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Collaborative Agreements (Details) | 1 Months Ended | 12 Months Ended
--- | --- | ---
Oct. 31, 2018 USD ($) | Nov. 30, 2013 USD ($) | Dec. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($)
Collaborative Agreements |  |  |  |  |
Revenue recognized |  |  | $ 91,245,000 | $ 36,930,000 | $ 4,958,000
Deferred reimbursements |  |  | 10,156,000 | 14,156,000 |
Accounts payable, accrued expenses, and other current liabilities |  |  | 80,625,000 | $ 53,890,000 |
Collaborative Arrangements |  |  |  |  |
Collaborative Agreements |  |  |  |  |
Payments for collaborative agreement | $ 7,000,000 |  |  |  |
Conditional aggregate payments per indication | $ 86,500,000 |  |  |  |
Collaborative Arrangements | GSK |  |  |  |  |
Collaborative Agreements |  |  |  |  |
Payments for collaborative agreement |  |  | 1,300,000 |  |
Revised Agreement | GSK |  |  |  |  |
Collaborative Agreements |  |  |  |  |
Upfront payment received |  | $ 0 |  |  |
Potential milestone payments upon achievement of post-approval and sales-based milestones |  | $ 40,000,000 |  |  |
Number of major markets outside the U.S. from whom parties to contractual arrangement is eligible to receive post-approval and sales-based milestones |  | 8 |  |  |
Revenue recognized |  |  | 6,900,000 |  |
Deferred reimbursements |  |  | 15,700,000 |  |
Accounts payable, accrued expenses, and other current liabilities |  |  | $ 3,400,000 |  |

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- Definition Represents the amount of potential payments upon achievement of post-approval and sales-based milestones. + References No definition available. + Details
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- Definition Represents information pertaining to the number of major markets outside the U.S. from whom parties to contractual arrangement is eligible to receive post-approval and sales-based milestones. + References No definition available. + Details
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- Definition Payments For Collaborative Arrangement + References No definition available. + Details
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- Definition Sum of the carrying values as of the balance sheet date of obligations incurred through that date and due within one year (or the operating cycle, if longer), including liabilities incurred (and for which invoices have typically been received) and payable to vendors for goods and services received, taxes, interest, rent and utilities, accrued salaries and bonuses, payroll taxes and fringe benefits. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.19,20) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
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- Definition Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. + References No definition available. + Details
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- Definition Carrying amount as of the balance sheet date of unearned revenue or income, not otherwise specified in the taxonomy, which is expected to be taken into income after one year or beyond the normal operating cycle, if longer and noncurrent obligations not separately disclosed in the balance sheet (other liabilities, noncurrent). + References No definition available. + Details
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- Definition Amount, including tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value-added and excise. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109196051&loc=SL49130539-203045 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=109196051&loc=SL49130545-203045 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 4 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109196051&loc=SL49130543-203045 + Details
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