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Consolidated Statements of Changes in Stockholders' Equity - USD ($) $ in Thousands | Scioderm Common Stock | Scioderm Additional Paid-In Capital | Scioderm | Callidus Common Stock | MiaMed Common Stock | MiaMed Additional Paid-In Capital | MiaMed | Common Stock | Additional Paid-In Capital | Warrants | Other Comprehensive Gain/ (Loss) | Accumulated Deficit | Total
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2014 |  |  |  |  |  |  |  | $ 1,015 | $ 568,743 |  | $ (132) | $ (447,448) | $ 122,178
Balance (in shares) at Dec. 31, 2014 |  |  |  |  |  |  |  | 95,556,277 |  |  |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |  |  |  |  |  |  |  |
Stock issued from exercise of stock options, net |  |  |  |  |  |  |  | $ 21 | 11,165 |  |  |  | 11,186
Stock issued from exercise of stock options, net (in shares) |  |  |  |  |  |  |  | 2,070,300 |  |  |  |  |
Stock issued from equity financing |  |  |  |  |  |  |  | $ 195 | 242,847 |  |  |  | 243,042
Stock issued from equity financing (in shares) |  |  |  |  |  |  |  | 19,528,302 |  |  |  |  |
Stock issued for acquisition | $ 59 | $ 82,787 | $ 82,846 |  |  |  |  |  |  |  |  |  |
Stock issued for acquisition (in shares) | 5,921,771 |  |  | 25,762 |  |  |  |  |  |  |  |  |
Stock issued from exercise of warrants |  |  |  |  |  |  |  | $ 16 | 3,984 |  |  |  | 4,000
Stock issued from exercise of warrants (in shares) |  |  |  |  |  |  |  | 1,600,000 |  |  |  |  |
Restricted stock vesting |  |  |  |  |  |  |  |  | (2,044) |  |  |  | (2,044)
Restricted stock vesting (in shares) |  |  |  |  |  |  |  | 324,622 |  |  |  |  |
Warrants issued in debt financing |  |  |  |  |  |  |  |  |  | $ 8,755 |  |  | 8,755
Stock-based compensation |  |  |  |  |  |  |  |  | 9,972 |  |  |  | 9,972
Unrealized holding gain/(loss) on available-for-sale securities |  |  |  |  |  |  |  |  |  |  | 17 |  | 17
Net loss |  |  |  |  |  |  |  |  |  |  |  | (132,118) | (132,118)
Balance at Dec. 31, 2015 |  |  |  |  |  |  |  | $ 1,306 | 917,454 | 8,755 | (115) | (579,566) | 347,834
Balance (in shares) at Dec. 31, 2015 |  |  |  |  |  |  |  | 125,027,034 |  |  |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |  |  |  |  |  |  |  |
Stock issued from exercise of stock options, net |  |  |  |  |  |  |  | $ 7 | 3,029 |  |  |  | 3,036
Stock issued from exercise of stock options, net (in shares) |  |  |  |  |  |  |  | 723,102 |  |  |  |  |
Stock issued for acquisition |  |  |  |  | $ 8 | $ 4,599 | $ 4,607 |  |  |  |  |  |
Stock issued for acquisition (in shares) |  |  |  |  | 825,603 |  |  |  |  |  |  |  |
Stock issued from ATM transactions |  |  |  |  |  |  |  | $ 150 | 96,918 |  |  |  | 97,068
Stock issued from ATM transactions (in shares) |  |  |  |  |  |  |  | 14,989,027 |  |  |  |  |
Restricted stock vesting |  |  |  |  |  |  |  |  | (1,282) |  |  |  | (1,282)
Restricted stock vesting (in shares) |  |  |  |  |  |  |  | 268,425 |  |  |  |  |
Stock issued for contingent consideration |  |  |  |  |  |  |  | $ 9 | 6,106 |  |  |  | 6,115
Stock issued for contingent consideration (in shares) |  |  |  |  |  |  |  | 858,795 |  |  |  |  |
Receivable from investor |  |  |  |  |  |  |  |  | 932 |  |  |  | 932
Warrants issued in debt financing |  |  |  |  |  |  |  |  |  | 7,321 |  |  | 7,321
Equity component of the Convertible Notes issuance, net of issuance costs of $2,709 |  |  |  |  |  |  |  |  | 88,346 |  |  |  | 88,346
Premium paid for Capped Call Confirmations |  |  |  |  |  |  |  |  | (13,450) |  |  |  | (13,450)
Stock-based compensation |  |  |  |  |  |  |  |  | 17,504 |  |  |  | 17,504
Unrealized holding gain/(loss) on available-for-sale securities |  |  |  |  |  |  |  |  |  |  | 217 |  | 217
Foreign currency translation adjustment |  |  |  |  |  |  |  |  |  |  | 1,945 |  | 1,945
Net loss |  |  |  |  |  |  |  |  |  |  |  | (200,042) | (200,042)
Balance at Dec. 31, 2016 |  |  |  |  |  |  |  | $ 1,480 | 1,120,156 | 16,076 | 2,047 | (779,608) | $ 360,151
Balance (in shares) at Dec. 31, 2016 |  |  |  |  |  |  |  | 142,691,986 |  |  |  |  | 142,691,986
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |  |  |  |  |  |  |  |
Stock issued from exercise of stock options, net |  |  |  |  |  |  |  | $ 29 | 16,272 |  |  |  | $ 16,301
Stock issued from exercise of stock options, net (in shares) |  |  |  |  |  |  |  | 2,878,681 |  |  |  |  |
Stock issued from equity financing |  |  |  |  |  |  |  | $ 212 | 242,825 |  |  |  | 243,037
Stock issued from equity financing (in shares) |  |  |  |  |  |  |  | 21,122,449 |  |  |  |  |
Restricted stock vesting |  |  |  |  |  |  |  |  | (1,596) |  |  |  | (1,596)
Restricted stock vesting (in shares) |  |  |  |  |  |  |  | 296,674 |  |  |  |  |
Stock-based compensation |  |  |  |  |  |  |  |  | 23,101 |  |  |  | 23,101
Unrealized holding gain/(loss) on available-for-sale securities |  |  |  |  |  |  |  |  |  |  | (538) |  | (538)
Foreign currency translation adjustment |  |  |  |  |  |  |  |  |  |  | (3,604) |  | (3,604)
Net loss |  |  |  |  |  |  |  |  |  |  |  | (284,002) | (284,002)
Balance at Dec. 31, 2017 |  |  |  |  |  |  |  | $ 1,721 | $ 1,400,758 | $ 16,076 | $ (2,095) | $ (1,063,610) | $ 352,850
Balance (in shares) at Dec. 31, 2017 |  |  |  |  |  |  |  | 166,989,790 |  |  |  |  | 166,989,790

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