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Consolidated Statements of Changes in Stockholders' Equity - USD ($)
$ in Thousands
Scioderm
Common Stock
Scioderm
Additional Paid-In Capital
Scioderm
Callidus
Common Stock
MiaMed
Common Stock
MiaMed
Additional Paid-In Capital
MiaMed
Common Stock
Additional Paid-In Capital
Warrants
Other Comprehensive Gain/ (Loss)
Accumulated Deficit
Total
Balance at Dec. 31, 2014               $ 1,015 $ 568,743   $ (132) $ (447,448) $ 122,178
Balance (in shares) at Dec. 31, 2014               95,556,277          
Increase (Decrease) in Stockholders' Equity                          
Stock issued from exercise of stock options, net               $ 21 11,165       11,186
Stock issued from exercise of stock options, net (in shares)               2,070,300          
Stock issued from equity financing               $ 195 242,847       243,042
Stock issued from equity financing (in shares)               19,528,302          
Stock issued for acquisition $ 59 $ 82,787 $ 82,846                    
Stock issued for acquisition (in shares) 5,921,771     25,762                  
Stock issued from exercise of warrants               $ 16 3,984       4,000
Stock issued from exercise of warrants (in shares)               1,600,000          
Restricted stock vesting                 (2,044)       (2,044)
Restricted stock vesting (in shares)               324,622          
Warrants issued in debt financing                   $ 8,755     8,755
Stock-based compensation                 9,972       9,972
Unrealized holding gain/(loss) on available-for-sale securities                     17   17
Net loss                       (132,118) (132,118)
Balance at Dec. 31, 2015               $ 1,306 917,454 8,755 (115) (579,566) 347,834
Balance (in shares) at Dec. 31, 2015               125,027,034          
Increase (Decrease) in Stockholders' Equity                          
Stock issued from exercise of stock options, net               $ 7 3,029       3,036
Stock issued from exercise of stock options, net (in shares)               723,102          
Stock issued for acquisition         $ 8 $ 4,599 $ 4,607            
Stock issued for acquisition (in shares)         825,603                
Stock issued from ATM transactions               $ 150 96,918       97,068
Stock issued from ATM transactions (in shares)               14,989,027          
Restricted stock vesting                 (1,282)       (1,282)
Restricted stock vesting (in shares)               268,425          
Stock issued for contingent consideration               $ 9 6,106       6,115
Stock issued for contingent consideration (in shares)               858,795          
Receivable from investor                 932       932
Warrants issued in debt financing                   7,321     7,321
Equity component of the Convertible Notes issuance, net of issuance costs of $2,709                 88,346       88,346
Premium paid for Capped Call Confirmations                 (13,450)       (13,450)
Stock-based compensation                 17,504       17,504
Unrealized holding gain/(loss) on available-for-sale securities                     217   217
Foreign currency translation adjustment                     1,945   1,945
Net loss                       (200,042) (200,042)
Balance at Dec. 31, 2016               $ 1,480 1,120,156 16,076 2,047 (779,608) $ 360,151
Balance (in shares) at Dec. 31, 2016               142,691,986         142,691,986
Increase (Decrease) in Stockholders' Equity                          
Stock issued from exercise of stock options, net               $ 29 16,272       $ 16,301
Stock issued from exercise of stock options, net (in shares)               2,878,681          
Stock issued from equity financing               $ 212 242,825       243,037
Stock issued from equity financing (in shares)               21,122,449          
Restricted stock vesting                 (1,596)       (1,596)
Restricted stock vesting (in shares)               296,674          
Stock-based compensation                 23,101       23,101
Unrealized holding gain/(loss) on available-for-sale securities                     (538)   (538)
Foreign currency translation adjustment                     (3,604)   (3,604)
Net loss                       (284,002) (284,002)
Balance at Dec. 31, 2017               $ 1,721 $ 1,400,758 $ 16,076 $ (2,095) $ (1,063,610) $ 352,850
Balance (in shares) at Dec. 31, 2017               166,989,790         166,989,790