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Share based Compensation (Tables)
 9 Months Ended
Sep. 30, 2018
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Schedule of Fair Value of Options
The fair value of the stock options granted is estimated on the date of grant using a Black-Scholes option pricing model with the following weighted-average assumptions:
 
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2018
 
2017
 
2018
 
2017
Expected stock price volatility
75.5
%
 
82.5
%
 
80.7
%
 
83.1
%
Risk free interest rate
2.7
%
 
1.8
%
 
2.4
%
 
2.0
%
Expected life of options (years)
5.62

 
5.89

 
5.62

 
6.21

Expected annual dividend per share
$
—

 
$
—

 
$
—

 
$
—
Schedule of Stock Options Activity
A summary of the Company’s stock options for the nine months ended September 30, 2018 were as follows:
 
 
Number of
Shares
 
Weighted
Average
Exercise Price
 
Weighted
Average
Remaining
Contractual Life
 
Aggregate
Intrinsic
Value
 
(in thousands)
 
 
 
 
 
(in millions)
Options outstanding, December 31, 2017
15,181

 
$
7.48

 
 
 
 

Granted
2,077

 
$
15.36

 
 
 
 

Exercised
(1,282
)
 
$
6.62

 
 
 
 

Forfeited
(200
)
 
$
9.75

 
 
 
 

Expired
(7
)
 
10.45

 
 
 
 
Options outstanding, September 30, 2018
15,769

 
$
8.56

 
7.0 years
 
$
65.8

Vested and unvested expected to vest, September 30, 2018
15,003

 
$
8.43

 
6.9 years
 
$
63.9

Exercisable at September 30, 2018
9,406

 
$
7.26

 
6.0 years
 
$
47.4
Schedule of Non-Vested RSU Activity under the Plan
A summary of non-vested RSU activity under the Plan for the nine months ended September 30, 2018 is as follows:
 
 
Number of Shares

 
Weighted
Average Grant Date
Fair Value
 
Weighted Average
Remaining Years
 
Aggregate Intrinsic
Value 
 
(in thousands)
 
 
 
 
 
(in millions)
Non-vested units as of December 31, 2017
2,575

 
$
5.85

 
 
 
 

Granted
1,635

 
$
16.57

 
 
 
 

Vested
(517
)
 
$
5.91

 
 
 
 

Forfeited
(58
)
 
$
10.23

 
 
 
 

Non-vested units as of September 30, 2018
3,635

 
$
10.49

 
2.7 years
 
$
44.0
Schedule of Equity Compensation Expenses
The following table summarizes information related to compensation expense recognized in the statements of operations related to the equity awards:
 
 
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
(in thousands)
 
2018
 
2017
 
2018
 
2017
Equity compensation expense recognized in:
 
 

 
 

 
 

 
 

Research and development expense
 
$
2,905

 
$
2,390

 
$
8,603

 
$
7,456

Selling, general and administrative expense
 
4,149

 
3,110

 
12,270

 
9,611

Total equity compensation expense
 
$
7,054

 
$
5,500

 
$
20,873

 
$
17,067