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Consolidated Statements of Operations - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Jun. 30, 2018
Jun. 30, 2017
Revenue:        
Net product sales $ 21,309 $ 7,158 $ 38,005 $ 11,327
Cost of goods sold 3,135 1,061 5,750 1,836
Gross Profit 18,174 6,097 32,255 9,491
Operating Expenses:        
Research and development 34,660 31,985 75,458 62,861
Selling, general and administrative 29,172 19,311 56,568 38,443
Changes in fair value of contingent consideration payable 300 1,050 1,400 5,628
Depreciation 973 812 1,942 1,636
Total operating expenses 65,105 53,158 135,368 108,568
Loss from operations (46,931) (47,061) (103,113) (99,077)
Other income (expense):        
Interest income 2,913 753 4,650 1,512
Interest expense (4,560) (4,179) (9,048) (8,469)
Change in fair value of derivatives (7,600) 0 (2,739) 0
Other (expense) income (5,316) 2,400 (2,554) 3,010
Loss before income tax (61,494) (48,087) (112,804) (103,024)
Income tax benefit (expense) (339) (49) 1,053 (105)
Net loss attributable to common stockholders $ (61,833) $ (48,136) $ (111,751) $ (103,129)
Net loss attributable to common stockholders per common share - basic and diluted (in dollars per share) $ (0.33) $ (0.34) $ (0.61) $ (0.72)
Weighted-average common shares outstanding - basic and diluted (in shares) 188,621,423 143,000,718 182,303,128 142,886,614