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v3.8.0.1

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Operating activities |  |  |
Net loss | $ (284,002) | $ (200,042) | $ (132,118)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Non-cash interest expense | 9,703 | 2,689 | 492
Depreciation | 3,593 | 3,242 | 1,833
Stock-based compensation | 23,101 | 17,504 | 9,972
Restructuring charges |  | 69 | 15
Change in fair value of derivative liability | (265) | 265 |
Non-cash changes in the fair value of contingent consideration payable | (234,322) | 6,760 | 4,377
Charges to research expense for stock issued in asset acquisition |  | 4,607 |
Loss on extinguishment of debt |  | 13,302 | 952
Foreign currency remeasurement (gain) loss | (5,620) | 3,660 |
Non-cash deferred taxes and other tax benefits | (167,305) | (3,742) |
(Gain) Loss on disposal of assets | (8) | 17 |
Impairment of IPR&D | 465,427 |  |
Changes in operating assets and liabilities: |  |  |
Accounts receivable | (7,725) | (1,419) |
Inventories | (897) | (3,651) |
Prepaid expenses and other current assets | (15,329) | (394) | 308
Other non-current assets | (2,519) | (1,357) | (666)
Account payable and accrued expenses | 12,563 | 7,131 | 15,467
Non-current liabilities | 720 | 825 | 93
Deferred reimbursements | (12,600) |  | (864)
Net cash used in operating activities | (215,485) | (150,534) | (100,139)
Investing activities |  |  |
Sale and redemption of marketable securities | 323,753 | 221,374 | 290,129
Purchases of marketable securities | (490,468) | (219,932) | (289,595)
Acquisitions, net of cash acquired |  |  | (141,060)
Purchases of property and equipment | (4,526) | (5,951) | (4,817)
Net cash used in investing activities | (171,241) | (4,509) | (145,343)
Financing activities |  |  |
Proceeds from issuance of common stock and warrants, net of issuance costs | 243,037 | 97,068 | 243,042
Payments of secured loan agreement |  | (80,000) | (15,291)
Payment of capital leases | (308) | (193) |
Purchase of vested restricted stock units | (1,596) | (1,282) | (2,044)
Proceeds from exercise of stock options | 16,301 | 3,036 | 11,186
Proceeds from exercise of warrants |  |  | 4,000
Payment of contingent consideration | (10,000) | (5,000) |
Proceeds from issuance of convertible senior notes, net of issuance costs |  | 242,536 |
Premiums paid for Capped Call Confirmations |  | (13,450) |
Proceeds from secured loan agreement |  | 30,000 | 50,000
Net cash provided by financing activities | 247,434 | 272,715 | 290,893
Effect of exchange rate changes on cash and cash equivalents | 1,326 | (131) |
Net (decrease)/increase in cash and cash equivalents | (137,966) | 117,541 | 45,411
Cash and cash equivalents at beginning of year/ period | 187,026 | 69,485 | 24,074
Cash and cash equivalents at end of year/period | 49,060 | 187,026 | 69,485
Supplemental disclosures of cash flow information |  |  |
Cash paid during the period for interest | $ 7,424 | 2,990 | $ 605
Contingent consideration paid in shares |  | 6,115 |
Capital expenditures funded by capital lease borrowings |  | $ 944 |

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- Definition The cash inflow from the issuance of a long-term debt instrument which can be exchanged for a specified amount of another security, typically the entity's common stock, at the option of the issuer or the holder. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3255-108585 + Details
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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3255-108585 + Details
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- Definition The cash inflow from amounts received from issuance of long-term debt that is wholly or partially secured by collateral. Excludes proceeds from tax exempt secured debt. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3255-108585 + Details
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- Definition The cash inflow associated with the sale or maturity (principal being due) of securities not classified as either held-to-maturity securities or trading securities which are classified as available-for-sale securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3179-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=82896770&loc=d3e26853-111562 + Details
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- Definition Amount of cash inflow from exercise of stock options granted under share-based compensation arrangement. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3255-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2A -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=96867065&loc=SL79508275-113901 + Details
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- Definition The cash inflow associated with the amount received from holders exercising their stock warrants. + References No definition available. + Details
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- Definition The consolidated profit or loss for the period, net of income taxes, including the portion attributable to the noncontrolling interest. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 55 -Paragraph 4K -URI http://asc.fasb.org/extlink&oid=84234705&loc=SL4591552-111686 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 45 -Paragraph 19 -URI http://asc.fasb.org/extlink&oid=96868048&loc=SL4569616-111683 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 50 -Paragraph 1A -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=84161450&loc=SL4573702-111684 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 55 -Paragraph 4J -URI http://asc.fasb.org/extlink&oid=84234705&loc=SL4591551-111686 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 50 -Paragraph 1A -Subparagraph (a)(2) -URI http://asc.fasb.org/extlink&oid=84161450&loc=SL4573702-111684 + Details
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- Definition The cash outflow during the period from the repayment of aggregate short-term and long-term debt and payment of capital lease obligations. + References No definition available. + Details
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- Definition The cash outflow to repay long-term debt that is wholly or partially secured by collateral. Excludes repayments of tax exempt secured debt. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3291-108585 + Details
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- Definition Amount of expenses associated with exit or disposal activities pursuant to an authorized plan. Excludes expenses related to a discontinued operation or an asset retirement obligation. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 420 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 5.P.3) -URI http://asc.fasb.org/extlink&oid=27011515&loc=d3e140864-122747 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3602-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 420 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6394359&loc=d3e17939-110869 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 420 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SAB Topic 5.P.4(b)) -URI http://asc.fasb.org/extlink&oid=27011515&loc=d3e140904-122747 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3602-108585 + Details
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