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Consolidated Statements of Operations - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2017
Jun. 30, 2016
Revenue:        
Net product sales $ 7,158   $ 11,327  
Cost of goods sold 1,061   1,836  
Gross Profit 6,097   9,491  
Operating Expenses:        
Research and development 31,985 $ 18,281 62,861 $ 41,706
Selling, general and administrative 19,311 19,300 38,443 35,001
Changes in fair value of contingent consideration payable 1,050 10,186 5,628 13,338
Restructuring charges   8   58
Depreciation 812 767 1,636 1,440
Total operating expenses 53,158 48,542 108,568 91,543
Loss from operations (47,061) (48,542) (99,077) (91,543)
Other income (expenses):        
Interest income 753 331 1,512 638
Interest expense (4,179) (1,055) (8,469) (2,000)
Other income (expense) 2,400 (2,237) 3,010 (2,289)
Loss before income tax (expense)/benefit (48,087) (51,503) (103,024) (95,194)
Income tax (expense)/ benefit (49) 453 (105) 453
Net loss attributable to common stockholders $ (48,136) $ (51,050) $ (103,129) $ (94,741)
Net loss attributable to common stockholders per common share - basic and diluted $ (0.34) $ (0.40) $ (0.72) $ (0.75)
Weighted-average common shares outstanding - basic and diluted 143,000,718 129,122,175 142,886,614 127,160,943