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Cash, Cash Equivalents, Marketable Securities and Restricted Cash (Details) - USD ($) $ in Thousands	3 Months Ended	12 Months Ended
	Mar. 31, 2018	Dec. 31, 2017	Mar. 31, 2017	Dec. 31, 2016
Cash, Money Market Funds and Marketable Securities
Cash and cash equivalents, Amortized Cost	$ 114,322	$ 49,060	$ 44,755	$ 187,026
Cash and cash equivalents, Fair Value		49,060
Gross Unrealized Gain	9	1
Gross Unrealized Loss	(886)	(437)
Total cash, cash equivalents and marketable securities	606,070	358,998
Cash and marketable securities, Fair Value	605,193	358,562
Available-for-sale investments
Realized gain (loss) on securities available-for-sale	0	0
Fair value of available for sale debt securities in unrealized loss positions	478,400	295,100
Reconciliation of cash and cash equivalents, and restricted cash
Cash and cash equivalents	114,322	49,060	44,755	187,026
Restricted cash	2,230	2,177	388	387
Cash and cash equivalents and restricted cash	116,552	51,237	$ 45,143	$ 187,413
Cash and cash equivalents
Cash, Money Market Funds and Marketable Securities
Cash and cash equivalents, Amortized Cost	114,327	49,060
Cash and cash equivalents, Fair Value	114,322	49,060
Gross Unrealized Loss	(5)
Reconciliation of cash and cash equivalents, and restricted cash
Cash and cash equivalents	114,327	49,060
Marketable securities
Cash, Money Market Funds and Marketable Securities
Marketable securities, Amortized Cost	491,743	309,938
Gross Unrealized Gain	9	1
Gross Unrealized Loss	(881)	(437)
Marketable securities, Fair Value	490,871	309,502
Corporate debt securities, current portion
Cash, Money Market Funds and Marketable Securities
Marketable securities, Amortized Cost	278,281	199,314
Gross Unrealized Gain	8	1
Gross Unrealized Loss	(509)	(303)
Marketable securities, Fair Value	277,780	199,012
Corporate debt securities, non-current portion
Cash, Money Market Funds and Marketable Securities
Marketable securities, Amortized Cost	30,400
Gross Unrealized Gain	1
Gross Unrealized Loss	(56)
Marketable securities, Fair Value	30,345
Commercial paper
Cash, Money Market Funds and Marketable Securities
Marketable securities, Amortized Cost	122,029	79,878
Gross Unrealized Loss	(169)	(75)
Marketable securities, Fair Value	121,860	79,803
Asset-backed securities
Cash, Money Market Funds and Marketable Securities
Marketable securities, Amortized Cost	47,924	30,346
Gross Unrealized Loss	(96)	(59)
Marketable securities, Fair Value	47,828	30,287
Money market funds
Cash, Money Market Funds and Marketable Securities
Marketable securities, Amortized Cost	350	350
Marketable securities, Fair Value	350	350
Certificates of deposit
Cash, Money Market Funds and Marketable Securities
Marketable securities, Amortized Cost	12,759	50
Gross Unrealized Loss	(51)
Marketable securities, Fair Value	$ 12,708	$ 50

X

- Definition

Cash includes currency on hand as well as demand deposits with banks or financial institutions. It also includes other kinds of accounts that have the general characteristics of demand deposits in that the customer may deposit additional funds at any time and effectively may withdraw funds at any time without prior notice or penalty. Cash equivalents, excluding items classified as marketable securities, include short-term, highly liquid Investments that are both readily convertible to known amounts of cash, and so near their maturity that they present minimal risk of changes in value because of changes in interest rates. Generally, only investments with original maturities of three months or less qualify under that definition. Also includes amount of investment in debt and equity securities categorized neither as held-to-maturity nor trading.

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Represents the portion of the balance sheet assertion valued at fair value by the entity whether such amount is presented as a separate caption or as a parenthetical disclosure. Additionally, this element may be used in connection with the fair value disclosures required in the footnote disclosures to the financial statements. The element may be used in both the balance sheet and disclosure in the same submission. This item represents cash and cash equivalents and short-term investments.

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Amount of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale), in continuous unrealized loss position for less than 12 months.

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Amount of realized gain (loss) on investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).

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Amount before tax of unrealized gain in accumulated other comprehensive income (AOCI) on investments in debt securities classified as available-for-sale.

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Amount before tax of unrealized loss in accumulated other comprehensive income (AOCI) on investments in debt securities classified as available-for-sale.

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This item represents the cost of debt securities, which are categorized neither as held-to-maturity nor trading, net of adjustments including accretion, amortization, collection of cash, previous other-than-temporary impairments recognized in earnings (less any cumulative-effect adjustments recognized, as defined), and fair value hedge accounting adjustments, if any.

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Amount of debt securities categorized neither as held-to-maturity nor trading.

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Amount of currency on hand as well as demand deposits with banks or financial institutions. Includes other kinds of accounts that have the general characteristics of demand deposits. Also includes short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates. Excludes cash and cash equivalents within disposal group and discontinued operation.

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Fair value portion of currency on hand as well as demand deposits with banks or financial institutions. Includes other kinds of accounts that have the general characteristics of demand deposits. Also includes short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates.

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Amount of cash and cash equivalents, and cash and cash equivalents restricted to withdrawal or usage. Excludes amount for disposal group and discontinued operations. Cash includes, but is not limited to, currency on hand, demand deposits with banks or financial institutions, and other accounts with general characteristics of demand deposits. Cash equivalents include, but are not limited to, short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates.

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Amount of cash and cash equivalents restricted as to withdrawal or usage, classified as current. Cash includes, but is not limited to, currency on hand, demand deposits with banks or financial institutions, and other accounts with general characteristics of demand deposits. Cash equivalents include, but are not limited to, short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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