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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2017
Income Taxes |
Schedule of income (loss) before income taxes | For financial reporting purposes, income (loss) before income taxes includes the following components (in thousands):
|  | Years Ended December 31, |
|  | 2017 |  | 2016 |  | 2015 |
United States |  | $ | (440,696 | ) | $ | (174,913 | ) | $ | (123,697 | )
Foreign |  |  | (8,425 | ) |  | (28,868 | ) |  | (8,421 | )
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Total |  | $ | (449,121 | ) | $ | (203,781 | ) | $ | (132,118 | )
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Schedule of income tax expense (benefit) | Following were the components of income tax expense (benefit) for the years ending December 31, 2017 and December 31, 2016:
|  | 2017 |  | 2016 |  | 2015 |
Current: |  |  |  |  |  |  |  |  |  |
State |  | $ | 9 |  | $ | 7 |  | $ | — |
Foreign |  |  | 2,276 |  |  | — |  |  | — |
Deferred |  |  |  |  |  |  |  |  |  |
Federal |  |  | (150,015 | ) |  | (1,101 | ) |  | — |
State |  |  | (17,389 | ) |  | (2,645 | ) |  | — |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Total |  | $ | (165,119 | ) | $ | (3,739 | ) | $ | — |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
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Schedule of reconciliation of the statutory tax rates and the effective tax rates |
|  | Years Ended December 31, |
|  | 2017 |  | 2016 |  | 2015 |
Statutory rate |  |  | (34 | )% |  | (34 | )% |  | (34 | )%
State taxes, net of federal benefit |  |  | (5 | ) |  | (5 | ) |  | (5 | )
Permanent adjustments |  |  | (1 | ) |  | 3 |  |  | 2 |
Contingent consideration |  |  | (18 | ) |  | — |  |  | — |
R&D credit |  |  | (2 | ) |  | (3 | ) |  | (3 | )
Foreign income tax rate differential |  |  | 5 |  |  | 2 |  |  | 1 |
Impact of 2017 Act |  |  | 27 |  |  | — |  |  | — |
Other |  |  | 5 |  |  | (1 | ) |  | 2 |
Valuation allowance |  |  | (14 | ) |  | 36 |  |  | 37 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Net |  |  | (37 | )% |  | (2 | )% |  | (0 | )%
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
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Schedule of significant components of the deferred tax assets and liabilities | The significant components of the deferred tax assets and liabilities are as follows (in thousands):
|  | For Years Ended December 31, |
|  | 2017 |  | 2016 |
Deferred tax assets |  |  |  |  |  |  |
Intellectual property |  | $ | 44,573 |  | $ | 95,956 |
Amortization/depreciation |  |  | 3,082 |  |  | 1,781 |
Research tax credit |  |  | 43,382 |  |  | 32,851 |
Net operating loss carry forwards |  |  | 221,912 |  |  | 223,758 |
Deferred revenue |  |  | 6,158 |  |  | 14,281 |
Non-cash stock issue |  |  | 10,751 |  |  | 11,649 |
Others |  |  | 7,328 |  |  | 3,358 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Gross deferred tax assets |  |  | 337,186 |  |  | 383,634 |
Deferred tax liabilities |  |  |  |  |  |  |
Business acquisition |  |  | (6,465 | ) |  | (173,771 | )
Royalty payable |  |  | (44,573 | ) |  | (96,829 | )
Convertible notes |  |  | (18,991 | ) |  | (29,845 | )
Advanced R&D payments |  |  | (3,069 | ) |  | — |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Total net deferred tax asset |  |  | 264,088 |  |  | 83,189 |
Less valuation allowance |  |  | (270,553 | ) |  | (256,960 | )
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Net deferred tax liability |  | $ | (6,465 | ) | $ | (173,771 | )
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​

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- Definition Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32537-109319 + Details
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- Definition Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32687-109319 + Details
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