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Description of Business (Details) - USD ($)
$ / shares in Units, $ in Thousands
 1 Months Ended 3 Months Ended 4 Months Ended 12 Months Ended
Feb. 21, 2018
Feb. 15, 2018
Jul. 18, 2017
Jul. 05, 2016
Jul. 31, 2017
Dec. 31, 2016
Sep. 30, 2017
Jul. 31, 2016
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Corporate Information, Status of Operations and Management Plans                      
Loss on impairment of intangible assets                 $ 463,700    
Changes in fair value of contingent consideration payable                 234,322 $ (6,760) $ (4,377)
Contingent consideration payable           $ 269,722     25,400 269,722  
Income tax benefit                 (165,119) (3,739)  
Number of common stock shares issued from underwriting agreement         21,122,449            
Price per share of common stock issued (in dollars per share)         $ 12.25            
Gross proceeds from issue of common stock before deducting underwriting discounts and commissions         $ 258,800       243,037   243,042
Net proceeds from the issuance of common stock after deducting underwriting discounts and commissions     $ 243,000           $ 243,037 $ 97,068 $ 243,042
Common stock, par value (in dollars per share)           $ 0.01     $ 0.01 $ 0.01  
Net proceeds from convertible notes to pay capped call transactions                   $ 13,450  
Net proceeds from stock issued at ATM transactions                   97,068  
Accumulated deficit           $ (779,608)     $ (1,063,610) $ (779,608)  
SD-101                      
Corporate Information, Status of Operations and Management Plans                      
Loss on impairment related to fixed assets                 1,700    
Changes in fair value of contingent consideration payable             $ 254,700        
Contingent consideration payable             0        
Selling, general and administrative costs due to wind-down             400        
Research and development expenses due to wind-down             8,100        
Income tax benefit             $ 164,700   $ 164,700    
Cowen and Company, LLC | Sales Agreement                      
Corporate Information, Status of Operations and Management Plans                      
Number of shares issued from ATM transactions (in shares)               15,000,000      
Net proceeds from stock issued at ATM transactions               $ 97,100      
Commission expenses incurred on issue of common stock               2,700      
Other expenses paid               $ 200      
Common Stock                      
Corporate Information, Status of Operations and Management Plans                      
Number of common stock shares issued from underwriting agreement         21,122,449       21,122,449   19,528,302
Price per share of common stock issued (in dollars per share)         $ 12.25            
Gross proceeds from issue of common stock before deducting underwriting discounts and commissions         $ 258,800       $ 212   $ 195
Net proceeds from the issuance of common stock after deducting underwriting discounts and commissions     $ 243,000                
Number of shares issued from ATM transactions (in shares)                   14,989,027  
Net proceeds from stock issued at ATM transactions                   $ 150  
Common Stock | Subsequent event                      
Corporate Information, Status of Operations and Management Plans                      
Number of common stock shares issued from underwriting agreement   19,354,839                  
Price per share of common stock issued (in dollars per share)   $ 15.50                  
Gross proceeds from issue of common stock before deducting underwriting discounts and commissions   $ 300,000                  
Net proceeds from the issuance of common stock after deducting underwriting discounts and commissions $ 282,000                    
Convertible Notes | 2016 Convertible Notes                      
Corporate Information, Status of Operations and Management Plans                      
Aggregate principal amount           $ 250,000       $ 250,000  
Fixed interest rate (as a percent)           3.00%       3.00%  
Proceeds from convertible notes, Net of issuance costs           $ 243,000          
Net proceeds from convertible notes to pay capped call transactions           $ 13,500          
Maximum | Cowen and Company, LLC | Sales Agreement                      
Corporate Information, Status of Operations and Management Plans                      
Fixed commission rate as a percentage of gross proceeds per Share sold               3.00%      
IPR&D | SD-101                      
Corporate Information, Status of Operations and Management Plans                      
Loss on impairment of intangible assets                 $ 463,700    
MiaMed Inc                      
Corporate Information, Status of Operations and Management Plans                      
Asset acquisition, potential aggregate deal value       $ 89,500              
Asset acquisition, total consideration, stock and cash       6,500              
MiaMed Inc | Clinical, Regulatory and Commercial milestones | Maximum                      
Corporate Information, Status of Operations and Management Plans                      
Contingent consideration payable upon achievement of milestones       $ 83,000