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Consolidated Statements of Operations - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Revenue:      
Net Product Sales $ 36,930 $ 4,958  
Total revenue 36,930 4,958  
Cost of goods sold 6,236 833  
Gross Profit 30,694 4,125  
Operating Expenses:      
Research and development 149,310 104,793 $ 76,943
Selling, general and administrative 88,671 71,151 47,269
Changes in fair value of contingent consideration payable (234,322) 6,760 4,377
Loss on impairment of assets 465,427    
Restructuring charges   69 15
Depreciation 3,593 3,242 1,833
Total operating expenses 472,679 186,015 130,437
Loss from operations (441,985) (181,890) (130,437)
Other income (expenses):      
Interest income 4,096 1,602 929
Interest expense (17,240) (5,398) (1,578)
Loss on extinguishment of debt   (13,302) (952)
Other income (expense) 6,008 (4,793) (80)
Loss before income tax benefit (449,121) (203,781) (132,118)
Income tax benefit 165,119 3,739  
Net loss attributable to common stockholders $ (284,002) $ (200,042) $ (132,118)
Net loss attributable to common stockholders per common share - basic and diluted $ (1.85) $ (1.49) $ (1.20)
Weighted-average common shares outstanding - basic and diluted 153,355,144 134,401,588 109,923,815