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Share based Compensation - Nonqualified Cash Plan and Equity Incentive Plans (Details) - USD ($)
1 Months Ended 3 Months Ended
Apr. 30, 2018
Mar. 31, 2018
Mar. 31, 2017
Number of Shares      
Options exercised (in shares) (453,214)    
Common stock options      
Fair value weighted-average assumptions:      
Expected stock price volatility (as a percent)   81.20% 83.20%
Risk free interest rate (as a percent)   2.30% 2.10%
Expected life of options (years)   5 years 7 months 13 days 6 years 3 months
Expected annual dividend per share (in dollars per share)   $ 0.00 $ 0.00
Number of Shares      
Balance at the beginning of the period (in shares) 16,176,800 15,181,100  
Options granted (in shares)   1,611,500  
Options exercised (in shares)   (562,200)  
Options forfeited (in shares)   (48,800)  
Options expired (in shares)   (4,800)  
Balance at the end of the period (in shares)   16,176,800  
Vested and unvested expected to vest as of the end of the period (in shares)   15,363,000  
Exercisable at the end of the period (in shares)   8,648,300  
Weighted Average Exercise Price      
Balance at the beginning of the period (in dollars per share) $ 8.30 $ 7.48  
Options granted (in dollars per share)   15.54  
Options exercised (in dollars per share)   7.08  
Options forfeited (in dollars per share)   7.43  
Options expired (in dollars per share)   9.03  
Balance at the end of the period (in dollars per share)   8.30  
Vested and unvested expected to vest as of the end of the period (in dollars per share)   8.15  
Exercisable at the end of the period (in dollars per share)   $ 6.97  
Weighted Average Remaining Contractual Life      
Balance at the end of the period   7 years 4 months 24 days  
Vested and unvested expected to vest at the end of the period   7 years 2 months 12 days  
Exercisable at the end of the period   6 years 2 months 12 days  
Aggregate Intrinsic Value      
Aggregate intrinsic value of options outstanding (in dollars)   $ 110,600  
Aggregate intrinsic value of options vested and unvested expected to vest (in dollars)   105,700  
Aggregate intrinsic value of options exercisable (in dollars)   70,100  
Total unrecognized compensation cost related to non-vested stock options granted (in dollars)   $ 40,600,000  
Period of recognition unrecognized compensation costs (in years)   3 years  
Restricted stock units (RSUs) | Amended and Restated 2007 Equity Incentive Plan      
Aggregate Intrinsic Value      
Estimated fair value (in dollars per share)   $ 16.99  
Period of recognition unrecognized compensation costs (in years)   3 years  
Restricted Stock Units, Number of Shares      
Non-vested units as of the beginning of the period (in shares) 3,540,700 2,575,100  
Granted (in shares)   1,335,100  
Vested (in shares)   (353,442)  
Forfeited (in shares)   (16,100)  
Non-vested units as of the end of the period (in shares)   3,540,700  
Weighted Average Grant Date Fair Value      
Non-vested units as of the beginning of the period (in dollars per share) $ 10.11 $ 5.85  
Granted (in dollars per share)   16.99  
Vested (in dollars per share)   5.26  
Forfeited (in dollars per share)   5.93  
Non-vested units as of the end of the period (in dollars per share)   $ 10.11  
Weighted Average Remaining Years      
Non-vested units as of the end of the period   3 years  
Aggregate Intrinsic Value      
Non-vested units as of the end of the period (in dollars)   $ 53,300,000  
Unrecognized compensation cost related to unvested RSU's (in dollars)   $ 26,500,000  
Clinical milestone | Restricted stock units (RSUs) | Amended and Restated 2007 Equity Incentive Plan      
Aggregate Intrinsic Value      
Vesting period   3 years  
Restricted Stock Units, Number of Shares      
Granted (in shares)   187,211  
Executive Officers | Market Performance-based Restricted Stock Units (MPRSUs) | Amended and Restated 2007 Equity Incentive Plan      
Aggregate Intrinsic Value      
Vesting period   3 years  
Estimated fair value (in dollars per share)   $ 25.44  
Restricted Stock Units, Number of Shares      
Granted (in shares)   187,222  
Weighted Average Grant Date Fair Value      
Granted (in dollars per share)   $ 25.44  
Executive Officers | Market Performance-based Restricted Stock Units (MPRSUs) | Amended and Restated 2007 Equity Incentive Plan | Cliff Vesting      
Aggregate Intrinsic Value      
Vesting period   3 years  
Maximum | Executive Officers | Market Performance-based Restricted Stock Units (MPRSUs) | Amended and Restated 2007 Equity Incentive Plan      
Fair value weighted-average assumptions:      
Vesting percentage   200.00%  
Number of Shares      
Exercisable at the end of the period (in shares)   374,444