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Stockholders' Equity - Common Stock and Warrants (Details)
$ / shares in Units, $ in Thousands
1 Months Ended 4 Months Ended 12 Months Ended
Dec. 21, 2016
USD ($)
$ / shares
Jul. 05, 2016
USD ($)
shares
Sep. 30, 2015
USD ($)
Apr. 30, 2016
USD ($)
Feb. 29, 2016
USD ($)
shares
Jun. 30, 2015
USD ($)
$ / shares
shares
Nov. 30, 2014
USD ($)
$ / shares
shares
Jul. 31, 2014
USD ($)
$ / shares
shares
Jul. 31, 2016
USD ($)
shares
Dec. 31, 2016
USD ($)
item
$ / shares
shares
Dec. 31, 2015
USD ($)
$ / shares
shares
Dec. 31, 2014
USD ($)
shares
Jun. 30, 2016
USD ($)
$ / shares
shares
Oct. 31, 2015
USD ($)
shares
Convertible Debt                            
Common stock, par value (in dollars per share) | $ / shares                   $ 0.01 $ 0.01      
Authorized number of shares of common stock | shares                   250,000,000 250,000,000      
Voting right for each share held, number | item                   1        
Common stock, par value (in dollars per share) | $ / shares                   $ 0.01 $ 0.01      
Net proceeds from stock issued at ATM transactions                   $ 97,068   $ 38,636    
Warrant liability                   16,076 $ 8,755      
Net proceeds from the issuance of common stock                   $ 97,068 $ 243,042 $ 135,805    
Common Stock                            
Convertible Debt                            
Common stock, par value (in dollars per share) | $ / shares             $ 0.01              
Common stock, par value (in dollars per share) | $ / shares             $ 0.01              
Number of shares issued from ATM transactions (in shares) | shares                   14,989,027   14,328,224    
Net proceeds from stock issued at ATM transactions                   $ 150   $ 143    
Stock issued from public offering / financing (in shares) | shares           19,500,000 15,900,000       19,528,302 15,927,500    
Public offering share price (in dollars per share) | $ / shares           $ 13.25 $ 6.50              
Net proceeds from the issuance of common stock           $ 243,000 $ 97,200              
Cowen and Company, LLC | Sales Agreement                            
Convertible Debt                            
Number of shares issued from ATM transactions (in shares) | shares                 15,000,000          
Net proceeds from stock issued at ATM transactions                 $ 97,100          
Commission expenses incurred on issue of common stock                 2,700          
Other Expenses                 $ 200          
Cowen and Company, LLC | Sales Agreement | Maximum                            
Convertible Debt                            
Fixed commission rate as a percentage of gross proceeds per Share sold         3.00%       3.00%          
Cowen and Company, LLC | At the market ("ATM") equity offering | Common Stock                            
Convertible Debt                            
Common stock, par value (in dollars per share) | $ / shares               $ 0.01            
Common stock, par value (in dollars per share) | $ / shares               $ 0.01            
Number of shares issued from ATM transactions (in shares) | shares               14,300,000            
Net proceeds from the issuance of common stock               $ 38,600            
Aggregate offering proceeds from issuance of common stock               $ 40,000            
Scioderm                            
Convertible Debt                            
Initial amount to Effective Time Holders     $ 223,900                      
Initial amount cash payment excluding Series B Preferred     141,100                      
Initial amount paid in shares of Common Stock     82,800                      
Scioderm | Revenue-based milestones                            
Convertible Debt                            
Upfront equity payments     257,000                      
Scioderm | Maximum | Clinical and Regulatory Approval milestones                            
Convertible Debt                            
Upfront cash payments     $ 361,000 $ 361,000                    
Scioderm | Maximum | Revenue-based milestones                            
Convertible Debt                            
Upfront equity payments                   $ 257,000        
MiaMed Inc                            
Convertible Debt                            
Total consideration, stock and cash   $ 6,500                        
Cash consideration paid   1,800                        
Contingent consideration payable upon achievement of milestones   83,000                        
Potential aggregate deal value   $ 89,500                        
MiaMed Inc | Amicus | Common Stock                            
Convertible Debt                            
Consideration paid in common stock | shares   825,603                        
October 2015 Purchase Agreement | Redmile Group                            
Convertible Debt                            
Fixed interest rate (as a percent)                           4.10%
Warrant liability                           $ 8,800
October 2015 Purchase Agreement | Redmile Group | Private Placement Purchase Agreement                            
Convertible Debt                            
Aggregate principle amount                           $ 50,000
October 2015 Purchase Agreement | Redmile Group | Private Placement Purchase Agreement | Warrants                            
Convertible Debt                            
Shares issuable for warrants (in shares) | shares                           1,300,000
February 2016 Purchase Agreement | Redmile Group | Private Placement Purchase Agreement | Maximum                            
Convertible Debt                            
Shares issuable for warrants (in shares) | shares         1,850,000                  
February 2016 Purchase Agreement | Beneficial Owner | Redmile Group | Maximum                            
Convertible Debt                            
Aggregate principle amount         $ 75,000                  
February 2016 Purchase Agreement | Beneficial Owner | Redmile Group | Private Placement Purchase Agreement                            
Convertible Debt                            
Aggregate principle amount         $ 50,000                  
Fixed interest rate (as a percent)         3.875%                  
February 2016 Purchase Agreement | Beneficial Owner | Redmile Group | Private Placement Purchase Agreement | Warrants                            
Convertible Debt                            
Shares issuable for warrants (in shares) | shares         1,800,000                  
2016 Convertible Notes | Convertible Notes                            
Convertible Debt                            
Aggregate principle amount $ 250,000                          
Fixed interest rate (as a percent) 3.00%                          
Debt conversion ratio (in shares) 0.1633987                          
Conversion price (in dollars per share) | $ / shares $ 6.12                          
Additional Note and Warrant Agreement June 2016 | Beneficial Owner | Redmile Group | Private Placement Purchase Agreement                            
Convertible Debt                            
Aggregate principle amount                         $ 30,000  
Fixed interest rate (as a percent)                         3.875%  
Common stock, par value (in dollars per share) | $ / shares                         $ 0.01  
Common stock, par value (in dollars per share) | $ / shares                         $ 0.01  
Additional Note and Warrant Agreement June 2016 | Beneficial Owner | Redmile Group | Private Placement Purchase Agreement | Warrants                            
Convertible Debt                            
Shares issuable for warrants (in shares) | shares                         1,300,000  
Additional Note and Warrant Agreement June 2016 | Beneficial Owner | Redmile Group | Private Placement Purchase Agreement | Maximum | Warrants                            
Convertible Debt                            
Shares issuable for warrants (in shares) | shares                         1,260,000