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Stockholders' Equity - Nonqualified Cash and Equity Incentive Plans (Details) - USD ($)
3 Months Ended 9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Sep. 30, 2017
Sep. 30, 2016
Common stock options        
Fair value weighted-average assumptions:        
Expected stock price volatility (as a percent) 82.50% 81.60% 83.10% 81.30%
Risk free interest rate (as a percent) 1.80% 1.20% 2.00% 1.50%
Expected life of options 5 years 10 months 21 days 6 years 3 months 6 years 2 months 16 days 6 years 3 months
Expected annual dividend per share (in dollars per share) $ 0.00 $ 0.00 $ 0.00 $ 0.00
Number of Shares        
Balance at the beginning of the period (in shares)     15,497,500  
Options granted (in shares)     3,279,500  
Options exercised (in shares)     (1,451,200)  
Options forfeited (in shares)     (1,113,800)  
Balance at the end of the period (in shares) 16,212,000   16,212,000  
Vested and unvested expected to vest as of the end of the period (in shares) 15,338,300   15,338,300  
Exercisable at the end of the period (in shares) 8,679,200   8,679,200  
Weighted Average Exercise Price        
Balance at the beginning of the period (in dollars per share)     $ 7.37  
Options granted (in dollars per share)     6.37  
Options exercised (in dollars per share)     6.10  
Options forfeited (in dollars per share)     9.59  
Balance at the end of the period (in dollars per share) $ 7.13   7.13  
Vested and unvested expected to vest as of the end of the period (in dollars per share) 7.10   7.10  
Exercisable at the end of the period (in dollars per share) $ 6.70   $ 6.70  
Weighted Average Remaining Contractual Life        
Balance at the end of the period     7 years 2 months 12 days  
Vested and unvested expected to vest at the end of the period     7 years 1 month 6 days  
Exercisable at the end of the period     6 years  
Aggregate Intrinsic Value        
Aggregate intrinsic value of options outstanding (in dollars) $ 129,500   $ 129,500  
Aggregate intrinsic value of options vested and unvested expected to vest (in dollars) 122,900   122,900  
Aggregate intrinsic value of options exercisable (in dollars) 73,000   73,000  
Total unrecognized compensation cost related to non-vested stock options granted (in dollars) $ 32,400,000   $ 32,400,000  
Period of recognition unrecognized compensation costs (in years)     3 years  
Restricted stock units (RSUs) | Amended and Restated 2007 Equity Incentive Plan        
Aggregate Intrinsic Value        
Estimated fair value (in dollars per share)     $ 5.69  
Period of recognition unrecognized compensation costs (in years)     3 years  
Restricted Stock Units, Number of Shares        
Non-vested units as of the beginning of the period (in shares)     744,400  
Granted (in shares)     2,348,700  
Vested (in shares)     (210,911)  
Forfeited (in shares)     (191,900)  
Non-vested units as of the end of the period (in shares) 2,690,300   2,690,300  
Weighted Average Grant Date Fair Value        
Non-vested units as of the beginning of the period (in dollars per share)     $ 7.86  
Granted (in dollars per share)     5.69  
Vested (in dollars per share)     8.57  
Forfeited (in dollars per share)     6.27  
Non-vested units as of the end of the period (in dollars per share) $ 6.03   $ 6.03  
Weighted Average Remaining Years        
Non-vested units as of the end of the period     2 years 8 months 5 days  
Aggregate Intrinsic Value        
Non-vested units as of the end of the period (in dollars) $ 40,600,000   $ 40,600,000  
Unrecognized compensation cost related to unvested RSU's (in dollars) $ 12,400,000   $ 12,400,000  
Clinical milestone | Restricted stock units (RSUs) | Amended and Restated 2007 Equity Incentive Plan        
Aggregate Intrinsic Value        
Vesting period     3 years  
Restricted Stock Units, Number of Shares        
Granted (in shares)     401,413  
Executive Officers | Market Performance-based Restricted Stock Units (MPRSUs) | Amended and Restated 2007 Equity Incentive Plan        
Aggregate Intrinsic Value        
Vesting period     3 years  
Estimated fair value (in dollars per share)     $ 8.08  
Restricted Stock Units, Number of Shares        
Granted (in shares)     401,413  
Weighted Average Grant Date Fair Value        
Granted (in dollars per share)     $ 8.08  
Executive Officers | Market Performance-based Restricted Stock Units (MPRSUs) | Amended and Restated 2007 Equity Incentive Plan | Cliff Vesting        
Aggregate Intrinsic Value        
Vesting period     3 years  
Maximum | Executive Officers | Market Performance-based Restricted Stock Units (MPRSUs) | Amended and Restated 2007 Equity Incentive Plan        
Fair value weighted-average assumptions:        
Vesting percentage     200.00%  
Number of Shares        
Exercisable at the end of the period (in shares) 802,826   802,826