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Accounts Payable and Accrued Expenses (Details) - USD ($) $ in Thousands | Dec. 31, 2017 | Dec. 31, 2016
--- | --- | ---
Accounts payable and accrued expenses |  |
Accounts payable | $ 7,867 | $ 12,905
Accrued professional fees | 5,845 | 5,079
Accrued contract manufacturing & contract research costs | 4,632 | 8,042
Accrued compensation and benefits | 19,620 | 9,686
Accrued facility costs | 1,665 | 1,740
Accrued program fees | 5,707 |
Foreign currency forward contract |  | 265
Capital lease, short term portion | 307 | 283
Royalties payable | 2,529 | 510
Accrued interest | 313 | 208
Accrued other | 5,405 | 2,290
Accounts payable and accrued expenses | $ 53,890 | $ 41,008

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- Definition Carrying value as of the balance sheet date of obligations incurred through that date and payable for professional fees, such as for legal and accounting services received. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section 45 -Paragraph 6 -URI http://asc.fasb.org/extlink&oid=82887183&loc=d3e6911-107765 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section 45 -Paragraph 8 -URI http://asc.fasb.org/extlink&oid=82887183&loc=d3e6935-107765 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.20) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
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