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Stockholders' Equity - Nonqualified Cash Plan and Equity Incentive Plans (Details) - USD ($)
$ / shares in Units, $ in Thousands
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Aggregate Intrinsic Value      
Proceeds from exercise of stock options $ 16,301 $ 3,036 $ 11,186
Nonqualified Cash Plan (the "Deferral Plan")      
Stockholders' Equity      
Deferred compensation investment 2,248 1,469  
Deferred compensation liability 2,258 1,479  
Investment income 66 34  
Unrealized gain $ 92 $ 32  
Common stock options      
Fair value weighted-average assumptions:      
Maximum term of option 10 years    
Expected stock price volatility (as a percent) 82.80% 81.30% 75.90%
Risk free interest rate (as a percent) 2.00% 1.50% 1.70%
Expected life of options 6 years 2 months 5 days 6 years 3 months 6 years 3 months
Expected annual dividend per share (in dollars per share) $ 0.00 $ 0.00 $ 0.00
Granted (in dollars per share) $ 5.09 $ 5.28 $ 7.51
Number of Shares      
Balance at the beginning of the period (in shares) 15,497,500 11,729,200 10,020,700
Options granted (in shares) 3,695,300 5,114,100 3,917,200
Options exercised (in shares) (2,878,700) (723,100) (2,070,300)
Options forfeited (in shares) (1,133,000) (622,700) (138,400)
Balance at the end of the period (in shares) 15,181,100 15,497,500 11,729,200
Vested and unvested expected to vest as of the end of the period (in shares) 14,398,500    
Exercisable at the end of the period (in shares) 7,985,600    
Weighted Average Exercise Price      
Balance at the beginning of the period (in dollars per share) $ 7.37 $ 7.11 $ 5.02
Options granted (in dollars per share) 7.17 7.67 11.61
Options exercised (in dollars per share) 5.67 4.20 5.43
Options forfeited (in dollars per share) 9.55 8.62 7.76
Balance at the end of the period (in dollars per share) 7.48 $ 7.37 $ 7.11
Vested and unvested expected to vest as of the end of the period (in dollars per share) 7.45    
Exercisable at the end of the period (in dollars per share) $ 7.05    
Weighted Average Remaining Contractual Life      
Balance at the end of the period 7 years 2 months 12 days    
Vested and unvested expected to vest at the end of the period 7 years 1 month 6 days    
Exercisable at the end of the period 6 years    
Aggregate Intrinsic Value      
Aggregate intrinsic value of options outstanding (in dollars) $ 105,800    
Aggregate intrinsic value of options vested and unvested expected to vest (in dollars) 100,900    
Aggregate intrinsic value of options exercisable (in dollars) 59,100    
Aggregate intrinsic value of options exercised (in dollars) 20,800 $ 2,600 $ 14,700
Proceeds from exercise of stock options 16,300 $ 3,000 $ 11,200
Total unrecognized compensation cost related to non-vested stock options granted (in dollars) $ 31,900    
Period of recognition unrecognized compensation costs (in years) 2 years 6 months    
Common stock options | 2007 Plan and 2007 Director Plan      
Fair value weighted-average assumptions:      
Percentage of options vest on the first year anniversary   25.00%  
Vesting percentage   2.08%  
Percentage of shares vested that may be exercised in whole or part   100.00%  
Restricted stock units (RSUs) | Amended and Restated 2007 Equity Incentive Plan      
Aggregate Intrinsic Value      
Estimated fair value (in dollars per share) $ 5.69 $ 6.21  
Period of recognition unrecognized compensation costs (in years) 2 years 5 months 19 days    
Restricted Stock Units, Number of Shares      
Non-vested units as of the beginning of the period (in shares) 744,400 478,500  
Granted (in shares) 2,348,700 582,700  
Vested (in shares) (318,200) (281,900)  
Forfeited (in shares) (199,800) (34,900)  
Non-vested units as of the end of the period (in shares) 2,575,100 744,400 478,500
Weighted Average Grant Date Fair Value      
Non-vested units as of the beginning of the period (in dollars per share) $ 7.86 $ 10.38  
Granted (in dollars per share) 5.69 6.21  
Vested (in dollars per share) 9.23 8.73  
Forfeited (in dollars per share) 6.24 7.71  
Non-vested units as of the end of the period (in dollars per share) $ 5.85 $ 7.86 $ 10.38
Weighted Average Remaining Years      
Non-vested units as of the end of the period 2 years 5 months 19 days    
Aggregate Intrinsic Value      
Non-vested units as of the end of the period (in dollars) $ 37,100    
Unrecognized compensation cost related to unvested RSU's (in dollars) $ 11,400    
Clinical milestone | Restricted stock units (RSUs) | Amended and Restated 2007 Equity Incentive Plan      
Aggregate Intrinsic Value      
Vesting period 3 years    
Restricted Stock Units, Number of Shares      
Granted (in shares) 401,413    
Executive Officers | Market Performance-based Restricted Stock Units (MPRSUs) | Amended and Restated 2007 Equity Incentive Plan      
Aggregate Intrinsic Value      
Vesting period 3 years    
Estimated fair value (in dollars per share) $ 8.08    
Restricted Stock Units, Number of Shares      
Granted (in shares) 401,413    
Weighted Average Grant Date Fair Value      
Granted (in dollars per share) $ 8.08    
Executive Officers | Market Performance-based Restricted Stock Units (MPRSUs) | Amended and Restated 2007 Equity Incentive Plan | Cliff Vesting      
Aggregate Intrinsic Value      
Vesting period 3 years    
Maximum | Common stock options | 2007 Plan and 2007 Director Plan      
Fair value weighted-average assumptions:      
Number of shares reserved for issuance 7,855,550    
Maximum | Executive Officers | Market Performance-based Restricted Stock Units (MPRSUs) | Amended and Restated 2007 Equity Incentive Plan      
Fair value weighted-average assumptions:      
Vesting percentage 200.00%    
Number of Shares      
Exercisable at the end of the period (in shares) 802,826