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Acquisitions (Details) - USD ($) $ / shares in Units, $ in Thousands |  |  | 1 Months Ended | 3 Months Ended |  |
--- | --- | --- | --- | --- | --- | ---
Jul. 05, 2016 | Sep. 30, 2015 | Apr. 30, 2017 | Apr. 30, 2016 | Mar. 31, 2017 | Mar. 31, 2016 | Dec. 31, 2016 | Dec. 31, 2015
Asset acquisition of MiaMed, Inc. |  |  |  |  |  |  |  |
Common stock, par value (in dollars per share) |  |  |  |  | $ 0.01 |  | $ 0.01 |
Contingent consideration payable |  |  |  |  | $ 274,300 |  | $ 269,722 |
Contingent consideration payable, current portion |  |  |  |  | 56,101 |  | 56,101 |
Changes in fair value of contingent consideration payable |  |  |  |  | 4,578 | $ 3,152 |  |
IPR&D |  |  |  |  |  |  |  |
Asset acquisition of MiaMed, Inc. |  |  |  |  |  |  |  |
Intangible assets-IPR&D |  |  |  |  | 486,700 |  | $ 486,700 |
Scioderm |  |  |  |  |  |  |  |
Asset acquisition of MiaMed, Inc. |  |  |  |  |  |  |  |
Initial amount to Effective Time Holders |  | $ 223,900 |  |  |  |  |  |
Initial amount cash payment excluding Series B Preferred |  | 141,100 |  |  |  |  |  |
Initial amount paid in shares of Common Stock |  | $ 82,800 |  |  |  |  |  |
Priority review voucher transfer years |  | 1 year |  |  |  |  |  |
Payment to be made if Priority Review Voucher is obtained and used |  | $ 100,000 |  |  |  |  |  |
Contingent consideration payable |  | 259,000 |  |  | $ 264,000 |  |  |
Enrollment rate (as a percent) |  |  |  |  | 100.00% |  |  |
Milestone payment |  |  | $ 10,000 |  |  |  |  |
Contingent consideration payable, current portion |  |  |  |  | $ 56,100 |  |  |
Scioderm | Changes in fair value of contingent consideration payable |  |  |  |  |  |  |  |
Asset acquisition of MiaMed, Inc. |  |  |  |  |  |  |  |
Changes in fair value of contingent consideration payable |  |  |  |  | 4,000 |  |  |
Scioderm | IPR&D |  |  |  |  |  |  |  |
Asset acquisition of MiaMed, Inc. |  |  |  |  |  |  |  |
Intangible assets-IPR&D |  |  |  |  |  |  |  | $ 463,700
Scioderm | Maximum |  |  |  |  |  |  |  |
Asset acquisition of MiaMed, Inc. |  |  |  |  |  |  |  |
Priority Review Voucher sale proceeds shared |  | $ 100,000 |  |  |  |  |  |
Priority Review Voucher sale proceeds shared (as a percent) |  | 50.00% |  |  |  |  |  |
Scioderm | Scioderm | Series B Preferred Stock |  |  |  |  |  |  |  |
Asset acquisition of MiaMed, Inc. |  |  |  |  |  |  |  |
Consideration paid in common stock |  | 5,900,000 |  |  |  |  |  |
MiaMed Inc |  |  |  |  |  |  |  |
Asset acquisition of MiaMed, Inc. |  |  |  |  |  |  |  |
Asset acquisition, total consideration, stock and cash | $ 6,500 |  |  |  |  |  |  |
Asset acquisition, cash consideration paid | 1,800 |  |  |  |  |  |  |
Asset acquisition, potential aggregate deal value | 89,500 |  |  |  |  |  |  |
Charges to research expense for stock issued in asset acquisition | $ 6,500 |  |  |  |  |  |  |
MiaMed Inc | Amicus | Common Stock |  |  |  |  |  |  |  |
Asset acquisition of MiaMed, Inc. |  |  |  |  |  |  |  |
Asset acquisition, consideration paid in common stock | 825,603 |  |  |  |  |  |  |
Common stock, par value (in dollars per share) | $ 0.01 |  |  |  |  |  |  |
Clinical, Regulatory and Commercial milestones | MiaMed Inc | Maximum |  |  |  |  |  |  |  |
Asset acquisition of MiaMed, Inc. |  |  |  |  |  |  |  |
Contingent consideration payable upon achievement of milestones | $ 83,000 |  |  |  |  |  |  |
Clinical and Regulatory Approval milestones | Scioderm |  |  |  |  |  |  |  |
Asset acquisition of MiaMed, Inc. |  |  |  |  |  |  |  |
Contingent consideration payable |  |  |  |  | 237,800 |  |  |
Clinical and Regulatory Approval milestones | Scioderm | Minimum |  |  |  |  |  |  |  |
Asset acquisition of MiaMed, Inc. |  |  |  |  |  |  |  |
Discount rate (as a percent) |  | 0.40% |  |  |  |  |  |
Clinical and Regulatory Approval milestones | Scioderm | Maximum |  |  |  |  |  |  |  |
Asset acquisition of MiaMed, Inc. |  |  |  |  |  |  |  |
Upfront cash payments |  | $ 361,000 |  | $ 361,000 |  |  |  |
Discount rate (as a percent) |  | 1.10% |  |  |  |  |  |
Revenue-based milestones | Scioderm |  |  |  |  |  |  |  |
Asset acquisition of MiaMed, Inc. |  |  |  |  |  |  |  |
Upfront equity payments |  | $ 257,000 |  |  |  |  |  |
Contingent consideration payable |  |  |  |  | 26,200 |  |  |
Revenue-based milestones | Scioderm | Minimum |  |  |  |  |  |  |  |
Asset acquisition of MiaMed, Inc. |  |  |  |  |  |  |  |
Discount rate (as a percent) |  | 1.00% |  |  |  |  |  |
Revenue-based milestones | Scioderm | Maximum |  |  |  |  |  |  |  |
Asset acquisition of MiaMed, Inc. |  |  |  |  |  |  |  |
Upfront equity payments |  |  |  |  | $ 257,000 |  |  |
Discount rate (as a percent) |  | 2.20% |  |  |  |  |  |
Clinical milestone | Scioderm | Maximum |  |  |  |  |  |  |  |
Asset acquisition of MiaMed, Inc. |  |  |  |  |  |  |  |
Upfront cash payments |  |  |  | 81,000 |  |  |  |
Regulatory Approval milestone | Scioderm | Maximum |  |  |  |  |  |  |  |
Asset acquisition of MiaMed, Inc. |  |  |  |  |  |  |  |
Upfront cash payments |  |  |  | $ 280,000 |  |  |  |

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