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Income Taxes - Statutory Rate (Details) - USD ($) $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Sep. 30, 2017 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Income (loss) before income taxes: |  |  |  |  |
United States |  |  | $ (440,696) | $ (174,913) | $ (123,697)
Foreign |  |  | (8,425) | (28,868) | (8,421)
Loss before income tax benefit |  |  | (449,121) | (203,781) | $ (132,118)
Current: |  |  |  |  |
State |  |  | 9 | 7 |
Foreign |  |  | 2,276 |  |
Deferred |  |  |  |  |
Federal |  |  | (150,015) | (1,101) |
State |  |  | (17,389) | (2,645) |
Total |  |  | $ (165,119) | $ (3,739) |
Reconciliation of the statutory tax rates and the effective tax rates |  |  |  |  |
Statutory rate (as a percent) |  |  | (34.00%) | (34.00%) | (34.00%)
State taxes, net of federal benefit (as a percent) |  |  | (5.00%) | (5.00%) | (5.00%)
Permanent adjustments (as a percent) |  |  | (1.00%) | 3.00% | 2.00%
Contingent consideration (as a percent) |  |  | (18.00%) |  |
R&D credit (as a percent) |  |  | (2.00%) | (3.00%) | (3.00%)
Foreign income tax rate differential (as a percent) |  |  | 5.00% | 2.00% | 1.00%
Impact of 2017 Act (as a percent) |  |  | 27.00% |  |
Other (as a percent) |  |  | 5.00% | (1.00%) | 2.00%
Valuation allowance (as a percent) |  |  | (14.00%) | 36.00% | 37.00%
Net (as a percent) |  |  | (37.00%) | (2.00%) | (0.00%)
Income tax benefit on reduction of income tax rate |  |  | $ (2,700) |  |
Income tax benefit |  |  | (165,119) | $ (3,739) |
Forecast |  |  |  |  |
Reconciliation of the statutory tax rates and the effective tax rates |  |  |  |  |
Statutory rate (as a percent) |  | (21.00%) |  |  |
SD-101 |  |  |  |  |
Deferred |  |  |  |  |
Total | $ 164,700 |  | 164,700 |  |
Reconciliation of the statutory tax rates and the effective tax rates |  |  |  |  |
Income tax benefit | $ 164,700 |  | $ 164,700 |  |

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