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Assets and Liabilities Measured at Fair Value (Tables)

12 Months Ended

Dec. 31, 2018

Fair Value Disclosures [Abstract]

Summary of assets and liabilities subject to fair value measurements

A summary of the fair value of the Company's recurring assets and liabilities aggregated by the level in the fair value hierarchy within which those measurements fall as of December 31, 2018 are identified in the following table:

(in thousands)	Level 2				Total
Assets:
Commercial paper	$	115,141			$	115,141
Asset-back securities	68,135				68,135
Corporate debt securities	240,726				240,726
Money market funds	3,082				3,082
	$	427,084			$	427,084

	Level 2				Level 3				Total
Liabilities:
Contingent consideration payable	$	—			$	19,700			$	19,700
Deferred compensation plan liability	2,732				—				2,732
	$	2,732			$	19,700			$	22,432

A summary of the fair value of the Company's assets and liabilities aggregated by the level in the fair value hierarchy within which those measurements fall as of December 31, 2017 are identified in the following table:

(in thousands)	Level 2				Total
Assets:
Commercial paper	$	79,803			$	79,803
Asset-back securities	30,287				30,287
Corporate debt securities	199,012				199,012
Money market funds	2,598				2,598
	$	311,700			$	311,700

	Level 2				Level 3				Total
Liabilities:
Contingent consideration payable	$	—			$	25,400			$	25,400
Deferred compensation plan liability	2,258				—				2,258
	$	2,258			$	25,400			$	27,658

Schedule of significant unobservable inputs used in the valuation of the contingent consideration payable

The following significant unobservable inputs were used in the valuation of the contingent consideration payable of Callidus for the ATB-200 Pompe program:

Contingent Consideration Liability		Fair value as of December 31, 2018		Valuation Technique		Unobservable Input		Range
						Discount rate		10%
Clinical and regulatory milestones		$19.2 million		Probability weighted discounted cash flow		Probability of achievement of milestones		71.0% - 100.0%
						Projected year of payments		2021 - 2022

Schedule of changes in contingent consideration payable

The following table shows the change in the balance of contingent consideration payable for the year ended December 31, 2018 and 2017, respectively:

	Year ended December 31,
(in thousands)	2018				2017
Balance, beginning of the period	$	25,400			$	269,722
Payment of contingent consideration in cash	—				(10,000		)
Milestone payable, included in accrued expenses	(9,000		)		—
Unrealized change in fair value change during the period, included in Statement of Operations	3,300				(234,322		)
Balance, end of the period	$	19,700			$	25,400

X

- Definition

Tabular disclosure of financial instruments measured at fair value, including those classified in shareholders' equity measured on a recurring or nonrecurring basis. Disclosures include, but are not limited to, fair value measurements recorded and the reasons for the measurements, level within the fair value hierarchy in which the fair value measurements are categorized and transfers between levels 1 and 2. Nonrecurring fair value measurements are those that are required or permitted in the statement of financial position in particular circumstances.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 820
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=99377789&loc=d3e19207-110258

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- Definition

Tabular disclosure of input and valuation technique used to measure fair value and change in valuation approach and technique for each separate class of asset and liability measured on recurring and nonrecurring basis.

+ References

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 820
-SubTopic 10
-Section 50
-Paragraph 2
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- Definition

Tabular disclosure of contingent payment arrangements including the terms that will result in payment and the accounting treatment that will be followed if such contingencies occur, including the potential impact on earnings per share if contingencies are to be settled in common stock of the entity. The description also may include the period over which amounts are expected to be paid, and changes in the amount since the previous reporting period. This also includes contingent options and commitments.

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