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Income Taxes - Statutory Rate (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Income (loss) before income taxes:
United States	$ (174,913)	$ (123,697)	$ (70,030)
Foreign	(28,868)	(8,421)	(9)
Loss before income tax benefit	$ (203,781)	$ (132,118)	$ (70,039)
Reconciliation of the statutory tax rates and the effective tax rates
Statutory rate (as a percent)	(34.00%)	(34.00%)	(34.00%)
State taxes, net of federal benefit (as a percent)	(5.00%)	(5.00%)	(4.00%)
Permanent adjustments (as a percent)	3.00%	2.00%	1.00%
R&D credit (as a percent)	(3.00%)	(3.00%)	(4.00%)
Foreign income tax rate differential (as a percent)	2.00%	1.00%
Other (as a percent)	(1.00%)	2.00%	1.00%
Valuation allowance (as a percent)	36.00%	37.00%	38.00%
Net (as a percent)	(2.00%)	(0.00%)	(2.00%)
Income tax benefit from the sale of net operating losses and research and development credits	$ 0	$ 0	$ 1,100
Income tax benefit	(3,739)		$ (1,113)
Reduction in valuation allowance related to income tax associated with gain on foreign currency translation	1,200
Income tax benefit in connection with the reduction in North Carolina state tax rates	$ 2,700

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