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Assets and Liabilities Measured at Fair Value (Details) - USD ($) $ in Thousands |  | 12 Months Ended |  |
--- | --- | --- | --- | ---
Jul. 05, 2016 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | Jun. 30, 2016 | Oct. 31, 2015
Financial assets and liabilities subject to fair value measurements |  |  |  |  |  |
Transfer of assets from Level 1 to Level 2 |  | $ 0 |  |  |  |
Transfer of assets from Level 2 to Level 1 |  | 0 |  |  |  |
Assets: |  |  |  |  |  |
Fair value of assets |  | 311,700 | $ 144,754 |  |  |
Liabilities: |  |  |  |  |  |
Contingent consideration payable |  | 25,400 | 269,722 |  |  |
Derivative liability |  |  | 265 |  |  |
Deferred compensation plan liability |  | 2,258 | 1,479 |  |  |
Fair value of liabilities |  | 27,658 | 271,466 |  |  |
Contingent consideration payable |  |  |  |  |  |
Balance, beginning of the period |  | 269,722 | 274,077 |  |  |
Payment of contingent consideration in cash |  | (10,000) | (5,000) |  |  |
Payment of contingent consideration in stock |  |  | (6,115) |  |  |
Unrealized change in fair value change during the period, included in Statement of Operations |  | (234,322) | 6,760 | $ 4,377 |  |
Balance, end of the period |  | 25,400 | 269,722 | $ 274,077 |  |
Callidus |  |  |  |  |  |
Liabilities: |  |  |  |  |  |
Contingent consideration payable |  | 25,400 |  |  |  |
MiaMed Inc |  |  |  |  |  |
Contingent consideration payable |  |  |  |  |  |
Asset acquisition, potential aggregate deal value | $ 89,500 |  |  |  |  |
Clinical and Regulatory Approval milestones | Callidus |  |  |  |  |  |
Liabilities: |  |  |  |  |  |
Contingent consideration payable |  | 25,000 |  |  |  |
Maximum | Clinical, Regulatory and Commercial milestones | MiaMed Inc |  |  |  |  |  |
Liabilities: |  |  |  |  |  |
Contingent consideration payable upon achievement of milestones | 83,000 |  |  |  |  |
Contingent consideration payable |  |  |  |  |  |
Contingent consideration payable upon achievement of milestones | $ 83,000 |  |  |  |  |
Commercial paper |  |  |  |  |  |
Assets: |  |  |  |  |  |
Fair value of assets |  | 79,803 | 68,390 |  |  |
Asset-backed securities |  |  |  |  |  |
Assets: |  |  |  |  |  |
Fair value of assets |  | 30,287 |  |  |  |
Corporate debt securities |  |  |  |  |  |
Assets: |  |  |  |  |  |
Fair value of assets |  | 199,012 | 74,535 |  |  |
Money market funds |  |  |  |  |  |
Assets: |  |  |  |  |  |
Fair value of assets |  | 2,598 | 1,829 |  |  |
Level 2 |  |  |  |  |  |
Assets: |  |  |  |  |  |
Fair value of assets |  | 311,700 | 144,754 |  |  |
Liabilities: |  |  |  |  |  |
Derivative liability |  |  | 265 |  |  |
Deferred compensation plan liability |  | 2,258 | 1,479 |  |  |
Fair value of liabilities |  | 2,258 | 1,744 |  |  |
Level 2 | Commercial paper |  |  |  |  |  |
Assets: |  |  |  |  |  |
Fair value of assets |  | 79,803 | 68,390 |  |  |
Level 2 | Asset-backed securities |  |  |  |  |  |
Assets: |  |  |  |  |  |
Fair value of assets |  | 30,287 |  |  |  |
Level 2 | Corporate debt securities |  |  |  |  |  |
Assets: |  |  |  |  |  |
Fair value of assets |  | 199,012 | 74,535 |  |  |
Level 2 | Money market funds |  |  |  |  |  |
Assets: |  |  |  |  |  |
Fair value of assets |  | 2,598 | 1,829 |  |  |
Level 3 |  |  |  |  |  |
Liabilities: |  |  |  |  |  |
Contingent consideration payable |  | 25,400 | 269,722 |  |  |
Fair value of liabilities |  | $ 25,400 | $ 269,722 |  |  |
Level 3 | Clinical and Regulatory Approval milestones | Probability weighted discounted cash flow | Callidus |  |  |  |  |  |
Liabilities: |  |  |  |  |  |
Discount rate (as a percent) |  | 11.50% |  |  |  |
Level 3 | Minimum | Clinical and Regulatory Approval milestones | Probability weighted discounted cash flow | Callidus |  |  |  |  |  |
Liabilities: |  |  |  |  |  |
Probability of achievement of milestones (as a percent) |  | 71.00% |  |  |  |
Level 3 | Maximum | Clinical and Regulatory Approval milestones | Probability weighted discounted cash flow | Callidus |  |  |  |  |  |
Liabilities: |  |  |  |  |  |
Probability of achievement of milestones (as a percent) |  | 100.00% |  |  |  |
Redmile Group | October 2015 Notes and Warrants Purchase Agreement | Private Placement Purchase Agreement |  |  |  |  |  |
Financial assets and liabilities subject to fair value measurements |  |  |  |  |  |
Debt Instrument, Face Amount |  |  |  |  |  | $ 50,000
Redmile Group | Additional Note and Warrant Agreement June 2016 | Beneficial Owner | Private Placement Purchase Agreement |  |  |  |  |  |
Financial assets and liabilities subject to fair value measurements |  |  |  |  |  |
Debt Instrument, Face Amount |  |  |  |  | $ 30,000 |

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