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Share based Compensation (Tables)
6 Months Ended
Jun. 30, 2018
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Schedule of Fair Value of Options
The fair value of the stock options granted is estimated on the date of grant using a Black-Scholes option pricing model with the following weighted-average assumptions:
 
 
Three Months Ended June 30,
 
Six Months Ended June 30,
 
2018
 
2017
 
2018
 
2017
Expected stock price volatility
81.1
%
 
82.7
%
 
81.2
%
 
83.2
%
Risk free interest rate
2.8
%
 
1.9
%
 
2.4
%
 
2.0
%
Expected life of options (years)
5.62

 
6.25

 
5.62

 
6.25

Expected annual dividend per share
$

 
$

 
$

 
$

Schedule of Stock Options Activity
A summary of the Company’s stock options for the six months ended June 30, 2018 were as follows:
 
 
Number of
Shares
 
Weighted
Average
Exercise Price
 
Weighted
Average
Remaining
Contractual Life
 
Aggregate
Intrinsic
Value
 
(in thousands)
 
 
 
 
 
(in millions)
Options outstanding, December 31, 2017
15,181

 
$
7.48

 
 
 
 

Granted
1,910

 
$
15.49

 
 
 
 

Exercised
(1,102
)
 
$
6.87

 
 
 
 

Forfeited
(113
)
 
$
9.75

 
 
 
 

Expired
(7
)
 
10.45

 
 
 
 
Options outstanding, June 30, 2018
15,869

 
$
8.47

 
7.2 years
 
$
114.0

Vested and unvested expected to vest, June 30, 2018
15,160

 
$
8.32

 
7.1 years
 
$
109.6

Exercisable at June 30, 2018
8,916

 
$
7.08

 
6.1 years
 
$
76.4

Schedule of Non-Vested RSU Activity under the Plan
A summary of non-vested RSU activity under the Plan for the six months ended June 30, 2018 is as follows:
 
 
Number of Shares

 
Weighted
Average Grant Date
Fair Value
 
Weighted Average
Remaining Years
 
Aggregate Intrinsic
Value 
 
(in thousands)
 
 
 
 
 
(in millions)
Non-vested units as of December 31, 2017
2,575

 
$
5.85

 
 
 
 

Granted
1,522

 
$
16.77

 
 
 
 

Vested
(511
)
 
$
5.82

 
 
 
 

Forfeited
(30
)
 
$
7.96

 
 
 
 

Non-vested units as of June 30, 2018
3,556

 
$
10.39

 
2.9 years
 
$
55.5

Schedule of Equity Compensation Expenses
The following table summarizes information related to compensation expense recognized in the statements of operations related to the equity awards:
 
 
 
Three Months Ended June 30,
 
Six Months Ended June 30,
(in thousands)
 
2018
 
2017
 
2018
 
2017
Equity compensation expense recognized in:
 
 

 
 

 
 

 
 

Research and development expense
 
$
2,641

 
$
2,313

 
$
5,698

 
$
5,066

Selling, general and administrative expense
 
3,700

 
3,224

 
8,121

 
6,501

Total equity compensation expense
 
$
6,341

 
$
5,537

 
$
13,819

 
$
11,567