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Stockholders' Equity - Common Stock and Warrants (Details) - USD ($) $ / shares in Units, $ in Thousands			1 Months Ended	3 Months Ended	9 Months Ended
	Feb. 16, 2018	Feb. 15, 2018	Apr. 30, 2018	Mar. 31, 2018	Sep. 30, 2018	Sep. 30, 2017	Jun. 07, 2018	Dec. 31, 2017
Collaborative Agreements
Common stock issued from underwriting agreement				20,239,839
Net proceeds from the issuance of common stock				$ 294,600	$ 294,584	$ 243,036
Proceeds from exercise of warrants					$ 3,617	$ 0
Common stock, par value (in dollars per share)					$ 0.01			$ 0.01
Common stock, shares authorized					500,000,000		500,000,000	250,000,000
Outstanding warrants, convertible to common stock
Collaborative Agreements
Common stock issued from underwriting agreement			453,214
Proceeds from exercise of warrants			$ 3,600
Common Stock
Collaborative Agreements
Price per share of common stock issued (in dollars per share)	$ 15.50	$ 15.50
Gross proceeds from issue of common stock before deducting underwriting discounts and commissions		$ 300,000
Net proceeds from the issuance of common stock					$ 294,600
Common Stock | Outstanding warrants, convertible to common stock
Collaborative Agreements
Warrants exercise price (in dollars per share)			$ 7.98
Common Stock
Collaborative Agreements
Common stock issued from underwriting agreement	885,000	19,354,839
Common Stock | Over-allotment Option
Collaborative Agreements
Number of days granted underwriters for purchase of shares		30 days
Maximum number of additional shares granted to underwriters	2,903,225

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