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Consolidated Statements of Operations - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Revenue:    
Net product sales $ 16,696 $ 4,169
Cost of goods sold 2,615 775
Gross Profit 14,081 3,394
Operating Expenses:    
Research and development 40,798 30,876
Selling, general and administrative 27,396 19,132
Changes in fair value of contingent consideration payable 1,100 4,578
Depreciation 969 823
Total operating expenses 70,263 55,409
Loss from operations (56,182) (52,015)
Other income (expense):    
Interest income 1,737 759
Interest expense (4,488) (4,290)
Change in fair value of derivatives 4,861  
Other income 2,764 610
Loss before income tax (51,308) (54,936)
Income tax benefit (expense) 1,392 (56)
Net loss attributable to common stockholders $ (49,916) $ (54,992)
Net loss attributable to common stockholders per common share - basic and diluted $ (0.28) $ (0.39)
Weighted-average common shares outstanding - basic and diluted 175,977,700 142,770,629