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Assets and Liabilities Measured at Fair Value (Details) - USD ($) $ in Thousands		3 Months Ended		9 Months Ended
	Jul. 05, 2016	Sep. 30, 2017	Sep. 30, 2016	Sep. 30, 2017	Sep. 30, 2016	Jun. 30, 2017	Dec. 31, 2016
Financial assets and liabilities subject to fair value measurements
Transfer of assets from Level 1 to Level 2		$ 0		$ 0
Transfer of assets from Level 2 to Level 1		0		0
Assets:
Fair value of assets		364,561		364,561			$ 144,754
Liabilities:
Contingent consideration payable		21,100		21,100			269,722
Derivative liability							265
Deferred compensation plan liability		2,134		2,134			1,479
Fair value of liabilities		23,234		23,234			271,466
Contingent consideration payable
Balance, beginning of the period		265,350	$ 276,300	269,722	$ 274,077
Payment of contingent consideration in cash				(10,000)	(5,000)
Payment of contingent consideration in stock					(6,115)
Changes in fair value during the period, included in Statement of Operations		(244,250)	(4,110)	(238,622)	9,228
Balance, end of the period		21,100	$ 272,190	21,100	$ 272,190
Other current liabilities
Foreign Currency Exchange Rate Exposure
Derivative liabilities		0		0			300
MiaMed Inc
Contingent consideration payable
Asset acquisition, potential aggregate deal value	$ 89,500
Maximum | Clinical and Regulatory Approval milestones | MiaMed Inc
Contingent consideration payable
Contingent consideration payable upon achievement of milestones	83,000
Maximum | Clinical, Regulatory and Commercial milestones | MiaMed Inc
Contingent consideration payable
Contingent consideration payable upon achievement of milestones	$ 83,000
ATB200 Pompe program | Clinical and Regulatory Approval milestones | Callidus
Liabilities:
Contingent consideration payable		20,700		20,700
Commercial paper
Assets:
Fair value of assets		123,881		123,881			68,390
Asset-backed securities
Assets:
Fair value of assets		30,326		30,326
Corporate debt securities
Assets:
Fair value of assets		207,890		207,890			74,535
Money market
Assets:
Fair value of assets		2,464		2,464			1,829
Level 2
Assets:
Fair value of assets		364,561		364,561			144,754
Liabilities:
Derivative liability							265
Deferred compensation plan liability		2,134		2,134			1,479
Fair value of liabilities		2,134		2,134			1,744
Level 2 | Commercial paper
Assets:
Fair value of assets		123,881		123,881			68,390
Level 2 | Asset-backed securities
Assets:
Fair value of assets		30,326		30,326
Level 2 | Corporate debt securities
Assets:
Fair value of assets		207,890		207,890			74,535
Level 2 | Money market
Assets:
Fair value of assets		2,464		2,464			1,829
Level 3
Liabilities:
Contingent consideration payable		21,100		21,100			269,722
Fair value of liabilities		$ 21,100		$ 21,100			$ 269,722
Level 3 | ATB200 Pompe program | Clinical and Regulatory Approval milestones | Probability weighted discounted cash flow | Callidus
Liabilities:
Discount rate (as a percent)				12.50%
Level 3 | ATB200 Pompe program | Minimum | Clinical and Regulatory Approval milestones | Probability weighted discounted cash flow | Callidus
Liabilities:
Probability of achievement of milestones (as a percent)		58.00%		58.00%		32.00%
Level 3 | ATB200 Pompe program | Maximum | Clinical and Regulatory Approval milestones | Probability weighted discounted cash flow | Callidus
Liabilities:
Probability of achievement of milestones (as a percent)		100.00%		100.00%		45.00%

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