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Stockholders' Equity - Nonqualified Cash Plan and Equity Incentive Plans (Details) - USD ($) $ / shares in Units, $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Aggregate Intrinsic Value |  |  |
Proceeds from exercise of stock options | $ 16,301 | $ 3,036 | $ 11,186
Nonqualified Cash Plan (the "Deferral Plan") |  |  |
Stockholders' Equity |  |  |
Deferred compensation investment | 2,248 | 1,469 |
Deferred compensation liability | 2,258 | 1,479 |
Investment income | 66 | 34 |
Unrealized gain | $ 92 | $ 32 |
Common stock options |  |  |
Fair value weighted-average assumptions: |  |  |
Maximum term of option | 10 years |  |
Expected stock price volatility (as a percent) | 82.80% | 81.30% | 75.90%
Risk free interest rate (as a percent) | 2.00% | 1.50% | 1.70%
Expected life of options | 6 years 2 months 5 days | 6 years 3 months | 6 years 3 months
Expected annual dividend per share (in dollars per share) | $ 0.00 | $ 0.00 | $ 0.00
Granted (in dollars per share) | $ 5.09 | $ 5.28 | $ 7.51
Number of Shares |  |  |
Balance at the beginning of the period (in shares) | 15,497,500 | 11,729,200 | 10,020,700
Options granted (in shares) | 3,695,300 | 5,114,100 | 3,917,200
Options exercised (in shares) | (2,878,700) | (723,100) | (2,070,300)
Options forfeited (in shares) | (1,133,000) | (622,700) | (138,400)
Balance at the end of the period (in shares) | 15,181,100 | 15,497,500 | 11,729,200
Vested and unvested expected to vest as of the end of the period (in shares) | 14,398,500 |  |
Exercisable at the end of the period (in shares) | 7,985,600 |  |
Weighted Average Exercise Price |  |  |
Balance at the beginning of the period (in dollars per share) | $ 7.37 | $ 7.11 | $ 5.02
Options granted (in dollars per share) | 7.17 | 7.67 | 11.61
Options exercised (in dollars per share) | 5.67 | 4.20 | 5.43
Options forfeited (in dollars per share) | 9.55 | 8.62 | 7.76
Balance at the end of the period (in dollars per share) | 7.48 | $ 7.37 | $ 7.11
Vested and unvested expected to vest as of the end of the period (in dollars per share) | 7.45 |  |
Exercisable at the end of the period (in dollars per share) | $ 7.05 |  |
Weighted Average Remaining Contractual Life |  |  |
Balance at the end of the period | 7 years 2 months 12 days |  |
Vested and unvested expected to vest at the end of the period | 7 years 1 month 6 days |  |
Exercisable at the end of the period | 6 years |  |
Aggregate Intrinsic Value |  |  |
Aggregate intrinsic value of options outstanding (in dollars) | $ 105,800 |  |
Aggregate intrinsic value of options vested and unvested expected to vest (in dollars) | 100,900 |  |
Aggregate intrinsic value of options exercisable (in dollars) | 59,100 |  |
Aggregate intrinsic value of options exercised (in dollars) | 20,800 | $ 2,600 | $ 14,700
Proceeds from exercise of stock options | 16,300 | $ 3,000 | $ 11,200
Total unrecognized compensation cost related to non-vested stock options granted (in dollars) | $ 31,900 |  |
Period of recognition unrecognized compensation costs (in years) | 2 years 6 months |  |
Common stock options | 2007 Plan and 2007 Director Plan |  |  |
Fair value weighted-average assumptions: |  |  |
Percentage of options vest on the first year anniversary |  | 25.00% |
Vesting percentage |  | 2.08% |
Percentage of shares vested that may be exercised in whole or part |  | 100.00% |
Restricted stock units (RSUs) | Amended and Restated 2007 Equity Incentive Plan |  |  |
Aggregate Intrinsic Value |  |  |
Estimated fair value (in dollars per share) | $ 5.69 | $ 6.21 |
Period of recognition unrecognized compensation costs (in years) | 2 years 5 months 19 days |  |
Restricted Stock Units, Number of Shares |  |  |
Non-vested units as of the beginning of the period (in shares) | 744,400 | 478,500 |
Granted (in shares) | 2,348,700 | 582,700 |
Vested (in shares) | (318,200) | (281,900) |
Forfeited (in shares) | (199,800) | (34,900) |
Non-vested units as of the end of the period (in shares) | 2,575,100 | 744,400 | 478,500
Weighted Average Grant Date Fair Value |  |  |
Non-vested units as of the beginning of the period (in dollars per share) | $ 7.86 | $ 10.38 |
Granted (in dollars per share) | 5.69 | 6.21 |
Vested (in dollars per share) | 9.23 | 8.73 |
Forfeited (in dollars per share) | 6.24 | 7.71 |
Non-vested units as of the end of the period (in dollars per share) | $ 5.85 | $ 7.86 | $ 10.38
Weighted Average Remaining Years |  |  |
Non-vested units as of the end of the period | 2 years 5 months 19 days |  |
Aggregate Intrinsic Value |  |  |
Non-vested units as of the end of the period (in dollars) | $ 37,100 |  |
Unrecognized compensation cost related to unvested RSU's (in dollars) | $ 11,400 |  |
Clinical milestone | Restricted stock units (RSUs) | Amended and Restated 2007 Equity Incentive Plan |  |  |
Aggregate Intrinsic Value |  |  |
Vesting period | 3 years |  |
Restricted Stock Units, Number of Shares |  |  |
Granted (in shares) | 401,413 |  |
Executive Officers | Market Performance-based Restricted Stock Units (MPRSUs) | Amended and Restated 2007 Equity Incentive Plan |  |  |
Aggregate Intrinsic Value |  |  |
Vesting period | 3 years |  |
Estimated fair value (in dollars per share) | $ 8.08 |  |
Restricted Stock Units, Number of Shares |  |  |
Granted (in shares) | 401,413 |  |
Weighted Average Grant Date Fair Value |  |  |
Granted (in dollars per share) | $ 8.08 |  |
Executive Officers | Market Performance-based Restricted Stock Units (MPRSUs) | Amended and Restated 2007 Equity Incentive Plan | Cliff Vesting |  |  |
Aggregate Intrinsic Value |  |  |
Vesting period | 3 years |  |
Maximum | Common stock options | 2007 Plan and 2007 Director Plan |  |  |
Fair value weighted-average assumptions: |  |  |
Number of shares reserved for issuance | 7,855,550 |  |
Maximum | Executive Officers | Market Performance-based Restricted Stock Units (MPRSUs) | Amended and Restated 2007 Equity Incentive Plan |  |  |
Fair value weighted-average assumptions: |  |  |
Vesting percentage | 200.00% |  |
Number of Shares |  |  |
Exercisable at the end of the period (in shares) | 802,826 |  |

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- Definition The number of equity-based payment instruments, excluding stock (or unit) options, that were forfeited during the reporting period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1)(iv)(3) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition Weighted average fair value as of the grant date of equity-based award plans other than stock (unit) option plans that were not exercised or put into effect as a result of the occurrence of a terminating event. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2)(iii)(3) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition The number of grants made during the period on other than stock (or unit) option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, performance target plan). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2)(iii)(1) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition The weighted average fair value at grant date for nonvested equity-based awards issued during the period on other than stock (or unit) option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, performance target plan). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2)(iii)(1) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition The number of non-vested equity-based payment instruments, excluding stock (or unit) options, that validly exist and are outstanding as of the balance sheet date. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2)(i)-(ii) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition The weighted average fair value of nonvested awards on equity-based plans excluding option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, revenue or profit achievement stock award plan) for which the employer is contingently obligated to issue equity instruments or transfer assets to an employee who has not yet satisfied service or performance criteria necessary to gain title to proceeds from the sale of the award or underlying shares or units. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2)(i)-(ii) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition The number of equity-based payment instruments, excluding stock (or unit) options, that vested during the reporting period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2)(iii)(2) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition The estimated measure of the percentage by which a share price is expected to fluctuate during a period. Volatility also may be defined as a probability-weighted measure of the dispersion of returns about the mean. The volatility of a share price is the standard deviation of the continuously compounded rates of return on the share over a specified period. That is the same as the standard deviation of the differences in the natural logarithms of the stock prices plus dividends, if any, over the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2)(ii) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition The weighted-average price as of the balance sheet date at which grantees can acquire the shares reserved for issuance on vested portions of options outstanding and currently exercisable under the stock option plan. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1)(iii) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition Amount of accumulated difference between fair value of underlying shares on dates of exercise and exercise price on options exercised (or share units converted) into shares. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d)(2) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition The number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1)(iv)(3) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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