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Stockholders' Equity - Nonqualified Cash and Equity Incentive Plans (Details) - USD ($)
 3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Common stock options    
Fair value weighted-average assumptions:    
Expected stock price volatility (as a percent) 83.20% 81.20%
Risk free interest rate (as a percent) 2.10% 1.80%
Expected life of options 6 years 3 months 6 years 3 months
Expected annual dividend per share (in dollars per share) $ 0.00 $ 0.00
Number of Shares    
Balance at the beginning of the period (in shares) 15,497,500  
Options granted (in shares) 2,605,300  
Options exercised (in shares) (88,400)  
Options forfeited (in shares) (192,600)  
Balance at the end of the period (in shares) 17,821,800  
Vested and unvested expected to vest as of the end of the period (in shares) 16,637,600  
Exercisable at the end of the period (in shares) 8,564,000  
Weighted Average Exercise Price    
Balance at the beginning of the period (in dollars per share) $ 7.37  
Options granted (in dollars per share) 5.19  
Options exercised (in dollars per share) 3.00  
Options forfeited (in dollars per share) 9.24  
Balance at the end of the period (in dollars per share) 7.05  
Vested and unvested expected to vest as of the end of the period (in dollars per share) 7.05  
Exercisable at the end of the period (in dollars per share) $ 6.80  
Weighted Average Remaining Contractual Life    
Balance at the end of the period 7 years 6 months  
Vested and unvested expected to vest at the end of the period 7 years 3 months 18 days  
Exercisable at the end of the period 5 years 10 months 24 days  
Aggregate Intrinsic Value    
Aggregate intrinsic value of options outstanding (in dollars) $ 26,100  
Aggregate intrinsic value of options vested and unvested expected to vest (in dollars) 24,800  
Aggregate intrinsic value of options exercisable (in dollars) 15,700  
Total unrecognized compensation cost related to non-vested stock options granted (in dollars) $ 37,200,000  
Period of recognition unrecognized compensation costs (in years) 2 years 9 months 18 days  
Restricted stock units (RSUs) | Amended and Restated 2007 Equity Incentive Plan    
Aggregate Intrinsic Value    
Estimated fair value (in dollars per share) $ 5.64  
Period of recognition unrecognized compensation costs (in years) 3 years  
Restricted Stock Units, Number of Shares    
Non-vested units as of the beginning of the period (in shares) 744,400  
Granted (in shares) 2,308,100  
Vested (in shares) (4,700)  
Forfeited (in shares) (25,900)  
Non-vested units as of the end of the period (in shares) 3,021,900  
Weighted Average Grant Date Fair Value    
Non-vested units as of the beginning of the period (in dollars per share) $ 7.86  
Granted (in dollars per share) 5.64  
Vested (in dollars per share) 14.08  
Forfeited (in dollars per share) 5.81  
Non-vested units as of the end of the period (in dollars per share) $ 6.17  
Weighted Average Remaining Years    
Non-vested units as of the end of the period 3 years  
Aggregate Intrinsic Value    
Non-vested units as of the end of the period (in dollars) $ 21,500,000  
Unrecognized compensation cost related to unvested RSU's (in dollars) $ 13,400,000  
Clinical milestone | Restricted stock units (RSUs) | Amended and Restated 2007 Equity Incentive Plan    
Aggregate Intrinsic Value    
Vesting period 3 years  
Restricted Stock Units, Number of Shares    
Granted (in shares) 401,413  
Executive Officers | Market Performance-based Restricted Stock Units (MPRSUs) | Amended and Restated 2007 Equity Incentive Plan    
Aggregate Intrinsic Value    
Vesting period 3 years  
Estimated fair value (in dollars per share) $ 8.08  
Restricted Stock Units, Number of Shares    
Granted (in shares) 401,413  
Weighted Average Grant Date Fair Value    
Granted (in dollars per share) $ 8.08  
Executive Officers | Market Performance-based Restricted Stock Units (MPRSUs) | Amended and Restated 2007 Equity Incentive Plan | Cliff Vesting    
Aggregate Intrinsic Value    
Vesting period 3 years  
Maximum | Executive Officers | Market Performance-based Restricted Stock Units (MPRSUs) | Amended and Restated 2007 Equity Incentive Plan    
Fair value weighted-average assumptions:    
Vesting percentage 200.00%  
Number of Shares    
Exercisable at the end of the period (in shares) 802,826