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Income Taxes - Statutory Rate (Details) - USD ($) |  | 12 Months Ended
--- | --- | ---
Dec. 22, 2017 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Income (loss) before income taxes: |  |  |  |
United States |  | $ (309,183,000) | $ (440,696,000) | $ (174,913,000)
Foreign |  | (39,906,000) | (8,425,000) | (28,868,000)
Loss before income tax |  | (349,089,000) | (449,121,000) | (203,781,000)
Current |  |  |  |
Federal |  | 0 | 0 | 0
State |  | 6,000 | 9,000 | 7,000
Foreign |  | (100,000) | 2,276,000 | 0
Deferred |  |  |  |
Federal |  | 0 | (150,015,000) | (1,101,000)
State |  | 0 | (17,389,000) | (2,645,000)
Foreign |  | 0 | 0 | 0
Total |  | $ (94,000) | $ (165,119,000) | $ (3,739,000)
Reconciliation of the statutory tax rates and the effective tax rates |  |  |  |
Statutory rate | (21.00%) | (21.00%) | (34.00%) | (34.00%)
State taxes, net of federal benefit |  | (4.00%) | (5.00%) | (5.00%)
Nondeductible IPR&D |  | 6.00% | (1.00%) | 3.00%
Contingent consideration |  | 1.00% | (18.00%) | (0.00%)
Tax credits |  | (10.00%) | (2.00%) | (3.00%)
Foreign income tax rate differential |  | 2.00% | 5.00% | 2.00%
Impact of 2017 Act |  | (0.00%) | 27.00% | (0.00%)
Other |  | (0.00%) | 5.00% | (1.00%)
Valuation allowance |  | 26.00% | (14.00%) | 36.00%
Net |  | (0.00%) | (37.00%) | (2.00%)
Income tax benefit |  | $ (94,000) | $ (165,119,000) | $ (3,739,000)
Foreign and state income tax expense (benefits) |  | (100,000) |  |
Accrual for interest and penalties |  | 0 |  |
Accrual for uncertain tax positions |  | $ 0 |  |

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- Definition Amount accrued for interest on an underpayment of income taxes and penalties related to a tax position claimed or expected to be claimed in the tax return. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 15 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32718-109319 + Details
Name: | us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestAccrued
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | instant