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Acquisitions (Details) - USD ($) $ in Thousands |  |  | 1 Months Ended | 3 Months Ended | 12 Months Ended
--- | --- | --- | --- | --- | ---
Jul. 05, 2016 | Sep. 30, 2015 | Apr. 30, 2016 | Nov. 30, 2013 | Jun. 30, 2016 | Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Acquisitions |  |  |  |  |  |  |  |
Contingent consideration payable |  |  |  |  |  | $ 269,722 | $ 274,077 |
Contingent consideration payable, current portion |  |  |  |  |  | 56,101 | 41,400 |
Changes in fair value of contingent consideration payable |  |  |  |  |  | 6,760 | 4,377 | $ 100
Payment of contingent consideration in stock, impact on stockholder's equity |  |  |  |  |  | 6,115 |  |
Scioderm |  |  |  |  |  |  |  |
Acquisitions |  |  |  |  |  |  |  |
Initial amount to Effective Time Holders |  | $ 223,900 |  |  |  |  |  |
Initial amount cash payment excluding Series B Preferred |  | 141,100 |  |  |  |  |  |
Initial amount paid in shares of Common Stock |  | $ 82,800 |  |  |  |  |  |
Priority review voucher transfer years |  | 1 year |  |  |  |  |  |
Payment to be made if Priority Review Voucher is obtained and used |  | $ 100,000 |  |  |  |  |  |
Contingent consideration payable |  | 259,000 |  |  |  | 260,000 |  |
Contingent consideration payable, current portion |  |  |  |  |  | 56,100 |  |
Scioderm | Changes in fair value of contingent consideration payable |  |  |  |  |  |  |  |
Acquisitions |  |  |  |  |  |  |  |
Changes in fair value of contingent consideration payable |  |  |  |  |  | 7,300 |  |
Scioderm | IPR&D |  |  |  |  |  |  |  |
Acquisitions |  |  |  |  |  |  |  |
Intangible assets-IPR&D |  |  |  |  |  |  | $ 463,700 |
Scioderm | Maximum |  |  |  |  |  |  |  |
Acquisitions |  |  |  |  |  |  |  |
Priority Review Voucher sale proceeds shared |  | $ 100,000 |  |  |  |  |  |
Priority Review Voucher sale proceeds shared (as a percent) |  | 50.00% |  |  |  |  |  |
Scioderm | Scioderm | Series B Preferred Stock |  |  |  |  |  |  |  |
Acquisitions |  |  |  |  |  |  |  |
Consideration paid in common stock |  | 5,900,000 |  |  |  |  |  |
Callidus |  |  |  |  |  |  |  |
Acquisitions |  |  |  |  |  |  |  |
Contingent consideration payable |  |  |  | $ 10,600 |  | 9,700 |  |
Discount rate (as a percent) |  |  |  | 13.50% |  |  |  |
Milestone payment, value of shares issued |  |  |  |  | $ 6,000 |  |  |
Payment of contingent consideration in stock, impact on stockholder's equity |  |  |  |  | 6,100 |  |  |
Callidus | Changes in fair value of contingent consideration payable |  |  |  |  |  |  |  |
Acquisitions |  |  |  |  |  |  |  |
Changes in fair value of contingent consideration payable |  |  |  |  |  | (500) |  |
MiaMed Inc |  |  |  |  |  |  |  |
Acquisitions |  |  |  |  |  |  |  |
Total consideration, stock and cash | $ 6,500 |  |  |  |  |  |  |
Cash consideration paid | 1,800 |  |  |  |  |  |  |
Contingent consideration payable upon achievement of milestones | 83,000 |  |  |  |  |  |  |
Potential aggregate deal value | 89,500 |  |  |  |  |  |  |
Research and development expense | $ 6,500 |  |  |  |  |  |  |
MiaMed Inc | Amicus | Common Stock |  |  |  |  |  |  |  |
Acquisitions |  |  |  |  |  |  |  |
Consideration paid in common stock | 825,603 |  |  |  |  |  |  |
Clinical, Regulatory and Commercial milestones | MiaMed Inc | Maximum |  |  |  |  |  |  |  |
Acquisitions |  |  |  |  |  |  |  |
Contingent consideration payable upon achievement of milestones | $ 83,000 |  |  |  |  |  |  |
Clinical and Regulatory Approval milestones | Scioderm |  |  |  |  |  |  |  |
Acquisitions |  |  |  |  |  |  |  |
Contingent consideration payable |  |  |  |  |  | 237,200 |  |
Milestone payment |  |  |  |  | $ 5,000 |  |  |
Clinical and Regulatory Approval milestones | Scioderm | Minimum |  |  |  |  |  |  |  |
Acquisitions |  |  |  |  |  |  |  |
Discount rate (as a percent) |  | 0.40% |  |  |  |  |  |
Clinical and Regulatory Approval milestones | Scioderm | Maximum |  |  |  |  |  |  |  |
Acquisitions |  |  |  |  |  |  |  |
Upfront cash payments |  | $ 361,000 | $ 361,000 |  |  |  |  |
Discount rate (as a percent) |  | 1.10% |  |  |  |  |  |
Clinical and Regulatory Approval milestones | Callidus |  |  |  |  |  |  |  |
Acquisitions |  |  |  |  |  |  |  |
Contingent consideration payable |  |  |  |  |  | 9,300 |  |
Revenue-based milestones | Scioderm |  |  |  |  |  |  |  |
Acquisitions |  |  |  |  |  |  |  |
Upfront equity payments |  | $ 257,000 |  |  |  |  |  |
Contingent consideration payable |  |  |  |  |  | 22,800 |  |
Revenue-based milestones | Scioderm | Minimum |  |  |  |  |  |  |  |
Acquisitions |  |  |  |  |  |  |  |
Discount rate (as a percent) |  | 1.00% |  |  |  |  |  |
Revenue-based milestones | Scioderm | Maximum |  |  |  |  |  |  |  |
Acquisitions |  |  |  |  |  |  |  |
Upfront equity payments |  |  |  |  |  | $ 257,000 |  |
Discount rate (as a percent) |  | 2.20% |  |  |  |  |  |
Clinical milestone | Scioderm | Maximum |  |  |  |  |  |  |  |
Acquisitions |  |  |  |  |  |  |  |
Upfront cash payments |  |  | 81,000 |  |  |  |  |
Regulatory Approval milestone | Scioderm | Maximum |  |  |  |  |  |  |  |
Acquisitions |  |  |  |  |  |  |  |
Upfront cash payments |  |  | $ 280,000 |  |  |  |  |

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