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Collaborative Agreements (Details)
$ in Thousands
 1 Months Ended 12 Months Ended
Nov. 30, 2013
USD ($)
item
Dec. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Collaborative Agreements      
Deferred reimbursements   $ 14,156 $ 21,906
Accounts payable, accrued expenses, and other current liabilities   53,890 $ 41,008
GSK | Revised Agreement      
Collaborative Agreements      
Upfront payment received $ 0    
Potential milestone payments upon achievement of post-approval and sales-based milestones $ 40,000    
Number of major markets outside the U.S. from whom parties to contractual arrangement is eligible to receive post-approval and sales-based milestones | item 8    
Milestone revenue recognized   3,900  
Deferred reimbursements   21,900  
Accounts payable, accrued expenses, and other current liabilities   $ 1,300