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Leases (Details)
$ in Thousands
12 Months Ended
Dec. 31, 2017
USD ($)
ft²
Dec. 31, 2016
USD ($)
Dec. 31, 2015
USD ($)
Minimum lease payments      
2018 $ 2,762    
2019 2,575    
2020 2,472    
2021 2,240    
2022 and beyond 8,467    
Total 18,516    
Rent expense, including fees for utilities and common area maintenances 3,900 $ 3,500 $ 2,600
Equipment      
Capital Leases      
Capital lease obligation   $ 900  
2018 356    
2019 134    
Total principal obligation $ 490    
Equipment | Minimum      
Capital Leases      
Fixed interest rate (as a percent)   0.20%  
Term of capital lease (in months)   36 months  
Equipment | Maximum      
Capital Leases      
Fixed interest rate (as a percent)   5.70%  
Term of capital lease (in months)   48 months  
Cranbury, New Jersey | Office and laboratory space      
Operating Leases      
Area of space leased (in square feet) | ft² 90,000    
Durham, North Carolina | Office space      
Operating Leases      
Area of space leased (in square feet) | ft² 5,603    
Buckinghamshire, United Kingdom | Office space      
Operating Leases      
Area of space leased (in square feet) | ft² 9,821    
Munich, Germany | Office space      
Operating Leases      
Area of space leased (in square feet) | ft² 4,751