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Consolidated Statements of Operations - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Revenue:        
Net product sales $ 20,596 $ 10,874 $ 58,601 $ 22,201
Cost of goods sold 4,310 1,790 10,060 3,626
Gross profit 16,286 9,084 48,541 18,575
Operating expenses:        
Research and development 138,227 40,641 213,685 103,502
Selling, general and administrative 31,867 21,647 88,435 60,090
Changes in fair value of contingent consideration payable 1,300 (244,250) 2,700 (238,622)
Loss on impairment of assets 0 465,427 0 465,427
Depreciation 1,073 851 3,015 2,486
Total operating expenses 172,467 284,316 307,835 392,883
Loss from operations (156,181) (275,232) (259,294) (374,308)
Other income (expense):        
Interest income 2,721 1,190 7,371 2,702
Interest expense (4,715) (4,351) (13,763) (12,820)
Change in fair value of derivatives 0 0 (2,739) 163
Other (expense) income (1,039) 2,044 (3,593) 4,891
Loss before income tax (159,214) (276,349) (272,018) (379,372)
Income tax benefit 51 164,683 1,104 164,578
Net loss attributable to common stockholders $ (159,163) $ (111,666) $ (270,914) $ (214,794)
Net loss attributable to common stockholders per common share - basic and diluted (in dollars per share) $ (0.84) $ (0.69) $ (1.47) $ (1.44)
Weighted-average common shares outstanding - basic and diluted (in shares) 189,162,841 160,796,841 184,606,790 148,963,864