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Debt Instruments and Related Party Transactions - Notes and Warrants Purchase Agreements (Details)	1 Months Ended			12 Months Ended
	Jun. 30, 2016 USD ($) $ / shares shares	Feb. 29, 2016 USD ($) item shares	Oct. 31, 2015 USD ($) installment shares	Dec. 31, 2016 USD ($) $ / shares	Dec. 31, 2015 USD ($)	Dec. 31, 2017 USD ($) $ / shares
Debt Instruments
Warrants				$ 16,076,000		$ 16,076,000
Common stock, par value (in dollars per share) | $ / shares				$ 0.01		$ 0.01
Loss on extinguishment of debt				$ 13,302,000	$ 952,000
Redmile Group | October 2015 Notes and Warrants Purchase Agreement
Debt Instruments
Number of installments for repayment of debt | installment			2
Fixed interest rate (as a percent)			4.10%
Warrants			$ 8,800,000
Redmile Group | October 2015 Notes and Warrants Purchase Agreement | Private Placement Purchase Agreement
Debt Instruments
Ownership position in the company (as a percent)			6.70%
Proceeds from note and warrant purchase agreement			$ 50,000,000
Redmile Group | October 2015 Notes and Warrants Purchase Agreement | Private Placement Purchase Agreement | Warrants
Debt Instruments
Warrant Term			5 years
Shares issuable for warrants (in shares) | shares			1,300,000
Redmile Group | February 2016 Notes and Warrants Purchase Agreement | Beneficial Owner | Maximum
Debt Instruments
Proceeds from note and warrant purchase agreement		$ 75,000,000
Redmile Group | February 2016 Notes and Warrants Purchase Agreement | Private Placement Purchase Agreement | Beneficial Owner
Debt Instruments
Proceeds from note and warrant purchase agreement		$ 50,000,000
Number of installments for repayment of debt | item		2
Fixed interest rate (as a percent)		3.875%
Redmile Group | February 2016 Notes and Warrants Purchase Agreement | Private Placement Purchase Agreement | Beneficial Owner | Maximum
Debt Instruments
Shares issuable for warrants (in shares) | shares		1,850,000
Redmile Group | February 2016 Notes and Warrants Purchase Agreement | Private Placement Purchase Agreement | Beneficial Owner | Warrants
Debt Instruments
Warrant Term		5 years
Shares issuable for warrants (in shares) | shares		1,800,000
Increment used for debt conversion		$ 1,000
Incremental fair value of warrant liability		$ 3,500,000
Redmile Group | February 2016 Notes and Warrants Purchase Agreement | Private Placement Purchase Agreement | Beneficial Owner | Warrants | Maximum
Debt Instruments
Shares of common stock issued per increment of note principal | shares		37
Redmile Group | Additional Note and Warrant Agreement June 2016 | Private Placement Purchase Agreement | Beneficial Owner
Debt Instruments
Proceeds from note and warrant purchase agreement	$ 30,000,000
Fixed interest rate (as a percent)	3.875%
Common stock, par value (in dollars per share) | $ / shares	$ 0.01
Redmile Group | Additional Note and Warrant Agreement June 2016 | Private Placement Purchase Agreement | Beneficial Owner | Warrants
Debt Instruments
Warrant Term	5 years
Shares issuable for warrants (in shares) | shares	1,300,000
Increment used for debt conversion	$ 1,000
Redmile Group | Additional Note and Warrant Agreement June 2016 | Private Placement Purchase Agreement | Beneficial Owner | Warrants | Maximum
Debt Instruments
Shares issuable for warrants (in shares) | shares	1,260,000
Shares of common stock issued per increment of note principal | shares	42
Redmile Group | December 2016 Note Purchase Agreement
Debt Instruments
Loss on extinguishment of debt				$ 13,300,000
Redmile Group | October 2017 payment | October 2015 Notes and Warrants Purchase Agreement
Debt Instruments
Installment payment			$ 15,000,000
Redmile Group | October 2017 payment | February 2016 Notes and Warrants Purchase Agreement | Private Placement Purchase Agreement | Beneficial Owner
Debt Instruments
Installment payment		$ 15,000,000
Redmile Group | October 2020 payment | October 2015 Notes and Warrants Purchase Agreement
Debt Instruments
Installment payment			$ 35,000,000
Redmile Group | October 2021 payment | February 2016 Notes and Warrants Purchase Agreement | Private Placement Purchase Agreement | Beneficial Owner
Debt Instruments
Installment payment		$ 35,000,000

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+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08.(i)(2))
-URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690

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-Section S99
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-Publisher FASB
-Name Accounting Standards Codification
-Topic 835
-SubTopic 30
-Section 55
-Paragraph 8
-URI http://asc.fasb.org/extlink&oid=64930739&loc=d3e28878-108400

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