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Stockholders' Equity - Common Stock and Warrants (Details) $ / shares in Units, $ in Thousands |  |  |  | 1 Months Ended | 4 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | --- | --- | --- | ---
Dec. 21, 2016 USD ($) $ / shares | Jul. 05, 2016 USD ($) shares | Sep. 30, 2015 USD ($) | Apr. 30, 2016 USD ($) | Feb. 29, 2016 USD ($) shares | Jun. 30, 2015 USD ($) $ / shares shares | Nov. 30, 2014 USD ($) $ / shares shares | Jul. 31, 2014 USD ($) $ / shares shares | Jul. 31, 2016 USD ($) shares | Dec. 31, 2016 USD ($) item $ / shares shares | Dec. 31, 2015 USD ($) $ / shares shares | Dec. 31, 2014 USD ($) shares | Jun. 30, 2016 USD ($) $ / shares shares | Oct. 31, 2015 USD ($) shares
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock, par value (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  | $ 0.01 | $ 0.01 |  |  |
Authorized number of shares of common stock | shares |  |  |  |  |  |  |  |  |  | 250,000,000 | 250,000,000 |  |  |
Voting right for each share held, number | item |  |  |  |  |  |  |  |  |  | 1 |  |  |  |
Common stock, par value (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  | $ 0.01 | $ 0.01 |  |  |
Net proceeds from stock issued at ATM transactions |  |  |  |  |  |  |  |  |  | $ 97,068 |  | $ 38,636 |  |
Warrant liability |  |  |  |  |  |  |  |  |  | 16,076 | $ 8,755 |  |  |
Net proceeds from the issuance of common stock |  |  |  |  |  |  |  |  |  | $ 97,068 | $ 243,042 | $ 135,805 |  |
Common Stock |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock, par value (in dollars per share) | $ / shares |  |  |  |  |  |  | $ 0.01 |  |  |  |  |  |  |
Common stock, par value (in dollars per share) | $ / shares |  |  |  |  |  |  | $ 0.01 |  |  |  |  |  |  |
Number of shares issued from ATM transactions (in shares) | shares |  |  |  |  |  |  |  |  |  | 14,989,027 |  | 14,328,224 |  |
Net proceeds from stock issued at ATM transactions |  |  |  |  |  |  |  |  |  | $ 150 |  | $ 143 |  |
Stock issued from public offering / financing (in shares) | shares |  |  |  |  |  | 19,500,000 | 15,900,000 |  |  |  | 19,528,302 | 15,927,500 |  |
Public offering share price (in dollars per share) | $ / shares |  |  |  |  |  | $ 13.25 | $ 6.50 |  |  |  |  |  |  |
Net proceeds from the issuance of common stock |  |  |  |  |  | $ 243,000 | $ 97,200 |  |  |  |  |  |  |
Cowen and Company, LLC | Sales Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of shares issued from ATM transactions (in shares) | shares |  |  |  |  |  |  |  |  | 15,000,000 |  |  |  |  |
Net proceeds from stock issued at ATM transactions |  |  |  |  |  |  |  |  | $ 97,100 |  |  |  |  |
Commission expenses incurred on issue of common stock |  |  |  |  |  |  |  |  | 2,700 |  |  |  |  |
Other Expenses |  |  |  |  |  |  |  |  | $ 200 |  |  |  |  |
Cowen and Company, LLC | Sales Agreement | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Fixed commission rate as a percentage of gross proceeds per Share sold |  |  |  |  | 3.00% |  |  |  | 3.00% |  |  |  |  |
Cowen and Company, LLC | At the market ("ATM") equity offering | Common Stock |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock, par value (in dollars per share) | $ / shares |  |  |  |  |  |  |  | $ 0.01 |  |  |  |  |  |
Common stock, par value (in dollars per share) | $ / shares |  |  |  |  |  |  |  | $ 0.01 |  |  |  |  |  |
Number of shares issued from ATM transactions (in shares) | shares |  |  |  |  |  |  |  | 14,300,000 |  |  |  |  |  |
Net proceeds from the issuance of common stock |  |  |  |  |  |  |  | $ 38,600 |  |  |  |  |  |
Aggregate offering proceeds from issuance of common stock |  |  |  |  |  |  |  | $ 40,000 |  |  |  |  |  |
Scioderm |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Initial amount to Effective Time Holders |  |  | $ 223,900 |  |  |  |  |  |  |  |  |  |  |
Initial amount cash payment excluding Series B Preferred |  |  | 141,100 |  |  |  |  |  |  |  |  |  |  |
Initial amount paid in shares of Common Stock |  |  | 82,800 |  |  |  |  |  |  |  |  |  |  |
Scioderm | Revenue-based milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront equity payments |  |  | 257,000 |  |  |  |  |  |  |  |  |  |  |
Scioderm | Maximum | Clinical and Regulatory Approval milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront cash payments |  |  | $ 361,000 | $ 361,000 |  |  |  |  |  |  |  |  |  |
Scioderm | Maximum | Revenue-based milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront equity payments |  |  |  |  |  |  |  |  |  | $ 257,000 |  |  |  |
MiaMed Inc |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total consideration, stock and cash |  | $ 6,500 |  |  |  |  |  |  |  |  |  |  |  |
Cash consideration paid |  | 1,800 |  |  |  |  |  |  |  |  |  |  |  |
Contingent consideration payable upon achievement of milestones |  | 83,000 |  |  |  |  |  |  |  |  |  |  |  |
Potential aggregate deal value |  | $ 89,500 |  |  |  |  |  |  |  |  |  |  |  |
MiaMed Inc | Amicus | Common Stock |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Consideration paid in common stock | shares |  | 825,603 |  |  |  |  |  |  |  |  |  |  |  |
October 2015 Purchase Agreement | Redmile Group |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Fixed interest rate (as a percent) |  |  |  |  |  |  |  |  |  |  |  |  |  | 4.10%
Warrant liability |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 8,800
October 2015 Purchase Agreement | Redmile Group | Private Placement Purchase Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate principle amount |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 50,000
October 2015 Purchase Agreement | Redmile Group | Private Placement Purchase Agreement | Warrants |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issuable for warrants (in shares) | shares |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,300,000
February 2016 Purchase Agreement | Redmile Group | Private Placement Purchase Agreement | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issuable for warrants (in shares) | shares |  |  |  |  | 1,850,000 |  |  |  |  |  |  |  |  |
February 2016 Purchase Agreement | Beneficial Owner | Redmile Group | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate principle amount |  |  |  |  | $ 75,000 |  |  |  |  |  |  |  |  |
February 2016 Purchase Agreement | Beneficial Owner | Redmile Group | Private Placement Purchase Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate principle amount |  |  |  |  | $ 50,000 |  |  |  |  |  |  |  |  |
Fixed interest rate (as a percent) |  |  |  |  | 3.875% |  |  |  |  |  |  |  |  |
February 2016 Purchase Agreement | Beneficial Owner | Redmile Group | Private Placement Purchase Agreement | Warrants |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issuable for warrants (in shares) | shares |  |  |  |  | 1,800,000 |  |  |  |  |  |  |  |  |
2016 Convertible Notes | Convertible Notes |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate principle amount | $ 250,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Fixed interest rate (as a percent) | 3.00% |  |  |  |  |  |  |  |  |  |  |  |  |
Debt conversion ratio (in shares) | 0.1633987 |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion price (in dollars per share) | $ / shares | $ 6.12 |  |  |  |  |  |  |  |  |  |  |  |  |
Additional Note and Warrant Agreement June 2016 | Beneficial Owner | Redmile Group | Private Placement Purchase Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate principle amount |  |  |  |  |  |  |  |  |  |  |  |  | $ 30,000 |
Fixed interest rate (as a percent) |  |  |  |  |  |  |  |  |  |  |  |  | 3.875% |
Common stock, par value (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  | $ 0.01 |
Common stock, par value (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  | $ 0.01 |
Additional Note and Warrant Agreement June 2016 | Beneficial Owner | Redmile Group | Private Placement Purchase Agreement | Warrants |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issuable for warrants (in shares) | shares |  |  |  |  |  |  |  |  |  |  |  |  | 1,300,000 |
Additional Note and Warrant Agreement June 2016 | Beneficial Owner | Redmile Group | Private Placement Purchase Agreement | Maximum | Warrants |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issuable for warrants (in shares) | shares |  |  |  |  |  |  |  |  |  |  |  |  | 1,260,000 |

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