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Description of Business (Details)
$ / shares in Units, $ in Thousands
 1 Months Ended 3 Months Ended 4 Months Ended 12 Months Ended
Dec. 21, 2016
USD ($)
Jul. 05, 2016
USD ($)
Feb. 29, 2016
Jun. 30, 2015
USD ($)
Nov. 30, 2014
USD ($)
$ / shares
Jul. 31, 2014
USD ($)
$ / shares
shares
Jun. 30, 2016
USD ($)
Jul. 31, 2016
USD ($)
shares
Dec. 31, 2016
USD ($)
$ / shares
shares
Dec. 31, 2015
USD ($)
$ / shares
Dec. 31, 2014
USD ($)
shares
Apr. 01, 2016
item
Corporate Information, Status of Operations and Management Plans                        
Number of Fabry causing mutations included in the label approved by the CHMP | item                       313
Net product sales                 $ 4,958      
Common stock, par value (in dollars per share) | $ / shares                 $ 0.01 $ 0.01    
Net proceeds from convertible notes to pay capped call transactions                 $ 13,450      
Common Stock, Par or Stated Value Per Share | $ / shares                 $ 0.01 $ 0.01    
Net proceeds from stock issued at ATM transactions                 $ 97,068   $ 38,636  
Proceeds from the issuance of common stock (in dollars)                 97,068 $ 243,042 $ 135,805  
Accumulated deficit                 $ (779,608) $ (579,566)    
Galafold | EU                        
Corporate Information, Status of Operations and Management Plans                        
Net product sales             $ 5,000          
Cowen and Company, LLC | Sales Agreement                        
Corporate Information, Status of Operations and Management Plans                        
Number of shares issued from ATM transactions (in shares) | shares               15,000,000        
Net proceeds from stock issued at ATM transactions               $ 97,100        
Commission expenses incurred on issue of common stock               2,700        
Other expenses paid               $ 200        
Common Stock                        
Corporate Information, Status of Operations and Management Plans                        
Common stock, par value (in dollars per share) | $ / shares         $ 0.01              
Common Stock, Par or Stated Value Per Share | $ / shares         $ 0.01              
Number of shares issued from ATM transactions (in shares) | shares                 14,989,027   14,328,224  
Net proceeds from stock issued at ATM transactions                 $ 150   $ 143  
Proceeds from the issuance of common stock (in dollars)       $ 243,000 $ 97,200              
Common Stock | Cowen and Company, LLC | At the market ("ATM") equity offering                        
Corporate Information, Status of Operations and Management Plans                        
Common stock, par value (in dollars per share) | $ / shares           $ 0.01            
Common Stock, Par or Stated Value Per Share | $ / shares           $ 0.01            
Number of shares issued from ATM transactions (in shares) | shares           14,300,000            
Proceeds from the issuance of common stock (in dollars)           $ 38,600            
Convertible Notes | 2016 Convertible Notes                        
Corporate Information, Status of Operations and Management Plans                        
Aggregate principle amount $ 250,000                      
Fixed interest rate (as a percent) 3.00%                      
Proceeds from Debt, Net of Issuance Costs $ 243,100                      
Net proceeds from convertible notes to pay capped call transactions $ 13,500                      
Maximum                        
Corporate Information, Status of Operations and Management Plans                        
Percentage of patients with Fabry disease caused by mutations included in the label approved by the CHMP                       0.5
Maximum | Cowen and Company, LLC | Sales Agreement                        
Corporate Information, Status of Operations and Management Plans                        
Fixed commission rate as a percentage of gross proceeds per Share sold     3.00%         3.00%        
MiaMed Inc                        
Corporate Information, Status of Operations and Management Plans                        
Total consideration, stock and cash   $ 6,500                    
Contingent consideration payable upon achievement of milestones   83,000                    
Potential aggregate deal value   $ 89,500