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Accounts Payable and Accrued Expenses (Details) - USD ($) $ in Thousands | Dec. 31, 2018 | Dec. 31, 2017
--- | --- | ---
Accounts payable and accrued expenses |  |
Accounts payable | $ 6,606 | $ 7,867
Accrued professional fees | 2,276 | 5,845
Accrued contract manufacturing & contract research costs | 5,890 | 4,632
Accrued compensation and benefits | 21,731 | 19,620
Accrued facility costs | 2,102 | 1,665
Accrued program fees | 16,674 | 5,707
Royalties payable | 4,463 | 2,529
Accrued interest | 4,189 | 313
Milestone payments | 9,000 | 0
Accrued sales rebates and discounts | 3,636 | 1,957
Other | 4,058 | 3,755
Accounts payable and accrued expenses | $ 80,625 | $ 53,890

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