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v3.7.0.1

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2017 | Mar. 31, 2016
Operating activities |  |
Net loss | $ (54,992) | $ (43,691)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Non-cash interest expense | 2,403 | 451
Depreciation | 823 | 673
Stock-based compensation | 6,030 | 4,283
Restructuring charges |  | 50
Change in fair value of derivative liability | (163) |
Non-cash changes in the fair value of contingent consideration payable | 4,578 | 3,152
Foreign currency remeasurement loss | (604) |
Non-cash deferred taxes | 49 |
Changes in operating assets and liabilities: |  |
Accounts receivable | (512) |
Inventories | (243) |
Prepaid expenses and other current assets | (5,846) | (94)
Other non-current assets | (459) | (377)
Accounts payable and accrued expenses | (1,271) | (9,763)
Non-current liabilities | 363 | 380
Net cash used in operating activities | (49,844) | (44,936)
Investing activities |  |
Sale and redemption of marketable securities | 69,443 | 53,157
Purchases of marketable securities | (161,123) | (50,721)
Purchases of property and equipment | (732) | (2,878)
Net cash used in investing activities | (92,412) | (442)
Financing activities |  |
Payment of capital leases | (71) |
Purchase of vested restricted stock units | (261) | (657)
Proceeds from exercise of stock options | 265 | 155
Payment of deferred financing fees | (28) |
Net cash used in financing activities | (95) | (502)
Effect of exchange rate changes on cash and cash equivalents | 80 | (95)
Net decrease in cash and cash equivalents | (142,271) | (45,975)
Cash and cash equivalents at beginning of year/period | 187,026 | 69,485
Cash and cash equivalents at end of year/period | 44,755 | $ 23,510
Supplemental disclosures of cash flow information |  |
Cash paid during the period for interest | $ 12 |

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- Definition Amount of expenses associated with exit or disposal activities pursuant to an authorized plan. Excludes expenses related to a discontinued operation or an asset retirement obligation. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3602-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 420 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6394359&loc=d3e17939-110869 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 420 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB TOPIC 5.P.3) -URI http://asc.fasb.org/extlink&oid=27011515&loc=d3e140864-122747 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 420 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SAB TOPIC 5.P.4(b)) -URI http://asc.fasb.org/extlink&oid=27011515&loc=d3e140904-122747 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Staff Accounting Bulletin (SAB) -Number Topic 5 -Section P -Subsection 3, 4 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3602-108585 + Details
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