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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Operating activities    
Net loss $ (270,914) $ (214,794)
Adjustments to reconcile net loss to net cash used in operating activities:    
Amortization of debt discount and deferred financing 7,868 7,179
Depreciation 3,015 2,486
Stock-based compensation 20,873 17,067
Loss on impairment 0 465,427
Gain on disposal of asset 0 (8)
Change in fair value of derivatives 2,739 (265)
Non-cash changes in the fair value of contingent consideration payable 2,700 (238,622)
Foreign currency remeasurement (gain)/ loss 775 (4,932)
Non-cash deferred taxes 0 (164,585)
Changes in operating assets and liabilities:    
Accounts receivable (5,182) (4,288)
Inventories (2,049) (3,386)
Prepaid expenses and other current assets 2,633 (3,358)
Other non-current assets (1,101) 344
Account payable and accrued expenses 3,684 13,037
Non-current liabilities 681 637
Deferred reimbursement (5,000) (12,600)
Net cash used in operating activities (239,278) (140,661)
Investing activities    
Sale and redemption of marketable securities 388,135 230,981
Purchases of marketable securities (440,963) (450,358)
Capital expenditures (4,571) (3,398)
Net cash used in investing activities (57,399) (222,775)
Financing activities    
Proceeds from issuance of common stock, net of issuance costs 294,584 243,036
Proceeds from senior secured term loan, net of issuance costs 146,622 0
Payment of capital leases (218) (212)
Payment of contingent consideration 0 (10,000)
Purchase of vested restricted stock units (2,681) (1,067)
Proceeds from exercise of stock options 8,492 8,841
Payment of deferred financing fees 0 (28)
Proceeds from exercise of warrants 3,617 0
Net cash provided by financing activities 450,416 240,570
Effect of exchange rate changes on cash, cash equivalents and restricted cash (1,146) 1,030
Net increase (decrease) in cash and cash equivalents and restricted cash 152,593 (121,836)
Cash and cash equivalents and restricted cash at beginning of period 51,237 187,413
Cash and cash equivalents and restricted cash at end of period 203,830 65,577
Supplemental disclosures of cash flow information    
Cash paid during the period for interest 3,787 3,662
Capital expenditures, unpaid 538 0
Capital expenditures funded by capital lease $ 80 $ 0