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Income Taxes - Loss Carryforwards (Details) $ in Millions	12 Months Ended
	Dec. 31, 2017 USD ($)
Net operating loss carry forwards
Period for measuring the change in ownership	3 years
Maximum change in ownership percentage allowed before statutory limitations imposed on the availability of net operating losses	50.00%
Research and experimentation tax credit carryforward
Net operating loss carry forwards
Tax credit carryforward amount	$ 35.2
Orphan drug tax credit carryforwards
Net operating loss carry forwards
Tax credit carryforward amount	8.2
Federal
Net operating loss carry forwards
Amount of net operating loss carry forwards	777.6
Write-down of NOLs and R&D credits subject to section 382 limitation	0.0
State
Net operating loss carry forwards
Amount of net operating loss carry forwards	781.8
Foreign
Net operating loss carry forwards
Amount of net operating loss carry forwards	$ 47.1

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- Definition

The limitation imposed by Section 382 related to the use of all operating loss carry forwards available to reduce future taxable income in the event of a more than specified percentage change in ownership.

+ References

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- Definition

Represents the period over which the basis percentage increase in the shareholders' equity is measured for the purpose of calculating the ownership change as defined in section 382 of the Internal Revenue Code of 1986, as amended, which will affect the ability of the entity to utilize its net operating loss carry forwards.

+ References

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Write-down to net realizable value of the federal NOL's and research and development credits subject to Section 382 limitations.

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- Definition

Amount of operating loss carryforward, before tax effects, available to reduce future taxable income under enacted tax laws.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 3
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32559-109319

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- Definition

The amount of the tax credit carryforward, before tax effects, available to reduce future taxable income under enacted tax laws.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 3
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32559-109319

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