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Income Taxes - Deferred and Valuation (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2016 | Dec. 31, 2015
Income Taxes |  |
Recognized interest and penalties |  | $ 0
Accrual for interest and penalties |  | 0
Accrual for uncertain tax positions |  | 0
Non-current deferred tax assets |  |
Intellectual property | $ 95,956 |
Amortization/depreciation | 1,781 | 2,657
Research tax credit | 32,851 | 27,170
Net operating loss carry forwards | 253,661 | 159,889
Deferred revenue | 14,281 | 14,281
Non-cash stock issue | 11,649 | 6,767
Others | 3,358 | 2,964
Gross deferred tax assets | 413,537 | 213,728
Deferred tax liability related to business acquisition | (173,771) | (176,219)
Deferred tax liability related to royalty payable | (96,829) |
Deferred tax liability related to convertible notes | (29,845) |
Total net deferred tax asset | 113,092 | 37,509
Less valuation allowance | (286,863) | (213,728)
Net deferred tax assets (liability) | (173,771) | (176,219)
Increase in the valuation allowance | $ 73,200 | $ 65,300

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