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Description of Business (Details) $ / shares in Units, $ in Thousands |  |  | 1 Months Ended | 3 Months Ended | 4 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | --- | --- | ---
Dec. 21, 2016 USD ($) | Jul. 05, 2016 USD ($) | Feb. 29, 2016 | Jun. 30, 2015 USD ($) | Nov. 30, 2014 USD ($) $ / shares | Jul. 31, 2014 USD ($) $ / shares shares | Jun. 30, 2016 USD ($) | Jul. 31, 2016 USD ($) shares | Dec. 31, 2016 USD ($) $ / shares shares | Dec. 31, 2015 USD ($) $ / shares | Dec. 31, 2014 USD ($) shares | Apr. 01, 2016 item
Corporate Information, Status of Operations and Management Plans |  |  |  |  |  |  |  |  |  |  |  |
Number of Fabry causing mutations included in the label approved by the CHMP | item |  |  |  |  |  |  |  |  |  |  |  | 313
Net product sales |  |  |  |  |  |  |  |  | $ 4,958 |  |  |
Common stock, par value (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  | $ 0.01 | $ 0.01 |  |
Net proceeds from convertible notes to pay capped call transactions |  |  |  |  |  |  |  |  | $ 13,450 |  |  |
Common Stock, Par or Stated Value Per Share | $ / shares |  |  |  |  |  |  |  |  | $ 0.01 | $ 0.01 |  |
Net proceeds from stock issued at ATM transactions |  |  |  |  |  |  |  |  | $ 97,068 |  | $ 38,636 |
Proceeds from the issuance of common stock (in dollars) |  |  |  |  |  |  |  |  | 97,068 | $ 243,042 | $ 135,805 |
Accumulated deficit |  |  |  |  |  |  |  |  | $ (779,608) | $ (579,566) |  |
Galafold | EU |  |  |  |  |  |  |  |  |  |  |  |
Corporate Information, Status of Operations and Management Plans |  |  |  |  |  |  |  |  |  |  |  |
Net product sales |  |  |  |  |  |  | $ 5,000 |  |  |  |  |
Cowen and Company, LLC | Sales Agreement |  |  |  |  |  |  |  |  |  |  |  |
Corporate Information, Status of Operations and Management Plans |  |  |  |  |  |  |  |  |  |  |  |
Number of shares issued from ATM transactions (in shares) | shares |  |  |  |  |  |  |  | 15,000,000 |  |  |  |
Net proceeds from stock issued at ATM transactions |  |  |  |  |  |  |  | $ 97,100 |  |  |  |
Commission expenses incurred on issue of common stock |  |  |  |  |  |  |  | 2,700 |  |  |  |
Other expenses paid |  |  |  |  |  |  |  | $ 200 |  |  |  |
Common Stock |  |  |  |  |  |  |  |  |  |  |  |
Corporate Information, Status of Operations and Management Plans |  |  |  |  |  |  |  |  |  |  |  |
Common stock, par value (in dollars per share) | $ / shares |  |  |  |  | $ 0.01 |  |  |  |  |  |  |
Common Stock, Par or Stated Value Per Share | $ / shares |  |  |  |  | $ 0.01 |  |  |  |  |  |  |
Number of shares issued from ATM transactions (in shares) | shares |  |  |  |  |  |  |  |  | 14,989,027 |  | 14,328,224 |
Net proceeds from stock issued at ATM transactions |  |  |  |  |  |  |  |  | $ 150 |  | $ 143 |
Proceeds from the issuance of common stock (in dollars) |  |  |  | $ 243,000 | $ 97,200 |  |  |  |  |  |  |
Common Stock | Cowen and Company, LLC | At the market ("ATM") equity offering |  |  |  |  |  |  |  |  |  |  |  |
Corporate Information, Status of Operations and Management Plans |  |  |  |  |  |  |  |  |  |  |  |
Common stock, par value (in dollars per share) | $ / shares |  |  |  |  |  | $ 0.01 |  |  |  |  |  |
Common Stock, Par or Stated Value Per Share | $ / shares |  |  |  |  |  | $ 0.01 |  |  |  |  |  |
Number of shares issued from ATM transactions (in shares) | shares |  |  |  |  |  | 14,300,000 |  |  |  |  |  |
Proceeds from the issuance of common stock (in dollars) |  |  |  |  |  | $ 38,600 |  |  |  |  |  |
Convertible Notes | 2016 Convertible Notes |  |  |  |  |  |  |  |  |  |  |  |
Corporate Information, Status of Operations and Management Plans |  |  |  |  |  |  |  |  |  |  |  |
Aggregate principle amount | $ 250,000 |  |  |  |  |  |  |  |  |  |  |
Fixed interest rate (as a percent) | 3.00% |  |  |  |  |  |  |  |  |  |  |
Proceeds from Debt, Net of Issuance Costs | $ 243,100 |  |  |  |  |  |  |  |  |  |  |
Net proceeds from convertible notes to pay capped call transactions | $ 13,500 |  |  |  |  |  |  |  |  |  |  |
Maximum |  |  |  |  |  |  |  |  |  |  |  |
Corporate Information, Status of Operations and Management Plans |  |  |  |  |  |  |  |  |  |  |  |
Percentage of patients with Fabry disease caused by mutations included in the label approved by the CHMP |  |  |  |  |  |  |  |  |  |  |  | 0.5
Maximum | Cowen and Company, LLC | Sales Agreement |  |  |  |  |  |  |  |  |  |  |  |
Corporate Information, Status of Operations and Management Plans |  |  |  |  |  |  |  |  |  |  |  |
Fixed commission rate as a percentage of gross proceeds per Share sold |  |  | 3.00% |  |  |  |  | 3.00% |  |  |  |
MiaMed Inc |  |  |  |  |  |  |  |  |  |  |  |
Corporate Information, Status of Operations and Management Plans |  |  |  |  |  |  |  |  |  |  |  |
Total consideration, stock and cash |  | $ 6,500 |  |  |  |  |  |  |  |  |  |
Contingent consideration payable upon achievement of milestones |  | 83,000 |  |  |  |  |  |  |  |  |  |
Potential aggregate deal value |  | $ 89,500 |  |  |  |  |  |  |  |  |  |

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