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Stockholders' Equity - Nonqualified Cash and Equity Incentive Plans (Details) - USD ($)
3 Months Ended 6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2017
Jun. 30, 2016
Common stock options        
Fair value weighted-average assumptions:        
Expected stock price volatility (as a percent) 82.70% 81.30% 83.20% 81.20%
Risk free interest rate (as a percent) 1.90% 1.30% 2.00% 1.70%
Expected life of options 6 years 3 months 6 years 3 months 6 years 3 months 6 years 3 months
Expected annual dividend per share (in dollars per share) $ 0.00 $ 0.00 $ 0.00 $ 0.00
Number of Shares        
Balance at the beginning of the period (in shares)     15,497,500  
Options granted (in shares)     2,889,500  
Options exercised (in shares)     (464,400)  
Options forfeited (in shares)     (648,000)  
Balance at the end of the period (in shares) 17,274,600   17,274,600  
Vested and unvested expected to vest as of the end of the period (in shares) 16,249,700   16,249,700  
Exercisable at the end of the period (in shares) 8,931,200   8,931,200  
Weighted Average Exercise Price        
Balance at the beginning of the period (in dollars per share)     $ 7.37  
Options granted (in dollars per share)     5.44  
Options exercised (in dollars per share)     3.82  
Options forfeited (in dollars per share)     11.06  
Balance at the end of the period (in dollars per share) $ 7.00   7.00  
Vested and unvested expected to vest as of the end of the period (in dollars per share) 7.00   7.00  
Exercisable at the end of the period (in dollars per share) $ 6.69   $ 6.69  
Weighted Average Remaining Contractual Life        
Balance at the end of the period     7 years 4 months 24 days  
Vested and unvested expected to vest at the end of the period     7 years 3 months 18 days  
Exercisable at the end of the period     6 years 2 months 12 days  
Aggregate Intrinsic Value        
Aggregate intrinsic value of options outstanding (in dollars) $ 60,600   $ 60,600  
Aggregate intrinsic value of options vested and unvested expected to vest (in dollars) 57,200   57,200  
Aggregate intrinsic value of options exercisable (in dollars) 34,200   34,200  
Total unrecognized compensation cost related to non-vested stock options granted (in dollars) $ 34,700,000   $ 34,700,000  
Period of recognition unrecognized compensation costs (in years)     2 years 7 months 6 days  
Restricted stock units (RSUs) | Amended and Restated 2007 Equity Incentive Plan        
Aggregate Intrinsic Value        
Estimated fair value (in dollars per share)     $ 5.69  
Period of recognition unrecognized compensation costs (in years)     3 years  
Restricted Stock Units, Number of Shares        
Non-vested units as of the beginning of the period (in shares)     744,400  
Granted (in shares)     2,348,700  
Vested (in shares)     203,106  
Forfeited (in shares)     (63,800)  
Non-vested units as of the end of the period (in shares) 2,826,200   2,826,200  
Weighted Average Grant Date Fair Value        
Non-vested units as of the beginning of the period (in dollars per share)     $ 7.86  
Granted (in dollars per share)     5.69  
Vested (in dollars per share)     8.40  
Forfeited (in dollars per share)     7.19  
Non-vested units as of the end of the period (in dollars per share) $ 6.04   $ 6.04  
Weighted Average Remaining Years        
Non-vested units as of the end of the period     2 years 10 months 24 days  
Aggregate Intrinsic Value        
Non-vested units as of the end of the period (in dollars) $ 28,500,000   $ 28,500,000  
Unrecognized compensation cost related to unvested RSU's (in dollars) $ 12,400,000   $ 12,400,000  
Clinical milestone | Restricted stock units (RSUs) | Amended and Restated 2007 Equity Incentive Plan        
Aggregate Intrinsic Value        
Vesting period     3 years  
Restricted Stock Units, Number of Shares        
Granted (in shares)     401,413  
Executive Officers | Market Performance-based Restricted Stock Units (MPRSUs) | Amended and Restated 2007 Equity Incentive Plan        
Aggregate Intrinsic Value        
Vesting period     3 years  
Estimated fair value (in dollars per share)     $ 8.08  
Restricted Stock Units, Number of Shares        
Granted (in shares)     401,413  
Weighted Average Grant Date Fair Value        
Granted (in dollars per share)     $ 8.08  
Executive Officers | Market Performance-based Restricted Stock Units (MPRSUs) | Amended and Restated 2007 Equity Incentive Plan | Cliff Vesting        
Aggregate Intrinsic Value        
Vesting period     3 years  
Maximum | Executive Officers | Market Performance-based Restricted Stock Units (MPRSUs) | Amended and Restated 2007 Equity Incentive Plan        
Fair value weighted-average assumptions:        
Vesting percentage     200.00%  
Number of Shares        
Exercisable at the end of the period (in shares) 802,826   802,826