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Stockholders' Equity - Common Stock and Warrants (Details) |  |  |  |  |  | 1 Months Ended | 4 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Feb. 21, 2018 USD ($) | Feb. 15, 2018 USD ($) $ / shares shares | Jul. 18, 2017 USD ($) | Dec. 21, 2016 USD ($) $ / shares | Jul. 05, 2016 USD ($) shares | Sep. 30, 2017 USD ($) shares | Jul. 31, 2017 USD ($) $ / shares shares | Jun. 30, 2016 USD ($) $ / shares shares | Feb. 29, 2016 USD ($) shares | Jul. 31, 2016 USD ($) shares | Dec. 31, 2017 USD ($) item $ / shares shares | Dec. 31, 2016 USD ($) item $ / shares shares | Dec. 31, 2015 USD ($) shares | Oct. 31, 2015 USD ($) shares
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Authorized number of shares of common stock | shares |  |  |  |  |  |  |  |  |  |  | 250,000,000 | 250,000,000 |  |
Voting right for each share held, number | item |  |  |  |  |  |  |  |  |  |  | 1 | 1 |  |
Common stock, par value (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  | $ 0.01 | $ 0.01 |  |
Number of common stock shares issued from underwriting agreement | shares |  |  |  |  |  |  | 21,122,449 |  |  |  |  |  |  |
Price per share of common stock issued (in dollars per share) | $ / shares |  |  |  |  |  |  | $ 12.25 |  |  |  |  |  |  |
Gross proceeds from issue of common stock before deducting underwriting discounts and commissions |  |  |  |  |  |  | $ 258,800,000 |  |  |  | $ 243,037,000 |  | $ 243,042,000 |
Net proceeds from the issuance of common stock after deducting underwriting discounts and commissions |  |  | $ 243,000,000 |  |  |  |  |  |  |  | 243,037,000 | $ 97,068,000 | $ 243,042,000 |
Net proceeds from stock issued at ATM transactions |  |  |  |  |  |  |  |  |  |  |  | 97,068,000 |  |
Warrant liability |  |  |  |  |  |  |  |  |  |  | $ 16,076,000 | $ 16,076,000 |  |
Common Stock |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of common stock shares issued from underwriting agreement | shares |  |  |  |  |  |  | 21,122,449 |  |  |  | 21,122,449 |  | 19,528,302 |
Price per share of common stock issued (in dollars per share) | $ / shares |  |  |  |  |  |  | $ 12.25 |  |  |  |  |  |  |
Gross proceeds from issue of common stock before deducting underwriting discounts and commissions |  |  |  |  |  |  | $ 258,800,000 |  |  |  | $ 212,000 |  | $ 195,000 |
Net proceeds from the issuance of common stock after deducting underwriting discounts and commissions |  |  | $ 243,000,000 |  |  |  |  |  |  |  |  |  |  |
Number of shares issued from ATM transactions (in shares) | shares |  |  |  |  |  |  |  |  |  |  |  | 14,989,027 |  |
Net proceeds from stock issued at ATM transactions |  |  |  |  |  |  |  |  |  |  |  | $ 150,000 |  |
Cowen and Company, LLC | Sales Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of shares issued from ATM transactions (in shares) | shares |  |  |  |  |  |  |  |  |  | 15,000,000 |  |  |  |
Net proceeds from stock issued at ATM transactions |  |  |  |  |  |  |  |  |  | $ 97,100,000 |  |  |  |
Commission expenses incurred on issue of common stock |  |  |  |  |  |  |  |  |  | 2,700,000 |  |  |  |
Other Expenses |  |  |  |  |  |  |  |  |  | $ 200,000 |  |  |  |
Cowen and Company, LLC | Sales Agreement | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Fixed commission rate as a percentage of gross proceeds per Share sold |  |  |  |  |  |  |  |  |  | 3.00% |  |  |  |
Scioderm |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Initial amount to Effective Time Holders |  |  |  |  |  | $ 223,900,000 |  |  |  |  |  |  |  |
Initial amount cash payment excluding Series B Preferred |  |  |  |  |  | 141,100,000 |  |  |  |  |  |  |  |
Initial amount paid in shares of Common Stock |  |  |  |  |  | $ 82,800,000 |  |  |  |  |  |  |  |
Scioderm | Amicus | Common Stock |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Consideration paid in common stock | shares |  |  |  |  |  | 5,900,000 |  |  |  |  |  |  |  |
MiaMed Inc |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Asset acquisition, total consideration, stock and cash |  |  |  |  | $ 6,500,000 |  |  |  |  |  |  |  |  |
Asset acquisition, cash consideration paid |  |  |  |  | 1,800,000 |  |  |  |  |  |  |  |  |
Asset acquisition, potential aggregate deal value |  |  |  |  | 89,500,000 |  |  |  |  |  |  |  |  |
MiaMed Inc | Maximum | Clinical, Regulatory and Commercial milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contingent consideration payable upon achievement of milestones |  |  |  |  | $ 83,000,000 |  |  |  |  |  |  |  |  |
MiaMed Inc | Amicus | Common Stock |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Consideration paid in common stock | shares |  |  |  |  | 825,603 |  |  |  |  |  |  |  |  |
October 2015 Notes and Warrants Purchase Agreement | Redmile Group |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Fixed interest rate (as a percent) |  |  |  |  |  |  |  |  |  |  |  |  |  | 4.10%
Warrant liability |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 8,800,000
October 2015 Notes and Warrants Purchase Agreement | Redmile Group | Private Placement Purchase Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate principal amount |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 50,000,000
October 2015 Notes and Warrants Purchase Agreement | Redmile Group | Private Placement Purchase Agreement | Warrants |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issuable for warrants (in shares) | shares |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,300,000
February 2016 Notes and Warrants Purchase Agreement | Beneficial Owner | Redmile Group | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate principal amount |  |  |  |  |  |  |  |  | $ 75,000,000 |  |  |  |  |
February 2016 Notes and Warrants Purchase Agreement | Beneficial Owner | Redmile Group | Private Placement Purchase Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate principal amount |  |  |  |  |  |  |  |  | $ 50,000,000 |  |  |  |  |
Fixed interest rate (as a percent) |  |  |  |  |  |  |  |  | 3.875% |  |  |  |  |
February 2016 Notes and Warrants Purchase Agreement | Beneficial Owner | Redmile Group | Private Placement Purchase Agreement | Warrants |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Increment used for debt conversion |  |  |  |  |  |  |  |  | $ 1,000 |  |  |  |  |
Shares issuable for warrants (in shares) | shares |  |  |  |  |  |  |  |  | 1,800,000 |  |  |  |  |
February 2016 Notes and Warrants Purchase Agreement | Beneficial Owner | Redmile Group | Private Placement Purchase Agreement | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issuable for warrants (in shares) | shares |  |  |  |  |  |  |  |  | 1,850,000 |  |  |  |  |
2016 Convertible Notes | Convertible Notes |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate principal amount |  |  |  |  |  |  |  |  |  |  |  | $ 250,000,000 |  |
Fixed interest rate (as a percent) |  |  |  |  |  |  |  |  |  |  |  | 3.00% |  |
Debt conversion ratio (in shares) |  |  |  | 0.1633987 |  |  |  |  |  |  |  |  |  |
Increment used for debt conversion |  |  |  | $ 1,000 |  |  |  |  |  |  |  |  |  |
Conversion price (in dollars per share) | $ / shares |  |  |  | $ 6.12 |  |  |  |  |  |  |  |  |  |
Additional Note and Warrant Agreement June 2016 | Beneficial Owner | Redmile Group | Private Placement Purchase Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate principal amount |  |  |  |  |  |  |  | $ 30,000,000 |  |  |  |  |  |
Fixed interest rate (as a percent) |  |  |  |  |  |  |  | 3.875% |  |  |  |  |  |
Common stock, par value (in dollars per share) | $ / shares |  |  |  |  |  |  |  | $ 0.01 |  |  |  |  |  |
Additional Note and Warrant Agreement June 2016 | Beneficial Owner | Redmile Group | Private Placement Purchase Agreement | Warrants |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Increment used for debt conversion |  |  |  |  |  |  |  | $ 1,000 |  |  |  |  |  |
Shares issuable for warrants (in shares) | shares |  |  |  |  |  |  |  | 1,300,000 |  |  |  |  |  |
Additional Note and Warrant Agreement June 2016 | Beneficial Owner | Redmile Group | Private Placement Purchase Agreement | Maximum | Warrants |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issuable for warrants (in shares) | shares |  |  |  |  |  |  |  | 1,260,000 |  |  |  |  |  |
Subsequent event | Common Stock |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Debt |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of common stock shares issued from underwriting agreement | shares |  | 19,354,839 |  |  |  |  |  |  |  |  |  |  |  |
Price per share of common stock issued (in dollars per share) | $ / shares |  | $ 15.50 |  |  |  |  |  |  |  |  |  |  |  |
Gross proceeds from issue of common stock before deducting underwriting discounts and commissions |  | $ 300,000,000 |  |  |  |  |  |  |  |  |  |  |  |
Net proceeds from the issuance of common stock after deducting underwriting discounts and commissions | $ 282,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |

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