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Share based Compensation (Tables)
 12 Months Ended
Dec. 31, 2018
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Schedule of Fair Value of Options
The fair value of the stock options granted is estimated on the date of grant using a Black-Scholes option pricing model with the following weighted-average assumptions:
 
Years Ended
December 31,
 
2018
 
2017
 
2016
Expected stock price volatility
78.6
%
 
82.8
%
 
81.3
%
Risk free interest rate
2.4
%
 
2.0
%
 
1.5
%
Expected life of options (years)
5.62

 
6.18

 
6.25

Expected annual dividend per share
$
0.00

 
$
0.00

 
$
0.00
Schedule of Stock Options Activity
A summary of the Company's stock options for the year ended December 31, 2018 were as follows:
 
Number of
Shares
 
Weighted
Average
Exercise
Price
 
Weighted
Average
Remaining
Contractual
Life
 
Aggregate
Intrinsic
Value
 
(in thousands)
 
 
 
 
 
(in millions)
Options outstanding, December 31, 2015
11,729.2

 
$
7.11

 
 
 
 
Granted
5,114.1

 
$
7.67

 
 
 
 
Exercised
(723.1
)
 
$
4.20

 
 
 
 
Forfeited
(622.7
)
 
$
8.62

 
 
 
 
Options outstanding, December 31, 2016
15,497.5

 
$
7.37

 
 
 
 
Granted
3,695.3

 
$
7.17

 
 
 
 
Exercised
(2,878.7
)
 
$
5.67

 
 
 
 
Forfeited
(1,133.0
)
 
$
9.55

 
 
 
 
Options outstanding, December 31, 2017
15,181.1

 
$
7.48

 
 
 
 
Granted
2,348.0

 
$
14.96

 
 
 
 
Exercised
(1,398.0
)
 
$
6.54

 
 
 
 
Forfeited
(313.1
)
 
$
9.55

 
 
 
 
Expired
(8.0
)
 
10.76
 
 
 
 
Options outstanding, December 31, 2018
15,810.0

 
$
8.63

 
6.7 years
 
$
37.6

Vested and unvested expected to vest, December 31, 2018
15,152.6

 
$
8.51

 
6.6 years
 
$
36.8

Exercisable at December 31, 2018
9,977.0

 
$
7.43

 
5.8 years
 
$
28.8
Schedule of Non-Vested RSU Activity under the Plan
A summary of non-vested RSU activity under the Plan for the year ended December 31, 2018 is as follows:
 
Number of
Share
 
Weighted
Average Grant
Date Fair
Value
 
Weighted
Average
Remaining
Years
 
Aggregate
Intrinsic
Value
 
(in thousands)
 
 
 
 
 
(in millions)
Non-vested units as of December 31, 2016
744.4

 
$
7.86

 
 
 
 
Granted
2,348.7

 
$
5.69

 
 
 
 
Vested
(318.2
)
 
$
9.23

 
 
 
 
Forfeited
(199.8
)
 
$
6.24

 
 
 
 
Non-vested units as of December 31, 2017
2,575.1

 
$
5.85

 
 
 
 
Granted
1,811.9

 
$
16.11

 
 
 
 
Vested
(530.0
)
 
$
6.01

 
 
 
 
Forfeited
(145.0
)
 
$
9.65

 
 
 
 
Non-vested units as of December 31, 2018
3,712.0

 
$
10.59

 
2.57
 
$
36.3
Schedule of Equity Compensation Expenses
The following table summarizes information related to compensation expense recognized in the statements of operations related to the equity awards:
 
Years Ended December 31,
 
2018
 
2017
 
2016
Equity compensation expense recognized in:
 
 
 
 
 
Research and development expense
$
11,740

 
$
10,328

 
$
8,071

Selling, general and administrative expense
17,520

 
12,773

 
9,433

Total equity compensation expense
$
29,260

 
$
23,101

 
$
17,504