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Debt Instruments and Related Party Transactions - Note and Warrant Purchase Agreements (Details) | 1 Months Ended | 12 Months Ended
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Jun. 30, 2016 USD ($) $ / shares shares | Feb. 29, 2016 USD ($) item shares | Oct. 31, 2015 USD ($) installment shares | Dec. 31, 2016 USD ($) $ / shares | Dec. 31, 2015 USD ($) $ / shares
Debt Instruments and Related Party Transactions [Line Items] |  |  |  |  |
Common stock, par value (in dollars per share) | $ / shares |  |  |  | $ 0.01 | $ 0.01
Warrants |  |  |  | $ 16,076,000 | $ 8,755,000
Loss on extinguishment of debt |  |  |  | 13,302,000 | $ 952,000
Redmile Group | October 2015 Purchase Agreement |  |  |  |  |
Debt Instruments and Related Party Transactions [Line Items] |  |  |  |  |
Number of installments for repayment of debt | installment |  |  | 2 |  |
Fixed interest rate (as a percent) |  |  | 4.10% |  |
Warrants |  |  | $ 8,800,000 |  |
Redmile Group | October 2015 Purchase Agreement | Private Placement Purchase Agreement |  |  |  |  |
Debt Instruments and Related Party Transactions [Line Items] |  |  |  |  |
Ownership position in the company (as a percent) |  |  | 6.70% |  |
Proceeds from note and warrant purchase agreement |  |  | $ 50,000,000 |  |
Redmile Group | October 2015 Purchase Agreement | Private Placement Purchase Agreement | Warrants |  |  |  |  |
Debt Instruments and Related Party Transactions [Line Items] |  |  |  |  |
Warrant Term |  |  | 5 years |  |
Shares issuable for warrants (in shares) | shares |  |  | 1,300,000 |  |
Redmile Group | February 2016 Purchase Agreement | Beneficial Owner | Maximum |  |  |  |  |
Debt Instruments and Related Party Transactions [Line Items] |  |  |  |  |
Proceeds from note and warrant purchase agreement |  | $ 75,000,000 |  |  |
Redmile Group | February 2016 Purchase Agreement | Private Placement Purchase Agreement | Maximum |  |  |  |  |
Debt Instruments and Related Party Transactions [Line Items] |  |  |  |  |
Shares issuable for warrants (in shares) | shares |  | 1,850,000 |  |  |
Redmile Group | February 2016 Purchase Agreement | Private Placement Purchase Agreement | Warrants | Maximum |  |  |  |  |
Debt Instruments and Related Party Transactions [Line Items] |  |  |  |  |
Shares of common stock issued per increment of note principal | shares |  | 37 |  |  |
Redmile Group | February 2016 Purchase Agreement | Private Placement Purchase Agreement | Beneficial Owner |  |  |  |  |
Debt Instruments and Related Party Transactions [Line Items] |  |  |  |  |
Proceeds from note and warrant purchase agreement |  | $ 50,000,000 |  |  |
Number of installments for repayment of debt | item |  | 2 |  |  |
Fixed interest rate (as a percent) |  | 3.875% |  |  |
Redmile Group | February 2016 Purchase Agreement | Private Placement Purchase Agreement | Beneficial Owner | Warrants |  |  |  |  |
Debt Instruments and Related Party Transactions [Line Items] |  |  |  |  |
Warrant Term |  | 5 years |  |  |
Shares issuable for warrants (in shares) | shares |  | 1,800,000 |  |  |
Increment used for debt conversion |  | $ 1,000 |  |  |
Incremental fair value of warrant liability |  | 3,500,000 |  |  |
Redmile Group | Additional Note and Warrant Agreement June 2016 | Private Placement Purchase Agreement | Beneficial Owner |  |  |  |  |
Debt Instruments and Related Party Transactions [Line Items] |  |  |  |  |
Proceeds from note and warrant purchase agreement | $ 30,000,000 |  |  |  |
Fixed interest rate (as a percent) | 3.875% |  |  |  |
Common stock, par value (in dollars per share) | $ / shares | $ 0.01 |  |  |  |
Redmile Group | Additional Note and Warrant Agreement June 2016 | Private Placement Purchase Agreement | Beneficial Owner | Warrants |  |  |  |  |
Debt Instruments and Related Party Transactions [Line Items] |  |  |  |  |
Warrant Term | 5 years |  |  |  |
Shares issuable for warrants (in shares) | shares | 1,300,000 |  |  |  |
Increment used for debt conversion | $ 1,000 |  |  |  |
Redmile Group | Additional Note and Warrant Agreement June 2016 | Private Placement Purchase Agreement | Beneficial Owner | Warrants | Maximum |  |  |  |  |
Debt Instruments and Related Party Transactions [Line Items] |  |  |  |  |
Shares issuable for warrants (in shares) | shares | 1,260,000 |  |  |  |
Shares of common stock issued per increment of note principal | shares | 42 |  |  |  |
Redmile Group | December Note Purchase Agreement |  |  |  |  |
Debt Instruments and Related Party Transactions [Line Items] |  |  |  |  |
Loss on extinguishment of debt |  |  |  | $ 13,300,000 |
Redmile Group | October 2017 payment | October 2015 Purchase Agreement |  |  |  |  |
Debt Instruments and Related Party Transactions [Line Items] |  |  |  |  |
Installment payment |  |  | $ 15,000,000 |  |
Redmile Group | October 2017 payment | February 2016 Purchase Agreement | Private Placement Purchase Agreement | Beneficial Owner |  |  |  |  |
Debt Instruments and Related Party Transactions [Line Items] |  |  |  |  |
Installment payment |  | 15,000,000 |  |  |
Redmile Group | October 2020 payment | October 2015 Purchase Agreement |  |  |  |  |
Debt Instruments and Related Party Transactions [Line Items] |  |  |  |  |
Installment payment |  |  | $ 35,000,000 |  |
Redmile Group | October 2021 payment | February 2016 Purchase Agreement | Private Placement Purchase Agreement | Beneficial Owner |  |  |  |  |
Debt Instruments and Related Party Transactions [Line Items] |  |  |  |  |
Installment payment |  | $ 35,000,000 |  |  |

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