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Income Taxes - Statutory Rate (Details) - USD ($) $ in Thousands	3 Months Ended	12 Months Ended
	Sep. 30, 2017	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Income (loss) before income taxes:
United States			$ (440,696)	$ (174,913)	$ (123,697)
Foreign			(8,425)	(28,868)	(8,421)
Loss before income tax benefit			(449,121)	(203,781)	$ (132,118)
Current:
State			9	7
Foreign			2,276
Deferred
Federal			(150,015)	(1,101)
State			(17,389)	(2,645)
Total			$ (165,119)	$ (3,739)
Reconciliation of the statutory tax rates and the effective tax rates
Statutory rate (as a percent)			(34.00%)	(34.00%)	(34.00%)
State taxes, net of federal benefit (as a percent)			(5.00%)	(5.00%)	(5.00%)
Permanent adjustments (as a percent)			(1.00%)	3.00%	2.00%
Contingent consideration (as a percent)			(18.00%)
R&D credit (as a percent)			(2.00%)	(3.00%)	(3.00%)
Foreign income tax rate differential (as a percent)			5.00%	2.00%	1.00%
Impact of 2017 Act (as a percent)			27.00%
Other (as a percent)			5.00%	(1.00%)	2.00%
Valuation allowance (as a percent)			(14.00%)	36.00%	37.00%
Net (as a percent)			(37.00%)	(2.00%)	(0.00%)
Income tax benefit on reduction of income tax rate			$ (2,700)
Income tax benefit			(165,119)	$ (3,739)
Forecast
Reconciliation of the statutory tax rates and the effective tax rates
Statutory rate (as a percent)		(21.00%)
SD-101
Deferred
Total	$ 164,700		164,700
Reconciliation of the statutory tax rates and the effective tax rates
Income tax benefit	$ 164,700		$ 164,700

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