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Income Taxes - Deferred and Valuation (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Income Taxes    
Recognized interest and penalties   $ 0
Accrual for interest and penalties   0
Accrual for uncertain tax positions   0
Non-current deferred tax assets    
Intellectual property $ 95,956  
Amortization/depreciation 1,781 2,657
Research tax credit 32,851 27,170
Net operating loss carry forwards 253,661 159,889
Deferred revenue 14,281 14,281
Non-cash stock issue 11,649 6,767
Others 3,358 2,964
Gross deferred tax assets 413,537 213,728
Deferred tax liability related to business acquisition (173,771) (176,219)
Deferred tax liability related to royalty payable (96,829)  
Deferred tax liability related to convertible notes (29,845)  
Total net deferred tax asset 113,092 37,509
Less valuation allowance (286,863) (213,728)
Net deferred tax assets (liability) (173,771) (176,219)
Increase in the valuation allowance $ 73,200 $ 65,300