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Assets and Liabilities Measured at Fair Value (Details) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($)
Assets: |  |  |
Fair value of assets | $ 427,084 | $ 311,700 |
Liabilities: |  |  |
Contingent consideration payable | 19,700 | 25,400 |
Deferred compensation plan liability | 2,732 | 2,258 |
Fair value of liabilities | 22,432 | 27,658 |
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] |  |  |
Balance, beginning of the period | 25,400 | 269,722 |
Payment of contingent consideration in cash | 0 | (10,000) | $ (5,000)
Milestone payable, included in accrued expenses | (9,000) | 0 |
Unrealized change in fair value change during the period, included in Statement of Operations | 3,300 | (234,322) | 6,760
Balance, end of the period | 19,700 | 25,400 | $ 269,722
Callidus |  |  |
Liabilities: |  |  |
Contingent consideration payable | 28,700 |  |
ATB-200 Pompe Program | Clinical and Regulatory Approval milestones | Callidus |  |  |
Liabilities: |  |  |
Contingent consideration payable | $ 19,200 |  |
ATB-200 Pompe Program | Minimum | Clinical and Regulatory Approval milestones | Callidus | Probability of Milestone Achievement |  |  |
Liabilities: |  |  |
Contingent consideration, measurement input | 0.710 |  |
ATB-200 Pompe Program | Maximum | Clinical and Regulatory Approval milestones | Callidus | Probability of Milestone Achievement |  |  |
Liabilities: |  |  |
Contingent consideration, measurement input | 1 |  |
Convertible Notes | 2016 Convertible Notes |  |  |
Liabilities: |  |  |
Fair value of the debt | $ 437,100 |  |
Commercial paper |  |  |
Assets: |  |  |
Fair value of assets | 115,141 | 79,803 |
Asset-backed securities |  |  |
Assets: |  |  |
Fair value of assets | 68,135 | 30,287 |
Corporate debt securities |  |  |
Assets: |  |  |
Fair value of assets | 240,726 | 199,012 |
Money market |  |  |
Assets: |  |  |
Fair value of assets | 3,082 | 2,598 |
Level 2 |  |  |
Assets: |  |  |
Fair value of assets | 427,084 | 311,700 |
Liabilities: |  |  |
Contingent consideration payable | 0 | 0 |
Deferred compensation plan liability | 2,732 | 2,258 |
Fair value of liabilities | 2,732 | 2,258 |
Level 2 | Commercial paper |  |  |
Assets: |  |  |
Fair value of assets | 115,141 | 79,803 |
Level 2 | Asset-backed securities |  |  |
Assets: |  |  |
Fair value of assets | 68,135 | 30,287 |
Level 2 | Corporate debt securities |  |  |
Assets: |  |  |
Fair value of assets | 240,726 | 199,012 |
Level 2 | Money market |  |  |
Assets: |  |  |
Fair value of assets | 3,082 | 2,598 |
Level 3 |  |  |
Liabilities: |  |  |
Contingent consideration payable | 19,700 | 25,400 |
Deferred compensation plan liability | 0 | 0 |
Fair value of liabilities | $ 19,700 | $ 25,400 |
Level 3 | ATB-200 Pompe Program | Clinical and Regulatory Approval milestones | Probability weighted discounted cash flow | Callidus | Discount Rate |  |  |
Liabilities: |  |  |
Contingent consideration, measurement input | 0.10 |  |

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