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Description of Business (Details) | 1 Months Ended | 3 Months Ended | 9 Months Ended |  |
--- | --- | --- | --- | --- | ---
Sep. 30, 2018 USD ($) medicine program | Sep. 30, 2018 USD ($) medicine program | Mar. 31, 2018 USD ($) shares | Sep. 30, 2018 USD ($) medicine program | Sep. 30, 2017 USD ($) | Oct. 08, 2018 program | Dec. 31, 2017 USD ($)
Business Acquisition [Line Items] |  |  |  |  |  |  |
Number of approved medicines for Fabry disease | medicine | 1 | 1 |  | 1 |  |  |
Number of gene therapy programs | program | 14 | 14 |  | 14 |  |  |
Number of gene therapy programs for Batten disease | program | 2 | 2 |  | 2 |  |  |
Number of gene therapy programs for neurologic LSDs developed | program | 10 |  |  |  |  |  |
Common stock issued from underwriting agreement (in shares) | shares |  |  | 20,239,839 |  |  |  |
Proceeds from issuance of common stock, net of issuance costs |  |  | $ 294,600,000 | $ 294,584,000 | $ 243,036,000 |  |
Retained earnings (accumulated deficit) | $ 1,334,141,000 | $ 1,334,141,000 |  | 1,334,141,000 |  |  | $ 1,063,610,000
Line of Credit |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |
New credit facility borrowing capacity | 150,000,000 | $ 150,000,000 |  | $ 150,000,000 |  |  |
Debt instrument term |  | 5 years |  |  |  |  |
Proceeds from issuance of debt | 146,600,000 |  |  |  |  |  |
Line of Credit | LIBOR |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |
Basis spread on variable rate |  | 7.50% |  |  |  |  |
Subsequent Event |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |
Number of gene therapy programs | program |  |  |  |  |  | 4 |
Celenex |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |
Research and development expense | $ 100,000,000 |  |  |  |  |  |

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