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Description of Business (Details) - USD ($) $ / shares in Units, $ in Thousands |  |  |  |  | 1 Months Ended | 3 Months Ended | 4 Months Ended | 12 Months Ended
--- | --- | --- | --- | --- | --- | --- | --- | ---
Feb. 21, 2018 | Feb. 15, 2018 | Jul. 18, 2017 | Jul. 05, 2016 | Jul. 31, 2017 | Dec. 31, 2016 | Sep. 30, 2017 | Jul. 31, 2016 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Corporate Information, Status of Operations and Management Plans |  |  |  |  |  |  |  |  |  |  |
Loss on impairment of intangible assets |  |  |  |  |  |  |  |  | $ 463,700 |  |
Changes in fair value of contingent consideration payable |  |  |  |  |  |  |  |  | 234,322 | $ (6,760) | $ (4,377)
Contingent consideration payable |  |  |  |  |  | $ 269,722 |  |  | 25,400 | 269,722 |
Income tax benefit |  |  |  |  |  |  |  |  | (165,119) | (3,739) |
Number of common stock shares issued from underwriting agreement |  |  |  |  | 21,122,449 |  |  |  |  |  |
Price per share of common stock issued (in dollars per share) |  |  |  |  | $ 12.25 |  |  |  |  |  |
Gross proceeds from issue of common stock before deducting underwriting discounts and commissions |  |  |  |  | $ 258,800 |  |  |  | 243,037 |  | 243,042
Net proceeds from the issuance of common stock after deducting underwriting discounts and commissions |  |  | $ 243,000 |  |  |  |  |  | $ 243,037 | $ 97,068 | $ 243,042
Common stock, par value (in dollars per share) |  |  |  |  |  | $ 0.01 |  |  | $ 0.01 | $ 0.01 |
Net proceeds from convertible notes to pay capped call transactions |  |  |  |  |  |  |  |  |  | $ 13,450 |
Net proceeds from stock issued at ATM transactions |  |  |  |  |  |  |  |  |  | 97,068 |
Accumulated deficit |  |  |  |  |  | $ (779,608) |  |  | $ (1,063,610) | $ (779,608) |
SD-101 |  |  |  |  |  |  |  |  |  |  |
Corporate Information, Status of Operations and Management Plans |  |  |  |  |  |  |  |  |  |  |
Loss on impairment related to fixed assets |  |  |  |  |  |  |  |  | 1,700 |  |
Changes in fair value of contingent consideration payable |  |  |  |  |  |  | $ 254,700 |  |  |  |
Contingent consideration payable |  |  |  |  |  |  | 0 |  |  |  |
Selling, general and administrative costs due to wind-down |  |  |  |  |  |  | 400 |  |  |  |
Research and development expenses due to wind-down |  |  |  |  |  |  | 8,100 |  |  |  |
Income tax benefit |  |  |  |  |  |  | $ 164,700 |  | $ 164,700 |  |
Cowen and Company, LLC | Sales Agreement |  |  |  |  |  |  |  |  |  |  |
Corporate Information, Status of Operations and Management Plans |  |  |  |  |  |  |  |  |  |  |
Number of shares issued from ATM transactions (in shares) |  |  |  |  |  |  |  | 15,000,000 |  |  |
Net proceeds from stock issued at ATM transactions |  |  |  |  |  |  |  | $ 97,100 |  |  |
Commission expenses incurred on issue of common stock |  |  |  |  |  |  |  | 2,700 |  |  |
Other expenses paid |  |  |  |  |  |  |  | $ 200 |  |  |
Common Stock |  |  |  |  |  |  |  |  |  |  |
Corporate Information, Status of Operations and Management Plans |  |  |  |  |  |  |  |  |  |  |
Number of common stock shares issued from underwriting agreement |  |  |  |  | 21,122,449 |  |  |  | 21,122,449 |  | 19,528,302
Price per share of common stock issued (in dollars per share) |  |  |  |  | $ 12.25 |  |  |  |  |  |
Gross proceeds from issue of common stock before deducting underwriting discounts and commissions |  |  |  |  | $ 258,800 |  |  |  | $ 212 |  | $ 195
Net proceeds from the issuance of common stock after deducting underwriting discounts and commissions |  |  | $ 243,000 |  |  |  |  |  |  |  |
Number of shares issued from ATM transactions (in shares) |  |  |  |  |  |  |  |  |  | 14,989,027 |
Net proceeds from stock issued at ATM transactions |  |  |  |  |  |  |  |  |  | $ 150 |
Common Stock | Subsequent event |  |  |  |  |  |  |  |  |  |  |
Corporate Information, Status of Operations and Management Plans |  |  |  |  |  |  |  |  |  |  |
Number of common stock shares issued from underwriting agreement |  | 19,354,839 |  |  |  |  |  |  |  |  |
Price per share of common stock issued (in dollars per share) |  | $ 15.50 |  |  |  |  |  |  |  |  |
Gross proceeds from issue of common stock before deducting underwriting discounts and commissions |  | $ 300,000 |  |  |  |  |  |  |  |  |
Net proceeds from the issuance of common stock after deducting underwriting discounts and commissions | $ 282,000 |  |  |  |  |  |  |  |  |  |
Convertible Notes | 2016 Convertible Notes |  |  |  |  |  |  |  |  |  |  |
Corporate Information, Status of Operations and Management Plans |  |  |  |  |  |  |  |  |  |  |
Aggregate principal amount |  |  |  |  |  | $ 250,000 |  |  |  | $ 250,000 |
Fixed interest rate (as a percent) |  |  |  |  |  | 3.00% |  |  |  | 3.00% |
Proceeds from convertible notes, Net of issuance costs |  |  |  |  |  | $ 243,000 |  |  |  |  |
Net proceeds from convertible notes to pay capped call transactions |  |  |  |  |  | $ 13,500 |  |  |  |  |
Maximum | Cowen and Company, LLC | Sales Agreement |  |  |  |  |  |  |  |  |  |  |
Corporate Information, Status of Operations and Management Plans |  |  |  |  |  |  |  |  |  |  |
Fixed commission rate as a percentage of gross proceeds per Share sold |  |  |  |  |  |  |  | 3.00% |  |  |
IPR&D | SD-101 |  |  |  |  |  |  |  |  |  |  |
Corporate Information, Status of Operations and Management Plans |  |  |  |  |  |  |  |  |  |  |
Loss on impairment of intangible assets |  |  |  |  |  |  |  |  | $ 463,700 |  |
MiaMed Inc |  |  |  |  |  |  |  |  |  |  |
Corporate Information, Status of Operations and Management Plans |  |  |  |  |  |  |  |  |  |  |
Asset acquisition, potential aggregate deal value |  |  |  | $ 89,500 |  |  |  |  |  |  |
Asset acquisition, total consideration, stock and cash |  |  |  | 6,500 |  |  |  |  |  |  |
MiaMed Inc | Clinical, Regulatory and Commercial milestones | Maximum |  |  |  |  |  |  |  |  |  |  |
Corporate Information, Status of Operations and Management Plans |  |  |  |  |  |  |  |  |  |  |
Contingent consideration payable upon achievement of milestones |  |  |  | $ 83,000 |  |  |  |  |  |  |

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