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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Operating activities    
Net loss $ (103,129) $ (94,741)
Adjustments to reconcile net loss to net cash used in operating activities:    
Non-cash interest expense 4,715 1,014
Depreciation 1,636 1,440
Stock-based compensation 11,567 8,748
Restructuring charges   58
(Gain)/ Loss on disposal of asset (8) 17
Change in fair value of derivative liability (265) 346
Non-cash changes in the fair value of contingent consideration payable 5,628 13,338
Foreign currency remeasurement loss (3,003) 1,892
Non-cash income tax benefit   (453)
Non-cash deferred taxes 98  
Changes in operating assets and liabilities:    
Accounts receivable (2,226)  
Inventories (351) (207)
Prepaid expenses and other current assets (2,103) (865)
Other non-current assets (521) (549)
Account payable and accrued expenses (4,297) (8,244)
Non-current liabilities 496 535
Net cash used in operating activities (91,763) (77,671)
Investing activities    
Sale and redemption of marketable securities 137,909 121,283
Purchases of marketable securities (184,494) (126,914)
Purchases of property and equipment (2,279) (4,608)
Net cash used in investing activities (48,864) (10,239)
Financing activities    
Proceeds from issuance of common stock, net of issuance costs   57,818
Proceeds from unsecured loan agreement   30,000
Payment of capital leases (142) (47)
Payment of contingent consideration (10,000) (5,000)
Purchase of vested restricted stock units (1,003) (657)
Proceeds from exercise of stock options 1,554 647
Payment of deferred financing fees (28)  
Net cash used in / (provided by) financing activities (9,619) 82,761
Effect of exchange rate changes on cash and cash equivalents 614 (680)
Net decrease in cash and cash equivalents (149,632) (5,829)
Cash and cash equivalents at beginning of year/ period 187,026 69,485
Cash and cash equivalents at end of year/period 37,394 63,656
Supplemental disclosures of cash flow information    
Cash paid during the period for interest 3,650 276
Contingent consideration resolution in shares   6,115
Capital expenditures unpaid at the end of the period $ 351  
Capital expenditures funded by capital lease borrowings   $ 850