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Share based Compensation (Tables)

3 Months Ended

Mar. 31, 2018

Stockholders' Equity

Schedule of fair value weighted-average assumptions

		Three Months Ended March 31,
		2018			2017
Expected stock price volatility		81.2		%	83.2		%
Risk free interest rate		2.3		%	2.1		%
Expected life of options (years)		5.62			6.25
Expected annual dividend per share		$	0.00		$	0.00

Summary of stock options outstanding

		Number of Shares		Weighted Average Exercise Price			Weighted Average Remaining Contractual Life		Aggregate Intrinsic Value
		(in thousands)							(in millions)
Options outstanding, December 31, 2017		15,181.1		$	7.48
Granted		1,611.5		$	15.54
Exercised		(562.2	)	$	7.08
Forfeited		(48.8	)	$	7.43
Expired		(4.8	)	$	9.03
Options outstanding, March 31, 2018		16,176.8		$	8.30		7.4 years		$	110.6
Vested and unvested expected to vest, March 31, 2018		15,363.0		$	8.15		7.2 years		$	105.7
Exercisable at March 31, 2018		8,648.3		$	6.97		6.2 years		$	70.1

Summary of non-vested Restricted Stock Units activity

		Number of Share (in thousands)		Weighted  Average Grant Date  Fair Value			Weighted Average  Remaining Years		Aggregate  Intrinsic Value  (in millions)
Non-vested units as of December 31, 2017		2,575.1		$	5.85
Granted		1,335.1		$	16.99
Vested		(353.4	)	$	5.26
Forfeited		(16.1	)	$	5.93
Non-vested units as of March 31, 2018		3,540.7		$	10.11		3.0 years		$	53.3

Summary of the equity-based compensation expense recognized in the statements of operations

		Three Months Ended March 31,
(in thousands):		2018			2017
Equity compensation expense recognized in:
Research and development expense		$	3,057		$	2,753
Selling, general and administrative expense		4,421			3,277
Total equity compensation expense		$	7,478		$	6,030

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Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed.

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-Publisher FASB
-Name Accounting Standards Codification
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-Section 50
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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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Disclosure of the number and weighted-average grant date fair value for restricted stock and restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock and restricted stock units that were granted, vested, or forfeited during the year.

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