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v3.8.0.1

Consolidated Statements of Operations - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Revenue: |  |  |
Net Product Sales | $ 36,930 | $ 4,958 |
Total revenue | 36,930 | 4,958 |
Cost of goods sold | 6,236 | 833 |
Gross Profit | 30,694 | 4,125 |
Operating Expenses: |  |  |
Research and development | 149,310 | 104,793 | $ 76,943
Selling, general and administrative | 88,671 | 71,151 | 47,269
Changes in fair value of contingent consideration payable | (234,322) | 6,760 | 4,377
Loss on impairment of assets | 465,427 |  |
Restructuring charges |  | 69 | 15
Depreciation | 3,593 | 3,242 | 1,833
Total operating expenses | 472,679 | 186,015 | 130,437
Loss from operations | (441,985) | (181,890) | (130,437)
Other income (expenses): |  |  |
Interest income | 4,096 | 1,602 | 929
Interest expense | (17,240) | (5,398) | (1,578)
Loss on extinguishment of debt |  | (13,302) | (952)
Other income (expense) | 6,008 | (4,793) | (80)
Loss before income tax benefit | (449,121) | (203,781) | (132,118)
Income tax benefit | 165,119 | 3,739 |
Net loss attributable to common stockholders | $ (284,002) | $ (200,042) | $ (132,118)
Net loss attributable to common stockholders per common share - basic and diluted | $ (1.85) | $ (1.49) | $ (1.20)
Weighted-average common shares outstanding - basic and diluted | 153,355,144 | 134,401,588 | 109,923,815

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