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Leases (Details) $ in Thousands | 12 Months Ended |
--- | --- | ---
Dec. 31, 2018 USD ($) ft² | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($) | Mar. 31, 2019 USD ($)
Minimum lease payments |  |  |  |
2019 | $ 6,244 |  |  |
2020 | 4,063 |  |  |
2021 | 3,560 |  |  |
2022 | 3,371 |  |  |
2023 and beyond | 13,649 |  |  |
Total | 30,887 |  |  |
Rent expense, including fees for utilities and common area maintenances | 5,700 | $ 3,900 | $ 3,500 |
Minimum | Forecast |  |  |  |
Minimum lease payments |  |  |  |
Future lease payments, 2019 |  |  |  | $ 1,500
Future lease payments, 2020 |  |  |  | 1,500
Future lease payments, 2021 |  |  |  | 1,500
Future lease payments, 2022 |  |  |  | 1,500
Future lease payments, 2023 |  |  |  | 1,500
Maximum | Forecast |  |  |  |
Minimum lease payments |  |  |  |
Future lease payments, 2019 |  |  |  | 6,100
Future lease payments, 2020 |  |  |  | 6,000
Future lease payments, 2021 |  |  |  | 6,000
Future lease payments, 2022 |  |  |  | 6,000
Future lease payments, 2023 |  |  |  | $ 6,000
Equipment |  |  |  |
Capital Leases |  |  |  |
Capital lease obligation | 200 |  | $ 900 |
2019 | 194 |  |  |
2020 | 60 |  |  |
2021 | 47 |  |  |
2022 | 30 |  |  |
2023 and beyond | 0 |  |  |
Total principal obligation | $ 331 |  |  |
Equipment | Minimum |  |  |  |
Capital Leases |  |  |  |
Fixed interest rate |  | 5.00% | 2.00% |
Term of capital lease |  | 36 months | 36 months |
Equipment | Maximum |  |  |  |
Capital Leases |  |  |  |
Fixed interest rate |  | 7.00% | 5.70% |
Term of capital lease |  | 48 months | 48 months |
Cranbury, New Jersey | Office and laboratory |  |  |  |
Operating Leased Assets [Line Items] |  |  |  |
Area of space leased (in square feet) | ft² | 90,000 |  |  |
United Kingdom | Office |  |  |  |
Operating Leased Assets [Line Items] |  |  |  |
Area of space leased (in square feet) | ft² | 46,617 |  |  |
Princeton, New Jersey | Office |  |  |  |
Operating Leased Assets [Line Items] |  |  |  |
Area of space leased (in square feet) | ft² | 21,922 |  |  |

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