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Assets and Liabilities Measured at Fair Value (Tables) | 12 Months Ended
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Dec. 31, 2018
Fair Value Disclosures [Abstract] |
Summary of assets and liabilities subject to fair value measurements | A summary of the fair value of the Company's recurring assets and liabilities aggregated by the level in the fair value hierarchy within which those measurements fall as of December 31, 2018 are identified in the following table:
(in thousands) | Level 2 |  | Total
Assets: |  |  |
Commercial paper | $ | 115,141 |  |  | $ | 115,141 |
Asset-back securities | 68,135 |  |  | 68,135 |
Corporate debt securities | 240,726 |  |  | 240,726 |
Money market funds | 3,082 |  |  | 3,082 |
| $ | 427,084 |  |  | $ | 427,084 |
| Level 2 |  | Level 3 |  | Total
Liabilities: |  |  |  |  |
Contingent consideration payable | $ | — |  |  | $ | 19,700 |  |  | $ | 19,700 |
Deferred compensation plan liability | 2,732 |  |  | — |  |  | 2,732 |
| $ | 2,732 |  |  | $ | 19,700 |  |  | $ | 22,432 |
A summary of the fair value of the Company's assets and liabilities aggregated by the level in the fair value hierarchy within which those measurements fall as of December 31, 2017 are identified in the following table:
(in thousands) | Level 2 |  | Total
Assets: |  |  |
Commercial paper | $ | 79,803 |  |  | $ | 79,803 |
Asset-back securities | 30,287 |  |  | 30,287 |
Corporate debt securities | 199,012 |  |  | 199,012 |
Money market funds | 2,598 |  |  | 2,598 |
| $ | 311,700 |  |  | $ | 311,700 |
| Level 2 |  | Level 3 |  | Total
Liabilities: |  |  |  |  |
Contingent consideration payable | $ | — |  |  | $ | 25,400 |  |  | $ | 25,400 |
Deferred compensation plan liability | 2,258 |  |  | — |  |  | 2,258 |
| $ | 2,258 |  |  | $ | 25,400 |  |  | $ | 27,658 |
Schedule of significant unobservable inputs used in the valuation of the contingent consideration payable | The following significant unobservable inputs were used in the valuation of the contingent consideration payable of Callidus for the ATB-200 Pompe program:
Contingent Consideration Liability |  | Fair value as of December 31, 2018 |  | Valuation Technique |  | Unobservable Input |  | Range
|  |  |  |  |  | Discount rate |  | 10%
Clinical and regulatory milestones |  | $19.2 million |  | Probability weighted discounted cash flow |  | Probability of achievement of milestones |  | 71.0% - 100.0%
|  |  |  |  |  | Projected year of payments |  | 2021 - 2022
Schedule of changes in contingent consideration payable | The following table shows the change in the balance of contingent consideration payable for the year ended December 31, 2018 and 2017, respectively:
| Year ended December 31,
(in thousands) | 2018 |  | 2017
Balance, beginning of the period | $ | 25,400 |  |  | $ | 269,722 |
Payment of contingent consideration in cash | — |  |  | (10,000 | )
Milestone payable, included in accrued expenses | (9,000 | ) |  | — |
Unrealized change in fair value change during the period, included in Statement of Operations | 3,300 |  |  | (234,322 | )
Balance, end of the period | $ | 19,700 |  |  | $ | 25,400 |

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- Definition Tabular disclosure of financial instruments measured at fair value, including those classified in shareholders' equity measured on a recurring or nonrecurring basis. Disclosures include, but are not limited to, fair value measurements recorded and the reasons for the measurements, level within the fair value hierarchy in which the fair value measurements are categorized and transfers between levels 1 and 2. Nonrecurring fair value measurements are those that are required or permitted in the statement of financial position in particular circumstances. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=99377789&loc=d3e19207-110258 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 3 -URI http://asc.fasb.org/extlink&oid=99377789&loc=d3e19279-110258 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2C -URI http://asc.fasb.org/extlink&oid=99377789&loc=SL7498348-110258 Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=99377789&loc=d3e19190-110258 Reference 5: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=99377789&loc=d3e19207-110258 Reference 6: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (bb) -URI http://asc.fasb.org/extlink&oid=99377789&loc=d3e19207-110258 + Details
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- Definition Tabular disclosure of input and valuation technique used to measure fair value and change in valuation approach and technique for each separate class of asset and liability measured on recurring and nonrecurring basis. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (bbb) -URI http://asc.fasb.org/extlink&oid=99377789&loc=d3e19207-110258 + Details
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- Definition Tabular disclosure of contingent payment arrangements including the terms that will result in payment and the accounting treatment that will be followed if such contingencies occur, including the potential impact on earnings per share if contingencies are to be settled in common stock of the entity. The description also may include the period over which amounts are expected to be paid, and changes in the amount since the previous reporting period. This also includes contingent options and commitments. + References No definition available. + Details
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