<SEC-DOCUMENT>0001425738-18-000009.txt : 20180214
<SEC-HEADER>0001425738-18-000009.hdr.sgml : 20180214
<ACCEPTANCE-DATETIME>20180214180520
ACCESSION NUMBER:		0001425738-18-000009
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20180214
DATE AS OF CHANGE:		20180214

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AMICUS THERAPEUTICS INC
		CENTRAL INDEX KEY:			0001178879
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				200422823
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-83043
		FILM NUMBER:		18614678

	BUSINESS ADDRESS:	
		STREET 1:		1 CEDAR BROOK DRIVE
		CITY:			CRANBURY
		STATE:			NJ
		ZIP:			08512
		BUSINESS PHONE:		(609) 662-2000

	MAIL ADDRESS:	
		STREET 1:		1 CEDAR BROOK DRIVE
		CITY:			CRANBURY
		STATE:			NJ
		ZIP:			08512

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Redmile Group, LLC
		CENTRAL INDEX KEY:			0001425738
		IRS NUMBER:				208592298
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		ONE LETTERMAN DRIVE
		STREET 2:		BUILDING D, SUITE D3-300
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94129
		BUSINESS PHONE:		415-489-9980

	MAIL ADDRESS:	
		STREET 1:		ONE LETTERMAN DRIVE
		STREET 2:		BUILDING D, SUITE D3-300
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94129
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>fold_13ga5.htm
<TEXT>
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<title>fold_13ga5.htm</title>

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<p style="margin: 0in 0in 12pt; text-align: center;" align="center"><b><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">UNITED
STATES<br>
SECURITIES AND EXCHANGE COMMISSION<br>
Washington, D.C. 20549</font></b></p>

<p style="margin: 0in 0in 0pt; text-align: center;" align="center"><b><font style="font-size: 12pt;" face="Times New Roman" lang="EN-US">SCHEDULE
13G<br>
</font></b><b><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">Under the Securities Exchange Act of 1934</font></b></p>

<p style="margin: 0in 0in 0pt; text-align: center;" align="center"><b><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">(Amendment
No. 5)*</font></b></p>

<p style="margin: 0in 0in 0pt; text-align: center;" align="center">&nbsp;</p>

<p style="margin: 0in 0in 0pt; text-align: center;" align="center">&nbsp;</p>

<div align="left">
<table style="width: 100%; border-collapse: collapse;" border="0" cellpadding="0" cellspacing="0" width="100%">

    <tr>
      <td style="padding: 0in 5.4pt;" valign="top" width="100%">
      <p style="margin: 0in 0in 0pt; text-align: center;" align="center"><u><font style="font-size: 10pt;" face="Times New Roman">Amicus Therapeutics, Inc.</font></u></p>
      </td>
    </tr>
    <tr>
      <td style="padding: 0in 5.4pt;" valign="top" width="100%">
      <p style="margin: 0in 0in 0pt; text-align: center;" align="center"><font style="font-size: 10pt;" face="Times New Roman">(Name of Issuer)</font></p>
      </td>
    </tr>
    <tr>
      <td style="padding: 0in 5.4pt;" valign="top" width="100%">
      <p style="margin: 12pt 0in 0pt; text-align: center;" align="center"><u><font style="font-size: 10pt;" face="Times New Roman">Common
Stock, $0.001 par value per share</font></u></p>
      </td>
    </tr>
    <tr>
      <td style="padding: 0in 5.4pt;" valign="top" width="100%">
      <p style="margin: 0in 0in 0pt; text-align: center;" align="center"><font style="font-size: 10pt;" face="Times New Roman">(Title of Class of
Securities)</font></p>
      </td>
    </tr>
    <tr>
      <td style="padding: 0in 5.4pt;" valign="top" width="100%">
      <p style="margin: 12pt 0in 0pt; text-align: center;" align="center"><u><font style="font-size: 10pt;" face="Times New Roman">03152W109</font></u></p>
      </td>
    </tr>
    <tr>
      <td style="padding: 0in 5.4pt;" valign="top" width="100%">
      <p style="margin: 0in 0in 12pt; text-align: center;" align="center"><font style="font-size: 10pt;" face="Times New Roman">(CUSIP
Number)</font></p>
      </td>
    </tr>
    <tr>
      <td style="padding: 0in 5.4pt;" valign="top" width="100%">
      <p style="margin: 12pt 0in 0pt; text-align: center;" align="center"><u><font style="font-size: 10pt;" face="Times New Roman">December 31, 2017</font></u></p>
      </td>
    </tr>
    <tr>
      <td style="padding: 0in 5.4pt;" valign="top" width="100%">
      <p style="margin: 0in 0in 0pt; text-align: center;" align="center"><font style="font-size: 10pt;" face="Times New Roman">(Date of Event Which
Requires Filing of this Statement)</font></p>
      </td>
    </tr>

</table>
</div>

<p style="margin: 12pt 0in 12pt 22.5pt;"><font style="font-size: 12pt;" face="Wingdings" lang="EN-US">&#253;</font><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US"> Rule 13d-1(b)</font></p>

<p style="margin: 0in 0in 12pt 22.3pt;"><font style="font-size: 12pt;" face="Wingdings" lang="EN-US">&#168;</font><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US"> Rule 13d-1(c)</font></p>

<p style="margin: 0in 0in 12pt 22.3pt;"><font style="font-size: 12pt;" face="Wingdings" lang="EN-US">&#168;</font><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US"> Rule 13d-1(d)</font></p>
<p style="margin: 0in 0in 12pt; text-align: justify;"><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">*The
remainder of this cover page shall be filled out for a reporting
person&#8217;s initial filing on this form with respect to the subject class
of securities, and for any subsequent amendment containing information
which would alter the disclosures provided in a prior cover page.</font></p>

<p style="margin: 0in 0in 12pt; text-align: justify;"><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">The
information required in the remainder of this cover page shall not be
deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the Securities
Exchange Act of 1934 (&#8220;Act&#8221;) or otherwise subject to the liabilities of
that section of the Act but shall be subject to all other provisions of
the Act (however, see the Notes).</font></p>

<hr align="center" noshade="noshade" size="2" width="100%">

<a name="page_2"></a>
<p style="margin: 0in 0in 0pt;">&nbsp;</p>

<div align="left">
<table style="width: 100%; border-collapse: collapse;" border="0" cellpadding="0" cellspacing="0" width="100%">

    <tr>
      <td style="border-top: 1pt solid windowtext; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" valign="top" width="6%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">(1)</font></p>
      </td>
      <td style="border-top: 1pt solid windowtext; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="4" valign="top" width="31%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">Names of Reporting Persons.</font></p>
      </td>
      <td style="border-top: 1pt solid windowtext; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="2" valign="top" width="63%">
      <p style="margin: 12pt 5.45pt 0pt 0in; text-align: right;" align="right"><font style="font-size: 10pt;" face="Times New Roman">Redmile Group, LLC</font></p>
      </td>
    </tr>
    <tr>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" valign="top" width="6%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">(2)</font></p>
      </td>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="5" valign="top" width="78%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">Check the Appropriate Box if a Member of a
Group (See Instructions)</font></p>
      </td>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" valign="top" width="16%">
      <p style="margin: 0in 0.1in 0pt 0in; text-align: right;" align="right"><font style="font-size: 10pt;" face="Times New Roman">(a)&nbsp;&nbsp;&nbsp;&nbsp;
      </font><font style="font-size: 12pt;" face="Wingdings">&#168;</font></p>
      <p style="margin: 0in 0.1in 0pt 0in; text-align: right;" align="right"><font style="font-size: 10pt;" face="Times New Roman">(b)&nbsp;&nbsp;&nbsp;&nbsp;
      </font><font style="font-size: 12pt;" face="Wingdings">&#168;</font></p>
      </td>
    </tr>
    <tr>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" valign="top" width="6%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">(3)</font></p>
      </td>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="6" valign="top" width="94%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">SEC Use Only</font></p>
      </td>
    </tr>
    <tr>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" valign="top" width="6%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">(4)</font></p>
      </td>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="5" valign="top" width="78%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">Citizenship or Place of Organization</font></p>
      </td>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" valign="top" width="16%">
      <p style="margin: 12pt 5.45pt 0pt 0in; text-align: right;" align="right"><font style="font-size: 10pt;" face="Times New Roman">DELAWARE</font></p>
      </td>
    </tr>
    <tr style="height: 23pt;">
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt; height: 23pt;" colspan="3" rowspan="4" width="21%">
      <p style="margin: 0in 0in 0pt; text-align: center;" align="center"><font style="font-size: 10pt;" face="Times New Roman">NUMBER OF</font></p>
      <p style="margin: 0in 0in 0pt; text-align: center;" align="center"><font style="font-size: 10pt;" face="Times New Roman">SHARES</font></p>
      <p style="margin: 0in 0in 0pt; text-align: center;" align="center"><font style="font-size: 10pt;" face="Times New Roman">BENEFICIALLY</font></p>
      <p style="margin: 0in 0in 0pt; text-align: center;" align="center"><font style="font-size: 10pt;" face="Times New Roman">OWNED BY EACH</font></p>
      <p style="margin: 0in 0in 0pt; text-align: center;" align="center"><font style="font-size: 10pt;" face="Times New Roman">REPORTING</font></p>
      <p style="margin: 0in 0in 0pt; text-align: center;" align="center"><font style="font-size: 10pt;" face="Times New Roman">PERSON WITH</font></p>
      </td>
      <td style="padding: 0in 5.4pt; height: 23pt;" valign="top" width="6%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">(5)</font></p>
      </td>
      <td style="padding: 0in 5.4pt; height: 23pt;" colspan="2" valign="top" width="57%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">Sole Voting Power</font></p>
      </td>
      <td style="padding: 0in 5.4pt; height: 23pt;" valign="top" width="16%">
      <p style="margin: 12pt 5.45pt 0pt 0in; text-align: right;" align="right"><font style="font-size: 10pt;" face="Times New Roman"> 0
</font></p>
      </td>
    </tr>
    <tr style="height: 23pt;">
      <td style="border-top: 1pt solid windowtext; padding: 0in 5.4pt; height: 23pt;" valign="top" width="6%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">(6)</font></p>
      </td>
      <td style="border-top: 1pt solid windowtext; padding: 0in 5.4pt; height: 23pt;" colspan="2" valign="top" width="57%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">Shared Voting Power</font></p>
      </td>
      <td style="border-top: 1pt solid windowtext; padding: 0in 5.4pt; height: 23pt;" valign="top" width="16%">
      <p style="margin: 12pt 5.45pt 0pt 0in; text-align: right;" align="right"><font style="font-size: 10pt;" face="Times New Roman">12,085,770</font></p>
      </td>
    </tr>
    <tr style="height: 23pt;">
      <td style="border-top: 1pt solid windowtext; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt; height: 23pt;" valign="top" width="6%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">(7)</font></p>
      </td>
      <td style="border-top: 1pt solid windowtext; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt; height: 23pt;" colspan="2" valign="top" width="57%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">Sole Dispositive Power</font></p>
      </td>
      <td style="border-top: 1pt solid windowtext; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt; height: 23pt;" valign="top" width="16%">
      <p style="margin: 12pt 5.45pt 0pt 0in; text-align: right;" align="right"><font style="font-size: 10pt;" face="Times New Roman"> 0
</font></p>
      </td>
    </tr>
    <tr style="height: 23pt;">
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt; height: 23pt;" valign="top" width="6%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">(8)</font></p>
      </td>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt; height: 23pt;" colspan="2" valign="top" width="57%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">Shared Dispositive Power</font></p>
      </td>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt; height: 23pt;" valign="top" width="16%">
      <p style="margin: 12pt 5.45pt 0pt 0in; text-align: right;" align="right"><font style="font-size: 10pt;" face="Times New Roman">12,085,770</font></p>
      </td>
    </tr>
    <tr>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="2" valign="top" width="7%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">(9)</font></p>
      </td>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="4" valign="top" width="77%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">Aggregate Amount Beneficially Owned by Each
Reporting Person</font></p>
      </td>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" valign="top" width="16%">
      <p style="margin: 12pt 5.45pt 0pt 0in; text-align: right;" align="right"><font style="font-size: 10pt;" face="Times New Roman"> 12,085,770
</font></p>
      </td>
    </tr>
    <tr>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="2" valign="top" width="7%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">(10)</font></p>
      </td>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="4" valign="top" width="77%">
      <p style="margin: 12pt 5.45pt 0pt 0in;"><font style="font-size: 10pt;" face="Times New Roman">Check if the Aggregate
Amount in Row (9) Excludes Certain Shares (See Instructions)</font></p>
      </td>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" valign="top" width="16%">
      <p style="margin: 12pt 5.45pt 0pt 0in; text-align: right;" align="right"><font style="font-size: 12pt;" face="Wingdings">&#168;</font></p>
      </td>
    </tr>
    <tr>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="2" valign="top" width="7%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">(11)</font></p>
      </td>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="4" valign="top" width="77%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">Percent of Class Represented by Amount in Row
(9)</font></p>
      </td>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" valign="top" width="16%">
      <p style="margin: 12pt 5.45pt 0pt 0in; text-align: right;" align="right"><font style="font-size: 10pt;" face="Times New Roman">7.18%</font></p>
      </td>
    </tr>
    <tr>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="2" valign="top" width="7%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">(12)</font></p>
      </td>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="4" valign="top" width="77%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">Type of Reporting Person (See Instructions)</font></p>
      </td>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" valign="top" width="16%">
      <p style="margin: 12pt 5.45pt 0pt 0in; text-align: right;" align="right"><font style="font-size: 10pt;" face="Times New Roman">IA,OO</font></p>
      </td>
    </tr>
    <tr height="0">
      <td width="6%"><br>
      </td>
      <td width="1%"><br>
      </td>
      <td width="14%"><br>
      </td>
      <td width="6%"><br>
      </td>
      <td width="10%"><br>
      </td>
      <td width="47%"><br>
      </td>
      <td width="16%"><br>
      </td>
    </tr>

</table>
</div>

<p style="margin: 0in 0in 0pt;">&nbsp;</p>

<p style="text-align: center;">2</p>

<hr align="center" noshade="noshade" size="2" width="100%">

<a name="page_3"></a>
<p style="margin: 0in 0in 0pt;">&nbsp;</p>

<div align="left">
<table style="width: 100%; border-collapse: collapse;" border="0" cellpadding="0" cellspacing="0" width="100%">

    <tr>
      <td style="border-top: 1pt solid windowtext; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" valign="top" width="6%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">(1)</font></p>
      </td>
      <td style="border-top: 1pt solid windowtext; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="4" valign="top" width="31%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">Names of Reporting Persons.</font></p>
      </td>
      <td style="border-top: 1pt solid windowtext; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="3" valign="top" width="63%">
      <p style="margin: 12pt 5.45pt 0pt 0in; text-align: right;" align="right"><font style="font-size: 10pt;" face="Times New Roman">JEREMY C. GREEN</font></p>
      </td>
    </tr>
    <tr>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" valign="top" width="6%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">(2)</font></p>
      </td>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="6" valign="top" width="79%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">Check the Appropriate Box if a Member of a
Group (See Instructions)</font></p>
      </td>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" valign="top" width="15%">
      <p style="margin: 0in 0.1in 0pt 0in; text-align: right;" align="right"><font style="font-size: 10pt;" face="Times New Roman">(a)&nbsp;&nbsp;&nbsp;&nbsp;
      </font><font style="font-size: 12pt;" face="Wingdings">&#168;</font></p>
      <p style="margin: 0in 0.1in 0pt 0in; text-align: right;" align="right"><font style="font-size: 10pt;" face="Times New Roman">(b)&nbsp;&nbsp;&nbsp;&nbsp;
      </font><font style="font-size: 12pt;" face="Wingdings">&#168;</font></p>
      </td>
    </tr>
    <tr>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" valign="top" width="6%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">(3)</font></p>
      </td>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="7" valign="top" width="94%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">SEC Use Only</font></p>
      </td>
    </tr>
    <tr>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" valign="top" width="6%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">(4)</font></p>
      </td>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="5" valign="top" width="75%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">Citizenship or Place of Organization</font></p>
      </td>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="2" valign="top" width="19%">
      <p style="margin: 12pt 5.45pt 0pt 0in; text-align: right;" align="right"><font style="font-size: 10pt;" face="Times New Roman">UNITED KINGDOM</font></p>
      </td>
    </tr>
    <tr style="height: 23pt;">
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt; height: 23pt;" colspan="3" rowspan="4" width="21%">
      <p style="margin: 0in 0in 0pt; text-align: center;" align="center"><font style="font-size: 10pt;" face="Times New Roman">NUMBER OF</font></p>
      <p style="margin: 0in 0in 0pt; text-align: center;" align="center"><font style="font-size: 10pt;" face="Times New Roman">SHARES</font></p>
      <p style="margin: 0in 0in 0pt; text-align: center;" align="center"><font style="font-size: 10pt;" face="Times New Roman">BENEFICIALLY</font></p>
      <p style="margin: 0in 0in 0pt; text-align: center;" align="center"><font style="font-size: 10pt;" face="Times New Roman">OWNED BY EACH</font></p>
      <p style="margin: 0in 0in 0pt; text-align: center;" align="center"><font style="font-size: 10pt;" face="Times New Roman">REPORTING</font></p>
      <p style="margin: 0in 0in 0pt; text-align: center;" align="center"><font style="font-size: 10pt;" face="Times New Roman">PERSON WITH</font></p>
      </td>
      <td style="padding: 0in 5.4pt; height: 23pt;" valign="top" width="6%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">(5)</font></p>
      </td>
      <td style="padding: 0in 5.4pt; height: 23pt;" colspan="2" valign="top" width="54%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">Sole Voting Power</font></p>
      </td>
      <td style="padding: 0in 5.4pt; height: 23pt;" colspan="2" valign="top" width="19%">
      <p style="margin: 12pt 5.45pt 0pt 0in; text-align: right;" align="right"><font style="font-size: 10pt;" face="Times New Roman">0</font></p>
      </td>
    </tr>
    <tr style="height: 23pt;">
      <td style="border-top: 1pt solid windowtext; padding: 0in 5.4pt; height: 23pt;" valign="top" width="6%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">(6)</font></p>
      </td>
      <td style="border-top: 1pt solid windowtext; padding: 0in 5.4pt; height: 23pt;" colspan="2" valign="top" width="54%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">Shared Voting Power</font></p>
      </td>
      <td style="border-top: 1pt solid windowtext; padding: 0in 5.4pt; height: 23pt;" colspan="2" valign="top" width="19%">
      <p style="margin: 12pt 5.45pt 0pt 0in; text-align: right;" align="right"><font style="font-size: 10pt;" face="Times New Roman"> 12,085,770
</font></p>
      </td>
    </tr>
    <tr style="height: 23pt;">
      <td style="border-top: 1pt solid windowtext; padding: 0in 5.4pt; height: 23pt;" valign="top" width="6%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">(7)</font></p>
      </td>
      <td style="border-top: 1pt solid windowtext; padding: 0in 5.4pt; height: 23pt;" colspan="2" valign="top" width="54%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">Sole Dispositive Power</font></p>
      </td>
      <td style="border-top: 1pt solid windowtext; padding: 0in 5.4pt; height: 23pt;" colspan="2" valign="top" width="19%">
      <p style="margin: 12pt 5.45pt 0pt 0in; text-align: right;" align="right"><font style="font-size: 10pt;" face="Times New Roman">0</font></p>
      </td>
    </tr>
    <tr style="height: 23pt;">
      <td style="border-top: 1pt solid windowtext; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt; height: 23pt;" valign="top" width="6%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">(8)</font></p>
      </td>
      <td style="border-top: 1pt solid windowtext; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt; height: 23pt;" colspan="2" valign="top" width="54%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">Shared Dispositive Power</font></p>
      </td>
      <td style="border-top: 1pt solid windowtext; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt; height: 23pt;" colspan="2" valign="top" width="19%">
      <p style="margin: 12pt 5.45pt 0pt 0in; text-align: right;" align="right"><font style="font-size: 10pt;" face="Times New Roman">12,085,770
</font></p>
      </td>
    </tr>
    <tr>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="2" valign="top" width="7%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">(9)</font></p>
      </td>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="4" valign="top" width="74%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">Aggregate Amount Beneficially Owned by Each
Reporting Person</font></p>
      </td>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="2" valign="top" width="19%">
      <p style="margin: 12pt 5.45pt 0pt 0in; text-align: right;" align="right"><font style="font-size: 10pt;" face="Times New Roman">12,085,770
</font></p>
      </td>
    </tr>
    <tr>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="2" valign="top" width="7%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">(10)</font></p>
      </td>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="4" valign="top" width="74%">
      <p style="margin: 12pt 5.45pt 0pt 0in;"><font style="font-size: 10pt;" face="Times New Roman">Check if the Aggregate
Amount in Row (9) Excludes Certain Shares (See Instructions)</font></p>
      </td>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="2" valign="top" width="19%">
      <p style="margin: 12pt 5.45pt 0pt 0in; text-align: right;" align="right"><font style="font-size: 12pt;" face="Wingdings">&#168;</font></p>
      </td>
    </tr>
    <tr>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="2" valign="top" width="7%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">(11)</font></p>
      </td>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="4" valign="top" width="74%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">Percent of Class Represented by Amount in Row
(9)</font></p>
      </td>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="2" valign="top" width="19%">
      <p style="margin: 12pt 5.45pt 0pt 0in; text-align: right;" align="right"><font style="font-size: 10pt;" face="Times New Roman">7.18%</font></p>
      </td>
    </tr>
    <tr>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="2" valign="top" width="7%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">(12)</font></p>
      </td>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="4" valign="top" width="74%">
      <p style="margin: 12pt 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">Type of Reporting Person (See Instructions)</font></p>
      </td>
      <td style="border-bottom: 1pt solid windowtext; padding: 0in 5.4pt;" colspan="2" valign="top" width="19%">
      <p style="margin: 12pt 5.45pt 0pt 0in; text-align: right;" align="right"><font style="font-size: 10pt;" face="Times New Roman">IN,HC</font></p>
      </td>
    </tr>
    <tr height="0">
      <td width="6%"><br>
      </td>
      <td width="1%"><br>
      </td>
      <td width="14%"><br>
      </td>
      <td width="6%"><br>
      </td>
      <td width="10%"><br>
      </td>
      <td width="44%"><br>
      </td>
      <td width="4%"><br>
      </td>
      <td width="15%"><br>
      </td>
    </tr>

</table>
</div>




<p style="margin: 0in 0in 0pt;">&nbsp;</p>

<p style="text-align: center;">3</p>

<hr align="center" noshade="noshade" size="2" width="100%">

<a name="page_6"></a>
<p style="margin: 0in 0in 0pt;">&nbsp;</p>

<p style="margin: 0in 0in 12pt 45pt; text-indent: -45pt;"><b><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">Item
1(a).&nbsp; Name of Issuer:</font></b></p>

<p style="margin: 0in 0in 12pt; text-indent: 0.65in; text-align: justify;"><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">Amicus Therapeutics, Inc.</font></p>

<p style="margin: 0in 0in 12pt 45pt; text-indent: -45pt;"><b><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">Item
1(b).&nbsp; Address of Issuer&#8217;s Principal Executive Offices:</font></b></p>

<p style="margin: 0in 0in 0pt; text-indent: 0.65in; text-align: justify;"><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">1 Cedar Brook Drive</font></p>

<p style="margin: 0in 0in 12pt; text-indent: 0.65in; text-align: justify;"><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">Cranbury, New Jersey 08512</font></p>

<p style="margin: 0in 0in 12pt 45pt; text-indent: -45pt;"><b><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">Item
2(a).&nbsp; Names of Persons Filing:</font></b></p>

<p style="margin: 0in 0in 0pt; text-indent: 0.65in; text-align: justify;"><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">Redmile Group, LLC (&#8220;Redmile&#8221;)</font></p>

<p style="margin: 0in 0in 0pt; text-indent: 0.65in; text-align: justify;"><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">Jeremy C. Green (&#8220;Jeremy Green&#8221;)</font></p>
<BR>
<p style="margin: 0in 0in 12pt 45pt; text-indent: -45pt;"><b><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">Item
2(b).&nbsp; Address of Principal Business Office or, if None, Residence:</font></b></p>

<p style="margin: 0in 0in 12pt; text-indent: 0.65in; text-align: justify;"><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">The
principal business address of each reporting person is One Letterman Drive, Bldg D, Ste D3-300, San Francisco, CA 94129.</font></p>

<p style="margin: 0in 0in 12pt 45pt; text-indent: -45pt;"><b><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">Item
2(c).&nbsp; Citizenship:</font></b></p>

<p style="margin: 0in 0in 12pt; text-indent: 0.65in; text-align: justify;"><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">Reference
is made to Item 4 of pages 2&#8211;3 of this Schedule 13G (this &#8220;Schedule&#8221;),
which Items are incorporated by reference herein.</font></p>

<p style="margin: 0in 0in 12pt 45pt; text-indent: -45pt;"><b><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">Item
2(d).&nbsp; Title of Class of Securities:</font></b></p>

<p style="margin: 0in 0in 12pt 0.4in; text-indent: 17.95pt; text-align: justify;"><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">Common
Stock, $.001 par value per share</font></p>

<p style="margin: 0in 0in 12pt 45pt; text-indent: -45pt;"><b><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">Item
2(e).&nbsp; CUSIP Number:</font></b></p>

<p style="margin: 0in 0in 12pt 0.4in; text-indent: 17.95pt; text-align: justify;"><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">03152W109</font></p>

<p style="margin: 0in 0in 12pt 45.35pt; text-indent: -45.35pt; line-height: 80%;"><b><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">Item
3.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; If this statement is filed pursuant to
&#167;&#167;240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing
is a:</font></b></p>

<p style="margin: 0in 0in 12pt 0.65in; text-indent: 0in; text-align: left;" align="left"><font style="font-size: 12pt;" face="Wingdings" lang="EN-US">&#168;</font><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">&nbsp;&nbsp;&nbsp;&nbsp;
(a)&nbsp;&nbsp;&nbsp; Broker or dealer registered under section 15 of
the Act (15 U.S.C. 78o).</font></p>

<p style="margin: 0in 0in 12pt 0.65in; text-indent: 0in; text-align: left;" align="left"><font style="font-size: 12pt;" face="Wingdings" lang="EN-US">&#168;</font><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">&nbsp;&nbsp;&nbsp;&nbsp;
(b)&nbsp;&nbsp;&nbsp; Bank as defined in section 3(a)(6) of the Act (15
U.S.C. 78c).</font></p>

<p style="margin: 0in 0in 12pt 0.65in; text-indent: 0in; text-align: left;" align="left"><font style="font-size: 12pt;" face="Wingdings" lang="EN-US">&#168;</font><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">&nbsp;&nbsp;&nbsp;&nbsp;
(c)&nbsp;&nbsp;&nbsp; Insurance company as defined in section 3(a)(19)
of the Act (15 U.S.C. 78c).</font></p>

<p style="margin: 0in 0in 12pt 0.65in; text-indent: 0in; text-align: left;" align="left"><font style="font-size: 12pt;" face="Wingdings" lang="EN-US">&#168;</font><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">&nbsp;&nbsp;&nbsp;&nbsp;
(d)&nbsp;&nbsp;&nbsp; Investment company registered under section 8 of
the Investment Company Act of 1940 (15 U.S.C 80a-8).</font></p>

<p style="margin: 0in 0in 12pt 0.65in; text-indent: 0in; text-align: left;" align="left"><font style="font-size: 12pt;" face="Wingdings" lang="EN-US">&#253;</font><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">&nbsp;&nbsp;&nbsp;&nbsp;
(e)&nbsp;&nbsp;&nbsp; An investment adviser in accordance with
&#167;240.13d-1(b)(1)(ii)(E);</font></p>

<p style="margin: 0in 0in 12pt 0.65in; text-indent: 0in; text-align: left;" align="left"><font style="font-size: 12pt;" face="Wingdings" lang="EN-US">&#168;</font><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">&nbsp;&nbsp;&nbsp;&nbsp;
(f)&nbsp;&nbsp;&nbsp; An employee benefit plan or endowment fund in
accordance with &#167;240.13d-1(b)(1)(ii)(F);</font></p>

<p style="margin: 0in 0in 12pt 0.65in; text-indent: 0in; text-align: left;" align="left"><font style="font-size: 12pt;" face="Wingdings" lang="EN-US">&#168;</font><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">&nbsp;&nbsp;&nbsp;&nbsp;
(g)&nbsp;&nbsp;&nbsp; A parent holding company or control person in
accordance with &#167; 240.13d-1(b)(1)(ii)(G);</font></p>

<p style="text-align: center;">4</p>

<hr align="center" noshade="noshade" size="2" width="100%">

<a name="page_7"></a>
<p style="margin: 0in 0in 12pt 45pt; text-indent: -45pt;">&nbsp;</p>

<p style="margin: 0in 0in 12pt 0.65in; text-indent: 0in; text-align: left;" align="left"><font style="font-size: 12pt;" face="Wingdings" lang="EN-US">&#168;</font><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">&nbsp;&nbsp;&nbsp;&nbsp;
(h)&nbsp;&nbsp;&nbsp; A savings associations as defined in Section 3(b)
of the Federal Deposit Insurance Act (12 U.S.C. 1813);</font></p>

<p style="margin: 0in 0in 12pt 93.5pt; text-indent: -46.7pt; text-align: left;" align="left"><font style="font-size: 12pt;" face="Wingdings" lang="EN-US">&#168;</font><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">&nbsp;&nbsp;&nbsp;&nbsp;
(i)&nbsp;&nbsp;&nbsp; A church plan that is excluded from the
definition of an investment company under section 3(c)(14) of
the&nbsp;&nbsp;&nbsp;&nbsp; Investment Company Act of 1940 (15 U.S.C.
80a-3);</font></p>

<p style="margin: 0in 0in 12pt 0.65in; text-indent: 0in; text-align: left;" align="left"><font style="font-size: 12pt;" face="Wingdings" lang="EN-US">&#168;</font><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">&nbsp;&nbsp;&nbsp;&nbsp;
(j)&nbsp;&nbsp;&nbsp; Group, in accordance with &#167;240.13d-1(b)(1)(ii)(J).</font></p>

<p style="margin: 0in 0in 12pt 45pt; text-indent: -45pt;"><b><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">Item
4.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Ownership.<sup>1</sup></font></div></b></p>

<p style="margin: 0in 0in 12pt; text-indent: 0.65in; text-align: justify;"><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">Reference
is hereby made to Items 5-9 and 11 of this Schedule above,
which Items are incorporated by reference herein.</font></p>


<div style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif; TEXT-ALIGN: left"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller">1</sup> Represented in part by 2,060,000 Warrants to purchase common stock, which may be exchanged for ordinary shares, par value $0.01 per share, at a 1:1 ratio.</div><BR>

<p style="margin: 0in 0in 12pt 45pt; text-indent: -45pt;"><b><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">Item
5.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Ownership of Five Percent or Less of a
Class</font></b></p>

<p style="margin: 0in 0in 12pt; text-indent: 0.65in; text-align: justify;"><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the&nbsp;</font><font style="font-size: 10pt;" color="black" face="Times New Roman" lang="EN-US">beneficial</font><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">&nbsp;owner of more than five percent of the class of securities, check the following&nbsp; [ ].</font></p>

<p style="margin: 0in 0in 12pt 45pt; text-indent: -45pt;"><b><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">Item
6.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Ownership of More than Five Percent on
Behalf of Another Person.</font></b></p>

<p style="margin: 0in 0in 12pt; text-indent: 0.65in; text-align: justify;"><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">N/A</font></p>

<p style="margin: 0in 0in 12pt 45pt; text-indent: -45pt;"><b><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">Item
7.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Identification and Classification of
the Subsidiary Which Acquired the Security Being Reported on By the
Parent Holding Company</font></b></p>

<p style="margin: 0in 0in 12pt; text-indent: 0.65in; text-align: justify;"><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">If a parent holding company or control person has filed this schedule, pursuant to Rule 13d-1(b)(1)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company or control person has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary. </font></p>

<p style="margin: 0in 0in 12pt; text-indent: 0.65in; text-align: justify;"><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">See Exhibit B attached hereto.</font></p>

<p style="margin: 0in 0in 12pt 45pt; text-indent: -45pt;"><b><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">Item
8.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Identification and Classification of
Members of the Group</font></b></p>

<p style="margin: 0in 0in 12pt; text-indent: 0.65in; text-align: justify;"><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">Not
Applicable.</font></p>

<p style="margin: 0in 0in 12pt 45pt; text-indent: -45pt;"><b><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">Item
9.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Notice of Dissolution of Group</font></b></p>

<p style="margin: 0in 0in 12pt; text-indent: 0.65in; text-align: justify;"><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">Not
Applicable.</font></p>

<p style="margin: 0in 0in 12pt 45pt; text-indent: -45pt;"><b><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">Item
10.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Certification</font></b></p>

<p style="margin: 0in 0in 12pt; text-indent: 0.65in; text-align: justify;"><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">By
signing below the undersigned certify that, to the best of their
knowledge and belief, the securities referred to above were acquired
and are held in the ordinary course of business and were not acquired
and are not held for the purpose of or with the effect of changing or
influencing the control of the issuer of the securities and were not
acquired and are not held in connection with or as a participant in any
transaction having that purpose or effect.</font></p>

<p style="margin: 0in 0in 12pt; text-indent: 0in; text-align: center;" align="center"><b><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">Signature</font></b></p>

<p style="margin: 0in 0in 12pt; text-indent: 0in; text-align: center;" align="center"><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US"></font></p>

<p style="margin: 0in 0in 12pt; text-indent: 0.65in; text-align: justify;"><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">After
reasonable inquiry and to the best of my knowledge and belief, the
undersigned certifies that the information set forth in this statement
is true, complete and correct.</font></p>

<div align="left">
<table style=border="0" cellpadding="0" cellspacing="0" width="100%">

    <tr style="page-break-inside: avoid;">
      <td style="padding: 0in 5.75pt;" valign="top" width="47%">
      <p style="margin: 0in 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">Dated:&nbsp; Feburary 14, 2018</font></p>
      </td>
      <td style="padding: 0in 5.75pt;" valign="top" width="53%">
      <p style="margin: 0in 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">REDMILE GROUP, LLC</font></p>
      <p style="margin: 0in 0in 0pt;">&nbsp;</p>
      <p style="margin: 0in 0in 0pt;">&nbsp;</p>
      <p style="margin: 0in 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">By:&nbsp;&nbsp;&nbsp; </font><u><font style="font-size: 10pt;" face="Times New Roman">/s/ Jeremy C. Green</font></u></p>
      <p style="margin: 0in 0in 0pt 24.3pt;"><font style="font-size: 10pt;" face="Times New Roman">Name: Jeremy C. Green</font></p>
      <p style="margin: 0in 0in 0pt 24.3pt;"><font style="font-size: 10pt;" face="Times New Roman">Title: Managing Member</font></p>
      <p style="margin: 0in 0in 0pt;">&nbsp;</p>
      </td>
    </tr>
<tr style="page-break-inside: avoid;">
      <td style="padding: 0in 5.75pt;" valign="top" width="47%">
      <p style="margin: 0in 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman"></font></p>
      </td>
      <td style="padding: 0in 5.75pt;" valign="top" width="53%">
      <p style="margin: 0in 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">JEREMY C. GREEN</font></p>
      <p style="margin: 0in 0in 0pt;">&nbsp;</p>
      <p style="margin: 0in 0in 0pt;">&nbsp;</p>
      <p style="margin: 0in 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">By:&nbsp;&nbsp;&nbsp; </font><u><font style="font-size: 10pt;" face="Times New Roman">/s/ Jeremy C. Green</font></u></p>
      <p style="margin: 0in 0in 0pt 24.3pt;"><font style="font-size: 10pt;" face="Times New Roman">Jeremy C. Green</font></p>
      <p style="margin: 0in 0in 0pt;">&nbsp;</p>
      </td>
    </tr>
</p></table>

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<p style="margin: 0in 0in 12pt; text-indent: 0in; text-align: center;" align="center"><b><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">Exhibit A</font></b></p>

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<p style="margin: 0in 0in 12pt; text-indent: 0.65in; text-align: justify;"><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">The undersigned agree that this Schedule 13G, dated Feburary 14, 2018, relating to the common stock, par value $0.001, of Amicus Therapeutics, Inc., shall be filed on behalf of the undersigned.</font></p>

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      <p style="margin: 0in 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">Dated:&nbsp; Feburary 14, 2018</font></p>
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      <p style="margin: 0in 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">REDMILE GROUP, LLC</font></p>
      <p style="margin: 0in 0in 0pt;">&nbsp;</p>
      <p style="margin: 0in 0in 0pt;">&nbsp;</p>
      <p style="margin: 0in 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">By:&nbsp;&nbsp;&nbsp; </font><u><font style="font-size: 10pt;" face="Times New Roman">/s/ Jeremy C. Green</font></u></p>
      <p style="margin: 0in 0in 0pt 24.3pt;"><font style="font-size: 10pt;" face="Times New Roman">Name: Jeremy C. Green</font></p>
      <p style="margin: 0in 0in 0pt 24.3pt;"><font style="font-size: 10pt;" face="Times New Roman">Title: Managing Member</font></p>
      <p style="margin: 0in 0in 0pt;">&nbsp;</p>
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      <p style="margin: 0in 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">JEREMY C. GREEN</font></p>
      <p style="margin: 0in 0in 0pt;">&nbsp;</p>
      <p style="margin: 0in 0in 0pt;">&nbsp;</p>
      <p style="margin: 0in 0in 0pt;"><font style="font-size: 10pt;" face="Times New Roman">By:&nbsp;&nbsp;&nbsp; </font><u><font style="font-size: 10pt;" face="Times New Roman">/s/ Jeremy C. Green</font></u></p>
      <p style="margin: 0in 0in 0pt 24.3pt;"><font style="font-size: 10pt;" face="Times New Roman">Jeremy C. Green</font></p>
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<p style="margin: 0in 0in 12pt; text-indent: 0in; text-align: center;" align="center"><b><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">Exhibit B</font></b></p>

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<p style="margin: 0in 0in 12pt; text-indent: 0.65in; text-align: justify;"><font style="font-size: 10pt;" face="Times New Roman" lang="EN-US">Redmile Group, LLC is the relevant entity for which Jeremy C. Green may be considered a control person.</font></p>




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