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Income Taxes - Deferred and Valuation (Details) - USD ($) $ in Thousands | 12 Months Ended |
--- | --- | ---
Dec. 31, 2017 | Dec. 31, 2016
Income Taxes |  |
Foreign and state income tax expenses | $ 2,300 |
Accrual for interest and penalties | 0 |
Accrual for uncertain tax positions | 0 |
Deferred tax assets |  |
Intellectual property | 44,573 | $ 95,956
Amortization/depreciation | 3,082 | 1,781
Research tax credit | 43,382 | 32,851
Net operating loss carry forwards | 221,912 | 223,758
Deferred revenue | 6,158 | 14,281
Non-cash stock issue | 10,751 | 11,649
Others | 7,328 | 3,358
Gross deferred tax assets | 337,186 | 383,634
Business acquisition | (6,465) | (173,771)
Royalty payable | (44,573) | (96,829)
Convertible notes | (18,991) | (29,845)
Advanced R&D payments | (3,069) |
Total net deferred tax asset | 264,088 | 83,189
Less valuation allowance | (270,553) | (256,960)
Net deferred tax liability | (6,465) | $ (173,771)
Increase in the valuation allowance | $ 13,600 |

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