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Acquisitions (Details) - Celenex $ in Millions	1 Months Ended
	Sep. 30, 2018 USD ($)
Business Acquisition [Line Items]
Upfront cash payment to acquire assets	$ 100.0
Development milestones	15.0
Submission and approval milestones	262.0
Maximum expected payment over next four years	75.0
Research and development expense	100.0
Nationwide Children's Hospital
Business Acquisition [Line Items]
Development milestones	$ 7.8

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- Definition

Asset Acquisition, Consideration Transferred

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- Definition

Revenue Recognition, Milestone Method, Contingent On Development

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- Definition

Revenue Recognition, Milestone Method, Contingent On Submission And Approval Milestones

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Revenue Recognition, Milestone Method, Maximum Expected Payment Over Next Four Years

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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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- Definition

The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 985
-SubTopic 20
-Section 50
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=6501960&loc=d3e128462-111756

Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
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-SubTopic 10
-Section 50
-Paragraph 1
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