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Share based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2018
Disclosure of Compensation Related Costs, Share-based Payments [Abstract] |
Schedule of Fair Value of Options | The fair value of the stock options granted is estimated on the date of grant using a Black-Scholes option pricing model with the following weighted-average assumptions:
| Years Ended December 31,
| 2018 |  | 2017 |  | 2016
Expected stock price volatility | 78.6 | % |  | 82.8 | % |  | 81.3 | %
Risk free interest rate | 2.4 | % |  | 2.0 | % |  | 1.5 | %
Expected life of options (years) | 5.62 |  |  | 6.18 |  |  | 6.25 |
Expected annual dividend per share | $ | 0.00 |  |  | $ | 0.00 |  |  | $ | 0.00 |
Schedule of Stock Options Activity | A summary of the Company's stock options for the year ended December 31, 2018 were as follows:
| Number of Shares |  | Weighted Average Exercise Price |  | Weighted Average Remaining Contractual Life |  | Aggregate Intrinsic Value
| (in thousands) |  |  |  |  |  | (in millions)
Options outstanding, December 31, 2015 | 11,729.2 |  |  | $ | 7.11 |  |  |  |  |
Granted | 5,114.1 |  |  | $ | 7.67 |  |  |  |  |
Exercised | (723.1 | ) |  | $ | 4.20 |  |  |  |  |
Forfeited | (622.7 | ) |  | $ | 8.62 |  |  |  |  |
Options outstanding, December 31, 2016 | 15,497.5 |  |  | $ | 7.37 |  |  |  |  |
Granted | 3,695.3 |  |  | $ | 7.17 |  |  |  |  |
Exercised | (2,878.7 | ) |  | $ | 5.67 |  |  |  |  |
Forfeited | (1,133.0 | ) |  | $ | 9.55 |  |  |  |  |
Options outstanding, December 31, 2017 | 15,181.1 |  |  | $ | 7.48 |  |  |  |  |
Granted | 2,348.0 |  |  | $ | 14.96 |  |  |  |  |
Exercised | (1,398.0 | ) |  | $ | 6.54 |  |  |  |  |
Forfeited | (313.1 | ) |  | $ | 9.55 |  |  |  |  |
Expired | (8.0 | ) |  | 10.76 |  |  |  |
Options outstanding, December 31, 2018 | 15,810.0 |  |  | $ | 8.63 |  |  | 6.7 years |  | $ | 37.6 |
Vested and unvested expected to vest, December 31, 2018 | 15,152.6 |  |  | $ | 8.51 |  |  | 6.6 years |  | $ | 36.8 |
Exercisable at December 31, 2018 | 9,977.0 |  |  | $ | 7.43 |  |  | 5.8 years |  | $ | 28.8 |
Schedule of Non-Vested RSU Activity under the Plan | A summary of non-vested RSU activity under the Plan for the year ended December 31, 2018 is as follows:
| Number of Share |  | Weighted Average Grant Date Fair Value |  | Weighted Average Remaining Years |  | Aggregate Intrinsic Value
| (in thousands) |  |  |  |  |  | (in millions)
Non-vested units as of December 31, 2016 | 744.4 |  |  | $ | 7.86 |  |  |  |  |
Granted | 2,348.7 |  |  | $ | 5.69 |  |  |  |  |
Vested | (318.2 | ) |  | $ | 9.23 |  |  |  |  |
Forfeited | (199.8 | ) |  | $ | 6.24 |  |  |  |  |
Non-vested units as of December 31, 2017 | 2,575.1 |  |  | $ | 5.85 |  |  |  |  |
Granted | 1,811.9 |  |  | $ | 16.11 |  |  |  |  |
Vested | (530.0 | ) |  | $ | 6.01 |  |  |  |  |
Forfeited | (145.0 | ) |  | $ | 9.65 |  |  |  |  |
Non-vested units as of December 31, 2018 | 3,712.0 |  |  | $ | 10.59 |  |  | 2.57 |  | $ | 36.3 |
Schedule of Equity Compensation Expenses | The following table summarizes information related to compensation expense recognized in the statements of operations related to the equity awards:
| Years Ended December 31,
| 2018 |  | 2017 |  | 2016
Equity compensation expense recognized in: |  |  |  |  |
Research and development expense | $ | 11,740 |  |  | $ | 10,328 |  |  | $ | 8,071 |
Selling, general and administrative expense | 17,520 |  |  | 12,773 |  |  | 9,433 |
Total equity compensation expense | $ | 29,260 |  |  | $ | 23,101 |  |  | $ | 17,504 |

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- Definition Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -URI http://asc.fasb.org/extlink&oid=115993241&loc=d3e301413-122809 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5047-113901 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d) -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901 + Details
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- Definition Disclosure of the number and weighted-average grant date fair value for restricted stock and restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock and restricted stock units that were granted, vested, or forfeited during the year. + References No definition available. + Details
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