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Consolidated Statements of Operations - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Revenue:      
Net product sales $ 91,245 $ 36,930 $ 4,958
Cost of goods sold 14,404 6,236 833
Gross profit 76,841 30,694 4,125
Operating expenses:      
Research and development 270,902 149,310 104,793
Selling, general and administrative 127,200 88,671 71,151
Unrealized change in fair value change during the period, included in Statement of Operations 3,300 (234,322) 6,760
Loss on impairment of assets 0 465,427 0
Restructuring charges 0 0 69
Depreciation 4,216 3,593 3,242
Total operating expenses 405,618 472,679 186,015
Loss from operations (328,777) (441,985) (181,890)
Other income (expenses):      
Interest income 10,461 4,096 1,602
Interest expense (22,402) (17,240) (5,398)
Change in fair value of derivatives (2,739) 0 0
Loss on extinguishment of debt 0 0 (13,302)
Other income (expense) (5,632) 6,008 (4,793)
Loss before income tax (349,089) (449,121) (203,781)
Income tax benefit 94 165,119 3,739
Net loss attributable to common stockholders $ (348,995) $ (284,002) $ (200,042)
Net loss attributable to common stockholders per common share - basic and diluted (in dollars per share) $ (1.88) $ (1.85) $ (1.49)
Weighted-average common shares outstanding - basic and diluted (in shares) 185,790,021 153,355,144 134,401,588