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Income Taxes - Statutory Rate (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Income (loss) before income taxes: |  |  |
United States | $ (174,913) | $ (123,697) | $ (70,030)
Foreign | (28,868) | (8,421) | (9)
Loss before income tax benefit | $ (203,781) | $ (132,118) | $ (70,039)
Reconciliation of the statutory tax rates and the effective tax rates |  |  |
Statutory rate (as a percent) | (34.00%) | (34.00%) | (34.00%)
State taxes, net of federal benefit (as a percent) | (5.00%) | (5.00%) | (4.00%)
Permanent adjustments (as a percent) | 3.00% | 2.00% | 1.00%
R&D credit (as a percent) | (3.00%) | (3.00%) | (4.00%)
Foreign income tax rate differential (as a percent) | 2.00% | 1.00% |
Other (as a percent) | (1.00%) | 2.00% | 1.00%
Valuation allowance (as a percent) | 36.00% | 37.00% | 38.00%
Net (as a percent) | (2.00%) | (0.00%) | (2.00%)
Income tax benefit from the sale of net operating losses and research and development credits | $ 0 | $ 0 | $ 1,100
Income tax benefit | (3,739) |  | $ (1,113)
Reduction in valuation allowance related to income tax associated with gain on foreign currency translation | 1,200 |  |
Income tax benefit in connection with the reduction in North Carolina state tax rates | $ 2,700 |  |

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