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Stockholders' Equity - Common Stock and Warrants (Details)
 1 Months Ended 4 Months Ended 12 Months Ended
Feb. 21, 2018
USD ($)
Feb. 15, 2018
USD ($)
$ / shares
shares
Jul. 18, 2017
USD ($)
Dec. 21, 2016
USD ($)
$ / shares
Jul. 05, 2016
USD ($)
shares
Sep. 30, 2017
USD ($)
shares
Jul. 31, 2017
USD ($)
$ / shares
shares
Jun. 30, 2016
USD ($)
$ / shares
shares
Feb. 29, 2016
USD ($)
shares
Jul. 31, 2016
USD ($)
shares
Dec. 31, 2017
USD ($)
item
$ / shares
shares
Dec. 31, 2016
USD ($)
item
$ / shares
shares
Dec. 31, 2015
USD ($)
shares
Oct. 31, 2015
USD ($)
shares
Convertible Debt                            
Authorized number of shares of common stock | shares                     250,000,000 250,000,000    
Voting right for each share held, number | item                     1 1    
Common stock, par value (in dollars per share) | $ / shares                     $ 0.01 $ 0.01    
Number of common stock shares issued from underwriting agreement | shares             21,122,449              
Price per share of common stock issued (in dollars per share) | $ / shares             $ 12.25              
Gross proceeds from issue of common stock before deducting underwriting discounts and commissions             $ 258,800,000       $ 243,037,000   $ 243,042,000  
Net proceeds from the issuance of common stock after deducting underwriting discounts and commissions     $ 243,000,000               243,037,000 $ 97,068,000 $ 243,042,000  
Net proceeds from stock issued at ATM transactions                       97,068,000    
Warrant liability                     $ 16,076,000 $ 16,076,000    
Common Stock                            
Convertible Debt                            
Number of common stock shares issued from underwriting agreement | shares             21,122,449       21,122,449   19,528,302  
Price per share of common stock issued (in dollars per share) | $ / shares             $ 12.25              
Gross proceeds from issue of common stock before deducting underwriting discounts and commissions             $ 258,800,000       $ 212,000   $ 195,000  
Net proceeds from the issuance of common stock after deducting underwriting discounts and commissions     $ 243,000,000                      
Number of shares issued from ATM transactions (in shares) | shares                       14,989,027    
Net proceeds from stock issued at ATM transactions                       $ 150,000    
Cowen and Company, LLC | Sales Agreement                            
Convertible Debt                            
Number of shares issued from ATM transactions (in shares) | shares                   15,000,000        
Net proceeds from stock issued at ATM transactions                   $ 97,100,000        
Commission expenses incurred on issue of common stock                   2,700,000        
Other Expenses                   $ 200,000        
Cowen and Company, LLC | Sales Agreement | Maximum                            
Convertible Debt                            
Fixed commission rate as a percentage of gross proceeds per Share sold                   3.00%        
Scioderm                            
Convertible Debt                            
Initial amount to Effective Time Holders           $ 223,900,000                
Initial amount cash payment excluding Series B Preferred           141,100,000                
Initial amount paid in shares of Common Stock           $ 82,800,000                
Scioderm | Amicus | Common Stock                            
Convertible Debt                            
Consideration paid in common stock | shares           5,900,000                
MiaMed Inc                            
Convertible Debt                            
Asset acquisition, total consideration, stock and cash         $ 6,500,000                  
Asset acquisition, cash consideration paid         1,800,000                  
Asset acquisition, potential aggregate deal value         89,500,000                  
MiaMed Inc | Maximum | Clinical, Regulatory and Commercial milestones                            
Convertible Debt                            
Contingent consideration payable upon achievement of milestones         $ 83,000,000                  
MiaMed Inc | Amicus | Common Stock                            
Convertible Debt                            
Consideration paid in common stock | shares         825,603                  
October 2015 Notes and Warrants Purchase Agreement | Redmile Group                            
Convertible Debt                            
Fixed interest rate (as a percent)                           4.10%
Warrant liability                           $ 8,800,000
October 2015 Notes and Warrants Purchase Agreement | Redmile Group | Private Placement Purchase Agreement                            
Convertible Debt                            
Aggregate principal amount                           $ 50,000,000
October 2015 Notes and Warrants Purchase Agreement | Redmile Group | Private Placement Purchase Agreement | Warrants                            
Convertible Debt                            
Shares issuable for warrants (in shares) | shares                           1,300,000
February 2016 Notes and Warrants Purchase Agreement | Beneficial Owner | Redmile Group | Maximum                            
Convertible Debt                            
Aggregate principal amount                 $ 75,000,000          
February 2016 Notes and Warrants Purchase Agreement | Beneficial Owner | Redmile Group | Private Placement Purchase Agreement                            
Convertible Debt                            
Aggregate principal amount                 $ 50,000,000          
Fixed interest rate (as a percent)                 3.875%          
February 2016 Notes and Warrants Purchase Agreement | Beneficial Owner | Redmile Group | Private Placement Purchase Agreement | Warrants                            
Convertible Debt                            
Increment used for debt conversion                 $ 1,000          
Shares issuable for warrants (in shares) | shares                 1,800,000          
February 2016 Notes and Warrants Purchase Agreement | Beneficial Owner | Redmile Group | Private Placement Purchase Agreement | Maximum                            
Convertible Debt                            
Shares issuable for warrants (in shares) | shares                 1,850,000          
2016 Convertible Notes | Convertible Notes                            
Convertible Debt                            
Aggregate principal amount                       $ 250,000,000    
Fixed interest rate (as a percent)                       3.00%    
Debt conversion ratio (in shares)       0.1633987                    
Increment used for debt conversion       $ 1,000                    
Conversion price (in dollars per share) | $ / shares       $ 6.12                    
Additional Note and Warrant Agreement June 2016 | Beneficial Owner | Redmile Group | Private Placement Purchase Agreement                            
Convertible Debt                            
Aggregate principal amount               $ 30,000,000            
Fixed interest rate (as a percent)               3.875%            
Common stock, par value (in dollars per share) | $ / shares               $ 0.01            
Additional Note and Warrant Agreement June 2016 | Beneficial Owner | Redmile Group | Private Placement Purchase Agreement | Warrants                            
Convertible Debt                            
Increment used for debt conversion               $ 1,000            
Shares issuable for warrants (in shares) | shares               1,300,000            
Additional Note and Warrant Agreement June 2016 | Beneficial Owner | Redmile Group | Private Placement Purchase Agreement | Maximum | Warrants                            
Convertible Debt                            
Shares issuable for warrants (in shares) | shares               1,260,000            
Subsequent event | Common Stock                            
Convertible Debt                            
Number of common stock shares issued from underwriting agreement | shares   19,354,839                        
Price per share of common stock issued (in dollars per share) | $ / shares   $ 15.50                        
Gross proceeds from issue of common stock before deducting underwriting discounts and commissions   $ 300,000,000                        
Net proceeds from the issuance of common stock after deducting underwriting discounts and commissions $ 282,000,000