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v3.10.0.1

Consolidated Statements of Operations - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Revenue: |  |  |
Net product sales | $ 91,245 | $ 36,930 | $ 4,958
Cost of goods sold | 14,404 | 6,236 | 833
Gross profit | 76,841 | 30,694 | 4,125
Operating expenses: |  |  |
Research and development | 270,902 | 149,310 | 104,793
Selling, general and administrative | 127,200 | 88,671 | 71,151
Unrealized change in fair value change during the period, included in Statement of Operations | 3,300 | (234,322) | 6,760
Loss on impairment of assets | 0 | 465,427 | 0
Restructuring charges | 0 | 0 | 69
Depreciation | 4,216 | 3,593 | 3,242
Total operating expenses | 405,618 | 472,679 | 186,015
Loss from operations | (328,777) | (441,985) | (181,890)
Other income (expenses): |  |  |
Interest income | 10,461 | 4,096 | 1,602
Interest expense | (22,402) | (17,240) | (5,398)
Change in fair value of derivatives | (2,739) | 0 | 0
Loss on extinguishment of debt | 0 | 0 | (13,302)
Other income (expense) | (5,632) | 6,008 | (4,793)
Loss before income tax | (349,089) | (449,121) | (203,781)
Income tax benefit | 94 | 165,119 | 3,739
Net loss attributable to common stockholders | $ (348,995) | $ (284,002) | $ (200,042)
Net loss attributable to common stockholders per common share - basic and diluted (in dollars per share) | $ (1.88) | $ (1.85) | $ (1.49)
Weighted-average common shares outstanding - basic and diluted (in shares) | 185,790,021 | 153,355,144 | 134,401,588

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