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Income Taxes - Deferred and Valuation (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016
Income Taxes
Foreign and state income tax expenses	$ 2,300
Accrual for interest and penalties	0
Accrual for uncertain tax positions	0
Deferred tax assets
Intellectual property	44,573	$ 95,956
Amortization/depreciation	3,082	1,781
Research tax credit	43,382	32,851
Net operating loss carry forwards	221,912	223,758
Deferred revenue	6,158	14,281
Non-cash stock issue	10,751	11,649
Others	7,328	3,358
Gross deferred tax assets	337,186	383,634
Business acquisition	(6,465)	(173,771)
Royalty payable	(44,573)	(96,829)
Convertible notes	(18,991)	(29,845)
Advanced R&D payments	(3,069)
Total net deferred tax asset	264,088	83,189
Less valuation allowance	(270,553)	(256,960)
Net deferred tax liability	(6,465)	$ (173,771)
Increase in the valuation allowance	$ 13,600

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