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Consolidated Statements of Operations - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Revenue:      
Net Product Sales $ 4,958    
Research revenue     $ 1,224
Total revenue 4,958   1,224
Cost of goods sold 833    
Gross Profit 4,125   1,224
Operating Expenses:      
Research and development 104,793 $ 76,943 47,624
Selling, general and administrative 71,151 47,269 20,717
Changes in fair value of contingent consideration payable 6,760 4,377 100
Restructuring charges 69 15 (63)
Depreciation 3,242 1,833 1,547
Total operating expenses 186,015 130,437 69,925
Loss from operations (181,890) (130,437) (68,701)
Other income (expenses):      
Interest income 1,602 929 223
Interest expense (5,398) (1,578) (1,484)
Loss on extinguishment of debt (13,302) (952)  
Other expense (4,793) (80) (77)
Loss before income tax benefit (203,781) (132,118) (70,039)
Income tax benefit 3,739   1,113
Net loss attributable to common stockholders $ (200,042) $ (132,118) $ (68,926)
Net loss attributable to common stockholders per common share - basic and diluted $ (1.49) $ (1.20) $ (0.93)
Weighted-average common shares outstanding - basic and diluted 134,401,588 109,923,815 74,444,157