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Assets and Liabilities Measured at Fair Value (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017	Dec. 31, 2017
Assets and Liabilities Measured at Fair Value
Transfer of assets from Level 1 to Level 2	$ 0
Transfer of assets from Level 2 to Level 1	0
Assets:
Derivative asset	2,238
Fair value of assets	482,892		$ 311,700
Liabilities:
Contingent consideration payable	26,500		25,400
Derivative liability	80,577
Deferred compensation plan liability	2,491		2,258
Fair value of liabilities	109,568		27,658
Fair value of the debt	642,300
Contingent consideration payable
Balance, beginning of the period	25,400	$ 269,722
Changes in fair value during the period, included in Statement of Operations	1,100	4,578
Balance, end of the period	26,500	$ 274,300
Clinical and Regulatory Approval milestones | Callidus
Liabilities:
Contingent consideration payable	26,000
Commercial paper
Assets:
Fair value of assets	121,860		79,803
Asset-backed securities
Assets:
Fair value of assets	47,828		30,287
Corporate debt securities
Assets:
Fair value of assets	308,125		199,012
Money market funds
Assets:
Fair value of assets	2,841		2,598
Level 2
Assets:
Fair value of assets	480,654		311,700
Liabilities:
Deferred compensation plan liability	2,491		2,258
Fair value of liabilities	2,491		2,258
Level 2 | Commercial paper
Assets:
Fair value of assets	121,860		79,803
Level 2 | Asset-backed securities
Assets:
Fair value of assets	47,828		30,287
Level 2 | Corporate debt securities
Assets:
Fair value of assets	308,125		199,012
Level 2 | Money market funds
Assets:
Fair value of assets	2,841		2,598
Level 3
Assets:
Derivative asset	2,238
Fair value of assets	2,238
Liabilities:
Contingent consideration payable	26,500		25,400
Derivative liability	80,577
Fair value of liabilities	$ 107,077		$ 25,400
Level 3 | Clinical and Regulatory Approval milestones | Probability weighted discounted cash flow | Callidus
Liabilities:
Discount rate (as a percent)	11.00%
Level 3 | Minimum | Clinical and Regulatory Approval milestones | Probability weighted discounted cash flow | Callidus
Liabilities:
Probability of achievement of milestones (as a percent)	71.00%
Level 3 | Maximum | Clinical and Regulatory Approval milestones | Probability weighted discounted cash flow | Callidus
Liabilities:
Probability of achievement of milestones (as a percent)	100.00%

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