15b8-456c-a9b7-f46a0f84efaf" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_ed8b9920-15b8-456c-a9b7-f46a0f84efaf_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_04c7fd27-2cec-43a2-9096-610a320dfb51" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_ed8b9920-15b8-456c-a9b7-f46a0f84efaf" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_04c7fd27-2cec-43a2-9096-610a320dfb51" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_f942d337-b2a2-4922-be0a-385ac40c8213" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_04c7fd27-2cec-43a2-9096-610a320dfb51" xlink:to="loc_us-gaap_EmployeeStockOptionMember_f942d337-b2a2-4922-be0a-385ac40c8213" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_442e8028-c840-4407-8d61-ea70c0a5d2cc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_04c7fd27-2cec-43a2-9096-610a320dfb51" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_442e8028-c840-4407-8d61-ea70c0a5d2cc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockAppreciationRightsSARSMember_bf509ba2-772f-474e-aa87-f79c7a13c42b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockAppreciationRightsSARSMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_04c7fd27-2cec-43a2-9096-610a320dfb51" xlink:to="loc_us-gaap_StockAppreciationRightsSARSMember_bf509ba2-772f-474e-aa87-f79c7a13c42b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_1a9478c2-0f4a-4981-85e2-0de60384f38e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_f0f48fc3-06a9-48ce-9698-29e0092b6790" xlink:to="loc_us-gaap_StatementClassOfStockAxis_1a9478c2-0f4a-4981-85e2-0de60384f38e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_1a9478c2-0f4a-4981-85e2-0de60384f38e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_1a9478c2-0f4a-4981-85e2-0de60384f38e" xlink:to="loc_us-gaap_ClassOfStockDomain_1a9478c2-0f4a-4981-85e2-0de60384f38e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_5b382d33-fe3c-4e9c-adcf-903b82a9e849" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_1a9478c2-0f4a-4981-85e2-0de60384f38e" xlink:to="loc_us-gaap_ClassOfStockDomain_5b382d33-fe3c-4e9c-adcf-903b82a9e849" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockOptionMember_9b792538-ca83-4827-8f59-4a8ff25d4fd9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_5b382d33-fe3c-4e9c-adcf-903b82a9e849" xlink:to="loc_us-gaap_StockOptionMember_9b792538-ca83-4827-8f59-4a8ff25d4fd9" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.energyfuels.com/role/SHAREBASEDPAYMENTSScheduleofSharebasedPaymentSARsValuationAssumptionsDetails" xlink:type="simple" xlink:href="efr-20220630.xsd#SHAREBASEDPAYMENTSScheduleofSharebasedPaymentSARsValuationAssumptionsDetails"/>
  <link:definitionLink xlink:role="http://www.energyfuels.com/role/SHAREBASEDPAYMENTSScheduleofSharebasedPaymentSARsValuationAssumptionsDetails" xlink:type="extended" id="i917abafe53004e1eb03981085b806ba3_SHAREBASEDPAYMENTSScheduleofSharebasedPaymentSARsValuationAssumptionsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_2c4e7d58-6b0c-4482-9b47-8bf847fddbe9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_a57cd15b-a6ef-404f-98a1-dd40a91cb96a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_2c4e7d58-6b0c-4482-9b47-8bf847fddbe9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_a57cd15b-a6ef-404f-98a1-dd40a91cb96a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_6a0cbd8d-5f68-4aa6-b4b2-3f9db1015090" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_2c4e7d58-6b0c-4482-9b47-8bf847fddbe9" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_6a0cbd8d-5f68-4aa6-b4b2-3f9db1015090" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_7d3d8118-8b88-472c-a884-a618ceefb7b0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_2c4e7d58-6b0c-4482-9b47-8bf847fddbe9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_7d3d8118-8b88-472c-a884-a618ceefb7b0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_5681b6c8-8683-4baa-8d0c-46a107d98a47" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_2c4e7d58-6b0c-4482-9b47-8bf847fddbe9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_5681b6c8-8683-4baa-8d0c-46a107d98a47" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_f2c8b5e8-9c45-4a43-bacb-c824d08bcfa7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_2c4e7d58-6b0c-4482-9b47-8bf847fddbe9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_f2c8b5e8-9c45-4a43-bacb-c824d08bcfa7" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_05d37f40-0c57-49ca-9e13-e35343727396" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_2c4e7d58-6b0c-4482-9b47-8bf847fddbe9" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_05d37f40-0c57-49ca-9e13-e35343727396" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_1dcc0436-f367-4fc8-a4cf-ae25aaa43b9a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_05d37f40-0c57-49ca-9e13-e35343727396" xlink:to="loc_us-gaap_AwardTypeAxis_1dcc0436-f367-4fc8-a4cf-ae25aaa43b9a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_1dcc0436-f367-4fc8-a4cf-ae25aaa43b9a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_1dcc0436-f367-4fc8-a4cf-ae25aaa43b9a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_1dcc0436-f367-4fc8-a4cf-ae25aaa43b9a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_9617a8de-d97a-4331-865d-537c44d70061" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_1dcc0436-f367-4fc8-a4cf-ae25aaa43b9a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_9617a8de-d97a-4331-865d-537c44d70061" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockAppreciationRightsSARSMember_d343631d-2cb5-422d-805a-4fe2e4e5f1d4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockAppreciationRightsSARSMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_9617a8de-d97a-4331-865d-537c44d70061" xlink:to="loc_us-gaap_StockAppreciationRightsSARSMember_d343631d-2cb5-422d-805a-4fe2e4e5f1d4" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.energyfuels.com/role/SUPPLEMENTALFINANCIALINFORMATIONNarrativeDetails" xlink:type="simple" xlink:href="efr-20220630.xsd#SUPPLEMENTALFINANCIALINFORMATIONNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.energyfuels.com/role/SUPPLEMENTALFINANCIALINFORMATIONNarrativeDetails" xlink:type="extended" id="i426afacf5a9c468ebd1cc6c6c5d8be77_SUPPLEMENTALFINANCIALINFORMATIONNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionLineItems_3ff2b7ab-21f2-492d-9c1e-c6b0548d95aa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RelatedPartyTransactionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_AccountsAndOtherReceivablesNet_0dab908a-360f-46f7-8840-24d5daa854c7" xlink:href="efr-20220630.xsd#efr_AccountsAndOtherReceivablesNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_3ff2b7ab-21f2-492d-9c1e-c6b0548d95aa" xlink:to="loc_efr_AccountsAndOtherReceivablesNet_0dab908a-360f-46f7-8840-24d5daa854c7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_79870340-deab-4fd3-8f2d-deacf3d88e1d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_3ff2b7ab-21f2-492d-9c1e-c6b0548d95aa" xlink:to="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_79870340-deab-4fd3-8f2d-deacf3d88e1d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_1b2aba78-2c22-44a0-921a-bd0f26026d4b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_79870340-deab-4fd3-8f2d-deacf3d88e1d" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_1b2aba78-2c22-44a0-921a-bd0f26026d4b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_1b2aba78-2c22-44a0-921a-bd0f26026d4b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_1b2aba78-2c22-44a0-921a-bd0f26026d4b" xlink:to="loc_us-gaap_RelatedPartyDomain_1b2aba78-2c22-44a0-921a-bd0f26026d4b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_25877d36-a012-4d17-adf3-c4e459c4c26d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_1b2aba78-2c22-44a0-921a-bd0f26026d4b" xlink:to="loc_us-gaap_RelatedPartyDomain_25877d36-a012-4d17-adf3-c4e459c4c26d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_ConsolidatedUraniumIncMember_276791f1-3e87-4944-b4c5-8ccd9c7be1eb" xlink:href="efr-20220630.xsd#efr_ConsolidatedUraniumIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_25877d36-a012-4d17-adf3-c4e459c4c26d" xlink:to="loc_efr_ConsolidatedUraniumIncMember_276791f1-3e87-4944-b4c5-8ccd9c7be1eb" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.energyfuels.com/role/COMMITMENTSANDCONTINGENCIESNarrativeDetails" xlink:type="simple" xlink:href="efr-20220630.xsd#COMMITMENTSANDCONTINGENCIESNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.energyfuels.com/role/COMMITMENTSANDCONTINGENCIESNarrativeDetails" xlink:type="extended" id="ie51dabb1ee4d4cb9b479a5a6c29ba09d_COMMITMENTSANDCONTINGENCIESNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCommitmentsLineItems_c243de59-feb8-4d48-9a3b-3dc762fc5e25" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherCommitmentsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyEstimateOfPossibleLoss_f3bb40ce-e3a2-410e-b02b-763f963979d8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingencyEstimateOfPossibleLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherCommitmentsLineItems_c243de59-feb8-4d48-9a3b-3dc762fc5e25" xlink:to="loc_us-gaap_LossContingencyEstimateOfPossibleLoss_f3bb40ce-e3a2-410e-b02b-763f963979d8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetRetirementObligation_11729ace-d93a-4365-8822-80530f268925" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetRetirementObligation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherCommitmentsLineItems_c243de59-feb8-4d48-9a3b-3dc762fc5e25" xlink:to="loc_us-gaap_AssetRetirementObligation_11729ace-d93a-4365-8822-80530f268925" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCommitmentsTable_b3769fcc-2223-483b-a7b0-5fe93f3a7424" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherCommitmentsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_OtherCommitmentsLineItems_c243de59-feb8-4d48-9a3b-3dc762fc5e25" xlink:to="loc_us-gaap_OtherCommitmentsTable_b3769fcc-2223-483b-a7b0-5fe93f3a7424" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_667e6fce-2efb-4795-85e6-bfcb64c9d113" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingenciesByNatureOfContingencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OtherCommitmentsTable_b3769fcc-2223-483b-a7b0-5fe93f3a7424" xlink:to="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_667e6fce-2efb-4795-85e6-bfcb64c9d113" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNatureDomain_667e6fce-2efb-4795-85e6-bfcb64c9d113_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_667e6fce-2efb-4795-85e6-bfcb64c9d113" xlink:to="loc_us-gaap_LossContingencyNatureDomain_667e6fce-2efb-4795-85e6-bfcb64c9d113_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNatureDomain_7eb5cc0f-2846-491a-8f9a-64353c6c4fe3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_667e6fce-2efb-4795-85e6-bfcb64c9d113" xlink:to="loc_us-gaap_LossContingencyNatureDomain_7eb5cc0f-2846-491a-8f9a-64353c6c4fe3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_CanyonProjectMember_c6e6d242-70cb-4d7c-acc5-46f1fcc69bb7" xlink:href="efr-20220630.xsd#efr_CanyonProjectMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingencyNatureDomain_7eb5cc0f-2846-491a-8f9a-64353c6c4fe3" xlink:to="loc_efr_CanyonProjectMember_c6e6d242-70cb-4d7c-acc5-46f1fcc69bb7" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.energyfuels.com/role/RELATEDPARTYTRANSACTIONSDetails" xlink:type="simple" xlink:href="efr-20220630.xsd#RELATEDPARTYTRANSACTIONSDetails"/>
  <link:definitionLink xlink:role="http://www.energyfuels.com/role/RELATEDPARTYTRANSACTIONSDetails" xlink:type="extended" id="i15100506ae724bd1832c9556af87fe53_RELATEDPARTYTRANSACTIONSDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionLineItems_bcd95e62-ec86-4493-9244-bd6cdd8d28b7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RelatedPartyTransactionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_3c990021-ac5f-4b0e-be5c-97878b03d22d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_bcd95e62-ec86-4493-9244-bd6cdd8d28b7" xlink:to="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_3c990021-ac5f-4b0e-be5c-97878b03d22d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromContributedCapital_19088b13-6fab-4ce2-b78e-821689cd5f7b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromContributedCapital"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_bcd95e62-ec86-4493-9244-bd6cdd8d28b7" xlink:to="loc_us-gaap_ProceedsFromContributedCapital_19088b13-6fab-4ce2-b78e-821689cd5f7b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_LessorOperatingLeaseAnnualLeaseExpense_21a97a1c-c751-4e54-9cb8-69490df8b69c" xlink:href="efr-20220630.xsd#efr_LessorOperatingLeaseAnnualLeaseExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_bcd95e62-ec86-4493-9244-bd6cdd8d28b7" xlink:to="loc_efr_LessorOperatingLeaseAnnualLeaseExpense_21a97a1c-c751-4e54-9cb8-69490df8b69c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_LessorOperatingLeaseMonthlyLeasePayment_0de89d20-3a8d-4127-b09f-bf277993b788" xlink:href="efr-20220630.xsd#efr_LessorOperatingLeaseMonthlyLeasePayment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_bcd95e62-ec86-4493-9244-bd6cdd8d28b7" xlink:to="loc_efr_LessorOperatingLeaseMonthlyLeasePayment_0de89d20-3a8d-4127-b09f-bf277993b788" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_RoyaltyPercentageofMineralsRecoveredSoldUnderMinimumPriceThreshold_4fcb026b-fa7c-475a-bc43-1de843c10047" xlink:href="efr-20220630.xsd#efr_RoyaltyPercentageofMineralsRecoveredSoldUnderMinimumPriceThreshold"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_bcd95e62-ec86-4493-9244-bd6cdd8d28b7" xlink:to="loc_efr_RoyaltyPercentageofMineralsRecoveredSoldUnderMinimumPriceThreshold_4fcb026b-fa7c-475a-bc43-1de843c10047" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_MineralPricePerPoundLowRange_57e42a70-e668-4e9e-b705-109410f29109" xlink:href="efr-20220630.xsd#efr_MineralPricePerPoundLowRange"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_bcd95e62-ec86-4493-9244-bd6cdd8d28b7" xlink:to="loc_efr_MineralPricePerPoundLowRange_57e42a70-e668-4e9e-b705-109410f29109" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_RoyaltyPercentageofMineralsRecoveredSoldBetweenPriceThresholds_5c878ce2-4f7c-4fcc-8305-65757d5cd058" xlink:href="efr-20220630.xsd#efr_RoyaltyPercentageofMineralsRecoveredSoldBetweenPriceThresholds"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_bcd95e62-ec86-4493-9244-bd6cdd8d28b7" xlink:to="loc_efr_RoyaltyPercentageofMineralsRecoveredSoldBetweenPriceThresholds_5c878ce2-4f7c-4fcc-8305-65757d5cd058" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_MineralPricePerPoundUpperRange_c2e263aa-4f10-42e2-8518-1bdf8bb323f6" xlink:href="efr-20220630.xsd#efr_MineralPricePerPoundUpperRange"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_bcd95e62-ec86-4493-9244-bd6cdd8d28b7" xlink:to="loc_efr_MineralPricePerPoundUpperRange_c2e263aa-4f10-42e2-8518-1bdf8bb323f6" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_RoyaltyPercentageofMineralsRecoveredSoldAboveMaximumPriceThreshold_573f5d59-b47e-43a6-b313-f59c5d3414ca" xlink:href="efr-20220630.xsd#efr_RoyaltyPercentageofMineralsRecoveredSoldAboveMaximumPriceThreshold"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_bcd95e62-ec86-4493-9244-bd6cdd8d28b7" xlink:to="loc_efr_RoyaltyPercentageofMineralsRecoveredSoldAboveMaximumPriceThreshold_573f5d59-b47e-43a6-b313-f59c5d3414ca" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_TestingPermitandLeaseOptionAgreementAccruedLiability_80ddba70-7058-40ee-899b-60106fd1969e" xlink:href="efr-20220630.xsd#efr_TestingPermitandLeaseOptionAgreementAccruedLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_bcd95e62-ec86-4493-9244-bd6cdd8d28b7" xlink:to="loc_efr_TestingPermitandLeaseOptionAgreementAccruedLiability_80ddba70-7058-40ee-899b-60106fd1969e" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableRelatedParties_d554eaac-633f-4cef-a69e-b2f78a57f124" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsReceivableRelatedParties"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_bcd95e62-ec86-4493-9244-bd6cdd8d28b7" xlink:to="loc_us-gaap_AccountsReceivableRelatedParties_d554eaac-633f-4cef-a69e-b2f78a57f124" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_7cb533eb-0d08-49e6-9c88-310fb0d5c23b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_bcd95e62-ec86-4493-9244-bd6cdd8d28b7" xlink:to="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_7cb533eb-0d08-49e6-9c88-310fb0d5c23b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_b034cbb4-1719-45b0-ae0a-7e8baeb76b83" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_7cb533eb-0d08-49e6-9c88-310fb0d5c23b" xlink:to="loc_dei_LegalEntityAxis_b034cbb4-1719-45b0-ae0a-7e8baeb76b83" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_b034cbb4-1719-45b0-ae0a-7e8baeb76b83_default" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_b034cbb4-1719-45b0-ae0a-7e8baeb76b83" xlink:to="loc_dei_EntityDomain_b034cbb4-1719-45b0-ae0a-7e8baeb76b83_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_f854cf45-9dff-4e1d-a866-1aa02556aee9" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_b034cbb4-1719-45b0-ae0a-7e8baeb76b83" xlink:to="loc_dei_EntityDomain_f854cf45-9dff-4e1d-a866-1aa02556aee9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_UnitedNuclearMember_2c38ebae-4340-4560-8600-914e8628ec7a" xlink:href="efr-20220630.xsd#efr_UnitedNuclearMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_f854cf45-9dff-4e1d-a866-1aa02556aee9" xlink:to="loc_efr_UnitedNuclearMember_2c38ebae-4340-4560-8600-914e8628ec7a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_74c31156-fb64-4822-93cf-1064f6c986f6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_7cb533eb-0d08-49e6-9c88-310fb0d5c23b" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_74c31156-fb64-4822-93cf-1064f6c986f6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_74c31156-fb64-4822-93cf-1064f6c986f6_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_74c31156-fb64-4822-93cf-1064f6c986f6" xlink:to="loc_us-gaap_RelatedPartyDomain_74c31156-fb64-4822-93cf-1064f6c986f6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_5a7571f7-7fd3-447f-bba9-c803ca2f2f49" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_74c31156-fb64-4822-93cf-1064f6c986f6" xlink:to="loc_us-gaap_RelatedPartyDomain_5a7571f7-7fd3-447f-bba9-c803ca2f2f49" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_DirectorMember_8612e843-bbe4-41d0-a15d-5e3f06407c4e" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_DirectorMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_5a7571f7-7fd3-447f-bba9-c803ca2f2f49" xlink:to="loc_srt_DirectorMember_8612e843-bbe4-41d0-a15d-5e3f06407c4e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_83e3bfa6-0768-4384-8d95-40c8f299181f" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_7cb533eb-0d08-49e6-9c88-310fb0d5c23b" xlink:to="loc_srt_CounterpartyNameAxis_83e3bfa6-0768-4384-8d95-40c8f299181f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_83e3bfa6-0768-4384-8d95-40c8f299181f_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_83e3bfa6-0768-4384-8d95-40c8f299181f" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_83e3bfa6-0768-4384-8d95-40c8f299181f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_49011f52-211f-4423-a466-7d30b4ee4d3c" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_83e3bfa6-0768-4384-8d95-40c8f299181f" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_49011f52-211f-4423-a466-7d30b4ee4d3c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_LeoncitoProjectL.L.C.Member_8fcebd32-b0b3-455e-b989-2790ee2aff06" xlink:href="efr-20220630.xsd#efr_LeoncitoProjectL.L.C.Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_49011f52-211f-4423-a466-7d30b4ee4d3c" xlink:to="loc_efr_LeoncitoProjectL.L.C.Member_8fcebd32-b0b3-455e-b989-2790ee2aff06" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.energyfuels.com/role/FAIRVALUEACCOUNTINGFairValueMeasurementsRecurringandNonrecurringDetails" xlink:type="simple" xlink:href="efr-20220630.xsd#FAIRVALUEACCOUNTINGFairValueMeasurementsRecurringandNonrecurringDetails"/>
  <link:definitionLink xlink:role="http://www.energyfuels.com/role/FAIRVALUEACCOUNTINGFairValueMeasurementsRecurringandNonrecurringDetails" xlink:type="extended" id="ib8dc99200b964b6f82e03faa2de0e3bc_FAIRVALUEACCOUNTINGFairValueMeasurementsRecurringandNonrecurringDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5b888397-e235-4b28-be91-0263a2a88e6b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsFairValueDisclosure_af621a12-8934-4c36-8b6a-eedc99f830a9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5b888397-e235-4b28-be91-0263a2a88e6b" xlink:to="loc_us-gaap_InvestmentsFairValueDisclosure_af621a12-8934-4c36-8b6a-eedc99f830a9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueNetAssetLiability_dd62fa0b-6d1a-482f-b6f9-dc733ecef4f2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueNetAssetLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5b888397-e235-4b28-be91-0263a2a88e6b" xlink:to="loc_us-gaap_FairValueNetAssetLiability_dd62fa0b-6d1a-482f-b6f9-dc733ecef4f2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_PercentageOfFairValueInvestment_40faf04f-0c38-4ee6-8ee7-a1cd90abb553" xlink:href="efr-20220630.xsd#efr_PercentageOfFairValueInvestment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5b888397-e235-4b28-be91-0263a2a88e6b" xlink:to="loc_efr_PercentageOfFairValueInvestment_40faf04f-0c38-4ee6-8ee7-a1cd90abb553" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_314f784a-0f30-4b22-bef0-da19085f6cdd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_5b888397-e235-4b28-be91-0263a2a88e6b" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_314f784a-0f30-4b22-bef0-da19085f6cdd" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_4dddc8b2-f3f8-431b-927c-b2cff741178c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_314f784a-0f30-4b22-bef0-da19085f6cdd" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_4dddc8b2-f3f8-431b-927c-b2cff741178c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_4dddc8b2-f3f8-431b-927c-b2cff741178c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_4dddc8b2-f3f8-431b-927c-b2cff741178c" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_4dddc8b2-f3f8-431b-927c-b2cff741178c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_cd5bcabe-5e5f-4e93-85f9-66cc1699f728" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_4dddc8b2-f3f8-431b-927c-b2cff741178c" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_cd5bcabe-5e5f-4e93-85f9-66cc1699f728" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_e3988f48-a317-41b6-b225-d6f63f1c2d0e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_cd5bcabe-5e5f-4e93-85f9-66cc1699f728" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_e3988f48-a317-41b6-b225-d6f63f1c2d0e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_62a06f47-d2f9-48d6-a657-d94ee30bb589" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_cd5bcabe-5e5f-4e93-85f9-66cc1699f728" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_62a06f47-d2f9-48d6-a657-d94ee30bb589" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_ee01c986-652f-443f-94bc-2bf161861171" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_cd5bcabe-5e5f-4e93-85f9-66cc1699f728" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_ee01c986-652f-443f-94bc-2bf161861171" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_47f7f06f-4fa9-4f5e-9f26-eae5c3a14cd8" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_314f784a-0f30-4b22-bef0-da19085f6cdd" xlink:to="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_47f7f06f-4fa9-4f5e-9f26-eae5c3a14cd8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_47f7f06f-4fa9-4f5e-9f26-eae5c3a14cd8_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_47f7f06f-4fa9-4f5e-9f26-eae5c3a14cd8" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_47f7f06f-4fa9-4f5e-9f26-eae5c3a14cd8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_37b79f9a-9d9e-4cb2-ba7f-ee2c2bc997be" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_47f7f06f-4fa9-4f5e-9f26-eae5c3a14cd8" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_37b79f9a-9d9e-4cb2-ba7f-ee2c2bc997be" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_VirginiaEnergyResourcesIncMember_0e97bcda-757c-4a7d-bc41-ef7db4ee30f3" xlink:href="efr-20220630.xsd#efr_VirginiaEnergyResourcesIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_37b79f9a-9d9e-4cb2-ba7f-ee2c2bc997be" xlink:to="loc_efr_VirginiaEnergyResourcesIncMember_0e97bcda-757c-4a7d-bc41-ef7db4ee30f3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_efr_ConsolidatedUraniumIncMember_b5f1ad05-f022-4d8e-97a3-0a743c6e5f72" xlink:href="efr-20220630.xsd#efr_ConsolidatedUraniumIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_37b79f9a-9d9e-4cb2-ba7f-ee2c2bc997be" xlink:to="loc_efr_ConsolidatedUraniumIncMember_b5f1ad05-f022-4d8e-97a3-0a743c6e5f72" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeAxis_adea1875-c604-4d74-950f-c797c3a97240" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_314f784a-0f30-4b22-bef0-da19085f6cdd" xlink:to="loc_us-gaap_InvestmentTypeAxis_adea1875-c604-4d74-950f-c797c3a97240" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_adea1875-c604-4d74-950f-c797c3a97240_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_InvestmentTypeAxis_adea1875-c604-4d74-950f-c797c3a97240" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_adea1875-c604-4d74-950f-c797c3a97240_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_a42a3ad7-14fe-44aa-b872-583dbf301dbe" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_InvestmentTypeAxis_adea1875-c604-4d74-950f-c797c3a97240" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_a42a3ad7-14fe-44aa-b872-583dbf301dbe" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesMember_60a02422-ca7d-46b0-bc77-6d5b7e2a455e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquitySecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_a42a3ad7-14fe-44aa-b872-583dbf301dbe" xlink:to="loc_us-gaap_EquitySecuritiesMember_60a02422-ca7d-46b0-bc77-6d5b7e2a455e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesMember_497b97be-72c0-4a14-8d5b-1883b33cc848" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_a42a3ad7-14fe-44aa-b872-583dbf301dbe" xlink:to="loc_us-gaap_DebtSecuritiesMember_497b97be-72c0-4a14-8d5b-1883b33cc848" xlink:type="arc" order="1"/>
  </link:definitionLink>
</link:linkbase>
