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v3.6.0.2

Consolidated Statements of Operations - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Revenue: |  |  |
Net Product Sales | $ 4,958 |  |
Research revenue |  |  | $ 1,224
Total revenue | 4,958 |  | 1,224
Cost of goods sold | 833 |  |
Gross Profit | 4,125 |  | 1,224
Operating Expenses: |  |  |
Research and development | 104,793 | $ 76,943 | 47,624
Selling, general and administrative | 71,151 | 47,269 | 20,717
Changes in fair value of contingent consideration payable | 6,760 | 4,377 | 100
Restructuring charges | 69 | 15 | (63)
Depreciation | 3,242 | 1,833 | 1,547
Total operating expenses | 186,015 | 130,437 | 69,925
Loss from operations | (181,890) | (130,437) | (68,701)
Other income (expenses): |  |  |
Interest income | 1,602 | 929 | 223
Interest expense | (5,398) | (1,578) | (1,484)
Loss on extinguishment of debt | (13,302) | (952) |
Other expense | (4,793) | (80) | (77)
Loss before income tax benefit | (203,781) | (132,118) | (70,039)
Income tax benefit | 3,739 |  | 1,113
Net loss attributable to common stockholders | $ (200,042) | $ (132,118) | $ (68,926)
Net loss attributable to common stockholders per common share - basic and diluted | $ (1.49) | $ (1.20) | $ (0.93)
Weighted-average common shares outstanding - basic and diluted | 134,401,588 | 109,923,815 | 74,444,157

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