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Stockholders' Equity - Common Stock and Warrants (Details) - USD ($) $ / shares in Units, $ in Thousands |  |  | 1 Months Ended | 3 Months Ended | 9 Months Ended |  |
--- | --- | --- | --- | --- | --- | --- | ---
Feb. 16, 2018 | Feb. 15, 2018 | Apr. 30, 2018 | Mar. 31, 2018 | Sep. 30, 2018 | Sep. 30, 2017 | Jun. 07, 2018 | Dec. 31, 2017
Collaborative Agreements |  |  |  |  |  |  |  |
Common stock issued from underwriting agreement |  |  |  | 20,239,839 |  |  |  |
Net proceeds from the issuance of common stock |  |  |  | $ 294,600 | $ 294,584 | $ 243,036 |  |
Proceeds from exercise of warrants |  |  |  |  | $ 3,617 | $ 0 |  |
Common stock, par value (in dollars per share) |  |  |  |  | $ 0.01 |  |  | $ 0.01
Common stock, shares authorized |  |  |  |  | 500,000,000 |  | 500,000,000 | 250,000,000
Outstanding warrants, convertible to common stock |  |  |  |  |  |  |  |
Collaborative Agreements |  |  |  |  |  |  |  |
Common stock issued from underwriting agreement |  |  | 453,214 |  |  |  |  |
Proceeds from exercise of warrants |  |  | $ 3,600 |  |  |  |  |
Common Stock |  |  |  |  |  |  |  |
Collaborative Agreements |  |  |  |  |  |  |  |
Price per share of common stock issued (in dollars per share) | $ 15.50 | $ 15.50 |  |  |  |  |  |
Gross proceeds from issue of common stock before deducting underwriting discounts and commissions |  | $ 300,000 |  |  |  |  |  |
Net proceeds from the issuance of common stock |  |  |  |  | $ 294,600 |  |  |
Common Stock | Outstanding warrants, convertible to common stock |  |  |  |  |  |  |  |
Collaborative Agreements |  |  |  |  |  |  |  |
Warrants exercise price (in dollars per share) |  |  | $ 7.98 |  |  |  |  |
Common Stock |  |  |  |  |  |  |  |
Collaborative Agreements |  |  |  |  |  |  |  |
Common stock issued from underwriting agreement | 885,000 | 19,354,839 |  |  |  |  |  |
Common Stock | Over-allotment Option |  |  |  |  |  |  |  |
Collaborative Agreements |  |  |  |  |  |  |  |
Number of days granted underwriters for purchase of shares |  | 30 days |  |  |  |  |  |
Maximum number of additional shares granted to underwriters | 2,903,225 |  |  |  |  |  |  |

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