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Income Taxes - Loss Carryforwards (Details) $ in Millions | 12 Months Ended
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Dec. 31, 2017 USD ($)
Net operating loss carry forwards |
Period for measuring the change in ownership | 3 years
Maximum change in ownership percentage allowed before statutory limitations imposed on the availability of net operating losses | 50.00%
Research and experimentation tax credit carryforward |
Net operating loss carry forwards |
Tax credit carryforward amount | $ 35.2
Orphan drug tax credit carryforwards |
Net operating loss carry forwards |
Tax credit carryforward amount | 8.2
Federal |
Net operating loss carry forwards |
Amount of net operating loss carry forwards | 777.6
Write-down of NOLs and R&D credits subject to section 382 limitation | 0.0
State |
Net operating loss carry forwards |
Amount of net operating loss carry forwards | 781.8
Foreign |
Net operating loss carry forwards |
Amount of net operating loss carry forwards | $ 47.1

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- Definition The limitation imposed by Section 382 related to the use of all operating loss carry forwards available to reduce future taxable income in the event of a more than specified percentage change in ownership. + References No definition available. + Details
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- Definition Represents the period over which the basis percentage increase in the shareholders' equity is measured for the purpose of calculating the ownership change as defined in section 382 of the Internal Revenue Code of 1986, as amended, which will affect the ability of the entity to utilize its net operating loss carry forwards. + References No definition available. + Details
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- Definition Write-down to net realizable value of the federal NOL's and research and development credits subject to Section 382 limitations. + References No definition available. + Details
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- Definition Amount of operating loss carryforward, before tax effects, available to reduce future taxable income under enacted tax laws. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 3 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32559-109319 + Details
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- Definition The amount of the tax credit carryforward, before tax effects, available to reduce future taxable income under enacted tax laws. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 3 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32559-109319 + Details
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